Collagen sustained-release carrier material for promoting repair of various traumas in oral and maxillofacial regions and method for preparing same

Abstract

The invention discloses a compound growth factor collagen sustained-release carrier material for promoting repair of various traumas in oral and maxillofacial regions and a method for preparing the same. In order to overcome the defect of poor curative effect existing in the conventional medicaments for treating the traumas of various tissues such as an oral cavity and a face, a bioactive collagen sustained-release material is prepared by combining collagen modified by liposome, chitosan, glycosaminoglycan and the like with one or more of a basic fibroblast growth factor (bFGF), a platelet derived growth factor (PDGF-BB), a vascular endothelial growth factor (VEGF) and a keratinocyte growth factor (KGF). The bioactive collagen sustained-release material is characterized in that: each gram of bioactive collagen sustained-release material contains not less than 10ng of growth factors, and the bioactive collagen sustained-release material has the obvious effect of treating various facial tissue traumas such as tooth extraction wound, oral ulcer, facial nerve injury, mandibular defect and the like. The collagen sustained-release carrier material can continuously release an effective amount of the growth factors to the wound for a long time, fully exert the inducing effect of the growth factors and obviously shorten the time for wound healing so as to fulfill the aim of treatment.

Description

technical field [0001] The present invention relates to a composite growth factor collagen sustained-release carrier material that promotes the repair of various wounds on the oral cavity and frontal face, in particular promotes the repair of wounds such as tooth extraction wounds, oral ulcers, facial nerve injuries, and jaw defects. and its preparation method. Background technique [0002] The oral and maxillofacial areas are exposed, and it is not easy to protect them at ordinary times. When human or animal oral and maxillofacial areas are subjected to various physical injuries caused by various surgical operations and traffic accidents, the damage and defect of nerve tissue, teeth, mucosal epithelial tissue, soft tissue and bone tissue are often caused, and bleeding and chance of infection. Under normal circumstances, wounds heal and repair naturally. The natural wound healing and repair process includes the first stage, hemostasis, in which sticky platelets attach to ...

AI Technical Summary

Problems solved by technology

[0003] However, the biggest disadvantage of these growth factors is that they cannot guarantee that the drug will be released slowly and play a role in an effective amount for a long time at the wound site, and the use of growth factors alone often cannot really effectively promote the comprehensive repair of the entire damaged tissue. As a protein drug, factor has the disadvantages of poor stability, short half-life in vivo after systemic administration, low local concentration after systemic administration, and easy degradation by body fluids.

Certain drugs with good tissue repair activity, such as growth factors, will not be able to be delivered to the wound site without the aid of an appropriate topical drug carrier to deliver an effective amount of the drug from a solid or semisolid carrier material for prolonged administration to the wound site. exert its therapeutic value