Multimodal contrast agent and use thereof

A contrast agent and multi-modal technology, applied in general/multifunctional contrast agents, echo/ultrasound imaging agents, preparations for in vivo tests, etc., can solve the problems of high preparation costs and achieve low production costs and low cytotoxicity , the effect is obvious
CN109675034AActive Publication Date: 2019-04-26CHONGQING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING MEDICAL UNIVERSITY
Publication Date
2019-04-26

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Abstract

The invention relates to the technical field of medicinal preparations, and in particular discloses a multimodal contrast agent and use thereof. The multimodal contrast agent is composite nanoparticles of mesoporous silica-supported copper sulfide and perfluorohexane; the cores of the composite nanoparticles are made from copper sulfide, and mesoporous silica is used as a shell for wrapping the copper sulfide; pores of the mesoporous silica are filled with the perfluorohexane, and the outer surface of the mesoporous silica is connected with polyethylene glycol. The multimodal contrast agent isapplied to an ultrasound imaging reagent, a photoacoustic imaging reagent, cavitation treatment and a photothermotherapy reagent. The multimodal contrast agent provided by the invention is low in cytotoxicity, good in biocompatibility, has the functions of bimodal imaging / photothermal therapy and cavitation treatment, realizes multi-mechanism treatment of tumor homologues, and improves the curative effect; furthermore, the multimodal contrast agent is simple in preparation process and low in cost.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, and specifically discloses a multimodal contrast agent and its application. Background technique

[0002] As a new type of cancer treatment technology, photothermal therapy can kill cancer cells by converting light energy into heat energy to rapidly heat up local tissues, realize fixed-point elimination of malignant tumors, and avoid systemic side effects. It is considered to replace surgical resection. One of the most promising technologies for the treatment of cancer. However, since biological tissues lack endogenous substances with significant photothermal effects in the near-infrared region, the effective implementation of photothermal therapy requires the assistance of phototherapeutic agents with strong absorption in the near-infrared region (700-1100nm). Generally speaking, phototherapeutic preparations (photothermal conversion materials) are required to have high phot...

Claims

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