152results about How to "Improve therapeutic efficacy" patented technology

A self-contained respiratory apparatus, including a blower delivering a gas, a headgear integrated with the blower to support a respiratory interface, and a sensor embedded in the headgear and mounted to deliver data to a microprocessor integrated with the blower, the blower being controlled through the response of the sensor and the control of the microprocessor to support the respiratory interface through the headgear.

The present invention relates to compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more adjuvants. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one adjuvant, which enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention have enhanced efficacy as the adjuvants of the composition promote recruitment of antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention results in a therapeutically and/or prophylactically effective immune response after a single intradermal dose, with lower doses of adjuvant than conventionally used, achieving therapeutic efficacy from a single administration.

A system and method are provided for using neuromodulation techniques and intravesical electrical stimulation to treat Urinary Incontinence and related bladder-system conditions. The system uses an electrical stimulation module, stimulation electrodes and catheters, and/or a measurement and feedback system to determine an electrical stimulation therapy program as a function of a pre-programmed library and, optionally, measured and patient-provided response data. IVES and other electrical stimulation signals are generated and conveyed to the patient via catheter electrodes placed in and around the bladder system and related nerves, nodes and motor control points. The system employs a variety of safety mechanisms, including safety algorithms, a one-time use catheter connection, and catheter electrical-shock protection mechanisms.

The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.

The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.

The present invention relates to a pharmaceutical composition comprising Δ9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), and at least one small molecule selected from Citric Acid, Ascorbic Acid, Citrus Essential Oil(s), Lecithin, one or more sugar(s), Resvertrol, and combinations thereof, wherein the composition exhibits an increased but negated psychoactivity with concurrent enhancement in therapeutic potency of THC and/or CBD. The present invention is further directed to methods of treating one or more disease(s) or disorder(s) modulated by the activation of the Cannabinoid CB1 and/or CB2 receptors, by administering a therapeutically effective amount of the composition of the present invention to a subject in need thereof.

The present invention relates to methods for administration of a substance into the junctional layer of a subject's skin, i.e., a transitory tissue between the reticular dermis and the hypodermis of the subcutaneous layer of the skin. The present invention provides an improved method of parenteral drug delivery in that it provides among other benefits, minimized unwanted immune response and inadvertent immunotoxic effects provoked by the substance administered. In addition, an improved pharmacokinetic profile can be obtained by employing the methods of the present invention. Devices that can be used in accordance with the methods of the invention are also disclosed.

The invention relates to a gold-gadolinium composite nano material as well as a preparation method and application of the gold-gadolinium composite nano material. The gold-gadolinium composite nano material provided by the invention comprises an inner core of a gold nano rod modified by silicon dioxide, and a gadolinium-containing silicon dioxide layer covering the outer side of the inner core. The gold-gadolinium composite nano material is high in gadolinium contain and each nano particle contains 1.5*10<6> Gd ions; the gold-gadolinium composite nano material is good in imaging effect and small in toxic side effect and can be used for loading a plurality of types of drugs and probe molecules, and target molecules can be adsorbed on the surface of the gold-gadolinium composite nano material, so that the drugs and the molecules can be efficiently transported to focus parts and multifunctional diagnosis and treatment can be realized. After the gold-gadolinium composite nano material is used as a carrier for loading the drugs, the gold-gadolinium composite nano material has the synergistic effect of thermal therapy and chemical therapy under laser irradiation in a treatment process of tumor-bearing mice, so that the growth of tumors is effectively inhibited; the gold-gadolinium composite nano material has multiple imaging functions including CT (Computed Tomography), MRI (Magnetic Resonance Imaging), photo-acoustic imaging and the like, and is suitable for being applied to complicated need tumor diagnosis and treatment.

The invention relates to a gold-core-composite nano-carrier as well as a preparation method and application thereof. According to the gold-core-composite nano-carrier, a silicon dioxide modified gold nanorod (Au@SiO2) is taken as an inner core and is coated with a layer of high polymer material sensitive to temperature and pH. The gold-core-composite nano-carrier can be used for coating various drug and probe molecules and transporting the drug and probe molecules to disease sites, and therefore, the targeted therapy is realized. After absorbing near-infrared laser, the gold-core-composite nano-carrier or a drug-loading nanoparticle can emit fluorescent light, and partial optical energy can be converted into heat to be applied to biological imaging, chemotherapy and thermal therapy; the gold-core-composite nano-carrier further has the pH-sensitive property and is capable of effectively releasing the drug molecules in a weakly acidic tumor microenvironment and cell lysosome; multiple tumor therapy functions of the gold-core-composite nano-carrier can be combined in use, so that the defects of a single tumor therapy method are overcome; the gold-core-composite nano-carrier is suitable for being applied to the complex tumor diagnosis and treatment.

The invention discloses a management method and system of obedience to medical advice on chronic diseases and relates to the field of chronic disease management. The method includes the steps that aninformation collecting module collects information and generates a disease type base and medical advice templates; a system diagnosis module conducts classified diagnosis; a medical advice managementmodule flexibly makes medical advice; a medical advice obedience management module evaluates and intervenes the obedience; a disease condition evaluation module periodically conducts comprehensive disease condition evaluation and then makes medical advice again according to the recovery condition, and a remote module conducts remote management outside a hospital, remote cooperative medical therapyand hierarchical diagnosis and treatment. With management of the obedience to the medical advice of patients as the center, a remote video medical technology and a remote mobile medical technology are utilized, continuous management of the obedience to the medical advice from inside to outside of the hospital is achieved through the medical advice obedience management module, the obedience to themedical advice is improved, and the control rate of the chronic diseases is increased.

CD8⁺ regulatory T (Treg) cells and γδ Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides.

The invention discloses a microwave ablation antenna with internally-arranged pipelines. The microwave ablation antenna with the internally-arranged pipelines comprises a microwave radiation antenna head 1, a matched insulation sleeve 2, an antenna mast 3, a microwave transmission cable 4, a handle and a coaxial connector 7. The inner pipeline 5 in the antenna mast 3 is communicated with the center pipeline 12 and a side through hole 13 in the microwave radiation antenna head 1. One end of the inner pipeline 5 is in butt joint with the center pipeline 12 and the other end of the inner pipeline 5 is an outer pipeline joint 8 located on the handle 6. The side through hole 13 is located on the side face of the microwave radiation antenna head 1. The injection function of the ablation antenna is achieved through the outer pipeline joint 8 via the inner pipeline 5, the center pipeline 12 and the side through hole 13. Living tissue cells are extracted through the side through hole 13 on the microwave radiation antenna head 1 into the center pipeline 12, the inner pipeline 5 and the outer pipeline joint 8.

The invention relates to a Chinese medicinal compound preparation for treating fracture, which comprises the following Chinese medicine raw materials in part by weight: 8 to 12 parts of peach seed, 13 to 17 parts of safflower, 8 to 12 parts of Szechuan lovage rhizome, 8 to 12 parts of red paeony root, 8 to 12 parts of Chinese angelica, 8 to 12 parts of root of red-rooted salvia, 13 to 17 parts of fortune drynaria rhizome, 13 to 17 parts of Himalayan teasel root and 2 to 4 parts of notoginseng root (electuary). A preparation method comprises the following steps of: cleaning the nine medicinal materials, mixing in a ratio, adding water in an amount which is 4 to 7 times the total weight of the medicinal materials or 70 volume percent ethanol, decocting for two times, 80 minutes each time, mixing two-time decoction, filtering, and concentrating to obtain liquid extract of which the specific gravity is 1.18 at the temperature of 60 DEG C. The conventional preparation process is adopted. The preparation can be prepared into any one pharmaceutical formulation such as tablets, capsules, granules, oral liquid, pills and syrup. By the Chinese medicinal compound preparation prepared by the method, fracture healing time is obviously shortened, calluses grow more quickly, firmly and reliably, and the curative effect is far superior to that of the conventional Chinese medicine for treating the fracture.

The invention relates to the technical field of medicinal preparations, and in particular discloses a multimodal contrast agent and use thereof. The multimodal contrast agent is composite nanoparticles of mesoporous silica-supported copper sulfide and perfluorohexane; the cores of the composite nanoparticles are made from copper sulfide, and mesoporous silica is used as a shell for wrapping the copper sulfide; pores of the mesoporous silica are filled with the perfluorohexane, and the outer surface of the mesoporous silica is connected with polyethylene glycol. The multimodal contrast agent isapplied to an ultrasound imaging reagent, a photoacoustic imaging reagent, cavitation treatment and a photothermotherapy reagent. The multimodal contrast agent provided by the invention is low in cytotoxicity, good in biocompatibility, has the functions of bimodal imaging/photothermal therapy and cavitation treatment, realizes multi-mechanism treatment of tumor homologues, and improves the curative effect; furthermore, the multimodal contrast agent is simple in preparation process and low in cost.

The invention discloses an oral liquid for strengthening healthy energy and relieving internal heat or fever for animals. The invention aims at providing an oral liquid which has convenient use, is in favor of absorption, and is mainly used for curing chicken bursal diseases. The oral liquid is prepared by comprising the following steps: weighing 20-80kg of isatis, 20-80kg of astragalus and 10-40kg of herba epimedii; adding water equal to eight times of herbs weight; heating and stewing; keeping boiling for 90 minutes; filtering; adding water equal to six times of herbs weight to filter residues; heating and stewing; keeping boiling for 60 minutes; filtering; abandoning the filter residues; mixing filtrates obtained by twice filtration; decompressing and concentrating to 100L; adding 150kg of ethanol with the concentration of 95%; standing for 24 hours after stirring uniformly; filtering; recovering the ethanol; decompressing and concentrating to 95L again to obtain traditional Chinese medicine concentrated liquor; taking 4L of water to dissolve 0.5kg of sodium benzoate; adding the traditional concentrated liquor; adding 0.5kg of Twain-80 after stirring uniformly; stirring uniformly again; and replenishing water to 100L. The oral liquid of the invention has stable property, removes unnecessary impurities, increases absorptivity of the poultry and enhances curative effect.

The invention provides a construction method of a nano drug loading system targeting cell endoplasmic reticulum. The construction method is realized by modifying Pardaxin polypeptide on the surface oflipidosome. Pardaxin is polypeptide containing 33 amino acid residues and of an amphiphilic cation alpha spiral structure having film penetrating effect. The nano drug loading system can be applied in preparing antiviral and antitumor drug taking cell endoplasmic reticulum as a target and can load water-soluble and lipid-soluble drug and transfer the drug to the cell endoplasmic reticulum, so that treatment efficacy of the drug is enhanced, and toxic and side effect is reduced. A nano carrier is not only limited to liposome and can also be solid lipid nanoparticle, nano emulsion, polymer micelle and inorganic nano material. A nano endoplasmic reticulum targeted nano carrier can remarkably improve concentration of drug taking endoplasmic reticulum as a target at an action target, and a newpath is provided for bringing treatment effect of the drug into play.

The invention provides application of protein DEPDC1 (Dishevelled and EGL-10, Pleckstrin Domain-Containing protein 1) as a marker for diagnosing the triple negative breast cancer, and also provides application of miR-26b for preparing a medicine for treating the triple negative breast cancer. The invention also provides application of miR-26b for preparing a medicine for inhibiting DEPDC1 mRNA (Ribonucleic Acid) expression. The invention finds that DEPDC1 expression is obviously higher than a paired para-carcinoma tissue in a triple negative breast cancer tissue. In the triple negative breastcancer cell, overexpression DEPDC1 can accelerate cell growth and tumor formation through FOXM1 (Forkhead box protein M1) expression up-regulation. On the contrary, after the DEPDC1 is knocked down,an inverse function is displayed. In addition, in the triple negative breast cancer, miR-26b serves as a tumor inhibiting factor to directly inhibit DEPDC1 expression and weaken the acceleration function of the DEPDC1 for cell growth and clone formation. The invention points out a new important mechanism for the occurrence, the development, the regulation and the control of the triple negative breast cancer.

The invention provides an oral cancer-resistance and body resistance-strengthening decoction. The decoction is characterized by being prepared from the following raw materials in parts by weight: 74-94 parts of codonopsis pilosula, 60-80 parts of fried rhizoma atractylodis macrocephalae, 60-80 parts of poria, 60-80 parts of fried tangerine peel, 190-230 parts of astragalus membranaceus, 60-80 parts of Chinese angelica, 95-115 parts of sculellaria barbata, 95-115 parts of oldenlandia diffusa, 36-48 parts of fried nidus vespae and 74-94 parts of pangolin. The oral cancer-resistance and body resistance-strengthening decoction has the beneficial effects of good curative effect, quick response and no toxic or side effect. More than ten years of clinical application proves that the traditional Chinese medicament is safe, convenient and practical to use, does not have pain, toxicity and allergic response, and is excellent in curative effect.

Methods and composition involving genetically engineered targeting conjugates with reversed orientation of VL and VH chains are provided. For example, in certain aspects targeting conjugates comprising VL and VH chains of anti-CD22 and anti-CD19 are described. In a further aspect, the invention provides methods and targeting conjugates comprising therapeutic agents or diagnostic agents for delivery to B cells.