165results about How to "Improve therapeutic efficacy" patented technology

A self-contained respiratory apparatus, including a blower delivering a gas, a headgear integrated with the blower to support a respiratory interface, and a sensor embedded in the headgear and mounted to deliver data to a microprocessor integrated with the blower, the blower being controlled through the response of the sensor and the control of the microprocessor to support the respiratory interface through the headgear.

Disclosed is a conjugate comprising a biologically active agent (drug) linked to a subcellular targeting moiety that targets a drug specifically to the nucleus. Targeting is achieved by attaching a steroid hormone (or an analog) to the drug. The steroid hormone attached to the drug binds its corresponding receptor, the formation of the receptor-ligand complex results in the internalization of the complex into the nucleus, thus resulting in nuclear translocation of the drug. Also disclosed is a conjugate (comprising the complex of the drug and the steroid hormone) bound to a polymer by spacers allowing for concurrent passive targeting to the tumor cell (afforded by attachment to the polymer by the EPR effect) and nuclear targeting of the conjugate (due to the presence of the steroid). Using a suitable degradable spacer allows for the release of free drug in the tumor and enhances nuclear targeting efficacy. The polymer can be further linked to a cellular targeting molecule, where the targeting molecule directs the polymer to specific cells. One may thus be able to effectively target drugs to the nucleus of tumor cells. With little or modifications, several therapeutic agents can be targeted using the invention.

The present invention relates to compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more adjuvants. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one adjuvant, which enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention have enhanced efficacy as the adjuvants of the composition promote recruitment of antigen presenting cells to the intradermal compartment and thus enhance presentation and / or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention results in a therapeutically and / or prophylactically effective immune response after a single intradermal dose, with lower doses of adjuvant than conventionally used, achieving therapeutic efficacy from a single administration.

Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and / or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.

A system and method are provided for using neuromodulation techniques and intravesical electrical stimulation to treat Urinary Incontinence and related bladder-system conditions. The system uses an electrical stimulation module, stimulation electrodes and catheters, and / or a measurement and feedback system to determine an electrical stimulation therapy program as a function of a pre-programmed library and, optionally, measured and patient-provided response data. IVES and other electrical stimulation signals are generated and conveyed to the patient via catheter electrodes placed in and around the bladder system and related nerves, nodes and motor control points. The system employs a variety of safety mechanisms, including safety algorithms, a one-time use catheter connection, and catheter electrical-shock protection mechanisms.

The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.

Conjugates of a gamma-aminobutyric acid (GABA) compound or a glycine compound and an analgesic drug are disclosed. Further disclosed are pharmaceutical compositions containing these conjugates and uses thereof in the treatment of CNS-associated diseases or disorders, optionally in combination with a psychotropic drug.

The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.

The present invention relates to a pharmaceutical composition comprising Δ9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), and at least one small molecule selected from Citric Acid, Ascorbic Acid, Citrus Essential Oil(s), Lecithin, one or more sugar(s), Resvertrol, and combinations thereof, wherein the composition exhibits an increased but negated psychoactivity with concurrent enhancement in therapeutic potency of THC and / or CBD. The present invention is further directed to methods of treating one or more disease(s) or disorder(s) modulated by the activation of the Cannabinoid CB1 and / or CB2 receptors, by administering a therapeutically effective amount of the composition of the present invention to a subject in need thereof.

The present invention relates to compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV) and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV) infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.

The present invention relates to methods for administration of a substance into the junctional layer of a subject's skin, i.e., a transitory tissue between the reticular dermis and the hypodermis of the subcutaneous layer of the skin. The present invention provides an improved method of parenteral drug delivery in that it provides among other benefits, minimized unwanted immune response and inadvertent immunotoxic effects provoked by the substance administered. In addition, an improved pharmacokinetic profile can be obtained by employing the methods of the present invention. Devices that can be used in accordance with the methods of the invention are also disclosed.

The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

The invention relates to a gold-gadolinium composite nano material as well as a preparation method and application of the gold-gadolinium composite nano material. The gold-gadolinium composite nano material provided by the invention comprises an inner core of a gold nano rod modified by silicon dioxide, and a gadolinium-containing silicon dioxide layer covering the outer side of the inner core. The gold-gadolinium composite nano material is high in gadolinium contain and each nano particle contains 1.5*10<6> Gd ions; the gold-gadolinium composite nano material is good in imaging effect and small in toxic side effect and can be used for loading a plurality of types of drugs and probe molecules, and target molecules can be adsorbed on the surface of the gold-gadolinium composite nano material, so that the drugs and the molecules can be efficiently transported to focus parts and multifunctional diagnosis and treatment can be realized. After the gold-gadolinium composite nano material is used as a carrier for loading the drugs, the gold-gadolinium composite nano material has the synergistic effect of thermal therapy and chemical therapy under laser irradiation in a treatment process of tumor-bearing mice, so that the growth of tumors is effectively inhibited; the gold-gadolinium composite nano material has multiple imaging functions including CT (Computed Tomography), MRI (Magnetic Resonance Imaging), photo-acoustic imaging and the like, and is suitable for being applied to complicated need tumor diagnosis and treatment.

The invention relates to a gold-core-composite nano-carrier as well as a preparation method and application thereof. According to the gold-core-composite nano-carrier, a silicon dioxide modified gold nanorod (Au@SiO2) is taken as an inner core and is coated with a layer of high polymer material sensitive to temperature and pH. The gold-core-composite nano-carrier can be used for coating various drug and probe molecules and transporting the drug and probe molecules to disease sites, and therefore, the targeted therapy is realized. After absorbing near-infrared laser, the gold-core-composite nano-carrier or a drug-loading nanoparticle can emit fluorescent light, and partial optical energy can be converted into heat to be applied to biological imaging, chemotherapy and thermal therapy; the gold-core-composite nano-carrier further has the pH-sensitive property and is capable of effectively releasing the drug molecules in a weakly acidic tumor microenvironment and cell lysosome; multiple tumor therapy functions of the gold-core-composite nano-carrier can be combined in use, so that the defects of a single tumor therapy method are overcome; the gold-core-composite nano-carrier is suitable for being applied to the complex tumor diagnosis and treatment.

The invention discloses a management method and system of obedience to medical advice on chronic diseases and relates to the field of chronic disease management. The method includes the steps that aninformation collecting module collects information and generates a disease type base and medical advice templates; a system diagnosis module conducts classified diagnosis; a medical advice managementmodule flexibly makes medical advice; a medical advice obedience management module evaluates and intervenes the obedience; a disease condition evaluation module periodically conducts comprehensive disease condition evaluation and then makes medical advice again according to the recovery condition, and a remote module conducts remote management outside a hospital, remote cooperative medical therapyand hierarchical diagnosis and treatment. With management of the obedience to the medical advice of patients as the center, a remote video medical technology and a remote mobile medical technology are utilized, continuous management of the obedience to the medical advice from inside to outside of the hospital is achieved through the medical advice obedience management module, the obedience to themedical advice is improved, and the control rate of the chronic diseases is increased.

The electrotherapeutic, magnetotherapeutic and laser therapeutic instrument consists of system unit, opto-magnetic head, two electrode plates and rectifying and charging power socket. There is a IC board, battery, charge socket and opto-magnetic output socket and electrotherapeutic output socket in the system unit. The rectifying and charging power socket is connected to the charge socket in the system unit via wires and plug; the opto-magnetic head is connected to the opto-magnetic output socket; and the two electrode plates are connected to the electrotherapeutic output socket. The present invention can apply three kinds of physical factors in the same part of reach enhanced therapeutic effect.

The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and agonize EphA4. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and inhibit cancer cell colony formation in soft agar or tubular network formation in three-dimensional basement membrane or extracellular matrix preparation. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that preferentially binds to an EphA4 epitope that is exposed on cancer cells but not non-cancer cells. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 with a very low Koff to reduce EphA4 expression and, thereby, inhibit tumor cell growth and / or metastasis. The invention also provides pharmaceutical compositions comprising one or more EphA4 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.

CD8+ regulatory T (Treg) cells and γδ Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides.

The invention discloses a microwave ablation antenna with internally-arranged pipelines. The microwave ablation antenna with the internally-arranged pipelines comprises a microwave radiation antenna head 1, a matched insulation sleeve 2, an antenna mast 3, a microwave transmission cable 4, a handle and a coaxial connector 7. The inner pipeline 5 in the antenna mast 3 is communicated with the center pipeline 12 and a side through hole 13 in the microwave radiation antenna head 1. One end of the inner pipeline 5 is in butt joint with the center pipeline 12 and the other end of the inner pipeline 5 is an outer pipeline joint 8 located on the handle 6. The side through hole 13 is located on the side face of the microwave radiation antenna head 1. The injection function of the ablation antenna is achieved through the outer pipeline joint 8 via the inner pipeline 5, the center pipeline 12 and the side through hole 13. Living tissue cells are extracted through the side through hole 13 on the microwave radiation antenna head 1 into the center pipeline 12, the inner pipeline 5 and the outer pipeline joint 8.

The invention relates to a method for increasing the therapeutic efficacy of curcuminoids and analogs. More specifically, the invention relates to a method for increasing the therapeutic efficacy of systemically administered formulations that contain curcuminoids and the equivalent therapeutics thereof. The method is characterized in that together with the administration of the formulation the patient is irradiated with visible, and optionally ultraviolet, radiation during a treatment. The invention also relates to phototherapy devices that emit visible radiation over a surface area greater than 0.2 m2 with an irradiance of more than 2 mW / cm2, the devices being suitable for use in the treatment of proliferative diseases, particularly moderate-to-severe psoriasis or tumor processes.

The invention relates to a Chinese medicinal compound preparation for treating fracture, which comprises the following Chinese medicine raw materials in part by weight: 8 to 12 parts of peach seed, 13 to 17 parts of safflower, 8 to 12 parts of Szechuan lovage rhizome, 8 to 12 parts of red paeony root, 8 to 12 parts of Chinese angelica, 8 to 12 parts of root of red-rooted salvia, 13 to 17 parts of fortune drynaria rhizome, 13 to 17 parts of Himalayan teasel root and 2 to 4 parts of notoginseng root (electuary). A preparation method comprises the following steps of: cleaning the nine medicinal materials, mixing in a ratio, adding water in an amount which is 4 to 7 times the total weight of the medicinal materials or 70 volume percent ethanol, decocting for two times, 80 minutes each time, mixing two-time decoction, filtering, and concentrating to obtain liquid extract of which the specific gravity is 1.18 at the temperature of 60 DEG C. The conventional preparation process is adopted. The preparation can be prepared into any one pharmaceutical formulation such as tablets, capsules, granules, oral liquid, pills and syrup. By the Chinese medicinal compound preparation prepared by the method, fracture healing time is obviously shortened, calluses grow more quickly, firmly and reliably, and the curative effect is far superior to that of the conventional Chinese medicine for treating the fracture.

The invention belongs to the technical field of medicine for animals, and particularly relates to right supporting and toxin eliminating oral liquid, which is prepared from the following raw material medicine in percentage by weight: 40 percent of isatis root, 40 percent of astragalus and 20 percent of epimedium herb. A preparation method of the oral liquid comprises the following steps that the raw material medicine is proportionally taken and is crushed into coarse powder, water accounting for 10 to 12 times of the weight of the raw material medicine is added, in addition, the pH is regulated to 2.0 to 3.0 by hydrochloric acid, the reflux extraction is carried out for 0.5 to 1 hour, next, the pH is regulated to 5.5 to 6.5 by sodium bicarbonate, the reflux extraction is carried out for 0.5 to 1 hour, the extraction liquid is concentrated to 1 to 2 times of the raw material medicine through pressure reduction after being filtered, then, clear liquid is obtained after the membrane separation, preservatives are added, the solution is diluted by adding water, and the oral liquid is obtained after the filling. The oral liquid has the advantages that the recipe is reasonable, the absorption rate is high, the addition can be realized through drinking water, and the use is convenient.

The invention provides paclitaxel slow-release temperature-sensitive gel and a preparation method thereof. The paclitaxel slow-release temperature-sensitive gel is prepared from, by weight, 0.01%-5% of paclitaxel, 0.5%-27% of organic solvent and the balance Soluplus-based temperature-sensitive gel matrix. The phase transition temperature of the paclitaxel slow-release temperature-sensitive gel system is more approximate to the body temperature compared with the gelatinization temperature of poloxamer 407 temperature-sensitive gel, administration is convenient, the strength of the gel formed in the body is higher than that of the poloxamer 407 temperature-sensitive gel, and drug slow release can last for at least seven days after a hypodermic injection while drug slow release of poloxamer 407 can only last for about one day. The paclitaxel slow-release temperature-sensitive gel is administrated through a by-tumor local injection or at a solid tumor removing position, the treatment effect of a cancer can be improved, the toxic and side effect on the whole body can be lowered, and the treatment effect is remarkable and better than that of paclitaxel-poloxamer 407 temperature-sensitive gel.

The invention relates to the technical field of medicinal preparations, and in particular discloses a multimodal contrast agent and use thereof. The multimodal contrast agent is composite nanoparticles of mesoporous silica-supported copper sulfide and perfluorohexane; the cores of the composite nanoparticles are made from copper sulfide, and mesoporous silica is used as a shell for wrapping the copper sulfide; pores of the mesoporous silica are filled with the perfluorohexane, and the outer surface of the mesoporous silica is connected with polyethylene glycol. The multimodal contrast agent isapplied to an ultrasound imaging reagent, a photoacoustic imaging reagent, cavitation treatment and a photothermotherapy reagent. The multimodal contrast agent provided by the invention is low in cytotoxicity, good in biocompatibility, has the functions of bimodal imaging / photothermal therapy and cavitation treatment, realizes multi-mechanism treatment of tumor homologues, and improves the curative effect; furthermore, the multimodal contrast agent is simple in preparation process and low in cost.

The invention discloses an oral liquid for strengthening healthy energy and relieving internal heat or fever for animals. The invention aims at providing an oral liquid which has convenient use, is in favor of absorption, and is mainly used for curing chicken bursal diseases. The oral liquid is prepared by comprising the following steps: weighing 20-80kg of isatis, 20-80kg of astragalus and 10-40kg of herba epimedii; adding water equal to eight times of herbs weight; heating and stewing; keeping boiling for 90 minutes; filtering; adding water equal to six times of herbs weight to filter residues; heating and stewing; keeping boiling for 60 minutes; filtering; abandoning the filter residues; mixing filtrates obtained by twice filtration; decompressing and concentrating to 100L; adding 150kg of ethanol with the concentration of 95%; standing for 24 hours after stirring uniformly; filtering; recovering the ethanol; decompressing and concentrating to 95L again to obtain traditional Chinese medicine concentrated liquor; taking 4L of water to dissolve 0.5kg of sodium benzoate; adding the traditional concentrated liquor; adding 0.5kg of Twain-80 after stirring uniformly; stirring uniformly again; and replenishing water to 100L. The oral liquid of the invention has stable property, removes unnecessary impurities, increases absorptivity of the poultry and enhances curative effect.

The invention provides a construction method of a nano drug loading system targeting cell endoplasmic reticulum. The construction method is realized by modifying Pardaxin polypeptide on the surface oflipidosome. Pardaxin is polypeptide containing 33 amino acid residues and of an amphiphilic cation alpha spiral structure having film penetrating effect. The nano drug loading system can be applied in preparing antiviral and antitumor drug taking cell endoplasmic reticulum as a target and can load water-soluble and lipid-soluble drug and transfer the drug to the cell endoplasmic reticulum, so that treatment efficacy of the drug is enhanced, and toxic and side effect is reduced. A nano carrier is not only limited to liposome and can also be solid lipid nanoparticle, nano emulsion, polymer micelle and inorganic nano material. A nano endoplasmic reticulum targeted nano carrier can remarkably improve concentration of drug taking endoplasmic reticulum as a target at an action target, and a newpath is provided for bringing treatment effect of the drug into play.

The present invention provides novel compounds of Formula (I′) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and / or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and / or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and / or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).

The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.

The invention belongs to the technical field of medicine, and relates to a biological adhesive compound lung aspiration nanometer composite microparticle and preparation thereof. The prepared nanometer composite microparticle is formed by simultaneously embedding nanometer crystals of one or two kinds of water-soluble anti-asthma and chronic pulmonary obstruction medicine and another kind of insoluble anti-asthma and chronic pulmonary obstruction medicine into a biological adhesive framework material. The composite microparticle uses a spray drying technology, and can realize the effects that1, the dissolution difficulty of the insoluble medicine is improved; the synchronous release of several kinds of medicine with different dissolution properties can be realized; the cooperated effectsare better achieved; 2, the uniform mixing of several kinds of medicine with different dose differences can be ensured; the technical process of the preparation is greatly simplified; the medicine quality is improved; the cost is reduced; the energy consumption is reduced; 3, through the application of the biological adhesive material, the lung mucous cilia clearing effect resistance can be effectively realized; the lung retention time is prolonged; the medicine concentration in the focus position is improved; the medicine absorption is delayed; the goals of improving the curative effect and reducing the whole body toxic and side effects can be achieved.

The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, plasmid DNA, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and / or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases (e.g., liver diseases), respiratory diseases (e.g., lung diseases), painful conditions, psychiatric disorders, metabolic disorders, and spleen diseases.