Application of recombinant mesenchymal stem cells in preparing drugs for treating myocardial infarction

A technology of stem cells and recombinant plasmids, applied in bone/connective tissue cells, cells modified by introducing foreign genetic material, applications, etc., can solve problems such as application, low effect and scar tissue formation that are not involved in the treatment of cardiac infarction
CN110656091AInactive Publication Date: 2020-01-07SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2020-01-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of IL-33 in preparing mesenchymal stem cell immunoregulatory preparations. A recombinant allosome MSCs for regulating an immune reaction is built, IL-33 is used formodifying MSCs, the survival rate of the MSCs in a low-oxygen condition is improved, and the immunosuppressive function of the MSCs is improved by improving the influence of the allosome MSCs on macrophage polarization. The invention further discloses application of recombinant mesenchymal stem cells in preparing drugs for treating myocardial infarction. The drugs can treat the myocardial infarction through allosome cell transplantation.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to the application of recombinant mesenchymal stem cells in the preparation of drugs for treating myocardial infarction. Background technique

[0002] Myocardial infarction is a cardiovascular disease that seriously endangers human health due to prolonged ischemia leading to myocardial cell death and fibrosis. With the development of social economy and the change of national lifestyle, the incidence of cardiovascular disease in my country is on the rise, and the mortality rate of acute myocardial infarction (AMI) is also increasing continuously. Moreover, it is difficult to cure it by existing methods. The most thorough method is heart transplantation, but heart transplantation is limited by the source of donors. Acute myocardial infarction will cause a severe innate immune response of heart cells, thereby mobilizing a large number of neutrophils, monocytes and macrophages to migrate to ...

Claims

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