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1436 results about "Tubular network" patented technology

Use of EphA4 and modulator of EphA4 for diagnosis, treatment and prevention of cancer

The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and agonize EphA4. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and inhibit cancer cell colony formation in soft agar or tubular network formation in three-dimensional basement membrane or extracellular matrix preparation. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that preferentially binds to an EphA4 epitope that is exposed on cancer cells but not non-cancer cells. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 with a very low Koff to reduce EphA4 expression and, thereby, inhibit tumor cell growth and/or metastasis. The invention also provides pharmaceutical compositions comprising one or more EphA4 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.
Owner:MEDIMMUNE LLC

Pipe network intelligent control method and system integrating augmented reality and virtual reality

The invention belongs to the technical field of smart city information processing, and discloses a pipe network intelligent control method and system integrating augmented reality and virtual reality.The method comprises the steps: performing the 3D modeling and 3D scene rendering of a pipe network, pipe network ancillary facilities and sensors and the 3D virtual reality roaming interaction of the pipe network based on the three-dimensional virtual reality management and control technology, and performing the visualization and query statistics of pipe network operation monitoring data; performing the early detection and discovery of problems; performing the integration of augmented reality and the Internet of Things, and superposing a ground real scene with a virtual model of an underground pipe network and the real-time monitoring data of the Internet of Things; combining with the location-based service LBS, and performing the real-time obtaining of the user location information. Themethod utilizes the location-based service LBS to realize the active push of the unit data of the real-time monitoring system of the underground pipeline network, improves the working efficiency of the pipe network inspection and maintenance services, changes a traditional underground pipeline network management mode and achieves the innovation of a working mode.
Owner:孙琤

Rapid three-dimensional mapping moulding method for ground and underground pipe network

The invention relates to a rapid three-dimensional mapping moulding method for ground and an underground pipe network, which comprises the following steps of: acquiring ground scene data and underground pipe data and respectively establishing three-dimensional model images of the ground and the underground pipe network; establishing the link between the ground and underground pipe network three-dimensional model images according to coordinates and storing the link into a database; carrying out rapid moulding in sections according to the moulding range of a rapid moulding machine to obtain underground pipe network sectioned distributing physical models; and splicing the sectioned distributing physical models to obtain an underground pipe network distributing physical model. The ground scene and an underground pipeline are combined and linked by the coordinates; people at different levels can vividly and visually find out the corresponding ground scene by a failure pipeline position and establish a maintenance scheme; similarly, an underground pipe network under a ground scene can be reformed and maintained; and the invention realizes the scientific management of urban infrastructure, saves the maintenance and construction cost, reduces the generating probability of accidents and improves the engineering safety degree and quality.
Owner:ZHEJIANG SCI-TECH UNIV

Compressed air system and intelligent pipe network leakage detecting method for same

The invention relates to technology of fault diagnosis, and aims to provide a compressed air system and an intelligent pipe network leakage detecting method for the same. The intelligent pipe network leakage detecting method includes that signals of the pressure, the temperature and the flow of compressed air are acquired by a sensor mounted on a terminal delivery pipe network, and are transmitted to a low-pass filter circuit, received signals are coarsely filtered and are transmitted back to an upper computer by an A/D (analog/digital) conversion circuit via a lower computer, the upper computer obtains change relation of flow parameters along with time and the length of a pipeline according to actually measured data of a starting point and actually measured data of a finish point, and then a pipeline leakage detection function is realized by means of comparing theoretic output with actual output. The intelligent pipe network leakage detecting method adopting detection technology is high in leakage detection accuracy which is higher than 95 degrees, false alarm rate is lower than 3%, detection time is shorter than 55 seconds, sensitivity is high, and leakage quantity higher than 1.5% of delivery quantity of the pipeline can be detected. In addition, when the intelligent pipe network leakage detecting method is used for positioning a leakage point, precision is high, positioning precision error is lower than 1% of the total length of the pipeline, shutdown of a factory is avoided by means of online detection, and labor intensity of manual detection is reduced by means of online detection.
Owner:HANGZHOU ZETA TECH

Underground pipe network laying method based on three-dimensional virtual city

The invention relates to an underground pipe network laying method based on a three-dimensional virtual city, comprising the following steps of: carrying out preprocessing on remote sensing image data, digital elevation model data and three-dimensional building model data to construct a three-dimensional virtual city system; realizing the generation and the management of an underground three-dimensional pipe network model based on pipe point data, pipe well data and two-dimensional pipeline data in the three-dimensional virtual city system; selecting a starting point and a terminal point needing a pipe network according to the underground three-dimensional pipe network model and generating various pipe network laying schemes; carrying out collision processing on the pipe network laying schemes according to relevant specifications and standards, searching pipe network ambient facilities and analyzing the pipe network laying influence factor; carrying out optimization analysis according to the pipe network laying influence factor to obtain an optimum scheme which is suitable for underground pipe network laying, and managing and showing a result in the three-dimensional virtual city system. The invention constructs the three-dimensional virtual city, generates optimization by dynamic modeling and various pipe network laying schemes, realize the laying of a pipe network on dependable basis and provides support for planning underground resources and pipe lines of the city.
Owner:SHENZHEN INST OF ADVANCED TECH

Integrated analysis device for leakage monitoring of water supply pipe network and method of analysis device

ActiveCN105716803ADetect early signs in timeReduce basic cost inputMeasurement of fluid loss/gain rateTransmission protocolThird party
The invention relates to an integrated analysis device for leakage monitoring of water supply pipe network and a method of the analysis device. The device comprises a flow monitoring device with a flow recorder, a third-party communication transmission medium and a main station system; the main station system communicates with the flow monitoring device via the third-party communication transmission medium in transmission protocols; and the flow monitoring device also comprises a first communication module. The installation manner is simple, the integrated degree is high, and the caliber testing range is wide. The method of the analysis device comprises the steps that a water supply pipe network system is divided into blocks, zero pressure test is carried out, the water inlet flow and pressure of a water inlet end of the pipe network block area are monitored in real time and uploaded to the main station system, and the main station system receives the real-time pressure and flow data, and displays, stores, analyzes and reports the data. Early indication of leakage of the water supply pipe network can be discovered timely, the identification range is wide, leakage points are located rapidly and effectively, an analysis result is verified rapidly and effectively, basic cost of the water supply system is reduced, and comprehensive benefits including the economical, cost, resource, management and service aspects of the water supply system are improved.
Owner:SHENZHEN JASON DIGITAL TECH CO LTD

Optimized layout method for pressure monitoring points of urban water supply pipe network

The invention discloses an optimized layout method for pressure monitoring points of an urban water supply pipe network. The method comprises the steps that S1, basic data of the urban water supply pipe network is acquired, EPANETH software is utilized to calculate hydraulic adjustment of the water supply pipe network, and a hydraulic model of the urban water supply pipe network is constructed; S2, a pressure difference matrix, a shortest distance matrix and a water volume influence fuzzy similar matrix are solved according to the hydraulic model of the urban water supply pipe network, and constraint conditions of an optimized layout model of the pressure monitoring points of the urban water supply pipe network are determined; S3, a model objective function is determined, and the optimized layout model of the pressure monitoring points of the urban water supply pipe network is constructed; and S4, a particle swarm algorithm is utilized to solve the optimized layout model of the pressure monitoring points of the urban water supply pipe network, and an optimal pressure monitoring point and monitoring areas of all the pressure monitoring points are determined. The method has the advantages of being simple in principle, easy to realize and high in efficiency and meets the requirements for representativeness, comparability and feasibility of point distribution.
Owner:SOUTH CHINA UNIV OF TECH

Method for generating pressure distribution chart of urban water supply pipeline network

The invention relates to a method for generating a pressure distribution chart of an urban water supply pipeline network in the technical field of monitoring. The method comprises the following steps of: firstly, collecting the pressure data of nodes of a pressure measurement point, a water plant, a pumping station and the like from the water supply pipeline network by utilizing an SCADA (Supervisory Control And Data Acquisition) system; secondly, preprocessing the collected node data; thirdly, carrying out restrictive cluster analysis on a sample of the collected pressure data; fourthly, zoning the water supply pipeline network according to a clustering result, selecting a representative pressure node from each zone so as to represent the pressure level of the zone in which the representative pressure node is in; and finally, displaying different colors according to the pressure value of each zone and outputting the pressure distribution chart of the water supply pipeline network. The method adopted by the invention is simple and has high efficiency and strong robustness. If the accidents of damage and leakage occur in pipelines, the representative pressure nodes still have the representativeness of the pressure values because the pipelines of the nodes in one class are adjacent and a causal relation exists in the pressure.
Owner:SHANGHAI JIAO TONG UNIV

Soft measurement method for sewage pumping station flow of urban drainage converged network

The invention discloses a soft measurement method for sewage pumping station flow of an urban drainage converged network. The conventional drainage pipe network system has lots of uncertain factors and high measurement hardware cost. The method comprises the following steps of: analyzing main influencing factors of converged node pumping station flow by using mechanism analysis and priori information, and primarily determining influencing factors of a back-propagation (BP) neural network, namely determining input/output variables; determining lag time of different upstream pumping station flows by using a grey correlation analysis method; and establishing a grey neural network model on the basis of pumping station historical operating data, and predicting the converging node pumping station flow. By combining two methods of grey correlation analysis and grey neural network, the method solves the problem of difference of drainage time delay of different upstream pumping stations, well simulates the nonlinear pipe network drainage process, realizes soft measurement of converged node sewage pumping station flow, saves the hardware resources, and is low in cost and high in accuracy.
Owner:ZHEJIANG SUPCON INFORMATION TECH CO LTD

BIM (building information modeling) and VR (virtual reality)-based smart city pipeline network integrated platform, management method thereof and construction method

The invention discloses a BIM (building information modeling) and VR (virtual reality)-based smart city pipeline network integrated platform, a management method thereof and a construction method of the BIM (building information modeling) and VR (virtual reality)-based smart city pipeline network integrated platform. The BIM and VR-based smart city pipeline network integrated platform includes monitoring devices which are deployed at key monitoring positions of a city pipeline network and are in wireless communication with a BIM center service platform, management and control valves which are deployed at key management and control positions of the city pipeline network and are in wireless communication with the BIM center service platform, the BIM center service platform which is composed of a 3D real city scene model database related to the city pipeline network and a management and control module, and a VR (virtual reality) platform which carries out information exchange with the BIM center service platform. According to the BIM and VR-based smart city pipeline network integrated platform of the invention, 3D real city scene models and the VR (virtual reality) platform are combined together so as to realize monitoring, management and control on the city pipeline network, and therefore, the efficiency and timeliness of management and control can be improved, and the cost of manpower and material resources can be reduced.
Owner:XIAMEN RUICHUANG ENERGY SAVING TECH CO LTD

Load prediction and room temperature feedback correction-based whole network balance adjusting method

The invention provides a load prediction and room temperature feedback correction-based whole network balance adjusting method. Most conventional heat supply adjustment is adjustment of a heat sourceor a heating station, and the extensive adjustment mode often makes fluctuation of room temperature be larger and even wastes energy sources. The adjusting method provided by the invention increases adjustment research of whole network balance based on the heat source or the heating station. The target of whole network balance adjustment achieves supply and demand matching and pipe network stabilizing of primary and secondary networks by adjusting parameters of a heat supply system. In order to achieve the target, it is needed to determine an adjustment and control period and a time node to predict the period of heat supply parameters dynamically. Centered by a target value of room temperature of a user, feedback correction is carried out on the predicted water supply temperature by meansof room temperature, and finally, the load prediction and room temperature feedback correction-based whole network balance adjusting method is formed. Fluctuation of room temperature adjusted by the method is relatively gentle, and phenomena of overheating and undercooling are alleviated obviously, and the energy-saving effect is obvious.
Owner:HEBEI GONGDA KEYA ENERGY TECH

Spatial arrangement method of pipe network pipe explosion monitoring network

ActiveCN107143750APipeline systemsEngineeringSpatial optimization
The invention discloses a spatial arrangement method of a pipe network pipe explosion monitoring network. The spatial arrangement method comprises the steps that basic data collection and analysis are conducted, specifically, a plurality of pressure and flow monitoring devices are arranged in a pipe network, and the fluctuation degree of the pressure and the flow in the pipe network is analyzed through data extraction; pipe explosion analysis is conducted, specifically, a hydraulic model is built, the impacting degree of pipe explosion on the pipe network is analyzed, and whether pipe explosion impacting exceeds the normal fluctuation amplitude of the pipe network is judged; and monitoring network optimization is conducted, specifically, the explosive leakage quantity is monitored as much as possible to build the monitoring network optimization function to conduct spatial optimization, the number of monitoring points is gradually increased to enable the pipe explosion monitoring coverage rate to be increased by the amount less than a certain amount and then stop. According to the spatial arrangement method of the pipe network pipe explosion monitoring network, the complete arrangement method of the pipe explosion monitoring network is built, through analysis of natural fluctuation of a pipe network, it is ensured that with pipe explosion impacting being captured by the monitoring network as the goal, spatial arrangement and number control of the monitoring network are reasonably conducted, and pipe network pipe explosion emergency early warning can be economically, reasonably and efficiently provided.
Owner:ZHEJIANG UNIV
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