30results about How to "Maximize response" patented technology

Wearable light device for providing additional light for activities in low light includes a wearable mount (20) including a light system (30) and power source (40). Light system (30) includes one or more arrays of light sources such as light-emitting diodes (33). Photo sensor (34) detects ambient light or emitted light returned from a reflective surface and causes control circuit (45) to dim light emission.

A base station receives signals from highway traffic and sends signals to selected vehicles on the highway to command them to increase / decrease speed or charge lane in order to more closely conform to a virtual model for vehicular use of the highway.

Described herein are methods, devices and system for selecting an optimum position of a stimulation electrode, and particularly methods, devices and systems for optimizing the position of a stimulation electrode for stimulating the inflammatory reflex and thereby inhibiting inflammation. The methods, devices and systems described herein may generally include the analysis of one or more artifact modalities arising after the application of a stimulation pulse. One or more of these artifact modalities (e.g., EMG, ECG, etc.) may be detected and used to generate a comparable indicator of the fitness of the position of the electrode relative to a target, such as a portion of the inflammatory reflex like the vagus nerve.

A probe instrument using room-temperature sensor(s) that can measure variations in magnetic susceptibilities. The instrument has sufficient resolution to monitor paramagnetic materials in a human body, such as iron in a human liver, by noninvasively examining patients with iron-overload diseases. The instrument includes room temperature magnetic sensors, and detects the sample, that is, the tissue response to an alternating current field applied by an applied field coil. The applied field coil dimensions are chosen so that the applied field is optimized for maximum response from the liver while minimizing the effects due to the overlying abdominal tissue and at the same time not unduly increasing the sensitivity of the instrument to the lung. To overcome variations in the sensor output due to fluctuations in the applied field, change in the ambient temperature and mechanical relaxation of the instrument, the sensor-sample distance is modulated. The detector assembly is oscillated while the examined patient remains stationary. An improved water-bag technique is employed to eliminate background tissue response. The detector assembly forms part of a probe instrument for performing noninvasively the paramagnetic concentration of a patient.

Wearable light device for providing additional light for activities in low light includes a wearable mount (20) including a light system (30) and power source (40). Light system (30) includes one or more arrays of light sources such as light-emitting diodes (33). Photo sensor (34) detects ambient light or emitted light returned from a reflective surface and causes control circuit (45) to dim light emission.

A cup waveguide antenna with integrated polarizer and OMT for simultaneously communicating left and right hand circularly polarized electromagnetic waves is adjustable to obtain efficient propagation and reception of electromagnetic waves. The antenna includes a circular waveguide having an orthomode transducer utilizing first and second pins longitudinally spaced apart and oriented orthogonally with respect to each other. Six radially-oriented adjustable polarizer screws extend from the exterior to the interior of the waveguide. A septum intermediate the first and second pins is aligned with the first pin. Adjustment of the polarizer screws enables maximized propagation of and / or response to left hand circularly polarized electromagnetic waves by the first pin while simultaneously enabling maximized propagation of and / or response to right hand circularly polarized electromagnetic waves by the second pin.

A system and method are provided for using neuromodulation techniques and intravesical electrical stimulation to treat Urinary Incontinence and related bladder-system conditions. The system uses an electrical stimulation module, stimulation electrodes and catheters, and / or a measurement and feedback system to determine an electrical stimulation therapy program as a function of a pre-programmed library and, optionally, measured and patient-provided response data. IVES and other electrical stimulation signals are generated and conveyed to the patient via catheter electrodes placed in and around the bladder system and related nerves, nodes and motor control points. The system employs a variety of safety mechanisms, including safety algorithms, a one-time use catheter connection, and catheter electrical-shock protection mechanisms.

Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

An integrated system and method to permit coaches, trainers and other life enhancement entities and individuals to monitor, manage, support, schedule, prompt and otherwise motivate clients to achieve set goals, establish new goals and continue routines during times of non-personal interaction between the coach, trainer or enhancement entity or person and the client.

A system and method for generating frequency-multiplexed synthetic sound-speech stimuli and for detecting and analyzing electrical brain activity of a subject in response to the stimuli. Frequency-multiplexing of speech copora and synthetic sounds helps the composite sound to blend into a single auditory object. The synthetic sounds are temporally aligned with the utterances of the speech corpus. Frequency multiplexing may include splitting the frequency axis into alternating bands of speech and synthetic sound to minimize the disruptive interaction between the speech and synthetic sounds along the basilar membrane and in their neural representations. The generated stimuli can be used with both traditional and advanced techniques to analyze electrical brain activity and provides a rapid, synoptic view into the functional health of the early auditory system, including how speech is processed at different levels and how these levels interact.

A multitone nonlinear radar system (and a method of operating such a system) comprising a transmitter that transmits a signal comprising at least two predetermined frequency components; a receiver operating to receive return signals comprising harmonics of at least two predetermined frequencies, combinations of the at least two predetermined frequency components, and combinations of the harmonics of the at least two predetermined frequency components that are within a predetermined selected frequency range that has been predetermined to enable detection and / or classification of an electronic device; at least one antenna operating to transmit and receive electromagnetic radiation operatively connected to the transmitter and receiver; the receiver comprising at least one high pass filter for attenuating linear reflections at the two predetermined frequencies, and an analyzer;whereby electronic devices may be detected and identified by analyzing return signals within a predetermined frequency range.

The present invention is an improved method of electrically stimulating percepts in a patient with a visual prosthesis, to induce a more controlled perception of light. In particular, the present invention is an improved electrode array to maximize retinal response. The array of the present invention is an array with a center section with no electrode, surrounded by a ring of small high density electrodes. Electrodes beyond to ring are gradually larger and more widely spaced.

A high-speed actuator to move a valve stopper to a closed position against a valve seat and an open position away from the valve seat is disclosed. The actuator includes a rod carrying first and second axially spaced solenoid armatures. The rod also has a valve stopper connector end. A first solenoid coil surrounds and is spaced from the rod to bias the first solenoid armature along with the rod and valve stopper toward the valve's open position. A second solenoid surrounds and is spaced from the rod. The second solenoid is axially spaced from the first solenoid to bias the first armature towards the valve's closed position. A linear variable differential transformer (LVDT) magnetically coupled to the second solenoid armature is included to determine the instantaneous position of the valve stopper relative to the valve's seat. The LVDT is responsive to the position of the second armature. The LVDT generates an instantaneous valve position signal in concert with the movements of the rod. A valve position control circuit is adapted to receive a valve position set point from a user's input, and a valve position feedback signal from the LVDT. The valve position control circuit includes first and second solenoid coil drive signals that urge the first armature, and hence the valve stopper to the valve position set point inputted by a user. A signal generator circuit is provided to vibrate the valve about a position set point in order to enhance material discharge down the discharge tube.

Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

A current equalizer is provided for first and second battery elements connected in parallel to supply a DC link. A first constant resistance carries a first current from the first battery element to the DC link. A first variable resistance is connected in parallel with the first constant resistance. A second constant resistance carries a second current from the second battery element to the DC link. A second variable resistance is connected in parallel with the second constant resistance. A balancer inversely adjusts the first and second variable resistances in response to relative magnitudes of the first and second currents. As a result, the total currents supplied from each battery element to the DC link are equalized because the effective total resistance in series with each battery element compensates for the difference in the internal battery resistances.

A thermal conductivity detector includes a heatable resistive detector configured to be physically arranged in an analytes flow eluting from a chromatography column and electrically arranged with resistors in separate arms of a measuring bridge, an amplifier which detects differential voltage between two opposite nodes of the bridge and applies an output voltage to other opposite nodes of the measuring bridge to maintain the detector at a constant operating temperature, and an additional resistor with a controllable switch in parallel connected in series with the detector or resistor arranged in one arm of the bridge, where the switch is periodically turned on and off at a predetermined duty cycle and / or controlled by information on characteristic times-of-arrival of analytes at the detector to compensate for operating temperature uncertainties due to manufacturing variations of the resistors and / or to allow for processing small and large peaks of a chromatogram with highest available resolution.

The present invention provides novel, stable, processable and pharmaceutically acceptable salt forms of 2R,6R-hydroxynorketamine or 2S,6S-hydroxynorketamine with high aqueous solubility.

A fast flexoelectro-optic switching device containing bimesogen-doped and polymer-stabilized vertical standing helix (PSVSH) in a cholesteric liquid crystal. The PSVSH device exhibits a response time of less than 0.7 millisecond, high contrast and negligible hysteresis which is suitable for applications including blur-free displays, field-sequential color displays and active optical elements.

A high-speed actuator moves a valve stopper to a selected position to control material flow. The actuator includes a rod carrying first and second axially spaced solenoid armatures attached to the stopper. First and second solenoid coil surround and are spaced from the rod to bias the first solenoid armature along with the rod and valve stopper. A linear variable differential transformer (LVDT) responsive to the position of the second armature determines the instantaneous position of the valve stopper. A valve position control circuit receives a valve position set point from a user's input, and a valve position feedback signal from the LVDT. The valve position control circuit includes first and second solenoid coil drive signals that urge the first armature and stopper to the valve position set point. A signal generator circuit vibrates the valve about a set point to enhance material discharge.

A system and method for generating frequency-multiplexed synthetic sound-speech stimuli and for detecting and analyzing electrical brain activity of a subject in response to the stimuli. Frequency-multiplexing of speech copora and synthetic sounds helps the composite sound to blend into a single auditory object. The synthetic sounds are temporally aligned with the utterances of the speech corpus. Frequency multiplexing may include splitting the frequency axis into alternating bands of speech and synthetic sound to minimize the disruptive interaction between the speech and synthetic sounds along the basilar membrane and in their neural representations. The generated stimuli can be used with both traditional and advanced techniques to analyze electrical brain activity and provides a rapid, synoptic view into the functional health of the early auditory system, including how speech is processed at different levels and how these levels interact.

A novel approach to the development of a personalized vaccine. This approach is based on: A) sequencing of the gag gene from an HIV-infected individual treated with antiretroviral therapy; B) sequencing of the HLA alleles of the same individual; C) selecting the epitopes recognized by the individual's own HLA Class I within the highly-conserved Gag256-377, Gag147-169 and / or Gag225-251 amino acid sequences. An original algorithm that designs the target peptide for the vaccine starting from viral and HLA sequences of an individual with HIV / AIDS, forms the core of the present invention. The original algorithm makes extensive use of existing open- source software for protein design. The peptides designed in this manner and accordingly synthesized may be exploited as a therapeutic vaccine against HIV / AIDS. Vehicles for such peptides may be an individual's own dendritic cells pulsed with the peptide combination or a specific viral or DNA vector leading to intracellular expression of the viral peptides. The present vaccine approach may contribute to control of viremia once antiretroviral therapies are suspended.

The present invention is an improved method of electrically stimulating percepts in a patient with a visual prosthesis, to induce a more controlled perception of light. In particular, the present invention is an improved electrode array to maximize retinal response. The array of the present invention is an array with a center section with no electrode, surrounded by a ring of small high density electrodes. Electrodes beyond to ring are gradually larger and more widely spaced.

A fast flexoelectro-optic switching device containing bimesogen-doped and polymer-stabilized vertical standing helix (PSVSH) in a cholesteric liquid crystal. The PSVSH device exhibits a response time of less than 0.7 millisecond, high contrast and negligible hysteresis which is suitable for applications including blur-free displays, field-sequential color displays and active optical elements.