Gold-gadolinium composite nano material as well as preparation method and application of gold-gadolinium composite nano material
A technology of composite nanomaterials and gold nanorods, which is applied in the field of preparation of gold-gadolinium composite nanomaterials, and can solve problems such as toxicity, unfavorable imaging detection, and low loading capacity
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[0129] Example 1
[0130] This example is used to illustrate the preparation of gold-gadolinium composite nanomaterials.
[0131] 1) Preparation of silica modified gold nanorods
[0132] In a 20mL beaker, mix 7.5mL cetyltrimethylammonium bromide aqueous solution (with a concentration of 0.1 mol / L) and 250 μL chloroauric acid aqueous solution (with a concentration of 0.01 mol / L), and add water to a total volume of 9.4 mL; Then add 0.6mL sodium borohydride aqueous solution (with a concentration of 0.01 mol / L) cooled by ice water, stir vigorously for 3 minutes, and place in a 27° C. thermostat for 2-5 hours to obtain a gold nanoparticle seed solution.
[0133] In a 150mL beaker, add 100mL cetyltrimethylammonium bromide (concentration of 0.1mol / L), 5mL chloroauric acid aqueous solution (concentration of 0.01mol / L), 0.8mL silver nitrate aqueous solution (concentration of 0.01mol / L), 1mL sulfuric acid aqueous solution (concentration 0.5mol / L), and 800μL ascorbic acid aqueous solution (conc...
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[0141] Example 2
[0142] Except that 40 μL of the gadolinium-containing aqueous solution and 20 μL of ethyl orthosilicate were added to the silica-modified gold nanorod aqueous solution, the other preparation methods and conditions were the same as in Example 1.
[0143] The thickness of the gadolinium-containing silicon layer of the gold-gadolinium composite nano material obtained in this embodiment is 15 nm ( Figure 1b ).
[0144] Figure 2b Shows the X-ray energy dispersive spectrum (EDS) diagram of the gold-gadolinium composite nanomaterial obtained in this example. It can be determined that the material mainly contains elements such as Au, Gd, Si, O, and the mass ratio of Au and Gd is about 3:1 , Each nanoparticle has 5×10 5 Gd ions.
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[0145] Example 3
[0146] Except for adding 160 μL of the gadolinium-containing aqueous solution and 80 μL of ethyl orthosilicate to the silica-modified gold nanorod aqueous solution, the other preparation methods and conditions are the same as in Example 1.
[0147] The thickness of the gadolinium-containing layer of the gold-gadolinium composite nano material obtained in this embodiment is 45 nm ( Figure 1c ).
[0148] Figure 2c Shows the X-ray energy dispersive spectrum (EDS) diagram of the gold-gadolinium composite nanomaterial obtained in this example. It can be determined that the material mainly contains elements such as Au, Gd, Si, O, and the mass ratio of Au and Gd is about 1:4 , Each nanoparticle has 6×10 6 Gd ions.
[0149] It can be seen from Examples 1-3 that by adjusting the amount of gadolinium-containing aqueous solution and silicate added, gold-gadolinium composite nanomaterials with different gadolinium layer thicknesses can be prepared, that is, by controlling the...
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