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Conjugated compound, preparation method, nano-targeted drug, application

A conjugated compound and nanotechnology, which is applied in the field of conjugated compounds, preparation, application, and nano-targeted drugs, can solve the problems of unable to repair periodontal tissue, achieve tissue damage repair, high biological safety, and broad market prospects Effect

Active Publication Date: 2022-02-11
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the embodiments of the present invention is to provide a conjugated compound to solve the problem that the existing ceria-based nano-medicine proposed in the above background technology cannot repair damaged periodontal tissue while inhibiting periodontal inflammation

Method used

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  • Conjugated compound, preparation method, nano-targeted drug, application
  • Conjugated compound, preparation method, nano-targeted drug, application
  • Conjugated compound, preparation method, nano-targeted drug, application

Examples

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preparation example Construction

[0058] Another object of the embodiments of the present invention is to provide a method for preparing a conjugated compound, the method for preparing a conjugated compound includes the following steps:

[0059] Weigh the amino-functionalized cerium oxide in proportion and disperse it in water, then add the anti-inflammatory component containing hydroxyl group that can promote the polarization of M2 macrophages in proportion to mix evenly, and carry out stirring reaction at 30-50°C , centrifuged to remove the supernatant, washed, and dried to obtain the conjugated compound.

[0060] As another preferred embodiment of the present invention, the anti-inflammatory component containing hydroxyl groups that can promote the polarization of M2 macrophages can be specifically preferably quercetin, usually, the quercetin is dissolved in water with a pH of 7.5 , Sodium monohydrogen phosphate and sodium dihydrogen phosphate can be used for pH adjustment.

[0061] As another preferred em...

Embodiment 1

[0070] A conjugated compound, see Figure 1-2 As shown, the specific preparation method is as follows:

[0071] 1) Preparation of octahedral ceria: weigh 434.3mg cerium nitrate hexahydrate (Ce(NO 3 ) 3 ·6H 2 O) be dissolved in 10ml deionized water, weigh 3.8mg trisodium phosphate dodecahydrate (Na 3 PO 4 12H 2 O) be dissolved in 30ml deionized water, then the obtained cerium nitrate hexahydrate solution and trisodium phosphate dodecahydrate solution are jointly added to the polytetrafluoroethylene bottle and mixed for 1 hour, then the polytetrafluoroethylene bottle is placed in the water Seal the high-pressure reaction kettle for thermal synthesis, then transfer the high-pressure reaction kettle to a temperature-controlled constant temperature blast drying oven and set the temperature at 170°C, take out the reactant after heating for 12 hours, and centrifuge at a speed of 9000rpm / min The precipitate was separated in 15 minutes, washed twice with absolute ethanol, once wi...

Embodiment 2

[0076] Compared with Example 1, except that the addition of the quercetin is replaced by 3.5mg, others are the same as Example 1.

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Abstract

The embodiment of the present invention relates to the technical field of nano-medicine, and specifically discloses a conjugated compound, a preparation method, a nano-targeted drug, and an application. The conjugated compound includes the following raw materials: octahedral ceria, hydroxyl-containing Anti-inflammatory components of M2-type macrophage polarization and 3‑aminopropyltriethoxysilane. The conjugated compounds provided in the examples of the present invention have excellent anti-inflammatory effects, and can regulate The immune differentiation of macrophages enables them to have a good effect on eliminating inflammation, and can also repair tissue damage caused by inflammation, which solves the problem that existing ceria-based nano-medicines cannot repair damaged periodontal inflammation while inhibiting periodontal inflammation. The problem of periodontal tissue damage is simple, the preparation method is simple, the biosafety is high, and it has broad market prospects.

Description

technical field [0001] The embodiment of the present invention relates to the technical field of nano-medicine, specifically a conjugated compound, a preparation method, a nano-targeted drug, and an application. Background technique [0002] Periodontitis, as a chronic inflammation of periodontal support tissue, is usually initiated by plaque and causes a series of chronic inflammatory diseases of host immune defense. If not controlled, it will cause loss of gingival attachment, periodontal pocket formation, and The resorption of the groove bone eventually leads to the loosening of the teeth and even loss of teeth, which brings a lot of inconvenience to people's daily life. [0003] At present, the method used clinically for the treatment of periodontitis is mainly to perform surface debridement by mechanical means. However, although mechanical debridement is effective for most patients, the actual therapeutic effect is not good. Because it only removes the plaque as the in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F7/08A61K33/244A61K31/352A61K47/54A61P29/00A61P39/06B82Y5/00
CPCC07F7/0836A61K33/244A61K31/352A61K47/54A61P29/00A61P39/06B82Y5/00C07B2200/11A61K2300/00
Inventor 王林李春艳王钰董彪孙悦
Owner JILIN UNIV
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