Administration of dipeptidyl peptidase inhibitors

a technology of dipeptidyl peptidase and inhibitor, which is applied in the direction of peptides, drug compositions, metabolic disorders, etc., can solve the problems of short half-life and rapid degradation of glp-1 (7-36)
US20070060530A1Inactive Publication Date: 2007-03-15TAKEDA PHARMA CO LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
TAKEDA PHARMA CO LTD
Publication Date
2007-03-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

Pharmaceutical compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.
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Description

RELATED APPLICATION

[0001] This application claims the benefit of U.S. Provisional Application No. 60 / 717,560 filed Sep. 14, 2005 and U.S. Provisional Application No. 60 / 747,280 filed May 15, 2006, each of which is incorporated herein by reference.FIELD OF THE INVENTION

[0002] The invention relates to the method of administering compounds used to inhibit dipeptidyl peptidase IV as well as treatment methods based on such administration. DESCRIPTION OF RELATED ART

[0003] Dipeptidyl Peptidase IV (IUBMB Enzyme Nomenclature EC.3.4.14.5) is a type II membrane protein that has been referred to in the literature by a wide a variety of names including DPP4, DP4, DAP-IV, FAPβ, adenosine deaminase complexing protein 2, adenosine deaminase binding protein (ADAbp), dipeptidyl aminopeptidase IV; Xaa-Pro-dipeptidyl-aminopeptidase; Gly-Pro naphthylamidase; postproline dipeptidyl aminopeptidase IV; lymphocyte antigen CD26; glycoprotein GP110; dipeptidyl peptidase IV; glycylproline aminopeptidase; gl...

Claims

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