Polyether-ether-ketone three-dimensional porous and modified polydopamine/gentamicin for anti-bacteria and and anti-inflammation effects and promotion of osseointegration of implant

A polyetheretherketone, gentamicin technology, applied in drug delivery, prosthesis, tissue regeneration, etc., can solve problems such as limiting clinical applications

Pending Publication Date: 2021-04-09
FUJIAN MEDICAL UNIV UNION HOSPITAL
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Although PEEK and carbon fiber-containing PEEK composites are widely used in orthopedic impl

Method used

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  • Polyether-ether-ketone three-dimensional porous and modified polydopamine/gentamicin for anti-bacteria and and anti-inflammation effects and promotion of osseointegration of implant
  • Polyether-ether-ketone three-dimensional porous and modified polydopamine/gentamicin for anti-bacteria and and anti-inflammation effects and promotion of osseointegration of implant
  • Polyether-ether-ketone three-dimensional porous and modified polydopamine/gentamicin for anti-bacteria and and anti-inflammation effects and promotion of osseointegration of implant

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Embodiment Construction

[0031] (1) The present invention will be described in detail below in conjunction with specific embodiments and accompanying drawings. It should be understood that the specific embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0032] (2) Example (preparation of three-dimensional porous modified polyether ether ketone with antibacterial, anti-inflammatory and osseointegration capabilities)

[0033] The three-dimensional porous polyetheretherketone (SPEEK) sample of this example was prepared through the following steps:

[0034] Take 25ml concentration of 98wt% concentrated sulfuric acid and place it in a 50 mL beaker, then put it into polyether ether ketone, in order to optimize the sulfonation time, set 4 series of sulfonation time, 0.5 minutes (SPEEK0.5), 3 minutes ( SPEEK3), 5 minutes (SPEEK5) and 10 minutes (SPEEK10), with untreated polyether ether ketone as the control. After t...

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Abstract

The invention discloses a simple porification and one-step deposition method of polyether-ether-ketone. The method uses a polydopamine and gentamicin coating to modify the surface of three-dimensional porous polyether-ether-ketone to realize the anti-bacteria effect and regulate macrophage polarization and inflammatory reaction, thereby preventing bacterial colonization and promoting osseointegration. In-vitro research results show that the polydopamine/gentamicin modified porous polyether-ether-ketone can more easily induce macrophages to differentiate into M2 types, has a relatively strong continuous killing effect on staphylococcus aureus and escherichia coli, has relatively high antibacterial and anti-inflammatory capabilities, and can be used as a novel implant material for clinical orthopedics. In-vivo experiment results show that the three-dimensional porous polyether-ether-ketone surface modified polydopamine/gentamicin can well control bacterial infection and promote osseointegration. The invention shows that the polyether-ether-ketone is porous, so that polydopamine and gentamicin can be immobilized at the same time, and the surface-activated polyether-ether-ketone has antibacterial, anti-inflammatory and osseointegration capabilities, and has relatively high application potential in regenerative medicine.

Description

technical field [0001] The invention relates to the application field of surface modification of orthopedic implant materials, in particular to three-dimensional porous materials. Background technique [0002] (1) Polyetheretherketone (PEEK) and its various copolymers not only have excellent mechanical properties and good chemical resistance, making them considered promising alternatives to metal and ceramic orthopedic implants, but also PEEK has properties close to natural The hardness of the bone. This helps prevent the stress shielding typically observed around harder implants composed of metal. In addition, PEEK is easier to process than ceramic materials due to its good ductility and chemical resistance. This elasticity helps improve the performance of crowns, preventing fracture during the chewing bite and not releasing toxic by-products when they biocorrode like metal implants. Although PEEK and carbon fiber-containing PEEK composites are widely used in orthopedic ...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/54A61L27/56
CPCA61L27/18A61L27/54A61L27/56A61L2430/02A61L2400/18A61L2300/232A61L2300/406C08L61/16C08L79/04
Inventor 陈敏孙安安黄集跃
Owner FUJIAN MEDICAL UNIV UNION HOSPITAL
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