303 results about "Peptide complex" patented technology

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.

Provided are a T-cell receptor (TCR) and the use thereof, wherein the TCR contains an α chain containing a variable region and / or a β chain containing a variable region. The TCR is capable of specifically recognizing an A1101-restricted KRASG12V mutation and an A1101-restricted KRASG12D mutation. A T cell transducing the TCR (TCR-T) can bind to an antigen short peptide-HLA-A1101 complex, and can be used for treating malignant tumors carrying the KRASG12V mutation and KRASG12D mutation.

The invention relates to the technical field of mask product production, in particular to an anti-aging and firming mask and a preparation method thereof.The anti-aging and firming mask is prepared from, by mass, 5-10 parts of seaweed extract, 3-7 parts of collagen peptide, 2-6 parts of sodium hyaluronate, 4-9 parts of peptide compound and 1-4 parts of vitamin E ester. The anti-aging compact facial mask is prepared through the preparation device of the anti-aging compact facial mask, a discharging roller and a collecting roller in the collecting and tightening structure are matched with a pressing roller, in the facial mask cutting process, the discharging roller conducts discharging, the collecting roller can rapidly collect cut facial mask belt waste and collect the cut facial mask belt waste in a coiled mode, the recovery efficiency of the facial mask preparation waste is improved, and the recovery efficiency of the facial mask preparation waste is improved. And arrangement of a production environment and resource recycling are facilitated.

The invention provides a polypeptide compound and application thereof, and belongs to the technical field of medical or dressing preparations. According to the invention, three specific polypeptides are synergistically proportioned to obtain the polypeptide compound, and the polypeptide compound has the effect of repairing a skin basement membrane in a targeted manner. The polypeptide compound has the advantages of being small in molecular weight, high in safety, low in allergy risk and high in permeability, and has excellent repairing and anti-aging functions. Experiments prove that the polypeptide compound provided by the invention, as an active peptide raw material, can remarkably promote the production of endogenous collagen IV, VII and XVII of skin, is also beneficial to repairing skin extracellular matrix, resisting DNA damage, improving skin cycle protein, inhibiting release of inflammatory factors and the like, can effectively repair a basement membrane, and has a wide application prospect.

Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-COV-2 antigen; and a trimerization domain. Disclosed are peptide complexes comprising three peptides, wherein each of the three peptides comprises a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-COV-2 antigen; and a trimerization domain. Disclosed are compositions comprising any of the disclosed peptides or peptide complexes. Disclosed are methods for eliciting a protective immune response against SARS-COV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. Disclosed are methods of treating a subject exposed to SARS-COV-2 or at risk of being exposed to SARS-COV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein.

The present invention relates to a heterotandem bicyclic peptide complex which comprises a first peptide ligand, which binds to Nectin-4, conjugated via a linker to two second peptide ligands, which bind to CD137. The invention also relates to the use of said heterotandem bicyclic peptide complex in preventing, suppressing or treating cancer.

The present invention relates to a use of a peptide complex in improving skin condition. The peptide complex of the present invention has an activity of alleviating skin cell damage by inhibiting activation of inflammatory responses, promotion of apoptosis, increased expression of MMP-1 and MMP-2, increased expression of RAGE, and decreased expression of glyoxalase, which are various skin-damaging actions induced by advanced glycation end products or precursors thereof in skin cells.

The invention relates to the technical field of food, in particular to geobacillus stearothermophilus cKM-Geo, application of the geobacillus stearothermophilus cKM-Geo, a shrimp shell oligosaccharide peptide compound and a preparation method of the shrimp shell oligosaccharide peptide compound. The invention provides geobacillus stearothermophilus cKM-Geo, the strain can grow in an oxygen-free environment, ventilation is not needed in the process, and proteolytic enzyme, cellulase, lipase and chitin deacetylase can be highly secreted and expressed; the invention further provides a preparation method for preparing the shrimp shell oligosaccharide peptide by utilizing geobacillus stearothermophilus cKM-Geo fermentation coupling steam explosion treatment, chitin and protein in the shrimp shell are converted into water-soluble oligopeptide and oligosaccharides, the water-soluble oligopeptide and oligosaccharides are separated from calcium carbonate in the shrimp shell, acid and alkali do not need to be used, in the process, waste water is little, pollution is little, and the method is suitable for industrial production. The resource utilization rate is high.

The peptide complex of the present invention promotes the expression of the SIRT1 gene, referred to as a longevity gene, promotes the expression of the FGF21 gene, and increases the phosphorylation of AMPK. In addition, the peptide complex of the present invention exhibits an anti-inflammatory effect. Therefore, the peptide complex of the present invention inhibits aging, promotes the expression of the longevity gene SIRT1 gene, and can be used for treating or preventing diseases associated with SIRT1.

The invention discloses a deep learning algorithm for predicting a monomer and compound structure of cyclic peptide and linear peptide containing non-standard amino acid. The deep learning algorithm specifically comprises the following steps: constructing a training data set containing head and tail cyclopeptide monomers and compounds, disulfide bond cyclopeptide monomers and compounds, and linear peptide monomers and compounds of non-standard amino acid; training and optimizing the peptide structure prediction model containing the basic protein knowledge; constructing a test data set of a linear peptide monomer containing non-standard amino acid, a linear peptide compound, a head-tail cyclopeptide monomer and a disulfide bond cyclopeptide monomer; and testing on the test data set by using the trained peptide structure prediction model. Compared with an existing peptide structure prediction model, high-precision structure prediction of monomers and compounds of cyclic peptide and linear peptide containing non-standard amino acid is proposed for the first time, structural information or pocket information of any target protein is not needed, and only one-dimensional sequences of the protein and side chain groups of the non-standard amino acid need to be input, so that the non-standard amino acid containing cyclic peptide and linear peptide is obtained. And the three-dimensional structure of the polypeptide can be accurately predicted.

To provide a novel squaraine dye-peptide complex that enables selective detection of esterase, being one of tumor markers.SOLUTION: A squaraine dye-peptide complex is prepared by incorporating an oligopeptide between two squaraine dyes represented by formula (1), where R1B and R2B each independently represent a C1 to C30 monovalent aliphatic hydrocarbon group, with at least one having a carboxyl group at a terminal, and R3B and R4B each independently represent H or a carboxyl group, with at least one being a carboxyl group.SELECTED DRAWING: Figure 3

The invention relates to tumor-targeted trimeric polypeptides based on the homotrimerization region from collagen XV or XVIII and which contain domains capable of specifically binding to and activating receptors of the TNFR family of costimulatory receptors as well as to the uses thereof in the treatment of cancer.

The present invention relates to a heterotandem bicyclic peptide complex BT7480, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and uses thereof.

The present invention relates to a peptide complex having an antidiabetic activity and to a use thereof. The peptide complex of the present invention promotes uptake of glucose into cells, suppresses insulin resistance signals, promotes insulin sensitivity signals, and suppresses the death of pancreatic beta cells, which are insulin-producing cells, thereby exhibiting an effect of lowering blood glucose levels. In addition, the present invention relates to a peptide having an antidiabetic activity and an antiobesity activity and to a use thereof. The peptide of the present invention has an activity of suppressing insulin resistance signals, promoting insulin sensitive signals, and promoting fat decomposition in adipocytes.

The invention relates to a preparation method and application of a sea cucumber egg-derived peptide compound. The preparation method of the sea cucumber egg source peptide compound comprises the following steps: performing synchronous enzymolysis on sea cucumber egg powder by using alkaline protease-trypsin; the sea cucumber ovum source active peptide is obtained by further carrying out ultrafiltration, sephadex chromatography and high performance liquid chromatography separation and adopting liquid chromatography-mass spectrometry technology analysis, a computer-aided screening technology and in-vitro verification, and the amino acid sequence of the sea cucumber ovum source active peptide comprises one or more of WGN, WI GG and GFPVG (Fibroblast Growth Factor Peptide Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth Growth). The sea cucumber ovum-derived peptide compound and the sea cucumber ovum-derived active peptide provided by the invention have double activities of resisting oxidation and inhibiting tyrosinase, can reduce the melanin content, and have the advantages of good water solubility, good safety and the like.

The invention provides an antigen binding polypeptide which is capable of binding to a HLA- E:peptide complex, wherein the antigen binding polypeptide is a HPV-specific TCR or CAR.

The present invention relates to the field of biomedicine, and mainly relates to a vaccine design method for enhancing an antigen-presenting effect. A target antigen and a ligand such as a polypeptide or a protein domain having an E3 ubiquitin ligase binding or recruitment function are jointly coded in a same nucleic acid sequence, thereby promoting the degradation of the antigen protein by means of a proteasome approach, increasing the number and abundance of antigen peptides having antigen epitopes, and forming more peptide-MHC (p-MHC) complexes, and the complexes are presented on the surfaces of the cells, thereby enhancing subsequent immune response, and exerting an efficient tumor immunotherapy effect. The nucleic acid, the protein and the polypeptide vaccine provided have an efficient antigen-presenting effect and strong immunogenicity, and have good clinical application prospects.

The invention provides a sodium hyaluronate gel compound for wound repair and a preparation process of the sodium hyaluronate gel compound, and belongs to the technical field of gel compound preparation. The preparation process comprises the following steps: preparing a pachymaran-antibacterial peptide compound; preparation of catechol graft modified gelatin; preparing oxidized sodium alginate; preparing a sodium alginate compound; and preparing the sodium hyaluronate gel compound. The preparation method comprises the following steps: grafting a catechol group on the side chain of gelatin, and carrying out a coordination effect between ferric ions and the catechol group and a Schiff base reaction between an amino group on the gelatin and an aldehyde group on oxidized sodium alginate to prepare the double dynamic bond cross-linked sodium alginate compound. The pachymaran-antibacterial peptide compound is introduced through total doping of the sodium alginate compound, and then the sodium alginate compound is compounded with sulfhydrylated sodium hyaluronate to prepare the sodium hyaluronate gel compound which has good biocompatibility and efficient antibacterial property and can remarkably promote wound healing.

The preparation method of the ganoderma lucidum protein peptide microelement chelate comprises the following steps: carrying out enzymolysis on ganoderma lucidum protein by adopting compound protease to prepare a ganoderma lucidum protein peptide compound solution; carrying out liquid chelation on the trace elements in the inorganic compound containing the trace elements and the ganoderma lucidum protein peptide in the ganoderma lucidum protein polypeptide compound solution by adopting a liquid chelation method, so as to prepare a ganoderma lucidum protein peptide-trace element chelation solution; and centrifuging, filtering and freeze-drying the ganoderma lucidum protein peptide-microelement chelate liquid to obtain the ganoderma lucidum protein peptide microelement chelate. According to the invention, the ganoderma lucidum protein from ganoderma lucidum is taken as a raw material, the extraction process of the ganoderma lucidum protein is optimized by an alkali-solution and acid-isolation method, and the activity of metal chelated calcium and metal chelated selenium is efficiently realized by controlling enzymolysis of compound protease and chelating active peptides by using calcium chloride and sodium selenite. The invention provides a new thought for the application of the ganoderma lucidum protein.

Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

The invention discloses an active peptide compound for improving sleep quality as well as a preparation method and application thereof, and relates to the technical field of polypeptide compounds. The active peptide compound is prepared from the following components in percentage by weight: 22.73 percent to 37.04 percent of collagen cyclic dipeptide, 22.73 percent to 37.04 percent of cow milk source sleep promoting peptide, 28.57 percent to 45.45 percent of tea leaf theanine and 6.25 percent to 14.29 percent of gamma-aminobutyric acid. According to the active peptide compound capable of improving the sleep quality, the preparation method and the application, theanine is used as a surfactant and a stabilizer to be combined with active peptides capable of improving the sleep quality, such as cow milk-derived bioactive peptides, on one hand, the active peptide compound capable of improving the sleep quality is provided, and on the other hand, the active peptide compound capable of improving the sleep quality is provided. And the dosage of additives in the cow milk-derived bioactive peptide sleep quality improving products can be reduced.

The invention discloses a multifunctional bone peptide compound and application thereof in prevention and treatment of osteoporotic osteoarthritis, and relates to the technical field of bone peptides. The multifunctional bone peptide compound is prepared from the following raw materials: giant salamander bone meal, bovine bone articular cartilage powder, bovine bone meal, sturgeon bone meal, oyster bone meal, deer-horn glue powder, calcium chloride and fructo-oligosaccharide. According to the multifunctional bone peptide compound disclosed by the invention, the composite aggregate is subjected to enzymolysis step by step by using the compound enzyme, the bone peptide and calcium ions are compounded through a chelation reaction, the absorbability of calcium is improved, one part of the bone peptide in the composite bone peptide has a function of promoting osteoblast activity, and the other part of the bone peptide possibly has a function of inhibiting overactivity of osteoclasts; part of the bone peptide has an anti-inflammatory effect, can regulate bone metabolism, repair articular cartilage and relieve inflammatory response, and can improve the effect of the bone peptide product in the aspects of preventing and treating osteoporosis, osteoarthritis and other diseases.

The present disclosure provides a polypeptide complex comprising a target binding polypeptide that binds to a molecule on a target cell or a molecule in an extracellular matrix (ECM); and small latent complexes comprising in particular a dimer latent related polypeptide (LAP) or a fragment or derivative thereof, and a dimer mature transforming growth factor beta (TGF beta) family polypeptide or a fragment or derivative thereof. Polypeptides (e.g., fusion polypeptides), and related polynucleotides, vectors, cells, and pharmaceutical compositions are also provided. Also provided are methods of treating subjects using, for example, these polypeptide complexes and / or these fusion polypeptides or pharmaceutical compositions thereof.

The invention relates in one aspect to a computer-implemented method for predicting the binding of at least one protein of interest, preferably at least one receptor, antibody, antibody fragment or equivalents thereof, or DARPin, to a peptide of interest, comprising a. providing sequence and / or structural data of at least one reference peptide, optionally providing sequence and / or structural data of at least one HLA molecule and / or of at least one HLA-peptide complex (pHLA), and / or the at least one reference peptide presented within a pHLA complex, b. providing binding data, preferably comprising the dissociation constant (KD), of the at least one reference peptide and / or the at least one reference peptide presented within a HLA-peptide complex (pHLA) with at least one protein of interest, c. training a machine learning (ML)-based model or artificial intelligence (AI) based on the data provided in a. and the binding data provided in b., d. providing sequence and / or structural data of at least one peptide of interest, e. employing the machine learning (ML)- based model or artificial intelligence (AI) trained in c. to predict the binding or interaction properties of the at least one peptide of interest, preferably when presented within a pHLA complex, to the at least one protein of interest.

A polypeptide complex, a protein, a nucleic acid, a composition and uses thereof. A cell specific high expression and long retention (ePR) strategy is employed to overexpress specific mRNA in hepatic stellate cells into therapeutic proteins and to promote long-term anchoring of the therapeutic proteins in a fibrotic matrix microenvironment. The first-generation and second-generation retinol derivatives containing carboxyl are determined, can partially replace cholesterol in lipoid nanoparticles (LNP), and are enriched in a fibrosis area through intravenous injection, so that the expression of mRNA in a fibrosis liver is improved by about 10 times. Furthermore, therapeutic mRNA has been engineered by coupling the gene sequence of the collagen binding domain (CBD) to the C-terminus of the therapeutic protein. In screening, it is found that the peptide sequence of placental growth factor (PLGF) shows the strongest collagen affinity, the liver residence time of overexpressed therapeutic protein can be prolonged, and systemic side effects are reduced to the minimum.

The invention relates to an SR-B1 targeted polypeptide compound and application thereof in preparation of antitumor drugs and immunotherapy sensitizers, and belongs to the technical field of biological drug manufacturing. In order to solve the problems that an existing PD-L1 inhibitor is single in action mechanism and immune system dysfunction is easily caused, the invention provides an SR-B1 targeted polypeptide compound which is composed of SR-B1 targeted polypeptide and Resiquimod. The SR-B1 targeting polypeptide comprises an SR-B1 targeting peptide fragment, a self-assembly peptide fragment and a hydrophobic molecule which are connected in sequence. The SR-B1 targeting polypeptide can recognize overexpressed SR-B1 in tumor cells, block cholesterol uptake, inhibit tumor progression and inhibit expression of PD-L1 at the same time. The polypeptide compound accurately delivers Resiquimod to a tumor site, anti-tumor immune response is activated, and sensitivity of tumor immunotherapy is greatly enhanced through combination of cholesterol metabolism regulation and immunotherapy.

A multispecific polypeptide complex, an isolated polynucleotide encoding the same, a pharmaceutical composition comprising the same, and uses thereof.

The invention discloses a preparation method of a red rice bran protein peptide compound with antioxidant and hypoglycemic effects. According to the method, red rice bran protein is extracted through an alkali-solution and acid-isolation method; hydrolyzing the red rice bran protein with alkaline protease to obtain a red rice bran protein hydrolysate; the red rice bran protein hydrolysate prepared by the invention has the functional characteristics of excellent emulsibility, foamability and oil absorbency, and has excellent antioxidant and hypoglycemic functional activities after being subjected to in-vitro simulated gastrointestinal digestion. The red rice bran protein hydrolysate can be used in plant-based food and dairy product substitutes and functional food with a hypoglycemic effect.

Disclosed herein are compositions and uses of tumor activated antibodies targeting EGFR and effector cell antigens. In particular, the present application provides isolated recombinant polypeptide complexes that comprise binding domains that selectively bind to an effector cell antigen and EGFR, in which one or more of the binding domains is selectively activated in the tumor microenvironment and the isolated polypeptide or polypeptide complex comprises a half-life extending molecule.

Methods of analyzing the presence or absence of immune cells capable of binding to an antigen peptide in a sample from one or more individuals are provided. Also provided are methods of detecting or treating cancer or a tumor, a pathogen infection, or an autoimmune disease. A display moiety is provided having particles associated with a plurality of MHC-peptide complexes, where at least two MHC-peptide complexes are different. Also provided are bait compositions having a plurality of display portions and methods of analyzing immune cells by using the display portions or bait compositions as screening tools.