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34 results about "Spiral ganglion" patented technology

The spiral (cochlear) ganglion is the group of nerve cells that serve the sense of hearing by sending a representation of sound from the cochlea to the brain. The cell bodies of the spiral ganglion neurons are found in the modiolus, the conical shaped central axis in the cochlea.

Methods and systems for customizing cochlear implant stimulation and applications of same

One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.
Owner:VANDERBILT UNIV

Treatment of hearing and balance impairments using compounds having erythropoietin activity

InactiveUS20110142834A1Prevent and reduce and treat incidence of and severityMaintain functional integritySenses disorderNervous disorderBiosimilar PharmaceuticalsSide effect
Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss, or degeneration, preferably of spiral ganglion neurons, by administration of a therapeutically effective amount of one or more molecules having erythropoietin activity selected from EPO, or a biosimilar, a variant, or a mutant thereof; a protein or peptide mimetic of EPO; a small molecule mimetic of EPO and an erythropoiesis stimulating agent. Also provided are improved compositions and methods for treatments of ototoxicity requiring administration of a pharmaceutical having an ototoxic side-effect in combination with a therapeutically effective amount of a molecule having erythropoietin activity.
Owner:EDISON PHARMA

Cochlear Implant

There is provided a cochlear implant for improving the hearing ability of a patient suffered from hearing impairment comprising an internal receiving unit implanted into the body, which comprises a receiving part for receiving external signal, an active electrode and a reference electrode, characterized in that the active electrode is constructed with a single electrode wire having different thickness in at least two different regions. The active electrode of the internal receiving unit is inserted into a space formed at between the mastoid bone and the ear canal skin and end of the active electrode is inserted into the scala tympani of the cochlea and directly stimulates spiral ganglion. The cochlear implant provides easier implantation into the body and improved hearing ability at a lower cost.
Owner:MATERIAL SOLUTIONS TECH CO LTD

Improvements for cochlear implants

The invention relates to a method of generating a place-frequency map for accurate positioning of a cochlear implant whereby the place-frequency map is used to relate a physical position of the cochlear implant to a tonotopic map of the basilar membrane / spiral ganglion. The invention also relates to a method of electrically positioning of an already inserted cochlear implant within the cochlea to provide stimuli to only the parts of the cochlea that have reduced or no residual hearing.
Owner:QUEENSLAND UNIV OF THE

Pre-bend electrode array couplet for cochlear implant

InactiveCN101366666AEasy surgical implantationImprove reliabilityProsthesisColloidElectrode array
The invention discloses a polar array of artificial cochlear implant pre-bent electrode, which comprises a colloid silica and a polar array pre-bent like a cochlea, wherein the polar array consists of an electrode ring and an electrode wire, and is packed with the colloid silica as a whole. The polar array of artificial cochlear implant pre-bent electrode is characterized in that a plurality of supporting sections are arranged on the colloid silica facing away from the polar array, and are connected with the colloid silica into a whole, slender through holes parallel to the polar array are arranged on the supporting sections, the through holes penetrate the supporting steel cores to straighten the pre-bent cochlea polar array. The polar array is simple in structure, compared with the prior art, brings great convenience to the implanting operation of the polar array of artificial cochlear implant pre-bent electrode, allows the electrode closer to the spiral ganglion cell of the cochlea so as to improve the language discernibility, is low in power consumption and ensures that the implanted electrode works normally in the human body for a long time.
Owner:SHANGHAI LISTENT MEDICAL TECH CO LTD

Cochlear implants

InactiveUS8554330B2Accurate perceptionImprove binaural hearingHead electrodesProsthesisCochlear implant surgeryFrequency map
The invention relates to a method of generating a place-frequency map for accurate positioning of a cochlear implant whereby the place-frequency map is used to relate a physical position of the cochlear implant to a tonotopic map of the basilar membrane / spiral ganglion. The invention also relates to a method of electrically positioning of an already inserted cochlear implant within the cochlea to provide stimuli to only the parts of the cochlea that have reduced or no residual hearing.
Owner:QUEENSLAND UNIV OF THE

Artificial cochlea ad sound processing method thereof

The invention relates to an artificial cochlea. The artificial cochlea comprises an external device and an implant, wherein the external device comprises a sound processing device and a power supply unit, the power supply unit is used for supplying power for the sound processing device, the sound processing device is used for processing acquired sound signals to form full frequency continuous sound signals which are sent to the implant, the continuous sound signals sent by the sound processing device are received by the implant, a spiral ganglion is further stimulated by utilizing electrical electrodes, and the continuous sound signals are transmitted to auditory nerves. The invention further relates to a sound processing method of the artificial cochlea. According to the artificial cochlea, after multi-channel sub-band processing on the sound signals, the sound signals are synthesized to form complete sine wave signals, the sine wave signals comprise all the sound information including tones, and patients are made to have real hearing feeling.
Owner:SHENYANG HONGDINGKANG MEDICAL DEVICE

Local cochlear application of statins for stimulating neurite regrowth in the cochlea

Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and / or hair cells of the cochlea following acoustic or toxic insult.
Owner:NORTHWESTERN UNIV

Application of mTOR signal path inhibitor to preparation of medicament for preventing or treating extragenetic hearing impairment

The invention discloses application of a mTOR signal path inhibitor to preparation of a medicament for preventing or treating extragenetic hearing impairment. The mTOR signal path inhibitor is selected from at least one of sirolimus, sirolimus analogue and second-generation mTOR signal path inhibitor; the sirolimus analogue is selected from at least one of everolimus, temsirolimus and Deforolimus;the second-generation mTOR signal path inhibitor is selected from at least one of PI3K / mTOR double inhibitor, selective mTORC1 / 2 inhibitor and ATP competitive mTOR kinase inhibitor. As found by the inventor of the application, the mTOR signal path inhibitor can effectively relieve damage to inner ear hair cells and spiral ganglion cells caused by non-genetic factors such as ototoxic drug, remarkably improve the impaired listening ability, and effectively prevent and treat extragenetic hearing impairment.
Owner:SOUTHERN MEDICAL UNIVERSITY

Anti-retraction pre-bending electrode with plurality of concave notches and implantation method of anti-retraction pre-bending electrode

The invention relates to the technical field of pre-bending electrodes, in particular to an anti-retraction pre-bending electrode with a plurality of concave notches and an implantation method of theanti-retraction pre-bending electrode. The anti-retraction pre-bending electrode comprises an electrode array, a pre-bending electrode internal signal transmission line, a guide wire and silica gel, wherein a silica gel body comprises a front section and a rear section; a guide wire passage is formed in the rear section; each of the front section and the rear section is in a circular arc shape; the curvature of the front section is smaller than the curvature of the adjacent rear section; a notch is formed between every two electrode contacts of the front section; and an anti-displacement device is arranged in a position, close to the tail end, of the rear section. The size and the rigidity of the front section can be reduced, so that the damage to a basilar membrane and tissues in the cochlea when the pre-bending electrode is implanted is reduced; cross stimulation of the electrode contacts onto the spiral ganglion cells is avoided; the rigidity of the front section is reduced; the flexibility of the pre-bending electrode is improved; residual audibility of a patient and the completeness of the electrode are effectively protected; the outward leakage of lymph in the cochlea in theoperation and the postoperative displacement are effectively prevented; and the success rate of an artificial cochlea implantation operation is increased.
Owner:CHINA JILIANG UNIV

Artificial cochlea pre-bent electrode array union

ActiveCN101889910AEasy surgical implantationImprove reliabilityProsthesisWhole bodyColloid
The invention discloses an artificial cochlea pre-bent electrode array union. The artificial cochlea pre-bent electrode array union comprises colloid silica and an electrode array union which is pre-bent into a cochlea shape, wherein the electrode array union consists of electrode rings and electrode wires; and the electrode array union and the colloid silica are packaged into a whole body. The artificial cochlea pre-bent electrode array union is characterized in that: a water filling cavity which is parallel to the electrode array union is formed on the colloid silica which is back to the electrode array union; one end of the water filling cavity is closed, while the other end is provided with a water filling hole which is in threaded connection; and the electrode array union which is pre-bent into the cochlea shape can be straightened by filling water into the water filling cavity. The artificial cochlea pre-bent electrode array union is simple in structure, and compared with the prior art, the artificial cochlea pre-bent electrode array union brings great convenience to the operation of implanting the artificial cochlea pre-bent electrode array union; and both the reliability and the safety of an implant are greatly improved, so that electrodes get closer to spiral ganglion cells of the cochlea, the language discrimination capacity is improved, and the long-term normal operation of the implanted electrodes in human bodies is ensured.
Owner:SHANGHAI LISTENT MEDICAL TECH CO LTD

Artificial sensory epithelium

ActiveUS9566428B2Head electrodesExternal electrodesSensory epitheliumMicroelectrode
An artificial sensory epithelium (1) to be embedded in a cochlea (301) of a patient includes a piezoelectric film (2) and multitude microelectrodes (3), (3), . . . arranged on the cochlea. The piezoelectric film is arranged along a basilar membrane (306) in the cochlea. A portion of the piezoelectric film that corresponds to a portion of the basilar membrane that is induced to vibrate by sound waves coming from outside the cochlea vibrates. A microelectrode of the microelectrodes that is arranged on the portion of the piezoelectric film provides electric stimuli to spiral ganglion neurons (311). The artificial sensory epithelium preferably includes a support member (4) configured to support the piezoelectric film and be fixable in the cochlea.
Owner:OSAKA UNIV

Methods and systems for customizing cochlear implant stimulation and applications of same

One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.
Owner:VANDERBILT UNIV

Local cochlear application of statins for stimulating neurite regrowth in the cochlea

ActiveUS20160022663A1Preventing and treating hearing lossBiocideOrganic chemistryPitavastatinStatine
Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear, as well as methods and kits for preventing damage to or treating damage of auditory neurons and / or hair cells of the cochlea following acoustic or toxic insult. An exemplary statin for these methods and kits includes Pitavastatin having the compound formula (VIII):
Owner:NORTHWESTERN UNIV

Novel application of aromatic cyclopropyl amine compound

The invention belongs to the technical field of biology, relates to a novel application of an aromatic cyclopropyl amine compound and provides an application of an aromatic cyclopropyl amine compound, which is used for preparing drugs for preventing and treating peripheral neuropathy as an effective ingredient. An animal model for in vitro injury and protection study of a spiral ganglion neuron is built by taking injury protection of the spiral ganglion neuron in sensorineural deafness as an example and a mouse as a model animal, and the result shows that the dimethylated histone H3K4 expression level can be obviously regulated up and Cleaved Caspase-3 expression of the spiral ganglion neuron can be significantly reduced through providing the aromatic cyclopropyl amine compound in vitro, and the aromatic cyclopropyl amine compound has a protective effect on peripheral nerve cells, especially the spiral ganglion neuron of a sensorineural deafness patient. A theoretical basis and a new way are provided for searching, preventing and treating the peripheral neuropathy, and the aromatic cyclopropyl amine compound has clinical application value.
Owner:EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV +1

Pharmaceutical composition for treating or preventing sensorineural hearing loss, containing cysteinyl leukotriene receptor antagonist and ginkgo leaf extract

The present invention provides a compound having an effect of preventing and / or treating the damage or degeneration of cochlear (and vestibular) mother cells and spiral ganglion neurons by downregulating a cysteinyl leukotriene receptor. Particularly, the present invention provides a composition for preventing or treating sensorineural hearing loss, containing a cysteinyl leukotriene receptor and a ginkgo biloba extract as active ingredients, on the basis of the co-administration of a cysteinyl leukotriene receptor and a ginkgo biloba extract having an excellent effect of protecting hearing.
Owner:AJOU UNIV IND ACADEMIC COOP FOUND

Local cochlear application of statins for stimulating neurite regrowth in the cochlea

Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and / or hair cells of the cochlea following acoustic or toxic insult.
Owner:NORTHWESTERN UNIV

Light-operated artificial cochlea device

InactiveCN103300941BTo achieve the purpose of treating deafnessAvoid damageProsthesisLED lampLight-emitting diode
The invention discloses a light-operated artificial cochlea device, which comprises a voice acquisition device, a voice processing device, a transmission device and a photic stimulation device capable of implanting cochleas, and is characterized in that the photic stimulation device comprises a micro LED (light-emitting diode) lamp containing blue and yellow light sources, and a flexible optical fiber output end connected with the micro LED lamp, the voice processing device is used for coding received electrical signals, the coded electrical signals are used for controlling the on and off of the lamp sources of the micro LED lamp, the frequency, the pulse width and the intensity of light and the alternating time between the blue light source and the yellow light source, the micro LED lamp applies the received electrical signals to driving the micro LED lamp and generating corresponding photic stimulation signals, and the photic stimulation signals are transmitted to spiral ganglion cells of photogenes expressing sensitivity to blue and yellow in advance through the flexible optical fiber output end and drive the spiral ganglion cells to generate excitement and inhibition intermittent auditory nerve impulse with certain frequency and a certain mode. The light-operated artificial cochlea device has the advantages of little trauma, simplified operation, high success ratio of an operation and high natural sound degree.
Owner:NINGBO UNIV

Application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy

The invention discloses application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy. The researches of the invention discover that the recombinanthuman neurite-promoting factor Neuritin has a curative effect on nerve deafness which is caused by cochlea spiral ganglion cell damage caused by noise damage, medicine damage, aging and the like and does not have evident hair cell damage. The curative mechanism of the recombinant human neurite-promoting factor Neuritin is characterized in that the recombinant human neurite-promoting factor Neuritin can effectively protect spiral ganglion cells, effectively maintain the number and arrangement of nerve fibers and guarantee the effective connection among the hair cells, the nerve fibers and the spiral ganglion cells so as to promote the functions of the spiral ganglion cells, the nerve fibers and the hair cells. Therefore, the recombinant human neurite-promoting factor Neuritin can be used for preparing medicine for treating the nerve deafness caused by cochlea spiral ganglion cell damage.
Owner:HANGZHOU NORMAL UNIVERSITY

Artificial cochlea pre-bent electrode array union

ActiveCN101889910BEasy surgical implantationImprove reliabilityProsthesisWhole bodyColloid
The invention discloses an artificial cochlea pre-bent electrode array union. The artificial cochlea pre-bent electrode array union comprises colloid silica and an electrode array union which is pre-bent into a cochlea shape, wherein the electrode array union consists of electrode rings and electrode wires; and the electrode array union and the colloid silica are packaged into a whole body. The artificial cochlea pre-bent electrode array union is characterized in that: a water filling cavity which is parallel to the electrode array union is formed on the colloid silica which is back to the electrode array union; one end of the water filling cavity is closed, while the other end is provided with a water filling hole which is in threaded connection; and the electrode array union which is pre-bent into the cochlea shape can be straightened by filling water into the water filling cavity. The artificial cochlea pre-bent electrode array union is simple in structure, and compared with the prior art, the artificial cochlea pre-bent electrode array union brings great convenience to the operation of implanting the artificial cochlea pre-bent electrode array union; and both the reliability and the safety of an implant are greatly improved, so that electrodes get closer to spiral ganglion cells of the cochlea, the language discrimination capacity is improved, and the long-term normal operation of the implanted electrodes in human bodies is ensured.
Owner:SHANGHAI LISTENT MEDICAL TECH CO LTD

Composition for preventing or treating hearing loss, containing vitis vinifera leaf extract as active ingredient

ActiveUS20210145919A1Preventing or ameliorating hearing lossSenses disorderDispersion deliveryElectrophonic hearingBULK ACTIVE INGREDIENT
A composition for preventing or treating hearing loss, containing a Vitis vinifera leaf extract as an active ingredient, is disclosed. A pharmaceutical composition for preventing or treating hearing loss, containing the extract (a Vitis vinifera leaf extract) as an active ingredient, protects auditory hair cells in the cochlea and spiral ganglion cells from damage caused by noise and the like and effectively reduces the hearing threshold measured in the auditory nerves, thereby being usable as an agent for preventing or treating hearing loss.
Owner:AJOU UNIV IND ACADEMIC COOP FOUND

Method for establishing adult mouse cochlea body culture system and application thereof

The invention relates to a method for establishing an adult mouse cochlea body culture system and application thereof. According to the invention, a co-culture structure of inner ear sensory epithelium and spiral ganglion neurons of an adult mouse, which are provided with a bony scaffolds, is placed into culture solution to carry out culture, and the culture solution is regularly replaced; and components of the culture solution comprises N2, B27 and penicillin. According to the invention, a first integrated culture system of the cochlea sensory epithelium and the spiral ganglion neurons of an adult mammal is established; completeness of an inner ear sensory epithelium structure and the survival of sustentacular cells and the spiral ganglion neurons can be maintained for a long term, a research model is provided for research on proliferation and transdifferentiation of the inner ear sustentacular cells, differentiation and maturation of hair cells, establishment of synaptic connection between newborn hair cells and the spiral ganglion neurons and the like for the adult mammals, the blank of models in the field is filled, and the research level reaches the international leading level.
Owner:EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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