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Preparation method of drug-loaded nanofiber medical dressing

A nanofiber and drug technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of iatrogenic pollution, damage to new tissue, wound adhesion, etc., and achieve accelerated healing, good absorption, and conducive to growth and regeneration Effect

Inactive Publication Date: 2011-12-07
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are many inconveniences in the use of medical dressings. Some dressings use non-degradable polyacrylonitrile materials as scaffold materials, causing iatrogenic pollution; When the new tissue is damaged, it brings great pain to the patient

Method used

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  • Preparation method of drug-loaded nanofiber medical dressing
  • Preparation method of drug-loaded nanofiber medical dressing
  • Preparation method of drug-loaded nanofiber medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) The mixture of CS powder and PEO (its weight ratio is CS / PEO=3 / 7) is dissolved in the acetic acid solution of 95wt%, is made into the solution that the percentage by weight is 3wt%, then the solution is fully stirred, so that completely After dissolving, the solution was placed in ultrasonic for 1 hour so that all the bubbles were separated out to obtain a transparent CS electrospinning solution.

[0033](2) Add the CS electrospinning solution prepared in step (1) into the syringe pump, adjust the voltage to 20kV; the distance from the spinneret to the collecting plate is 12cm; the flow rate of the spinneret spinning solution is 0.5mL / h. The device was activated for electrospinning, and CS nanofibers (such as figure 1 ).

[0034] (3) Cross-link the CS nanofibers obtained in step (2) with glutaraldehyde for 2 hours, soak the cross-linked chitosan nanofibers in the solvent of the pore-forming agent, and selectively remove the pore-forming agent and excess cross-link...

Embodiment 2

[0037] (1) HA powder of Mw=1,000,000 and PVP (its weight ratio is HA / PVP=5 / 5) are dissolved in deionized water, formic acid and N, in the mixed solvent that N-dimethylformamide forms (deionized Water / formic acid / N, N-dimethylformamide=25 / 50 / 25), be made into the solution of 1wt% by weight percent, then the solution is fully stirred, so that dissolve completely, the solution is placed in ultrasonic for 2 hours to make All the bubbles are separated out to obtain a transparent HA solution.

[0038] (2) Add the HA electrospinning solution prepared in step (1) to the syringe pump, adjust the voltage to 15kV; the distance from the spinneret to the collecting plate is 15cm; the flow rate of the spinneret spinning solution is 0.5mL / h; The spinning ambient temperature was 18°C. The device was activated for electrospinning of hyaluronic acid, and HA nanofibers (such as Figure 4 ).

[0039] (3) Cross-linking the hyaluronic acid nanofibers obtained in step (2) with divinyl sulfone for...

Embodiment 3

[0042] (1) The mixture of CS powder and PEG (its weight ratio is CS / PEG=9 / 1) is dissolved in the acetic acid solution of 10wt%, is made into the solution that weight percent is 8wt%, then fully stirs solution, so that completely Dissolved, the solution was placed in ultrasonic for 2 hours to make all the bubbles precipitate out to obtain a transparent CS electrospinning solution.

[0043] (2) Add the CS electrospinning solution prepared in step (1) into the syringe pump, adjust the voltage to 25kV; the distance from the spinneret to the collecting plate is 20cm; the flow rate of the spinneret spinning solution is 1mL / h. The device was activated for electrospinning, and CS nanofibers were obtained on the collecting plate.

[0044] (3) The CS nanofibers obtained in step (2) were crosslinked with genipin for 2 hours, and the crosslinked chitosan nanofibers were soaked in the solvent of the pore-forming agent to selectively remove the pore-forming agent and excess crosslinking ag...

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Abstract

The present invention relates to a method for preparing a drug-loaded biodegradable nanofiber medical dressing. The dressing is a nanofiber membrane that mainly co-spun hyaluronic acid (chitosan) and pore-forming agent to obtain composite nanofibers. The hyaluronic acid (chitosan) is cross-linked using a cross-linking agent, and then selectively The pore-forming agent and cross-linking agent are removed to obtain hyaluronic acid (chitosan) porous nanofibers. Finally, the free binding characteristics of polycations and anions are used to encapsulate therapeutic drugs in hyaluronic acid (chitosan) nanofibers. The obtained drug-loaded biodegradable nanofiber medical dressing can well absorb permeate, maintain moisture around the wound, and can continuously release therapeutic drugs for a long time. It is biodegradable, antibacterial, and hemostatic, and is beneficial to wound tissue. The growth and regeneration can accelerate wound healing and other functions.

Description

Technical field [0001] The present invention relates to a method for preparing a drug-loaded biodegradable nanofiber medical dressing. Background technique [0002] Electrospinning is a processing method that produces polymer ultrafine fibers by jetting a charged polymer solution or melt in an electrostatic field. When the external electric field reaches a certain critical value, the fibers will be ejected from the spinneret. , at the same time, the solvent gradually evaporates and leaves the charged fibers, and the dry fibers fall on the collection plate to form ultra-fine nanofiber non-woven fabrics. The prepared nanofiber non-woven fabric has the advantages of large specific surface area, high porosity, high fiber fineness and uniformity, and large aspect ratio. Generally, the smaller the material system that carries the drug, the easier it is for the drug to be absorbed by the body. Therefore, nanofibers have great application possibilities in drug sustained release. ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 聂俊马贵平梁鹏总孟准
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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