Polyether-ether-ketone three-dimensional porous and modified polydopamine/gentamicin for anti-bacteria and and anti-inflammation effects and promotion of osseointegration of implant

Abstract

The invention discloses a simple porification and one-step deposition method of polyether-ether-ketone. The method uses a polydopamine and gentamicin coating to modify the surface of three-dimensional porous polyether-ether-ketone to realize the anti-bacteria effect and regulate macrophage polarization and inflammatory reaction, thereby preventing bacterial colonization and promoting osseointegration. In-vitro research results show that the polydopamine / gentamicin modified porous polyether-ether-ketone can more easily induce macrophages to differentiate into M2 types, has a relatively strong continuous killing effect on staphylococcus aureus and escherichia coli, has relatively high antibacterial and anti-inflammatory capabilities, and can be used as a novel implant material for clinical orthopedics. In-vivo experiment results show that the three-dimensional porous polyether-ether-ketone surface modified polydopamine / gentamicin can well control bacterial infection and promote osseointegration. The invention shows that the polyether-ether-ketone is porous, so that polydopamine and gentamicin can be immobilized at the same time, and the surface-activated polyether-ether-ketone has antibacterial, anti-inflammatory and osseointegration capabilities, and has relatively high application potential in regenerative medicine.

Description

technical field [0001] The invention relates to the application field of surface modification of orthopedic implant materials, in particular to three-dimensional porous materials. Background technique [0002] (1) Polyetheretherketone (PEEK) and its various copolymers not only have excellent mechanical properties and good chemical resistance, making them considered promising alternatives to metal and ceramic orthopedic implants, but also PEEK has properties close to natural The hardness of the bone. This helps prevent the stress shielding typically observed around harder implants composed of metal. In addition, PEEK is easier to process than ceramic materials due to its good ductility and chemical resistance. This elasticity helps improve the performance of crowns, preventing fracture during the chewing bite and not releasing toxic by-products when they biocorrode like metal implants. Although PEEK and carbon fiber-containing PEEK composites are widely used in orthopedic ...

AI Technical Summary

Problems solved by technology

Although PEEK and carbon fiber-containing PEEK composites are widely used in orthopedic implants, the biological inertness of their surfaces greatly limits their clinical applications.

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