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Application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy

A growth factor, human nerve technology, applied in the field of biomedicine, can solve the problems of rare literature reports on Neuritin research

Pending Publication Date: 2019-08-16
HANGZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned NTFs have shown an important role in promoting the recovery of impaired hearing function, but there are few literature reports on the study of Neuritin in the auditory system

Method used

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  • Application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy
  • Application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy
  • Application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy

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Embodiment 1

[0022] 1. Primer Design

[0023] The Neuritin sequence of Mongolian long-clawed gerbil was downloaded from NCBI. After analysis and comparison, fluorescent quantitative PCR primers were designed using Primer Premier5.0 software. The primers were synthesized by Shanghai Jierui Bioengineering Co., Ltd.

[0024]

[0025] 2. Cochlear Sample Preparation

[0026] a. Ten gerbils of 20-day embryo, 1-3 day, 7-day, 21-day, and 56-day after birth were sacrificed by cervical dissection respectively, the skin and muscle tissue were bluntly separated, the auditory bulb was quickly exposed, the cochlea was taken out, and the Put it into a liquid nitrogen environment to prevent protein and RNA degradation, and then store it at -80°C for subsequent protein and RNA detection tests.

[0027] b Take out the 56-day-old gerbil, quickly take out the cochlea according to the above operation, peel off the residual muscle and blood tissue under the dissecting microscope, drill a small hole in the c...

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Abstract

The invention discloses application of recombinant human neurite-promoting factor Neuritin and medicine for treating auditory neuropathy. The researches of the invention discover that the recombinanthuman neurite-promoting factor Neuritin has a curative effect on nerve deafness which is caused by cochlea spiral ganglion cell damage caused by noise damage, medicine damage, aging and the like and does not have evident hair cell damage. The curative mechanism of the recombinant human neurite-promoting factor Neuritin is characterized in that the recombinant human neurite-promoting factor Neuritin can effectively protect spiral ganglion cells, effectively maintain the number and arrangement of nerve fibers and guarantee the effective connection among the hair cells, the nerve fibers and the spiral ganglion cells so as to promote the functions of the spiral ganglion cells, the nerve fibers and the hair cells. Therefore, the recombinant human neurite-promoting factor Neuritin can be used for preparing medicine for treating the nerve deafness caused by cochlea spiral ganglion cell damage.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of a recombinant human neurite growth factor Neuritin protein and a medicine for treating auditory neuropathy. Background technique [0002] Deafness is one of the most common clinically disabling diseases. According to the data of the World Health Organization in 2018, about 466 million people worldwide suffer from hearing loss, including 34 million children. Reaching 900 million, it has become a major health and socioeconomic problem in all countries. Hearing loss will not only drastically reduce the efficiency of information transmission, but also seriously lead to impairment of speech and cognitive function development in children, and bring serious emotional and social economic burdens to human beings. [0003] Deafness can be roughly divided into three types according to the different parts of the damage: conductive deafness, sensorineural deafness and ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P27/16A61P25/00
CPCA61K38/185A61K9/0046A61P27/16A61P25/00
Inventor 杨磊黄瑾桂飞宋晓明汪海燕孙筱品洪玉杨怡谌容胡金池黄娟
Owner HANGZHOU NORMAL UNIVERSITY
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