2 results about "Postmenopausal symptoms" patented technology

This invention provides a traditional Chinese medicine composition, preparation method, and application for treating frequent urination with incontinence in various postmenopausal symptoms. The traditional Chinese medicine composition, by weight, consists of the following raw materials: Astragalus membranaceus 10-20 parts, Codonopsis pilosula 10-15 parts, Atractylodes macrocephala 7.5-10 parts, Ziziphus jujuba var. spinosa 10-15 parts, Mantis religiosa ootheca 4-5 parts, Paeonia lactiflora 7.5-15 parts, Rehmannia glutinosa 6-10 parts, Angelica sinensis 7.5-10 parts, Cinnamomum cassia 1.5-2.5 parts, Poria cocos 6-7.5 parts, Lindera strychnifolia 5-6 parts, Schisandra chinensis 5-6 parts, Psoralea corylifolia 4-6 parts, Alpinia oxyphylla 4-6 parts, Citrus reticulata 4-6 parts, Polygala tenuifolia 3-4 parts, Cane sucrose (peeled) 10-30 parts, Zingiber officinale (peeled) 5-7.5 parts, Ziziphus jujuba 5-7.5 parts, and Glycyrrhiza uralensis (processed) 3-4 parts. The traditional Chinese medicine composition of the present invention has definite curative effect, is safe to use, and has no obvious toxic side effects.

The present invention is based on the realization and verification that inhibition of Luteinizing hormone (LH) and / or luteinizing hormone / choriogonadotropin receptor (LHCGR) is useful in the treatment, alleviation or prevention of different medical states related to perimenopause and menopause in women or hypogonadism in men. Thus, an aspect of the present invention relates to LH and / or LHCGR inhibitors for use in the treatment of postmenopausal osteoporosis in a female subject. Another aspect relates to LH and / or LHCGR inhibitors for use in the reduction of fat mass in a postmenopausal female subject. A further aspect relates to LH and / or LHCGR inhibitors for use in the treatment, hypergonadotropic hypogonadism in a male subject. In addition, another aspect relates to LH and / or LHCGR inhibitors for use in the treatment of symptoms of perimenopause and / or postmenopause such as hot flashes, night sweats, osteoporosis, weight gain, hypothyroidism, conversion of T4 to T3, and / or primary hyperparathyroidism.