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85results about How to "Advantages" patented technology

Multi-material building three-dimensional printing and molding method

The invention discloses a three-dimensional printing and molding method for manufacturing a multi-material building or a large-size object layer by layer by adopting a plurality of nozzles, a plurality of types of materials and a three-dimensional printing technology. The three-dimensional printing and molding method comprises the following steps: establishing a three-dimensional CAD (Computer Aided Design) solid model of the multi-material building according to a pre-three-dimensional printed multi-material building; slicing and layering the three-dimensional CAD solid model to obtain machining information including solid structure information, material distribution information, movement tracks and the like of each layer; in a printing process of the multi-material building, conveying a plurality of types of molding materials by adopting a plurality of printing heads respectively, stacking layer by layer and carrying out printing and molding; carrying out treatment including polishing, spraying, wire arrangement, supporting removal and the like of the printed building model so as to obtain the building containing a plurality of types of materials. With the adoption of the three-dimensional printing and molding method, the integration of designing and manufacturing of a three-dimensional structure and a material of the multi-material building is realized; the comprehensive performance of the building is greatly improved; the three-dimensional printing and molding method is particularly applicable to the printing and molding of a functional building, and has a wide application prospect in the field of molding of buildings or models of landscape sculptures, artificial hills, home furniture and the like.
Owner:南京三帝智能装备制造有限公司

Operation optimizing and energy-saving control method for intermediate storage iron shot mill flour milling system

The invention relates to a method for the optimization of operation and control of energy conservation for a reserve ball-grinding powder system. Firstly, a non-linear neural network model about the consumption of powder of a powder-making system and operating parameters is established through collecting the service data of the powder-making system, then the negative pressure and the temperature at the entrance of a coal mill and the temperature at the outlet of the coal mill are obtained through the non-linear optimization with restricted conditions as a set value for controlling the system, wherein, the negative pressure, the temperature at the entrance and the outlet lead to lower consumption of powder; the entire optimized controlling of the powder-making system is carried out through the intelligent control of rotation of the coal mill and multivariable decoupling control of parameters at the entrance of the coal mill based on the operating experience as well as an intelligent down draft control technology, so as to ensure that the powder-making system strictly runs at an optimal condition and effectively reduces the powder consumption. The method provided by the invention can effectively inhibit the fluctuations of a primary air pressure in the on / off process of the powder-making system, put an end to serious accidents such as flameout in a boiler caused by down draft and effectively reduce the operating intensity for the staff.
Owner:SOUTHEAST UNIV

Motor parameter detector

The invention discloses a motor parameter detector to solve the technical problem of real-time detection of motor parameters. The detector comprises a hardware platform composed of a central processing unit (CPU) micro control unit (MCU) module, a measurement module, a display module, a communication module and the like. A C8051F340 single chip microcomputer serving as the CPU forms a main control circuit, wherein the single chip microcomputer is connected with a digital signal processor (DSP) chip for power energy metering through a software process improvement (SPI) bus, is connected with a torque sensor, a rotation speed sensor, a winding temperature rising sensor, a liquid crystal display (LCD) screen, a keyboard and a relevant interface circuit, and communicates with principal computer (PC) software through a 485 network, so that further analysis and management of uploaded data are achieved on computers, and a human-computer interaction is achieved; and the DSP chip for power energy metering is connected with a voltage transformer and a current transformer so as to detect three-phase voltage and current signals. The motor parameter detector has the advantages of being capable of collecting electrical parameters for alternating current induction motors and synchronous motors, high in automation degree, and simple to operate, and guaranteeing the accuracy of measurement results and the stability of the system operation on the basis of increasing the instrument operation speed.
Owner:ZHEJIANG SCI-TECH UNIV

Ultra high molecular weight polyethylene core spun yarn and preparation method thereof

ActiveCN104862843AResilience advantageAntibacterial AdvantageYarnYarnFiber
The invention discloses ultra high molecular weight polyethylene core spun yarn and a processing method thereof. Ultra high molecular weight polyethylene filaments serves as yarn for the core spun yarn, and ultra high molecular weight polyethylene chopped fibers evenly cover the ultra high molecular weight polyethylene filaments to form the core spun yarn. Due to the ultra high molecular weight polyethylene filaments, the core spun yarn has the advantages of being high in strength, resistant to abrasion and corrosion and low in density, the fabric forming performance is improved, the yarn touch and style are improved, spun yarn can serve as a stab-resistance armor fabric, an anti-cutting glove, various ropes and a fishing net and the like, and the product application range is expanded.
Owner:汕头市明达纺织有限公司

Unidirectional lead core rubber vibration insulation support

The invention discloses a unidirectional lead core rubber vibration insulation support which comprises an interlayer steel plate, interlayer rubber, outer wrapping rubber, upper seal plate, a cover plate, a lead core, a Teflon sliding plate, a stainless steel plate, an upper support plate, a lower support plate, limiting plates, an upper connecting plate, a lower connecting plate, an anchor bolt, a lateral stainless steel bar and a guide sliding strip. The led core is tightly pressed into a support reserved hole, and the cover plate is arranged on the lead core. The Teflon sliding plate and the stainless steel plate form a support sliding face, and lubrication between the stainless steel plate and the Teflon sliding plate is conducted through silicone grease. The upper seal plate is bonded with the Teflon sliding plate which is provided with the surface coated with epoxy resin and is subjected to surface activation treatment. The limiting plates are arranged on all the side edges of the upper support plate and allow longitudinal sliding but limit transverse moving. By means of the unidirectional lead core rubber vibration insulation support, the problem that a total link bridge length is large or large longitudinal deformation generated under the conventional load action may be restrained when the vibration insulation support is adopted for a large stride bridge is solved, the application range of the vibration insulation support is broadened, and vibration resistance of the overall bridge is improved.
Owner:NANJING UNIV OF TECH

Anti-pulling embedded-type gate-type steel frame steel-joint column foot and construction method thereof

The invention discloses an anti-pulling embedded-type gate-type steel frame steel-joint column foot and a construction method thereof. The anti-pulling embedded-type gate-type steel frame steel-joint column foot is characterized in that a basic short column (1) is composed of injecting concrete, wherein a local-pressure-proof rebar net chip (2) is arranged on the top of the basic short column (1), a basic reverse cup-shaped hole (3) is formed inside the basic short column (1), the lower section of a steel column (8) is inserted into the basic reverse cup-shaped hole (3), a steel column base plate (4) is welded on the bottom of the steel column (8), a steel column toggle pin (5) is welded in the range of the height of the lower section of the steel column (8), a horizontal stiffening plate (6) is welded on the lower section, at the position of 100mm below the top of the basic short column (1), of the steel column (8), and the basic short column (1) is combined with the steel column (8) by the fact that cement mortars are injected in the basic reverse cup-shaped hole (3). According to the structure of the anti-pulling embedded-type gate-type steel frame steel-joint column foot, foundation bolts do not need to be arranged, the dimensions of the basic short column are small, structure is simple, steel materials are saved, and using is safe and reliable.
Owner:GUIYANG AL-MG DESIGN & RES INST

Subway safety door capable of lifting vertically

The invention discloses a subway safety door capable of lifting vertically. The subway safety door comprises a door frame (1) formed by a left upright (11), a right upright (12) and a cross beam (13), a moving door body (2) and a lifting rope (3), wherein the insides of the left and right uprights are provided with protruding guide rails (14); the cross beam is provided with a fixed support (15) extending downward; the support is provided with an electrically driven device (16) and a drum device (17) driven by the electrically driven device; the outsides of the mullions of the moving door body are provided with grooves (21) which are matched with the guide rails (14) in a sliding manner, the inside of the moving door body is provided with a glass door body (22) and a sealing device (23); and one end of the lifting rope is fixed and wound on the drum device and the other end is fixed on the middle of the horizontal frame of the moving door body. The subway safety door can be installed in special place without occupying the side space and be better to be used at the end of the subway safety door.
Owner:FANGDA INTELLIGENT INNOVATION TECH CO LTD

Serum-free medium of human amniotic epithelial stem cell and culture method thereof

ActiveCN106834218AOvercoming difficulties in obtaining materialsOvercome limitationsCell dissociation methodsCulture processCuticleSingle cell suspension
The invention relates to a serum-free medium of a human amniotic epithelial stem cell and a culture method thereof. The serum-free medium is formed by adding a human epidermal growth factor, human transferring, human insulin, sodium selenite, alanyl-L-glutamine dipeptide, alanine, asparaginate, aspartic acid, glutamic acid, glycine, proline and serine to a DMEM / F12 basic medium. The culture method comprises the steps of digesting 2.5g / L of trypsin for a human amniotic membrane, obtaining the human amniotic epithelial stem cell and filtering to prepare a single cell suspension; putting the human amniotic epithelial stem cell into a CO2 incubator of which the saturated humidity and the volume fraction are 5% at 37 DEG C through the serum-free medium under a serum-free condition and achieving growth and amplification of the amniotic epithelial stem cell through liquid exchange and subculture under the serum-free culture condition, the serum-free medium has the characteristics of stem cells, and is free of other animal sources, wide in source and free of ethical restriction.
Owner:沈阳艾米奥生物工程技术研发中心有限公司

Rolling bearing component

Thin walled roller bearing component is produced from a cold strip made from a tempered steel having a tensile strength of not more than 480 N / mm 2>, a breaking elongation of at least 24%, an apparent yielding point of not more than 380 N / mm 2> and an anisotropic value R of 0.85-1.05 with delta Rmax = 0.3 mm. The cold worked roller bearing component has a surface hardness of at least 700 HV and a core hardness of no more than 650 HV.
Owner:SCHAEFFLER TECH AG & CO KG

Method for optimizing start and terminal point set customized public transport operation based on Internet and vehicle-path cooperation

The invention belongs to the technical field of data processing, and discloses a method for optimizing start and terminal point set customized public transport operation based on Internet and vehicle-path cooperation. The method includes the steps of sorting passenger starting time, start point and terminal point conditions, determining a start and terminal point set including a plurality of different start points and terminal points to increase the coverage area of a customized public transport and increase potential passengers, and planning optimal paths within the start and terminal point set to save operation cost, when the number of passengers satisfies the customized public transport operation conditions. Vehicles may not stop during a long-distance driving process between start points and terminal points, thereby achieving the purpose of avoiding traffic jam and rapid transit based on real-time planed driving paths. Conventional customized public transport only has one start point and one terminal point, the coverage area is small and the passengers are less, so that the operation bottom line is hard to reach. Fixed stops for passengers to get on are set along a path, which fix the driving path. According to the method, the coverage area and the number of potential passengers are increased, so that the successful rate of start operation of customized public transport is increased. Path flexibility during driving is increased, thereby effectively avoiding traffic jam and saving travelling time.
Owner:CHONGQING JIAOTONG UNIVERSITY

Preparation method of nanometer drug delivery system carrying tanshinone IIA and application thereof

The invention discloses a preparation method of a nanometer drug delivery system carrying tanshinone IIA. The preparation method comprises the following steps: step 1. preparing methoxy polyethylene glycol-polylactic acid glycolic acid-polylysine modified by valine-arginine-glycine-aspartic acid-glutamic acid cyclopeptide; and step 2. preparing methoxy polyethylene glycol-polylactic acid glycolic acid-polylysine nanoparticle carrying the tanshione IIA and modified by the valine-arginine-glycine-aspartic acid-glutamic acid cyclopeptide when the molar ratio of the methoxy polyethylene glycol-polylactic acid glycolic acid-polylysine nanoparticle modified by the valine-arginine-glycine-aspartic acid-glutamic acid cyclopeptide and the tanshinone IIA is 1-60:1-60. The invention also discloses the application for the nanometer drug delivery system carrying the tanshinone IIA prepared by the method. The nanometer drug delivery system carrying the tanshinone IIA prepared by the method can effectively lower the toxicity of the tanshinone IIA and increase the targeting of the tanshinone IIA and the treatment effect.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M

Mild safe liquid laundry detergent and preparing method thereof

A mild safe liquid laundry detergent comprises the following raw materials in weight percents: 1.5-5.0% of fatty alcohol-polyoxyethylene ether, 5.0-12.0% of glucoside, 1.5-5.0% of alcohol ether carboxylate, 0.1-1.05 of thickening agent, 0.1-5% of other auxiliaries, and rest being de-ionized water. The mild safe liquid laundry detergent is mild, safe, and suitable for hand wash.
Owner:CHINA RES INST OF DAILY CHEM IND

Method, apparatus, computer program product and device providing semi-parallel low density parity check decoding using a block structured parity check matrix

The invention relates to low density parity check decoding. A method for decoding an encoded data block is described. Encoded data block comprising data sub-blocks are stored. Decoding is performed in a pipelined manner using an irregular, block- structured parity check matrix, where at least two data sub-block matrices of the parity check matrix are read from and written in each of a plurality of clock cycles. The reading and writing of the data sub-blocks is evenly distributed between at least two area of a memory. The decoding is performed with shift values which eliminate cycles at or below a predetermined threshold length. An apparatus, computer program product and device are also described.
Owner:CORE WIRELESS LICENSING R L

Fluorescence probe and synthetic method thereof and application of fluorescence probe in circulating tumor cell detection

The invention discloses a fluorescence probe and a synthetic method thereof and an application of the fluorescence probe in circulating tumor cell detection. The fluorescence probe comprises a fluorescence group, a cathepsin B substrate and folic acid molecules, the fluorescence group is connected with the cathepsin B substrate through a self-degradation bond, and then is connected with the folic acid molecules; the fluorescence group is excited by the excitation light under a dissociation state, and then is enable covalent connection with other molecules for quenching. The fluorescence probe is the switching-mode fluorescence probe having a spontaneous cascade amplification function, can be used for avoiding complex operation steps of antibody or nucleic acid detection during a circulating tumor cell detection process, is used for an automatic biochemical analyzer as a matching reagent, is in favor of promoting automation detection of tumor cells, and has the advantages of simple and convenient operation, short time consuming, and low apparatus requirement. The fluorescence probe can be used for positioning minimal tumor cells and tubercle in clinical operation, and has wide application prospect and large market value.
Owner:THE FIFTH AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV

Phenyl urazan nitrogen nitric oxide donor 2-aniline pyrimidine derivatives, preparation method, compound containing the same and use thereof

The invention discloses a compound used as a general formula (I) of protein kinase inhibitor, the salt accepted pharmaceutically and the preparation method; wherein, X is -(CH2)m-COO-; m is equal to 1 to 5 or direct bond; Y is -(CH2)n-O- or -(CH2)n-PhO-; n is equal to1 to 10 or direct bond; the preparation method comprises a step which uses N-(5-amino-2- methyl-phenyl)-4- (3-pyridyl)-2-pyrimidinamine and general formula (II) compound as raw material synthesis. The invention also discloses the preparation method of the compound, comprising the compound and the treatment of being used as tyrosine protein kinase inhibitor in diseases such as cancer relative to tyrosine in particular to Bcr-Abl.
Owner:JIANGSU TASLY DIYI PHARMA CO LTD

Children health pectoral mixture for treating child wind and heat caused by exopathogen and its preparing method

The children's cough relieving mixture with combined cough relieving and fever allaying functions is prepared with honeysuckle, Japanese felt fern frond, burdock fruit, isatis leaf, wolfberry bark and other five kinds of Chinese medicinal materials. The preparation process includes distilling partial material to collect distillate, decocting other medicine materials, filtering, concentrating filtrate, alcohol precipitation, concentrating supernatant, water precipitation, filtering supernatant, concentration, preparing syrup with cane sugar, merging, adding benzoic acid to regulate specific weight, sterilizing and other steps.
Owner:SINOPHARM GRP ZHIJUN SHENZHEN PINGSHAN PHARMA CO LTD

Preparation method and application of potassium ferrate

The invention discloses a preparation method and application of potassium ferrate. The method comprises the following steps: (1) introducing chlorine to a saturated sodium hydroxide liquor to prepare a high concentration sodium hypochlorite liquor, wherein the liquor per litter contains 400-500g of sodium hydroxide; (2) cooling the liquor to ice point, filtering and removing crystals in the liquor; (3) adding a saturated ferric trichloride aqueous liquor to the liquor, controlling the temperature near the ice point, and quickly stirring to form a sodium ferrate liquor; (4) filtering the sodium ferrate liquor, casting potassium hydroxide to the filtrate and slowly stirring to obtain crystals of potassium ferrate; and (5) filtering the crystals of potassium ferrate prepared by the step (4), and washing the potassium ferrate solid and vacuum drying to obtain the final product potassium ferrate. The potassium ferrate prepared by the method provided by the invention is higher in purity which is normally not greater than 98.5%, and the yield of the product is greater than 80%. The potassium ferrate of the product stored in a closed and lucifugal room temperature condition is less than 1%.
Owner:常州和方环保科技有限公司

Driving arrangement for the motorized displacement of a motor vehicle door or the like

ActiveCN101802336AMotor adjustmentAny gear ratioPower-operated mechanismMotor vehicle partDrive motor
The invention relates to a driving arrangement for the motorized displacement of a motor vehicle door (1) or the like, wherein at least one door drive (4) is provided with a driving motor (5), wherein a belt drive (6) with a driving belt pulley (7), an output belt pulley (8) and a driving belt (9) is provided in the drive train of the door drive (4), wherein the belt drive (6) is assigned a belt-tensioning arrangement (10) with an adjustable tensioning element (11) which is in engagement, or can be brought into engagement, with the driving belt (9) for tensioning purposes. It is proposed thata further driving motor (12) which is assigned to the belt-tensioning arrangement (10) is provided, by means of which driving motor (12) the tensioning element (11) can be adjusted in a motorized manner and therefore the driving belt (9) can be tensioned and relaxed in a motorized manner.
Owner:BROSE SCHLIESSSYSTEME GMBH & CO KG

Refining method for tolfirinib citrate compound

The invention provides a refining method for a tofartinib citrate compound. The method comprises the following steps: preparing a tofartinib citrate crude product by a tofartinib crude product and citric acid monohydrate; adding a prepared mixed solvent, heating and stirring the mixture to be completely dissolved to obtain a clear solution, adding activated carbon, performing keeping warm and stirring, performing filtering, cooling a filtrate and performing recrystallization, performing filtering, washing a filter cake, and performing vacuum drying to obtain a tofatinib citrate refined product. The refining method has simple operation and high yield, the purity of tofartinib citrate reaches 99.93% or more, the maximum single impurity content is controlled to be 0.06% or less, and the totalimpurity content is controlled to be within 0.08%.
Owner:SHANDONG LUOXIN PHARMA GRP HENGXIN PHARMA CO LTD +2

Adhesive tape stamping device and method for stamping an adhesive tape section onto an object

InactiveCN101657371AEasy to useDo not require operating precisionMetal-working apparatusAdhesivesAdhesive beltEngineering
The invention provides an adhesive tape stamping device and method for stamping an adhesive tape section onto an object. The adhesive tape stamping device is configured to implement a course of movement in stead of hand operation and used for stamping the adhesive section having a defined length onto an object along a stamping direction.
Owner:伯勒尔有限公司

Electrode active material for lithium ion battery, pole piece of lithium ion battery, preparation method of lithium ion battery pole piece and lithium ion battery

InactiveCN106898736AConductiveImprove first charge efficiencyCell electrodesSecondary cellsPole pieceLithium-ion battery
The invention provides an electrode active material for a lithium ion battery, a pole piece of the lithium ion battery, a preparation method of the pole piece and the lithium ion battery containing the pole piece. The electrode active material contains an active substance and a polymer lithium salt protecting layer coating the surface of the active substance, wherein polymer lithium salt is water soluble polymer lithium salt and is organic electrolyte insoluble in a battery, and a polymer main chain segment of the polymer lithium salt contains polar groups. Therefore, the electrode active material has relatively excellent cycle performance and storage property.
Owner:BYD CO LTD

Individual calcium phosphate bionic bone tissue bracket and preparation method and application thereof

The invention provides an individual calcium phosphate bionic bone tissue bracket and a preparation method and application thereof. The individual calcium phosphate bionic bone tissue bracket comprises a central passage layer and a periphery structure which is in radial arrangement taking the central passage layer as a center, wherein the periphery structure comprises plate layer pieces which aresequentially arranged in a stacking manner, a gap is formed between every two plate layer pieces, the gap ratio is 65-70%, and the gap is in the shape of plate layers. The structure of the individualcalcium phosphate bionic bone tissue bracket solves the problem that incomplete osteogenesis caused by the situation that nutrient substances in a previous compact internal porous structure are difficult to transport from outside to inside, cells and new vessels can enabled to grow in depth in the bracket, and the osteogenesis is more complete; macropores in the center of the bracket can infiltrate degradable polymeric materials, so that the mechanical property of the bracket can be wholly improved; a bone repair bracket of which the shape is matched is prepared through an individual mold, sothat the bracket has greater advantages in the structure and the functions.
Owner:THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV

High-speed low clock signal oscillation amplitude driving conditional precharging CMOS trigger

A high and low clock signal amplitude pre-fill CMOS trigger characterizes in connecting substrates of all PMOS tubes in the first stage latch of SAFF-CD conditional pre-fill structure driven by the low voltage amplitude clock signals to the power supply directly, the same time when omitting the only grating connected with NMOS tubes of the same supply end, two coupled NMOS tubes at the drain are removed, so that the drain of NMOS tubes with the substrate and the source all connected with the earth is connected with the drain of two remained NMOS tubes, finally, two compensated output ends of the first state latch are connected with two mutual independent single clock phase latches with the same circuit parameters.
Owner:TSINGHUA UNIV

Ultrasonic strengthening extraction separation method of cerium-rich rare earth nitrate solution

The invention discloses an ultrasonic strengthening extracting separating method of enriched cerium from rare earth nitrate solution, which comprises the following steps: extracting enriched material of light, middle and heavy rare earth nitrate through ultrasound; oxidizing Ce3+ into Ce4+; extracting refined cerium solution through ultrasound; reserving Ce3+ and other tervalent rare earth elements in the solution.
Owner:YANGZHOU UNIV +2

Traditional Chinese medicine composition and application thereof in preparation of medicines for treating hypertension

The invention belongs to the technical field of traditional Chinese medicines, relates to a traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition and application thereof in preparation of medicines for treating hypertension. The traditional Chinese medicine composition is prepared from16 commonly used traditional Chinese medicines, namely uncaria, eucommia ulmoides, concha haliotidis, wolfberry, selfheal, radix paeoniae alba, angelica sinensis, gastrodia elata, ligusticum wallichii, jasmine, the root of red-rooted salvia, hawthorn, salix leaf, loranthus parasiticus, earthworm and the root of kudzu vine. The traditional Chinese medicine composition has an obvious clinical effect in lowering blood pressure, and has no toxic and side effects. Furthermore, the invention also relates to a preparation method for the traditional Chinese medicine composition.
Owner:邢立志

Paper-cut metamaterial with adjustable auxetic characteristic under large stretching amount and design method of paper-cut metamaterial

ActiveCN112949136AAdjustable trend of auxetic propertiesReduce in-plane stressGeometric CADDesign optimisation/simulationShear mouthGeometric reconstruction
The invention relates to a paper-cut metamaterial with an adjustable auxetic characteristic under a large stretching amount and a design method thereof, the paper-cut metamaterial is composed of a plurality of square unit cells which are arranged in order, and the plurality of unit cells are arranged in the paper-cut metamaterial in a periodic, gradient or irregular mode. Corresponding paper-cut metamaterials respectively have a uniform auxetic characteristic, a gradient auxetic characteristic and a specified non-uniform auxetic characteristic. The design method comprises the steps that firstly, a structure optimization method is adopted, out-of-plane deformation constraint is fully considered, and heuristic design of a unit cell configuration is obtained; secondly, geometric reconstruction and parameter modeling are carried out on an optimization result obtained in the above steps, and the tension and expansion characteristics under different geometric parameters are obtained; and finally, the plurality of unit cell configurations are arranged according to a specific arrangement sequence, and the paper-cut metamaterial is constructed. According to the invention, by modifying the parameters of the shear mouth, a plurality of tension and expansion characteristic change trends which can be adjusted along with the tension amount can be realized; compared with the existing paper-cut metamaterial, the metamaterial provided by the invention has obvious advantages in structural design, application range and application prospect.
Owner:DALIAN UNIV OF TECH

Method for preparing baloxavir intermediate and intermediate obtained by method

The invention belongs to the technical field of chemical synthesis, and provides a method for preparing a balosavir intermediate. The method comprises the following steps: (1) methylating 3,4-difluorobromobenzene to obtain a compound A-1; (2) reacting the compound A-1 with a Grignard reagent, then introducing carbon dioxide gas for reaction, and adding acid for acidification to obtain a compound A-2; (3) brominating the compound A-2 to obtain a compound A-3; (4) adding diphenyl disulfide and a reducing agent 1 into THF, dropwise adding methanol, dropwise adding the compound A-3, and reacting to obtain a compound A-4; (5) carrying out ring closing reaction on the compound A-4 in polyphosphoric acid to obtain a compound A-5; and (6) reducing the compound A-5 into alcohol by adopting a reducing agent 2 to obtain a compound A-6. According to the method, highly toxic and foul thiophenol is prevented from being used while expensive reagents are prevented from being used, so that the processcost is reduced. The invention also provides an intermediate compound prepared by the method.
Owner:HEADING NANJING PHARMTECH CO LTD
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