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Multimodal contrast agent and use thereof

A contrast agent and multi-modal technology, applied in general/multifunctional contrast agents, echo/ultrasound imaging agents, preparations for in vivo tests, etc., can solve the problems of high preparation costs and achieve low production costs and low cytotoxicity , the effect is obvious

Active Publication Date: 2019-04-26
CHONGQING MEDICAL UNIVERSITY
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Problems solved by technology

[0005] The present invention intends to provide a multimodal contrast agent and its application. The multimodal contrast agent has the advantages of low cytotoxicity and good biocompatibility, and can be applied in ultrasonic imaging reagents, photoacoustic imaging reagents, and cavitation therapy. As well as photothermal therapy reagents, the preparation process is simple and the preparation cost is low, so as to solve the problem of high preparation cost of gold-based nanomaterials

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  • Multimodal contrast agent and use thereof

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Embodiment 1

[0038] The preparation method of the multimodal contrast agent in this embodiment includes the following steps:

[0039] (1) 850 mg of copper chloride (CuCl 2 ) was dissolved in 1000mL of deionized water to prepare A solution with a solubility of 0.85mg / mL, and 2.4g of sodium sulfide (Na 2 S) Dissolve in 10 mL of deionized water to prepare solution B, add 20 mL of solution A and 80 μL of cetyltrimethylammonium chloride (CTAC) to 80 mL of deionized water, stir at room temperature for 30 min, Add 100 μL of solution B dropwise, continue stirring for 5 minutes to form a mixed solution, transfer the above mixed solution to a water bath for reaction, the temperature of the water bath is 90°C, and the reaction time is 15 minutes, then immediately cooled in an ice bath to obtain the product CuS-CTAC aqueous solution.

[0040] In step (1), it is necessary to immediately transfer the mixed solution in the water bath for ice bath operation. The existing operation is usually to manually...

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Abstract

The invention relates to the technical field of medicinal preparations, and in particular discloses a multimodal contrast agent and use thereof. The multimodal contrast agent is composite nanoparticles of mesoporous silica-supported copper sulfide and perfluorohexane; the cores of the composite nanoparticles are made from copper sulfide, and mesoporous silica is used as a shell for wrapping the copper sulfide; pores of the mesoporous silica are filled with the perfluorohexane, and the outer surface of the mesoporous silica is connected with polyethylene glycol. The multimodal contrast agent isapplied to an ultrasound imaging reagent, a photoacoustic imaging reagent, cavitation treatment and a photothermotherapy reagent. The multimodal contrast agent provided by the invention is low in cytotoxicity, good in biocompatibility, has the functions of bimodal imaging / photothermal therapy and cavitation treatment, realizes multi-mechanism treatment of tumor homologues, and improves the curative effect; furthermore, the multimodal contrast agent is simple in preparation process and low in cost.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, and specifically discloses a multimodal contrast agent and its application. Background technique [0002] As a new type of cancer treatment technology, photothermal therapy can kill cancer cells by converting light energy into heat energy to rapidly heat up local tissues, realize fixed-point elimination of malignant tumors, and avoid systemic side effects. It is considered to replace surgical resection. One of the most promising technologies for the treatment of cancer. However, since biological tissues lack endogenous substances with significant photothermal effects in the near-infrared region, the effective implementation of photothermal therapy requires the assistance of phototherapeutic agents with strong absorption in the near-infrared region (700-1100nm). Generally speaking, phototherapeutic preparations (photothermal conversion materials) are required to have high phot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/10A61K47/04A61K47/06A61P35/00A61K49/22A61K49/00
CPCA61K41/0052A61K47/02A61K47/06A61K47/10A61K49/0002A61K49/22A61P35/00
Inventor 冉海涛张伟曹阳
Owner CHONGQING MEDICAL UNIVERSITY
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