The invention discloses a large-caliber packaging tin manufacturing method. The method comprises the following steps that 1, an aluminum foil and a metal sheet are prepared; 2, first-time deformation forming is carried out, and a first-time deformation model blank is formed; 3, second-time deformation forming is carried out, and a second-time deformation model blank is formed; 4, third-time deformation forming is carried out, a semi-product formed a time is formed, and the semi-product is a packaging tin semi-product with a tin body and a bottom cover formed integrally; 5, shear mouth punching machining and size fine adjustment are carried out, and a second-time semi-product is formed; 6, a top cover matched with an opening of the second-time semi-product is manufactured; and 7, the turnup part of the second-time semi-product is hooked to the curve part of the top cover to form an interlocking structure, the aluminum foil is arranged at a notch of the top cover, the sealing combination is achieved by means of a bonding manner, and a large-caliber packaging tin is formed. The invention further discloses the large-caliber packaging tin. The manufacturing method is simple and reasonable in technology, and the manufactured large-caliber packaging tin is high in packaging strength, good in airtightness, good in photophobism, capable of effectively guaranteeing the performance like food safety.