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A gold-gadolinium composite nanomaterial, preparation method and use thereof

A technology of composite nanomaterials and gold nanorods, which is applied in the field of preparation of gold-gadolinium composite nanomaterials, and can solve problems such as toxicity, side effects of gadolinium elements, and unfavorable imaging detection.

Active Publication Date: 2019-07-16
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of gadolinium chelates is still very toxic to the human body. Gadolinium is grafted or chemically bonded to the surface of the macromolecule. Conducive to imaging detection, in the preparation method of gold nanomaterial surface modification gadolinium ion reported in the literature at present, usually each nanoparticle surface has about 10 4 Gd ions (small, 2014, 10, 556–565; Nature Medicine, 2012, 18, 829-835), even though the highest content of gadolinium disclosed in the prior art is the content of Gd ions per nanoparticle surface reported in a literature Only up to 5×10 5 (Nanoscale, 2011,3,1990-1996), therefore, it is necessary to develop a composite material with high gadolinium content and low toxic side effects

Method used

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  • A gold-gadolinium composite nanomaterial, preparation method and use thereof
  • A gold-gadolinium composite nanomaterial, preparation method and use thereof
  • A gold-gadolinium composite nanomaterial, preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0130] This example is used to illustrate the preparation of gold-gadolinium composite nanomaterials.

[0131] 1) Preparation of silica-modified gold nanorods

[0132] In a 20mL beaker, mix 7.5mL cetyltrimethylammonium bromide aqueous solution (concentration: 0.1mol / L) with 250μL chloroauric acid aqueous solution (concentration: 0.01mol / L), add water to a total volume of 9.4 mL; then add 0.6 mL of sodium borohydride aqueous solution (concentration: 0.01 mol / L) cooled by ice water, stir vigorously for 3 min, and place in a thermostat at 27°C for 2-5 h to obtain a gold nanoparticle seed solution.

[0133] In a 150mL beaker, add 100mL cetyltrimethylammonium bromide (concentration is 0.1mol / L), 5mL chloroauric acid aqueous solution (concentration is 0.01mol / L), 0.8mL silver nitrate aqueous solution (concentration is 0.1mol / L) respectively. 0.01mol / L), 1mL aqueous sulfuric acid (concentration: 0.5mol / L), and 800 μL ascorbic acid aqueous solution (concentration: 0.1mol / L); then add...

Embodiment 2

[0142] Except that 40 μL of the above-mentioned gadolinium-containing aqueous solution and 20 μL of tetraethyl orthosilicate were added to the aqueous solution of silica-modified gold nanorods, other preparation methods and conditions were the same as in Example 1.

[0143] The thickness of the gadolinium-containing silicon layer of the gold-gadolinium composite nanomaterial obtained in this embodiment is 15nm ( Figure 1b ).

[0144] Figure 2b Represent the X-ray energy dispersive spectrum (EDS) figure of the gold-gadolinium composite nanomaterial that present embodiment obtains, can determine that mainly contain elements such as Au, Gd, Si, O in the material, wherein the mass ratio of Au and Gd is about 3:1 , each nanoparticle has 5×10 5 a Gd ion.

Embodiment 3

[0146] Except that 160 μL of the above-mentioned gadolinium-containing aqueous solution and 80 μL of ethyl orthosilicate were added to the aqueous solution of silica-modified gold nanorods, other preparation methods and conditions were the same as in Example 1.

[0147] The thickness of the gadolinium-containing layer of the gold-gadolinium composite nanomaterial obtained in the present embodiment is 45nm ( Figure 1c ).

[0148] Figure 2c Represent the X-ray energy dispersive spectrum (EDS) figure of the gold-gadolinium composite nanomaterial obtained in this embodiment, it can be determined that the material mainly contains elements such as Au, Gd, Si, O, wherein the mass ratio of Au and Gd is about 1:4 , each nanoparticle has 6×10 6 a Gd ion.

[0149] As can be seen from Examples 1-3, by adjusting the amount of the added gadolinium-containing aqueous solution and silicate, gold-gadolinium composite nanomaterials with different gadolinium layer thicknesses can be prepare...

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Abstract

The invention relates to a gold-gadolinium composite nano material as well as a preparation method and application of the gold-gadolinium composite nano material. The gold-gadolinium composite nano material provided by the invention comprises an inner core of a gold nano rod modified by silicon dioxide, and a gadolinium-containing silicon dioxide layer covering the outer side of the inner core. The gold-gadolinium composite nano material is high in gadolinium contain and each nano particle contains 1.5*10<6> Gd ions; the gold-gadolinium composite nano material is good in imaging effect and small in toxic side effect and can be used for loading a plurality of types of drugs and probe molecules, and target molecules can be adsorbed on the surface of the gold-gadolinium composite nano material, so that the drugs and the molecules can be efficiently transported to focus parts and multifunctional diagnosis and treatment can be realized. After the gold-gadolinium composite nano material is used as a carrier for loading the drugs, the gold-gadolinium composite nano material has the synergistic effect of thermal therapy and chemical therapy under laser irradiation in a treatment process of tumor-bearing mice, so that the growth of tumors is effectively inhibited; the gold-gadolinium composite nano material has multiple imaging functions including CT (Computed Tomography), MRI (Magnetic Resonance Imaging), photo-acoustic imaging and the like, and is suitable for being applied to complicated need tumor diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of drug carriers, and relates to a gold-gadolinium composite nanomaterial, a preparation method and an application thereof. Background technique [0002] Although people's understanding of cancer has made great progress in the past few decades, cancer is still one of the major diseases threatening human health. Chemotherapy is one of the most commonly used means of cancer treatment. However, in clinical treatment, the effect of chemotherapy is not good. For solid tumors with internal high pressure and hypoxia, chemotherapy drugs rarely reach the tumor tissue, and it is difficult to penetrate into the tumor, thus limiting its therapeutic effect. In addition, chemotherapeutic drugs lack the recognition of tumor tissue and have certain toxicity to normal tissues and cells, so they have obvious toxic side effects: for example, doxorubicin hydrochloride has obvious cardiotoxicity. In cancer treatment, the comb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/08A61K49/22A61K49/04A61K41/00A61K47/52A61K31/704A61P35/00
CPCA61K31/704A61K41/0052A61K49/04A61K49/08A61K49/22A61K2300/00
Inventor 陈春英刘晶王静刘颖李佳阳曹明晶
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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