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Individual calcium phosphate bionic bone tissue bracket and preparation method and application thereof

A calcium phosphate bionic bone and tissue scaffold technology, used in tissue regeneration, prosthesis, medical science, etc., can solve the problem of incomplete osteogenesis of nutrients, achieve complete osteogenesis and improve mechanical properties.

Active Publication Date: 2019-01-08
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the related art, the present invention provides a personalized calcium phosphate biomimetic bone tissue scaffold and its preparation method and application. The peripheral structure of the cloth, the peripheral structure includes lamellar sheets arranged in sequence, and there are gaps between the lamellar sheets, which solves the problem of bone formation caused by the difficulty in transporting nutrients from the outside to the inside in the past in the dense external and internal porous structures. incomplete question

Method used

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  • Individual calcium phosphate bionic bone tissue bracket and preparation method and application thereof
  • Individual calcium phosphate bionic bone tissue bracket and preparation method and application thereof
  • Individual calcium phosphate bionic bone tissue bracket and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] 1. Configure BCP (HA: β-TCP is 3:7) slurry with a volume fraction of 15%:

[0075] Weigh 15g of nanoscale BCP (particle size of 1000nm), 35g of nanoscale β-TCP (particle size of 5000nm), and 0.5g of MgO into a ball mill jar, ball mill at a speed of 30r / min for 24h, and sieve to obtain 50g of biphasic Calcium phosphate powder is ready for use; put 50g of biphasic calcium phosphate powder in a ball mill jar, add 1ml of 40% vt ammonium polyacrylate, 5ml of 10% vt polyvinyl alcohol, and 91ml of deionized water and mix thoroughly with 30r / min ball mill for 24h to obtain the volume For the BCP slurry with a fraction of 15%, the biphasic calcium phosphate powder accounts for 15% vt of the slurry, the dispersant accounts for 0.9% vt, and the binder accounts for 4% vt.

[0076] 2. Slurry freezing and drying:

[0077] Inject the ball-milled slurry into a personalized mold, set the temperature of the cold source to -15°C, control the ambient temperature to 1-4°C, and freeze for 2...

Embodiment 2

[0082] 1. Configure BCP (HA: β-TCP is 2:8) slurry with a volume fraction of 20%:

[0083] Weigh 10g of nanoscale BCP (particle size of 1000nm), 40g of nanoscale β-TCP (particle size of 5000nm), and 0.5g of MgO into a ball mill jar, ball mill for 24 hours at a speed of 30r / min, and sieve to obtain 50g of biphasic Calcium phosphate powder is ready for use; put 50g of biphasic calcium phosphate powder in a ball mill tank, add 61.3ml of deionized water, 1ml of 40% vt ammonium polyacrylate, 2.5ml of 10% vt polyvinyl alcohol and mix thoroughly by ball milling at 30r / min for 24h. A BCP slurry with a volume fraction of 20% was obtained, wherein the biphasic calcium phosphate powder accounted for 30% vt of the slurry, the dispersant accounted for 1.2% vt, and the binder accounted for 3% vt.

[0084] 2. Slurry freezing and drying

[0085] Inject the ball-milled slurry into a personalized mold, set the temperature of the cold source to -20°C, control the ambient temperature to 1-4°C, an...

Embodiment 3

[0089] 1. Configure BCP (HA: β-TCP is 4:6) slurry with a volume fraction of 25%:

[0090] Weigh 20g nanoscale BCP (particle size is 5000nm), 30g nanoscale β-TCP (particle size is 1000nm), 0.5gMgO, put them into a ball mill jar, ball mill at a speed of 30r / min for 12h, and sieve to obtain 50g biphasic Calcium phosphate powder is ready for use; put 50g of biphasic calcium phosphate powder in a ball mill tank, add 48ml of deionized water, 0.8ml of 40% vt ammonium polyacrylate, 3.5ml of 10% vt polyvinyl alcohol and mix thoroughly by ball milling at 30r / min for 24h. A BCP slurry with a mass fraction of 25% was obtained, wherein the biphasic calcium phosphate powder accounted for 25% vt of the slurry, the dispersant accounted for 1.2% vt, and the binder accounted for 5.4% vt.

[0091] 2. Slurry freezing and drying

[0092] Inject the ball-milled slurry into a personalized mold, set the temperature of the cold source to -25°C, control the ambient temperature at 1-4°C, and freeze for...

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Abstract

The invention provides an individual calcium phosphate bionic bone tissue bracket and a preparation method and application thereof. The individual calcium phosphate bionic bone tissue bracket comprises a central passage layer and a periphery structure which is in radial arrangement taking the central passage layer as a center, wherein the periphery structure comprises plate layer pieces which aresequentially arranged in a stacking manner, a gap is formed between every two plate layer pieces, the gap ratio is 65-70%, and the gap is in the shape of plate layers. The structure of the individualcalcium phosphate bionic bone tissue bracket solves the problem that incomplete osteogenesis caused by the situation that nutrient substances in a previous compact internal porous structure are difficult to transport from outside to inside, cells and new vessels can enabled to grow in depth in the bracket, and the osteogenesis is more complete; macropores in the center of the bracket can infiltrate degradable polymeric materials, so that the mechanical property of the bracket can be wholly improved; a bone repair bracket of which the shape is matched is prepared through an individual mold, sothat the bracket has greater advantages in the structure and the functions.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a personalized calcium phosphate bionic bone tissue scaffold and its preparation method and application. Background technique [0002] Scaffold materials for bone repair should have good plasticity, biocompatibility, osteoconductivity, bioactivity, and degradability, as well as high porosity, interconnected porous structure, and sufficient mechanical strength. However, the existing bone repair materials, such as metal implant materials such as titanium and titanium alloys, stainless steel, and cobalt-chromium alloys, can be individually designed according to the shape of bone defects and have good mechanical strength, but they lack biological activity and do not degrade. ; Calcium phosphate ceramics have biological activity and can be degraded in vivo, but their mechanical strength is low; polymer materials can be degraded in vivo, but their mechanical strength is lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/42A61L27/56A61L27/58C04B35/447C04B35/622C04B35/626C04B35/64
CPCA61L27/425A61L27/56A61L27/58A61L2430/02C04B35/447C04B35/622C04B35/62605C04B35/64C04B2235/6562C04B2235/6567C04B2235/661
Inventor 陈良建
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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