29results about How to "Avoid polarization" patented technology

The invention discloses a sound production device and electronic equipment, and relates to the technical field of electroacoustic transduction, each central magnetic part of a magnetic circuit system of the sound production device, edge magnetic parts arranged around the central magnetic part and a common magnetic part are enclosed to form a magnetic gap, and a vibration system comprises a diaphragm assembly, a conductive support chip, at least two voice coils and four centering support chips, the plurality of voice coils are arranged side by side, the voice coils at the two ends are respectively connected with the two corresponding centering support chips along the side-by-side direction of the plurality of voice coils, and the lead parts of the two adjacent voice coils are respectively and electrically connected with the conductive support chips, so that the two adjacent voice coils are arranged in series; the conductive support chip comprises a connecting part and two bonding pad parts, and the projection of the connecting part in the vibration direction of the vibration system is located in the middle of the common magnetic part. According to the sound production device, the conductive support chip is arranged between the two adjacent voice coils, so that the setting volume of the magnet in the magnetic circuit system can be increased, the BL value of the product is improved, and the loudness and sensitivity of the sound production device are further improved.

The invention discloses a grid-controlled pixel driving circuit which comprises a first transistor, a second transistor and a third transistor, a first source drain electrode of the first transistor is coupled to a data signal line, a second source drain electrode of the first transistor is coupled to a pre-storage capacitor and a grid electrode of the second transistor, and the grid electrode of the first transistor is coupled to a control signal line; a first source drain electrode of the second transistor is coupled to a reference signal line, and a second source drain electrode of the second transistor is coupled to a first source drain electrode of the third transistor; the grid electrode of the third transistor is coupled to the transfer signal line, and the second source drain electrode is coupled to the pixel capacitor and the holding capacitor.

The invention relates to the field of lithium ion batteries, and discloses a lithium titanate composite material and a preparation method thereof, a negative pole piece and a preparation method thereof, a lithium battery and a battery pack. The surfaces of lithium titanate particles are sequentially coated with the nitrogen-doped carbon intermediate layer and the two-dimensional MXene material outer layer, and the MXene material outer layer is formed by bridging adjacent particles through hydrogen bonds, so that a'core-shell-bridge 'three-dimensional conductive network structure is constructed, the electronic conductivity of the lithium titanate composite material is remarkably improved, the electron / ion transmission efficiency of the lithium titanate negative electrode is improved, and the lithium titanate negative electrode has a good application prospect. The lithium ion battery has excellent rate capability and cycle performance; and through collaborative optimization of the three-dimensional composite material and the electrolyte, the interface impedance is reduced, and polarization is inhibited, so that the lithium battery still keeps high capacity and long cycle stability under ultrahigh rate, and meanwhile, the problems of discontinuous conductive network and high interface impedance in the prior art are solved. And excellent rate capability and cycle performance can be achieved under ultrahigh rate.

The invention discloses a sound production device, a sound production module and electronic equipment, and relates to the technical field of electroacoustic transduction, a magnetic circuit system of the sound production device is provided with a mounting hole penetrating through a magnetic conductive yoke and a central magnetic part, a conductive bracket is arranged in the mounting hole, and a diaphragm assembly of a vibration system comprises a vibration part, a first folding ring part and a second folding ring part, the inner side of the second folding ring part is connected with the conductive support. The two ends of the centering disk are electrically connected with a bonding pad of the conductive support and a lead of the voice coil respectively. Wherein the vibration part is provided with a convex hull part protruding in the direction away from the magnetic circuit system, and a lead of the voice coil is wired along the inner wall of the convex hull part and is electrically connected with the centering disk. According to the sound production device, the magnetic circuit system is arranged in a hollow manner and is provided with the conductive support, and the centering disk is electrically connected with the voice coil and the conductive support respectively, so that the setting volume of the edge magnetic part can be increased, the magnetic field intensity can be improved, and the BL value of a product can be increased, thereby improving the acoustic performance; in addition, the sound production device is low in magnetic flux leakage and meets the use requirements.

Compared with the prior art, the anti-polarization mechanism for the continuous casting vibration device provided by the utility model comprises a vibration base; a vibration table board; one end of the first plate spring is fixed on the vibration table top and the other end is fixed on the vibration base; one end of the second plate spring is fixed on the vibration table, and the other end is fixed on the vibration base; the first plate spring and the second plate spring are arranged in parallel, compared with the prior art, the polarization prevention mechanism for the continuous casting vibration device has the advantages that a flexible parallel four-connecting-rod structure is formed by the installation mode of the first plate spring and the second plate spring, and the polarization prevention effect is good. When the vibration device vibrates, due to the fact that the first plate spring and the second plate spring are fixed to the vibration base and the first plate spring and the second plate spring are also fixed to the vibration table top, the vibration table top is limited by the first plate spring and the second plate spring to be kept in a horizontal state, the polarization problem is solved, and the function of preventing polarization of the vibration table top is achieved.

The invention relates to the field of battery design, and relates to a cylindrical battery and a design method thereof. The relation between a pole piece and a diaphragm of the cylindrical battery meets the following formula: Ha1 + Hc1 + 2 * Hs1 = Ha2 + Hc2 + k * 2 * Hs2, Ha1 is the thickness of a negative pole piece in a 0% SOC state, Hc1 is the thickness of a positive pole piece in a 0% SOC state, and Hs1 is the thickness of a diaphragm in a 0% SOC state; ha2 is the thickness of the negative plate in the 100% SOC state, Hc2 is the thickness of the positive plate in the 100% SOC state, Hs2 is the thickness of the diaphragm in the 100% SOC state, and k is a coefficient of 0.85-1; sigma2 is in a range of 30-60%, Sigma2 = Hs2 / Hs1 * Sigma1, Sigma1 is the porosity of the diaphragm in a 0% SOC state, Sigma2 is the porosity of the diaphragm in a 100% SOC state, and Sigma1 is 30-60%. The cylindrical battery has relatively good cycle performance.

The invention discloses a sound production device, a sound production module and electronic equipment, and relates to the technical field of electroacoustic transduction, the sound production device comprises a shell, a magnetic circuit system, a conductive support and a vibration system, the magnetic circuit system is provided with a mounting hole penetrating through a magnetic conductive yoke and a central magnetic part, the conductive support is arranged in the mounting hole, and the conductive support and the magnetic conductive yoke are integrally formed through injection molding; one end of a centering disk of the vibration system is electrically connected with a bonding pad of the conductive support, and the other end of the centering disk is connected with the diaphragm assembly and electrically connected with a lead of the voice coil. Wherein the vibrating diaphragm assembly is of an annular structure, the outer side of the vibrating diaphragm assembly is connected with the shell, and the inner side of the vibrating diaphragm assembly is connected with the conductive support. According to the sounding device, the magnetic circuit system is hollow and is provided with the conductive support, and the centering disk is electrically connected with the voice coil and the conductive support respectively, so that the setting volume of the edge magnetic part can be increased, the magnetic field intensity can be improved, the BL value of a product can be increased, and the acoustic performance can be improved; in addition, the sound production device is low in magnetic flux leakage and meets the use requirements.

The invention relates to a step special-shaped battery cell and a preparation method thereof and a step special-shaped lithium ion battery, the step special-shaped battery cell comprises a first battery cell unit and a second battery cell unit which are arranged in a stacked mode, and in the length direction and the width direction, the size of the first battery cell unit is larger than that of the second battery cell unit; the first battery cell unit and the second battery cell unit respectively comprise a first positive pole piece, a second positive pole piece, a first negative pole piece, a second negative pole piece and a diaphragm; the first positive pole piece and the second positive pole piece respectively and independently comprise a first positive active material, and the first negative pole piece and the second negative pole piece respectively and independently comprise a first negative active material; the second positive pole piece further comprises a second positive active material, and the second negative pole piece further comprises a second negative active material. According to the step special-shaped battery cell provided by the invention, by adding the high-rate second positive electrode active material and the high-rate second negative electrode active material, the current bearing capacity of the small second battery cell unit is effectively improved, and the current distribution between the small second battery cell unit and the high-rate second negative electrode active material is improved, so that the capacity retention ratio and the safety performance of the step special-shaped battery are greatly improved.

The invention provides application of glycyrrhizic acid in preparation of a medicine for preventing or treating prostatitis. Experiments show that glycyrrhizic acid can significantly relieve inflammatory response and pain symptoms in prostate tissues; meanwhile, polarization of M1 type macrophages can be effectively inhibited, so that inflammatory response of chronic abacterial prostatitis is relieved, and the compound can be used for developing related drugs for treating chronic abacterial prostatitis.

The invention discloses application of scylla serrata dodecapeptide in preparation of a skin relieving composition. The amino acid sequence of the scylla serrata dodecapeptide is as shown in SEQ ID NO.01. The invention further discloses a preparation method of the scylla serrata dodecapeptide. The blue crab dodecapeptide can effectively inhibit polarization of LPS-induced mouse macrophages RAW 264.7 to type 1 macrophages, secretion of proinflammatory factors and increase secretion of anti-inflammatory factors, can effectively relieve irritation of SDS to zebra fish embryos, does not show cytotoxicity to the mouse macrophages RAW 264.7, does not have an obvious stimulation effect on the zebra fish embryos, and can be used for preparing the anti-inflammatory and anti-inflammatory drugs. The traditional Chinese medicine composition has the effect of relieving inflammation and is relatively good in safety.

The invention discloses a sound production device, a sound production module and electronic equipment, and relates to the technical field of electroacoustic transduction, a magnetic circuit system of the sound production device is provided with a mounting hole penetrating through a magnetic conductive yoke and a central magnetic part, a conductive bracket is arranged in the mounting hole, and the conductive bracket comprises a first connecting part and a second connecting part which are connected with each other; the inner side of a vibrating diaphragm assembly of the vibrating system is connected with the second connecting part, one end of a centering disk is electrically connected with a bonding pad of the conductive bracket, and the other end of the centering disk is connected with the vibrating diaphragm assembly and is electrically connected with a lead of the voice coil; wherein the second connecting part is recessed and extends inwards relative to the first connecting part so as to form an avoiding space for avoiding the centering disk. According to the sound production device, the magnetic circuit system is arranged in a hollow manner and is provided with the conductive support, and the centering disk is electrically connected with the voice coil and the conductive support respectively, so that the setting volume of the edge magnetic part can be increased, the magnetic field intensity can be improved, and the BL value of a product can be increased, thereby improving the acoustic performance; in addition, the sound production device is low in magnetic flux leakage and meets the use requirements.

The utility model belongs to the technical field of kettles for paint production, and particularly relates to a paint production kettle convenient to clean, which comprises a reaction kettle, four support legs which are arranged in an annular array are fixedly connected to the side surface of the reaction kettle, a kettle cover is arranged at the upper end of the reaction kettle, a servo motor is fixedly mounted in the middle of the upper end of the kettle cover, and the servo motor is connected with the reaction kettle. An output shaft of the servo motor is rotatably connected with the kettle cover, the output shaft of the servo motor is fixedly connected with a stirring paddle, the supporting legs on the left and right sides are fixedly provided with synchronous motors, and output shafts of the synchronous motors are rotatably connected with the supporting legs. According to the utility model, components such as the kettle cover, the stirring paddle and the like are detached, water jet cleaning can be carried out inside the stainless steel reaction kettle, and under the action of the structures such as the synchronous motor, the winding wheel and the pull wire, the scraping ring can slide along the inner wall of the reaction kettle to rub and clean attachments on the inner wall of the reaction kettle, so that the cleaning effect on the reaction kettle is improved.

The application provides a preparation method of an agricultural nanometer friction power generation electrode interface modification material, and belongs to the technical field of nanometer material preparation, and comprises the following steps: step 1, preparation of a nanometer titanium dioxide sol; step 2, preparation of a polypyrrole / titanium dioxide composite sol; step 3, pretreatment of an agricultural-grade red copper foil electrode; step 4, spraying and coating of the composite sol; and step 5, solidification and shaping to form a nanometer modification layer. The modification material prepared by the application can effectively inhibit solid-liquid interface polarization after coating, significantly improve the charge storage and transmission efficiency of the electrode, and optimize the output performance of a power generation device. The modification layer prepared by the application has strong adhesion with the copper foil, is resistant to high temperature and high humidity in agricultural environments, does not fall off or corrode, improves the electrode adaptability and service life, and guarantees stable power generation output. The application adopts a sol-gel method for preparation, discards traditional complex modification processes, has a simple process, raw materials are easy to obtain, and the cost is low, and is suitable for large-scale production and agricultural practical application.

The invention discloses a low-conductivity resin composition and a preparation method thereof, and particularly relates to the technical field of polymer composites.The composition comprises 100 parts of liquid crystal epoxy resin, 5-15 parts of polyhedral oligomeric silsesquioxane, 20-40 parts of flaky boron nitride, 10-20 parts of spherical aluminum oxide and 30-50 parts of a maleimide-allyl bisphenol A copolymer curing agent. The preparation method comprises the following steps: S1, prepolymer preparation; S2, filler hybridization; and S3, curing molding. Nano pores are constructed in a matrix through octa-aminopropyl POSS, so that the dielectric constant is effectively reduced, a heat conduction path is formed through directional arrangement of flaky boron nitride, the technical problem that low dielectricity and high heat conduction of a resin material are difficult to consider at the same time is cooperatively solved, and meanwhile, the material has high heat resistance and is particularly suitable for the fields of 5G communication, semiconductor packaging and the like.

This invention discloses an adaptive drug delivery system for ischemic stroke, its preparation method, and its application. MMP-2 responsive peptide-drug dimers are loaded onto the surface of mesoporous polydopamine for intervention or treatment of cerebral ischemia-reperfusion injury. The system allows for targeted drug delivery based on individual differences in disease progression among patients, precisely promoting brain injury repair. This invention applies MMP-2 responsive peptides to the treatment of ischemic stroke, using mesoporous polydopamine as a drug carrier, providing reactive sites and loading space for efficient drug loading. The chemical reaction between catechol on the polydopamine surface and the thiol groups on the MMP-2 responsive peptides loads the peptide-drug dimers, thereby achieving responsive drug release on the carrier surface. Simultaneously, this invention utilizes the ability of polydopamine to scavenge reactive oxygen species (ROS), rapidly clearing local ROS and reducing acute damage caused by ischemic stroke.

The invention discloses a sound production device, a sound production module and electronic equipment, and relates to the technical field of electroacoustic transduction, a magnetic circuit system of the sound production device is provided with a mounting hole penetrating through a magnetic conductive yoke and a central magnetic part, and a conductive bracket is arranged in the mounting hole; a vibrating diaphragm assembly of the vibrating system comprises a vibrating part, a first folding ring part arranged on the outer side of the vibrating part and a second folding ring part arranged on the inner side of the vibrating part, the concave direction of the first folding ring part is opposite to that of the second folding ring part, the inner side of the second folding ring part is connected with a conductive support, and one end of a centering disk is electrically connected with a bonding pad of the conductive support. And the other end of the centering disk is connected with the vibrating diaphragm assembly and is electrically connected with a lead of the voice coil. According to the sound production device, the magnetic circuit system is arranged in a hollow manner and is provided with the conductive support, and the centering disk is electrically connected with the voice coil and the conductive support respectively, so that the setting volume of the edge magnetic part can be increased, the magnetic field intensity can be improved, and the BL value of a product can be increased, thereby improving the acoustic performance; in addition, the sound production device is low in magnetic flux leakage and meets the use requirements.

A power battery charging method, device, equipment and medium are disclosed, including: monitoring the actual state of charge of a target battery during a target battery charging process; when the actual state of charge is less than a preset state of charge, determining the actual charging stage in which the target battery is currently located according to the actual state of charge; determining the target limit charging rate corresponding to the actual charging stage according to the correspondence between the actual charging stage and the limit charging rate; determining the actual charging rate according to the target limit charging rate, and controlling the target battery to charge at the actual charging rate in the actual charging stage. The present application charges within the range of less than or equal to the limit charging rate, can avoid the occurrence of obvious polarization phenomenon, reduce the polarization degree, that is, increase the charging rate as much as possible under the premise of low polarization degree, shorten the charging time, improve the charging efficiency, and at the same time improve the charged power.

The invention discloses a sound production device, a sound production module and electronic equipment, and relates to the technical field of electroacoustic transduction, a magnetic circuit system of the sound production device is provided with a mounting hole penetrating through a magnetic conductive yoke and a central magnetic part, a conductive bracket is arranged in the mounting hole, a vibration system comprises a vibrating diaphragm assembly, a voice coil and a centering disk, the vibrating diaphragm assembly is of an annular structure, and the voice coil is arranged in the mounting hole. The centering support chip comprises a main body part and a support leg part, the main body part is connected to the top of the conductive support and is electrically connected with the bonding pad of the conductive support, the inner side of the vibrating diaphragm assembly is fixed on the main body part, one end of the support leg part is connected with the main body part, and the other end of the support leg part is connected with the vibrating diaphragm assembly and is electrically connected with a lead of the voice coil. According to the sound production device, the magnetic circuit system is arranged in a hollow manner and is provided with the conductive support, and the centering disk is electrically connected with the voice coil and the conductive support respectively, so that the setting volume of the edge magnetic part can be increased, the magnetic field intensity can be improved, and the BL value of a product can be increased, thereby improving the acoustic performance; in addition, the sound production device is low in magnetic flux leakage and meets the use requirements.

The application discloses a cholesteric liquid crystal display circuit, a driving method thereof and electronic paper, and relates to the technical field of cholesteric liquid crystal display. The voltage time sequence of the gate drive circuit, the source drive circuit and the common electrode end is set. In different time periods, when the corresponding pixel is in a liquid crystal torsion state, the gate-source voltage of the switching transistor is the same; when the corresponding pixel is in a liquid crystal non-torsion state, the gate-source voltage of the switching transistor is the same. In different time periods, when the corresponding pixel is in a liquid crystal torsion state, the source electrode voltage of the switching transistor is greater than the common electrode end; when the corresponding pixel is in a liquid crystal non-torsion state, the source electrode voltage of the switching transistor is less than the common electrode end. Not only the size relationship between the source electrode voltage of the switching transistor and the voltage of the common electrode end is switched to prevent liquid crystal polarization, but also the bistable failure, the reflectivity reduction or the state mis-switching of the cholesteric liquid crystal display panel caused by the leakage in the long-time static keeping process can be inhibited, the picture keeping time is prolonged, and the display reliability is improved.

The utility model discloses a simple salt concentration test circuit with low power consumption, which comprises a salt concentration detection circuit, a singlechip control circuit, a power supply circuit, a water flow detection circuit and a nixie tube display circuit, and the power supply circuit is respectively connected with and supplies power to the salt concentration detection circuit, the singlechip control circuit and the nixie tube display circuit. The single-chip microcomputer control circuit is connected with the water flow detection circuit so as to detect the water inlet state. The single chip microcomputer control circuit is connected with the salt concentration detection circuit so as to realize detection operation on the salt concentration in water; and the singlechip control circuit is connected with the nixie tube display circuit so as to output and display the salt concentration detection result. According to the utility model, the operational amplifier form is adopted, so that the reliability and precision of measurement are further improved, and the accuracy of measurement results is ensured.

Embodiments of this application provide a solid-state electrolyte. The solid-state electrolyte includes a porous coordination polymer having an unsaturated metal site, an anionic group coordinated with and grafted on the unsaturated metal site, and a cation bound with the anionic group. The anionic group includes one or more substituted carboxylate anionic groups and / or one or more substituted sulfonate anionic groups. The cation includes one or more of a lithium ion, a sodium ion, a potassium ion, a magnesium ion, a zinc ion, and an aluminum ion. The solid-state electrolyte presents a conduction characteristic of a single cation, so that concentration polarization in a battery system can be effectively avoided and growth of a metal negative electrode dendrite can be suppressed, thereby improving electrochemical performance and safety performance of a battery. Embodiments of this application further provide a preparation method of the solid-state electrolyte and a secondary battery including the solid-state electrolyte.

The utility model relates to the technical field of circulating water treatment, and particularly discloses an electrolytic bath based on electrochemical descaling, which comprises a processing box body, a groove is arranged on the surface of the processing box body, an upper sealing cover is arranged on the upper surface of the processing box body, and an electrode group is fixedly connected with the bottom surface of the groove of the processing box body. A power module is fixedly installed on the lower surface of the machining box body, an electromagnetic generator is arranged on the outer surface of the machining box body, and a magnetic field distributor is installed on the outer surface of the machining box body. The electrolytic bath based on electrochemical descaling is provided with the electrode group and the electromagnetic generator, so that when the electrolytic bath works, through a titanium-based coating anode and a stainless steel cathode of the electrode group, periodic automatic electrode reversing is performed, polarization is prevented, hydrogen ions and active oxygen are generated during electrolysis, a calcium carbonate or magnesium scale layer is reduced and dissolved, and ion crystallization is interfered through an electromagnetic frequency mixing field; and finally, suspended matters are adsorbed through the medicament.

The invention discloses a water-jet-guided laser head and a water-jet-guided laser processing device, relates to the technical field of laser processing, and aims to solve the problems that an existing water-jet-guided laser head cannot cool a lens and cannot dry the interior of the existing water-jet-guided laser head. According to the water guide laser head, the vortex separation structure is arranged on the shell, so that input high-pressure gas can be separated into cold airflow and hot airflow; wherein cold air flow can flow into the mirror cavity from the cold air outlet of the vortex separation channel through the cooling channel, is directly contacted with the lens assembly, exchanges heat with the lens assembly and then is discharged from the cold air discharge hole, so that the temperature of the lens is effectively reduced, and the mirror cavity is dried and cleaned; the hot air flow can flow into the fit clearance of the drying chamber and the nozzle from the hot air outlet of the vortex separation channel to dry the interior of the water guide laser head, and is discharged through the hot air discharge structure while taking away internal moisture and impurities to form positive pressure air flow blown outwards, so that the interior of the water guide laser head is further ensured to be dry and clean.

The invention discloses a selenium-coated zinc / cerium-based nano-enzyme and an application thereof in regulating intestinal microenvironment to treat inflammatory bowel disease, the selenium-coated zinc / cerium-based nano-enzyme can realize effective multiple active oxygen removal and regulate intestinal flora, a selenium layer outside the zinc / cerium-based nano-enzyme promotes excitation of an Nrf2 endogenous antioxidant pathway, efficient and lasting oxidation resistance is realized, and the selenium-coated zinc / cerium-based nano-enzyme can be used for treating inflammatory bowel disease. The strong antioxidant activity of the nano enzyme can effectively relieve damage caused by oxidative stress and promote generation of glutathione peroxidase 4 at the same time, so that ferroptosis of intestinal barrier cells is inhibited. The nano-enzyme disclosed by the invention can efficiently remove active oxygen, regulate intestinal flora and recover intestinal barrier tissues, so that effective treatment on inflammatory bowel diseases is realized.

This invention provides a polarization method for a porous piezoelectric electret material. The porous piezoelectric electret material includes a porous polymer film, a first electrode, and a second electrode, with the porous polymer film disposed between the first and second electrodes. This invention identifies the minimum and maximum thickness pores among multiple pores in the porous piezoelectric electret material to be polarized. Based on the Poisson breakdown voltage curve obtained from the Townsend model, the gas pressure inside the pores is adjusted in order of decreasing or increasing thickness, and an optimal breakdown voltage is applied synchronously and continuously for polarization. This ensures that pores of different thicknesses can be polarized at the same voltage value, thereby avoiding the need to apply higher polarization voltages to polarize pores that deviate from the optimal breakdown thickness, and the risk of breaking down the porous polymer film due to applying higher polarization voltages.

The invention relates to the technical field of lithium ion batteries, and discloses a composite coated ternary positive electrode material as well as a preparation method and application thereof. According to the composite coated ternary positive electrode material provided by the invention, the antimony element is doped in the matrix, so that the crystal structure can be stabilized by Sb < 5 + > with high valence and large ion radius, and the mixed arrangement of cations is reduced; the cobalt and lithium elements of the first coating layer can form a stable spinel structure on the surface of a matrix, and interface side reaction is inhibited; surface coating of the tungsten element, the aluminum element, the titanium element and the zirconium element inhibits interface side reaction, the structural stability of the positive electrode material is improved, and the cycling stability and the thermal stability of the lithium ion battery are further improved.

The invention discloses a preparation method for realizing safe and effective antibacterial gene therapy of colorectal cancer by combining antibiosis and anti-tumor, and belongs to the field of drug carrier materials. The preparation method comprises the following steps: modifying lauric acid (LA) resisting fusobacterium nucleatum (Fn) and a targeting molecule 4-carboxyphenylboronic acid (PBA) into low-molecular-weight polyethyleneimine (OEI), and self-assembling with LA to obtain LA-OLP (AFs); the AFs is compounded with an anti-angiogenesis gene (sFlt-1), and the AFs and distearoyl phosphatidyl ethanolamine-methoxy polyethylene glycol (DSPE-mPEG) are co-assembled to obtain the nano particle LA (at) OLP / sFlt-1 / DSPE-mPEG (AFGTs-PEG). The method has the advantages of low cost and simple and feasible process flow, can be widely applied to the fields of materials science, biology, medicine and the like, and cooperates with antibacterial and anti-angiogenic gene therapy to enhance gene therapy on colorectal cancer.

The invention discloses an application of SIRT1 activator dihydromyricetin in preparation of a medicine for treating acute liver injury. It is proved for the first time that dihydromyricetin serves as an effective liver protective agent, and acute liver injury is relieved through an unknown acetylation-dependent mechanism. DMY mitigates ALI by mitigating oxidative stress and inhibiting inflammatory response. In mechanism, DMY recovers expression of deacetylase SIRT1 in liver macrophages, SIRT1 and PRDX1 directly interact with each other, and deacetylation is carried out on the PRDX1 at a lysine 35 site. This deacetylation event reactivates the antioxidant function of PRDX1, inhibits the generation of proinflammatory cytokines, and inhibits polarization of M1 type macrophages, thereby remodeling the inflammatory microenvironment during ALI. The protection effect of DMY is reproduced through gene recovery SIRT1, and an SIRT1-PRDX1 shaft is determined as a core mediating factor of the SIRT1-PRDX1 shaft.

The invention provides a metal organic framework composite delivery material for targeted therapy of sepsis. The metal organic framework composite delivery material is characterized by comprising a carrier and Zr-MOFs confinement converted nitrogen-doped carbon embedded superfine Fe-regulated nickel nanoparticles, the load factor, the cGAS inhibitor, the antioxidant nanoparticles and the specific cell membrane are loaded on the carrier, and the cell membrane can be phagocytized by macrophages. The composite delivery material has a wide application prospect in preparation of drugs for treating sepsis.