46 results about "Perillyl alcohol" patented technology

The present invention refers to a composition based on monoterpenes with chemopreventive and chemotherapeutic effects in malignant neoplasias of humans and animals containing from 0,03% to 30% of monoterpenes and 99,97% of solvents. Another objective of the present invention is an application of monoterpenes in inhibition of cell growth and metastasis control of primary tumors being applied in vitro and in vivo gliomas cell lines C6 and U 87 and A172. Further another objective of the present invention refers to a specific methods for applying the composition with chemopreventive and chemotherapeutic effects in humans and animals showing malignant neoplasias by inhalation and nebulization treatment, oral and intratumoral, followed or not by radiotherapy with dilutions from 0,03% to 30% of the monoterpene perillyl or its derived metabolites diluted in the solvents specified by the usual techniques.

The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

The invention discloses a cream for eliminating wrinkles and a preparation method thereof. The invention is a cream which is prepared by taking interleukin IL-12, glucan chelating aloe, perillyl alcohol, chamomile, xanthan, hyaluronic acid, black cohosh, VE oil, camu extract, whale oil and collagen as main agents. The cream has the advantages that the efficacy of the cream is increased by tens oftimes compared with the cream before chelation by the organic complex formula which chelates a plurality of natural plants for eliminating wrinkles by interleukin IL-12 and glucan, the cream has the best effects on eliminating skin wrinkles, skin laxation and pouches, and simultaneously has the moistening and whitening and other functions on skin.

The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene for sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

A process for making perillyl alcohol is disclosed. The process comprises isomerizing a starting material comprising trans-isocarveol at a temperature within the range of 100° C. to 220° C. in the presence of a Group 5 metal catalyst to produce perillyl alcohol. We surprisingly found that trans-isocarveol, which can be selectively produced from a commercially available mixture of cis- and trans-LMO, can be isomerized directly to perillyl alcohol. Yields of perillyl alcohol are improved when the isomerization is performed under an inert atmosphere and / or in the presence of a phenolic antioxidant. Performing the isomerization in the presence of a high-boiling alcohol and / or distilling the perillyl alcohol product from the reaction mixture in the presence of a high-boiling alcohol, enhances yields and maximizes catalyst use. The resulting distillation residue, which contains recovered Group 5 metal catalyst, is valuable for catalyzing additional trans-isocarveol isomerizations.

The invention provides make-up base containing chamomile. A formula of the make-up base comprises raw materials by weight as follows: 0.03 parts of metallothionein, 9 parts of grape seed oil, 5 parts of stinging nettles, 5 parts of perillyl alcohol, 20 parts of a chamomile extract, 3 parts of rosemary essential oil, 3 parts of black cohosh, 20 parts of lavender essential oil, 0.05 parts of jojoba oil, 1 part of vitamin E, 1 part of collagen, 0.05 parts of amino acid and the balance of distilled water in terms of 200 parts of the raw materials. The usage and physicochemical properties of the raw materials have a synergistic effect, so that the anti-inflammation, anti-allergic, isolating and anti-oxidation effects are realized; the PH value of the make-up base is similar to that of the human skin, and the make-up base is non-irritant to the skin; after using of the make-up base, a user obviously feels comfortable and soft and does not feel greasy, and the make-up base has the obvious effects of relieving itching, diminishing inflammation and protecting skin through isolating.

The invention discloses an application of a composition containing cryptolepine analogues and small molecule terpene compounds in prevention and treatment of plant diseases. The bactericidal composition comprises the following effective components: cryptolepine, neocryptolepine, sclareol, sclareolide, (+ / -)-limonene, citronellol, ambergris, perilla alcohol, perillaldehyde, 2-hexenal, 4-terpene alcohol, terpilenol, alpha-terpilenol, camphor, citral, geraniol, menthol, nerolidol, eudesmol, curcumenol, cedrol and beta-ionone. The bactericidal composition disclosed by the invention can be used for preventing and treating plant diseases caused by rhizoctonia solani, Rape sclerotinia stem rot bacteria, botrytis cinerea, fusarium graminearum, magnaporthe oryzae and phytophthora capsici. The components are all natural products, have the characteristics of low toxicity, low residue, environmental compatibility, difficult generation of drug resistance and the like, can cope with occurrence of drug resistance of diseases and reduce the drug cost, and are beneficial to comprehensive management of the diseases.

The invention provides a sachet sticker with antibacterial, antiviral and nerve-calming effects and a preparation method thereof, and belongs to the technical field of spices, essences and daily chemicals, the sachet sticker comprises sodium polyacrylate, polyacrylamide, tartaric acid, dihydroxyaluminium aminoacetate, glycerin, water, povidone, Tween 80 and aromatic components; the aromatic component comprises traditional Chinese medicine powder, a plant extract and essential oil; wherein the traditional Chinese medicine powder comprises chrysanthemum powder, rose flower powder and mint powder; the plant extract comprises a kaempferol extract, a perilla alcohol extract and an agastache rugosus alcohol extract; the essential oil comprises lavender oil, sandalwood oil, blumea oil, atractylodes lancea oil and grassleaf sweelflag rhizome oil. The sachet paste adopts a gel paste product form, can be pasted on a mask, a collar, cuffs, a nose bridge, ear peripheries, a forehead and other parts in use, has antibacterial, antiviral and nerve-calming effects, and is long in lasting time.

Preferred compositions used to inhibit the growth of bacteria, fungi and yeast include perillyl aldehyde as an active ingredient. Other active ingredients include perillyl alcohol. The compositions are formed as gels, creams, liquids and dry formulations.

Belonging to the technical field of plant extraction, the invention particularly relates to an extraction method of perillaldehyde. The method includes the processes of: (1) spraying a treatment agentA to the surfaces of perilla leaves, then performing refrigeration immediately, then taking the product out, and after the perilla leaves restore to room temperature, conducting refrigeration again;(2) spraying a treatment agent B to the surfaces of the refrigerated perilla leaves, performing crushing, then adding ethyl acetate for microwave extraction, conducting filtering, and removing pigmentfrom the filtrate to obtain an extracted liquid 1; (3) adding a solid oxidant into the extracted liquid 1 for reaction, performing filtering, and then conducting pressure reduced recovery of ethyl acetate in the filtrate to obtain an extracted liquid 2; and (4) concentrating the extracted liquid 2 by a reverse osmosis membrane, and freeze-drying the concentrated liquid into powder. The extractionmethod of perillaldehyde provided by the invention can improve the dissolution rate of perillaldehyde in perilla leaves, prevent oxidation reaction of perillaldehyde in the extraction process, at thesame time can convert part of the perillyl alcohol extracted from perilla leaves into perillaldehyde, and increases the extraction rate of perillaldehyde in perilla leaves.

The present invention provides a method for treating inflammation in a mammal. The method includes delivering to the mammal a therapeutically effective amount of a composition including a perillyl alcohol (POH) conjugated with linoleic acid.

The invention relates to an external quick-acting medicament for treating a tumor and a breast cancer and production process thereof. The medicament comprises the following raw material components in percentage by weight: 25 to 30 percent of peach twig extract dry powder, 40 to 50 percent of perilla leaf extract dry powder and 25 to 30 percent of oxalicacid crystal product extract dry powder. In addition, each 150g of medicament is mixed with 20 to 30g of clerodendrum bungei extract paste for diminishing inflammation of wounds and curing the wounds. The peach twig extract dry powder contains 1 to 1.6 percent of natural plant antibiotics with properties of alkaloid, and also contains amyrin, naringenin, persicoside, persicogenin and salipurposide; a perilla leaf extract comprises alpha-bergamotene, beta-caryophyllene, cumic acid, dihydro perillyl alcohol, isoegomaketone, l-limonene, linalool, menthol-b, 1.2methylenedioxy-4-methoxy-5-allyl-benzene-3-alkynyl-beta-D-glucopyranoside, perilla olefine aldehyde, and beta-sitosterol; and the oxalicacid crystal dry powder is water-soluble powder. The external quick-acting medicament has the effects of killing viral cells one time, calcifying lesion tissues and discharging focus out of body, and achieves obvious and quick effect of treating both tip and root.

The invention relates to a preparation method of aromatized coating with lotus and loquat, consisting of the following components by weight percent: 31%-35% of polyvinylalcohol aqueous solution, 13%-17% of SQ-86 base stock, 11%-15% of whitening talcum powder, 2%-4% of dispersing agent, 3%-5% of fluorescent whitening agent, 5%-7% of lotus alcohol, 5%-7% of loquat alcohol, 3%-5% of lotus microcapsule essence, 3%-5% of loquat microcapsule essence, 0.5%-1.5% of orchid microcapsule essence, 0.5%-1.5% of corn poppy microcapsule essence, 0.5%-1.5% of murraya paniculata microcapsule essence, 0.5%-1.5% of southern magnolia microcapsule essence, 0.5%-1.5% of ginnol, 0.5%-1.5% of corydalis tuber alcohol, 0.5%-1.5% of perillyl alcohol, 1%-3% of trichosanthes kirilowii maxim alcohol, 0.5%-1.5% of radix ophiopogonis alcohol, and 1%-3% of polyporus lucidus aocohol.

The invention provides a high-aroma permeable powder essence for areca nuts and a preparation method thereof. The preparation method comprises the following steps: (1) mixing whey fermentation liquor, a glucomannan aqueous solution and a chitosan aqueous solution to obtain a composite film-forming solution; (2) mixing orange oil, sweet orange oil and ethyl lactate with 5-hydroxydecanoic acid glycerin to obtain a perfume mixture A; (3) adding 5-hydroxydecanoic acid glycerol into perillyl alcohol, leaf alcohol and citral, and mixing to obtain a perfume mixture B; (4) mixing maltol, taurine, disodium succinate and maltodextrin with water to obtain a perfume mixture C; (5) adding polyglycerol fatty acid ester and a perfume mixture A into the composite film-forming solution, and carrying out ultrasonic oscillation mixing and stirring to obtain a mixed primary emulsion; and (6), adding the perfume mixture B and the perfume mixture C, and performing ultrasonic oscillation mixing and stirring. The obtained high-aroma permeable powder essence for the areca nuts is high in permeability to the areca nuts, the flavor in areca nuts is enhanced, and the high-aroma permeable powder essence has the advantages of being high in aroma persistence, thick and uniform in aroma and long in storage life.

A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).

Preferred compositions used to inhibit the growth of bacteria, fungi and yeast include perillyl aldehyde as an active ingredient. Other active ingredients include perillyl alcohol. The compositions are formed as gels, creams, liquids and dry formulations.

The invention discloses a perillyl alcohol ambradiol carbonate precursor aroma substance and a preparation method and application thereof. The preparation method comprises the steps of dissolving perillyl alcohol and 1,1'-carbonyldiimidazole in dry tetrahydrofuran, and conducting heating and stirring for a reaction; tracking the reaction endpoint by TLC, after the reaction is completed, adding dichloromethane and deionized water into the organic phase, carrying out liquid separation, removing water from the organic phase by using anhydrous magnesium sulfate, and conducting concentrating to obtain a liquid A; adding ambradiol and N,N-dimethylformamide into the liquid A, conducting heating and stirring to react, and conducting cooling to room temperature after the reaction; and adding deionized water and dichloromethane into the organic phase, conducting liquid separation, washing the organic phase with deionized water and a saturated NaCl solution in sequence, dewatering the organic phase with anhydrous magnesium sulfate, conducting concentrating to obtain oily liquid, and then conducting column chromatography separation and purification to obtain the perillyl alcohol ambradiol carbonate precursor aroma substance. According to the invention, a good model is provided for the application of perfume micromolecules with high volatility and smaller threshold value, the ambergris note and the flower note can be increased and enriched, and the application range of the ambergris raw material and the perilla alcohol is widened.

The invention discloses a gasoline desulfurization agent and a preparation method and application thereof. The gasoline desulfurization agent comprises, by weight, 21-29 parts of illite, 1-5 parts ofperillyl alcohol, 3-7 parts of salicylic acid and 5-12 parts of triethylene diamine. The preparation method includes: crushing the illite, adding a triethylene diamine solution, heating and stirring in a sealed manner, dropwise adding the salicylic acid, performing ultrasonic treatment, adding a perillyl alcohol solution, stirring until dryness is achieved, and calcining to obtain the desulfurization agent. The gasoline desulfurization agent has the advantages that RON loss of gasoline is allowed to be smaller than 2.0, and the ultralow-sulfur-content gasoline with the sulfur content being below 6 microgram / g can be obtained; the gasoline desulfurization agent is good in sulfur selectivity, high in desulfurization depth, capable of deeply removing sulfur-containing compounds in the gasoline and avoiding octane value loss caused by olefin hydrogenation saturation, long in service life, environmentally friendly, free of secondary pollution and good in regeneration performance. The preparation method is simple in process, easy in raw material obtaining, low in production cost and suitable for industrial production.