Composition with macrophage polarization targeted adjustment function and preparation method and application thereof
A technology of macrophages and compositions, applied in the field of medicine, can solve the problems of less attention to aseptic inflammatory response, narrow beneficiary population, and little curative effect, so as to increase active targeting, inhibit recurrence and metastasis, and reduce phagocytosis Effect
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Embodiment 1
[0027] This embodiment provides a method for preparing a composition capable of targeting and regulating the polarization of macrophages, including the following steps:
[0028] Preparation of NaOH / DEG precursor: Weigh 2g of NaOH with a balance and place it in a 50ml three-necked flask, inject 20ml of diethylene glycol into the flask, vacuumize at room temperature for 3min to discharge the air in the system, and heat the three-necked flask to 120°C under nitrogen protection , and reacted for 1h to obtain the NaOH / DEG precursor.
[0029] Preparation of water-soluble iron oxide nanoparticles (IONPs): Weigh 0.7g of polyacrylic acid and 0.54g of FeCl with a balance 3 ·6H 2 O was dissolved in 15mL of diethylene glycol, and the solution was vacuumed at 100°C for 30 minutes to discharge the air; heated to 220°C under nitrogen protection, and reacted with magnetic stirring for 30 minutes; extracted 2NaOH / DEG precursor, injected quickly, and continued to react for 10 minutes; the reac...
Embodiment 2
[0033] This embodiment provides a method for preparing a composition capable of targeting and regulating the polarization of macrophages, including the following steps:
[0034] Preparation of NaOH / DEG precursor: Weigh 0.5g NaOH with a balance and place it in a 50ml three-necked flask, inject 10ml of diethylene glycol into the flask, vacuumize at room temperature for 3-10min to discharge the air in the system, and heat the three-necked flask under nitrogen protection To 100°C, react for 0.5h to obtain the NaOH / DEG precursor.
[0035] Preparation of water-soluble iron oxide nanoparticles: weigh 0.05g of polyacrylic acid and 0.1g of FeCl with a balance 3 ·6H 2 O was dissolved in 10mL of diethylene glycol, and the solution was evacuated at 100°C for 30 minutes to discharge the air; heated to 180°C under nitrogen protection, and stirred by magnetic force for 30 minutes; extract 2ml of NaOH / DEG precursor, inject it quickly, and continue to react for 5-30 minutes; After the reacti...
Embodiment 3
[0038] This embodiment provides a method for preparing a composition capable of targeting and regulating the polarization of macrophages, including the following steps:
[0039] Preparation of NaOH / DEG precursor: Weigh 2.5g NaOH with a balance and place it in a 50ml three-necked flask, inject 20ml of diethylene glycol into the flask, vacuumize at room temperature for 10min to discharge the air in the system, and heat the three-necked flask to 120°C under nitrogen protection. °C, reacted for 2h to obtain the NaOH / DEG precursor.
[0040] Preparation of water-soluble iron oxide nanoparticles: weigh 1.5g of polyacrylic acid and 2g of FeCl with a balance 3 ·6H 2 O was dissolved in 20mL of diethylene glycol, and the solution was vacuumed at 100°C for 30 minutes to discharge the air; heated to 230°C under nitrogen protection, and reacted with magnetic stirring for 30 minutes; extracted 10ml of NaOH / DEG precursor, injected quickly, and continued to react for 30 minutes; the reaction ...
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