43 results about "Perillyl alcohol" patented technology

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivativesuch as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.

The invention provides a sachet sticker with antibacterial, antiviral and nerve-calming effects and a preparation method thereof, and belongs to the technical field of spices, essences and daily chemicals, the sachet sticker comprises sodium polyacrylate, polyacrylamide, tartaric acid, dihydroxyaluminium aminoacetate, glycerin, water, povidone, Tween 80 and aromatic components; the aromatic component comprises traditional Chinese medicine powder, a plant extract and essential oil; wherein the traditional Chinese medicine powder comprises chrysanthemum powder, rose flower powder and mint powder; the plant extract comprises a kaempferol extract, a perilla alcohol extract and an agastache rugosus alcohol extract; the essential oil comprises lavender oil, sandalwood oil, blumea oil, atractylodes lancea oil and grassleaf sweelflag rhizome oil. The sachet paste adopts a gel paste product form, can be pasted on a mask, a collar, cuffs, a nose bridge, ear peripheries, a forehead and other parts in use, has antibacterial, antiviral and nerve-calming effects, and is long in lasting time.

The invention discloses a cream for eliminating wrinkles and a preparation method thereof. The invention is a cream which is prepared by taking interleukin IL-12, glucan chelating aloe, perillyl alcohol, chamomile, xanthan, hyaluronic acid, black cohosh, VE oil, camu extract, whale oil and collagen as main agents. The cream has the advantages that the efficacy of the cream is increased by tens oftimes compared with the cream before chelation by the organic complex formula which chelates a plurality of natural plants for eliminating wrinkles by interleukin IL-12 and glucan, the cream has the best effects on eliminating skin wrinkles, skin laxation and pouches, and simultaneously has the moistening and whitening and other functions on skin.

A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).

The invention belongs to the technical field of medicine, and relates to a series of perilla alcohol derivatives disclosed as Formula I, and preparation and application thereof. The invention also relates to pharmaceutically acceptable salts and solvates of the perilla alcohol derivatives, and a pharmaceutical composition containing the perilla alcohol derivatives or pharmaceutically acceptable salts thereof as active components, which can be used for treating cancers. The perilla alcohol derivatives and pharmaceutical salts thereof have favorable anticancer activity. The preparation method is simple and feasible, and is easy to operate.

The invention relates to an external quick-acting medicament for treating a tumor and a breast cancer and production process thereof. The medicament comprises the following raw material components in percentage by weight: 25 to 30 percent of peach twig extract dry powder, 40 to 50 percent of perilla leaf extract dry powder and 25 to 30 percent of oxalicacid crystal product extract dry powder. In addition, each 150g of medicament is mixed with 20 to 30g of clerodendrum bungei extract paste for diminishing inflammation of wounds and curing the wounds. The peach twig extract dry powder contains 1 to 1.6 percent of natural plant antibiotics with properties of alkaloid, and also contains amyrin, naringenin, persicoside, persicogenin and salipurposide; a perilla leaf extract comprises alpha-bergamotene, beta-caryophyllene, cumic acid, dihydro perillyl alcohol, isoegomaketone, l-limonene, linalool, menthol-b, 1.2methylenedioxy-4-methoxy-5-allyl-benzene-3-alkynyl-beta-D-glucopyranoside, perilla olefine aldehyde, and beta-sitosterol; and the oxalicacid crystal dry powder is water-soluble powder. The external quick-acting medicament has the effects of killing viral cells one time, calcifying lesion tissues and discharging focus out of body, and achieves obvious and quick effect of treating both tip and root.

A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).

Preferred compositions used to inhibit the growth of bacteria, fungi and yeast include perillyl aldehyde as an active ingredient. Other active ingredients include perillyl alcohol. The compositions are formed as gels, creams, liquids and dry formulations.

The invention discloses a perillyl alcohol ambradiol carbonate precursor aroma substance and a preparation method and application thereof. The preparation method comprises the steps of dissolving perillyl alcohol and 1,1'-carbonyldiimidazole in dry tetrahydrofuran, and conducting heating and stirring for a reaction; tracking the reaction endpoint by TLC, after the reaction is completed, adding dichloromethane and deionized water into the organic phase, carrying out liquid separation, removing water from the organic phase by using anhydrous magnesium sulfate, and conducting concentrating to obtain a liquid A; adding ambradiol and N,N-dimethylformamide into the liquid A, conducting heating and stirring to react, and conducting cooling to room temperature after the reaction; and adding deionized water and dichloromethane into the organic phase, conducting liquid separation, washing the organic phase with deionized water and a saturated NaCl solution in sequence, dewatering the organic phase with anhydrous magnesium sulfate, conducting concentrating to obtain oily liquid, and then conducting column chromatography separation and purification to obtain the perillyl alcohol ambradiol carbonate precursor aroma substance. According to the invention, a good model is provided for the application of perfume micromolecules with high volatility and smaller threshold value, the ambergris note and the flower note can be increased and enriched, and the application range of the ambergris raw material and the perilla alcohol is widened.

NEO218 (3-bromo-2-oxyylidene-propionic acid 4-isopropenyl-cyclohex-1-enyl methyl ester) (see formula I) is produced from two unrelated reagents: 3-bromopyruvate (3‑BP; an alkylating agent that inhibits cancer cell metabolism) and perillyl alcohol (POH; a natural monoterpene with anticancer properties) resulting in a novel molecule. Also disclosed are methods of synthesizing NEO218, pharmaceutical compositions comprising NEO218, and methods of using NEO218 to treat cancer.

The invention belongs to the technical field of plant extraction, in particular to a method for extracting perilla aldehyde, comprising the following steps: (1) spraying treatment agent A on the surface of perilla leaves, refrigerating immediately after spraying, taking out after refrigerating, and waiting for the perilla leaves to recover to room temperature, and then refrigerated; (2) spray treatment agent B on the surface of refrigerated perilla leaves, add ethyl acetate to microwave extraction after crushing, filter, remove the pigment in the filtrate, and obtain extract 1; (3) Add a solid oxidant to the extract 1 to react, filter, and recover the ethyl acetate in the filtrate under reduced pressure to obtain the extract 2; (4) use a reverse osmosis membrane to concentrate the extract 2, and freeze-dry the concentrate to powder . The method for extracting perillaldehyde provided by the present invention can improve the dissolution rate of perillaldehyde in perilla leaves, prevent the oxidation reaction of perillaldehyde in the extraction process, and at the same time, part of the perillyl alcohol extracted from perilla leaves The conversion into perillaldehyde improves the extraction rate of perillaldehyde in perilla leaves.

A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH. The brain metastases can be originated or spread from breast cancer. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. The chemotherapeutic agents that may be used in the present invention include a DNA alkylating agent, a topoisomerase inhibitor, an endoplasmic reticulum stress inducing agent, a platinum compound, an antimetabolite, an enzyme inhibitor, and a receptor antagonist.