Composite medicine for treating male's impotence and prospermia and its prepn process

A drug and impotence technology, applied in the field of drugs, can solve the problems of inconvenience, pain and local tissue necrosis, and achieve the effects of non-invasiveness, good drug absorption, and improved curative effect

Inactive Publication Date: 2002-12-11
陈建明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, the injection of lidocaine into the cavernous body has obvious therapeutic effects on premature ejaculation, but local injection is easy to cause pain and local tissue necrosis, and it is inconvenient to use. At present, there is no good drug for treating impotence and premature ejaculation at the same time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 2

[0050] Phentolamine mesylate 21.7g (or lidocaine 80g), Tween-80 50g, stearic acid 120g, glyceryl monostearate 50g, stearyl alcohol 60g, white petrolatum 50g, liquid paraffin 60ml, Ethyl parkinate 1g, propylene glycol 90ml, appropriate amount of essence, distilled water added to 1000g.

[0051] Method: According to the composition of the prescription, take white vaseline, glyceryl monostearate, liquid paraffin, stearic acid and stearyl alcohol, heat and melt in a water bath, keep it warm at about 80°C, and use it as the oil phase; take an appropriate amount of distilled water and heat it in another container until At about 80°C, add ethylparaben and propylene glycol in turn to dissolve, and finally add Tween-80 and stir well as the water phase; slowly add the oil phase to the water phase while stirring, degas at the same time, and keep stirring until it condenses into a paste When the temperature is below 50°C, add phentolamine mesylate aqueous solution (or lidocaine aqueous so...

example 3

[0052] Phentolamine mesylate 21.7g (or lidocaine 80g), sodium lauryl sulfate 10g, stearic acid 100g, glyceryl monostearate 60g, triethanolamine 5g, white petrolatum 50g, liquid paraffin 100ml, propylene glycol 100ml , ethyl paraben 1g, appropriate amount of essence, distilled water added to 1000g.

[0053] Method: According to the composition of the prescription, take stearic acid, glyceryl monostearate, white petrolatum and liquid paraffin in a water bath to heat and melt, keep warm at about 80°C, and use it as the oil phase; Dissolve triethanolamine and propylene glycol in the above water at the same temperature as the water phase; slowly add the oil phase to the water phase while stirring, degas at the same time, keep stirring until it condenses into a paste, and when the temperature is below 50 ° C, add methanesulfonate Acid phentolamine aqueous solution (or lidocaine aqueous solution) is added to the above-mentioned matrix, and an appropriate amount of essence is added, e...

example 4

[0054] Phentolamine Mesylate 21.7g (or Lidocaine 80g), Pinpinga 25g, Stearic Acid 120g, Glyceryl Monostearate 120g, White Petrolatum 40g, Liquid Paraffin 120ml, Propylene Glycol 90ml, Ethyl Paraben 1g, appropriate amount of essence, add distilled water to 1000g.

[0055] Method: Take the oil phase (stearic acid, glyceryl monostearate, white vaseline, liquid paraffin) and water phase (Pinga, ethylparaben, propylene glycol, distilled water) in the prescription and heat them on a water bath to about 85°C, slowly add the oil phase to the water phase while stirring, degas at the same time, keep stirring until it condenses into a paste, and when the temperature is below 50°C, add the phentolamine mesylate aqueous solution (or lidocaine aqueous solution) Add it to the above base, add an appropriate amount of essence, make it even, pack it separately, and get it. Example 5:

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PUM

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Abstract

The composite medicine consists of emulsified transdermal Phentolaminum paste in oil-in-water preparation of 0.5-10 wt% concentration and emulsified transdermal Lidocaine paste in oil-in-water preparation of 1-20 wt% concentration. The preparation process is also disclosed. According to the features of male's sexual dysfunction, the present invention provides the medicine capable of treating bothimpotence and prospermia simultaneously through combining emulsified transdermal Phentolaminum paste and emulsified transdermal Lidocaine paste. The present invention has high curative effect and less side effect.

Description

Technical field: [0001] The invention relates to the field of medicines, in particular to a combined medicine for treating male impotence and premature ejaculation and a preparation method. Background technique: [0002] With the increasing degree of social industrialization, various pollutions such as waste gas and radioactivity are increasing day by day, people's work pressure is increasing day by day, and the body is exhausted, which leads to more and more patients with male sexual dysfunction. It is estimated that at least 80 million Chinese men over the age of 40 suffer from sexual dysfunction. Male sexual dysfunction is mainly manifested as impotence and premature ejaculation. According to traditional medicine, premature ejaculation is the mild or early manifestation of impotence, and impotence is the evolution result of premature ejaculation, that is, severe premature ejaculation can lead to impotence, and impotence is often accompanied by premature ejaculation. There...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61P15/10
Inventor 陈建明傅顺根
Owner 陈建明
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