34 results about "Spiral ganglion" patented technology

One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. The method includes determining a position for each of the plurality of electrodes and spiral ganglion nerves that the electrode array stimulates, determining a geometric relationship between neural pathways within the cochlea and the electrode array implanted therein, and using one or more electrodes of the electrode array to stimulate a group of SG neural pathways of the cochlea based on the location of the one or more electrodes and their geometric relationship with the neural pathways.

There is provided a cochlear implant for improving the hearing ability of a patient suffered from hearing impairment comprising an internal receiving unit implanted into the body, which comprises a receiving part for receiving external signal, an active electrode and a reference electrode, characterized in that the active electrode is constructed with a single electrode wire having different thickness in at least two different regions. The active electrode of the internal receiving unit is inserted into a space formed at between the mastoid bone and the ear canal skin and end of the active electrode is inserted into the scala tympani of the cochlea and directly stimulates spiral ganglion. The cochlear implant provides easier implantation into the body and improved hearing ability at a lower cost.

Method and apparatus for optically and electrically stimulating neurons of auditory nerve pathways of a person to provide auditory sensations for the person including generating a plurality of pulsed light signals having one or more successive pulses, delivering the plurality of pulsed light signals to one or more auditory nerve pathways of the cochlea of the person and selectively controlling the plurality of light signals to optically stimulate and trigger nerve action potentials (NAPs) in the one or more auditory nerve pathways. In some embodiments, the present invention also includes one or more electrical stimulation electrodes used to stimulate the low frequency portions of the auditory nerves.

The invention discloses a polar array of artificial cochlear implant pre-bent electrode, which comprises a colloid silica and a polar array pre-bent like a cochlea, wherein the polar array consists of an electrode ring and an electrode wire, and is packed with the colloid silica as a whole. The polar array of artificial cochlear implant pre-bent electrode is characterized in that a plurality of supporting sections are arranged on the colloid silica facing away from the polar array, and are connected with the colloid silica into a whole, slender through holes parallel to the polar array are arranged on the supporting sections, the through holes penetrate the supporting steel cores to straighten the pre-bent cochlea polar array. The polar array is simple in structure, compared with the prior art, brings great convenience to the implanting operation of the polar array of artificial cochlear implant pre-bent electrode, allows the electrode closer to the spiral ganglion cell of the cochlea so as to improve the language discernibility, is low in power consumption and ensures that the implanted electrode works normally in the human body for a long time.

Presented herein are trans-modiolar stimulation techniques in which stimulation current is sourced (delivered) by at least one intra-cochlear stimulating contact and is sunk at a group of other intra-cochlear stimulating contacts. The group of other infra-cochlear stimulating contacts is positioned (located) across a section of the recipient's modiolus from the intra-cochlear stimulating contact that sources the stimulation. As such, stimulation current generally passes through the modiolus to stimulate spiral ganglion cells and evoke a hearing percept.

The invention relates to the technical field of pre-bending electrodes, in particular to an anti-retraction pre-bending electrode with a plurality of concave notches and an implantation method of theanti-retraction pre-bending electrode. The anti-retraction pre-bending electrode comprises an electrode array, a pre-bending electrode internal signal transmission line, a guide wire and silica gel, wherein a silica gel body comprises a front section and a rear section; a guide wire passage is formed in the rear section; each of the front section and the rear section is in a circular arc shape; the curvature of the front section is smaller than the curvature of the adjacent rear section; a notch is formed between every two electrode contacts of the front section; and an anti-displacement device is arranged in a position, close to the tail end, of the rear section. The size and the rigidity of the front section can be reduced, so that the damage to a basilar membrane and tissues in the cochlea when the pre-bending electrode is implanted is reduced; cross stimulation of the electrode contacts onto the spiral ganglion cells is avoided; the rigidity of the front section is reduced; the flexibility of the pre-bending electrode is improved; residual audibility of a patient and the completeness of the electrode are effectively protected; the outward leakage of lymph in the cochlea in theoperation and the postoperative displacement are effectively prevented; and the success rate of an artificial cochlea implantation operation is increased.

The invention discloses an artificial cochlea pre-bent electrode array union. The artificial cochlea pre-bent electrode array union comprises colloid silica and an electrode array union which is pre-bent into a cochlea shape, wherein the electrode array union consists of electrode rings and electrode wires; and the electrode array union and the colloid silica are packaged into a whole body. The artificial cochlea pre-bent electrode array union is characterized in that: a water filling cavity which is parallel to the electrode array union is formed on the colloid silica which is back to the electrode array union; one end of the water filling cavity is closed, while the other end is provided with a water filling hole which is in threaded connection; and the electrode array union which is pre-bent into the cochlea shape can be straightened by filling water into the water filling cavity. The artificial cochlea pre-bent electrode array union is simple in structure, and compared with the prior art, the artificial cochlea pre-bent electrode array union brings great convenience to the operation of implanting the artificial cochlea pre-bent electrode array union; and both the reliability and the safety of an implant are greatly improved, so that electrodes get closer to spiral ganglion cells of the cochlea, the language discrimination capacity is improved, and the long-term normal operation of the implanted electrodes in human bodies is ensured.

Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear, as well as methods and kits for preventing damage to or treating damage of auditory neurons and/or hair cells of the cochlea following acoustic or toxic insult. An exemplary statin for these methods and kits includes Pitavastatin having the compound formula (VIII):

The invention discloses application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy. The researches of the invention discover that the recombinanthuman neurite-promoting factor Neuritin has a curative effect on nerve deafness which is caused by cochlea spiral ganglion cell damage caused by noise damage, medicine damage, aging and the like and does not have evident hair cell damage. The curative mechanism of the recombinant human neurite-promoting factor Neuritin is characterized in that the recombinant human neurite-promoting factor Neuritin can effectively protect spiral ganglion cells, effectively maintain the number and arrangement of nerve fibers and guarantee the effective connection among the hair cells, the nerve fibers and the spiral ganglion cells so as to promote the functions of the spiral ganglion cells, the nerve fibers and the hair cells. Therefore, the recombinant human neurite-promoting factor Neuritin can be used for preparing medicine for treating the nerve deafness caused by cochlea spiral ganglion cell damage.

A composition for preventing or treating hearing loss, containing a Vitis vinifera leaf extract as an active ingredient, is disclosed. A pharmaceutical composition for preventing or treating hearing loss, containing the extract (a Vitis vinifera leaf extract) as an active ingredient, protects auditory hair cells in the cochlea and spiral ganglion cells from damage caused by noise and the like and effectively reduces the hearing threshold measured in the auditory nerves, thereby being usable as an agent for preventing or treating hearing loss.

The invention relates to a method for establishing an adult mouse cochlea body culture system and application thereof. According to the invention, a co-culture structure of inner ear sensory epithelium and spiral ganglion neurons of an adult mouse, which are provided with a bony scaffolds, is placed into culture solution to carry out culture, and the culture solution is regularly replaced; and components of the culture solution comprises N2, B27 and penicillin. According to the invention, a first integrated culture system of the cochlea sensory epithelium and the spiral ganglion neurons of an adult mammal is established; completeness of an inner ear sensory epithelium structure and the survival of sustentacular cells and the spiral ganglion neurons can be maintained for a long term, a research model is provided for research on proliferation and transdifferentiation of the inner ear sustentacular cells, differentiation and maturation of hair cells, establishment of synaptic connection between newborn hair cells and the spiral ganglion neurons and the like for the adult mammals, the blank of models in the field is filled, and the research level reaches the international leading level.