90results about How to "Overcome tolerance" patented technology

The invention discloses a method for preparing a meso-porous silicon nano medicine carrier with cell specificity target, reduction responsiveness and triple anticancer treatment effects. The method comprises the following steps: firstly, synthesizing meso-porous silicon nano particles by using a gel dissolution method, subsequently, introducing a disulfide bond onto the surface of a meso-porous silicon nano reservoir by using a chemical modification method, innovatively fixing cytochrome C with an apoptosis-inducing function onto the surface of the meso-porous silicon nano reservoir, blocking meso-porous channels with medicines, finally modifying DNA (Deoxyribose Nucleic Acid) aptamer single chain molecules (AS1411, with a cancer cell apoptosis-inducing function) onto the surface of a meso-porous silicon/cytochrome C nano composite system, and taking the system as specificity ligand of a receptor (nucleolin protein) which is overexpressed on the surface of liver cancer cytomembrane, thereby establishing a multifunctional composite type nano medicine carrier system for achieving triple anticancer treatment under combined action of medicines, blocking substances and target molecules inside meso-pores.

The invention relates to a magnetic device capable of performing facial beautifying and wrinkle removing on a human body and a beautifying method thereof. The magnetic device is composed of an AC filtering circuit, a rectifying and DC filtering circuit, a power factor adjusting and boosting circuit, a startup slow starting circuit, a high-voltage energy storage circuit, an energy-storage capacitor discharging circuit, a safety protection discharging circuit, an auxiliary power supply module, a computer control module and an adjustment display module. The beautifying method comprises the steps that a central part of an inductance coil is placed at the part which needs to be beautified, the inductance coil keeps a small distance away from the skin or is slightly contacted with the skin, or a piece of soft tissue paper is arranged between the inductance coil and the part to be beautified; the output frequency of the inductance coil is controlled to be between 30Hz and 300Hz by the computer control module; the output magnetic intensity of the inductance coil is controlled and adjusted by the computer control module so as to set the stimulation intensity which gives rise to contraction of subcutaneous muscles; the action time is set to be between 0.4s and 3.0s, the interval time is 1.0s-3.0s, the beautifying time is 15-30min for one time, beautifying is performed once a day, and 10 times form a course of treatment.

The invention discloses a composite nano-drug for integrated tumor diagnosis and treatment and a preparation method thereof. A chemotherapeutic drug, a photodynamic drug and shRNA plasmids capable of reversing multidrug-resistant MDR1 genes of tumor cells are located through a nano-carrier, a magnetic nano-sphere with precious metal nano-particles arranged on the surface serves as a kernel of the nano-carrier, mesoporous silica with the surface modified with amino groups serves as a shell of the nano-carrier, and a polyelectrolyte thin film layer structure with pH response is formed on the surface of the kernel-shell structure through a layer-by-layer self-assembly technology. The composite nano-drug integrates targeted drug delivery, multimode imaging, chemotherapy, photodynamic therapy and gene therapy, can be applied to early diagnosis of tumors, image mediation and real-time monitoring treatment at the same time and overcomes the defect that tumor diagnosis and treatment are separate in the prior art; besides, the composite nano-drug is simple in preparation process, high in operability and suitable for industrial production.

The invention discloses a flat paper tube reeling machine, comprising a rack, a paper placing device which is connected to the rack, a paper guiding device, a pasting device, a, paper cutting device, a paper feeding detaching device, a tube reeling device and a tube cutting device, wherein the pasting device comprises a sizing roller; a paper passing device is fixedly arranged between the pasting device and the paper cutting device; an paper inlet surface of the paper passing device and the top surface of the sizing roller are in a same plane; and an paper outlet surface of the paper passing device and a paper cutting surface of the paper cutting device are in a same plane. According to the flat paper tube reeling machine provided by the invention, the thickness of paper can be reduced; and during the tube reeling, the adherence force between two pieces of paper is increased, so that the paper tube quality is improved.

The invention relates to mitochondrial-targeting protein nanoparticles, and relates to an amino acid sequence, a coding nucleic acid sequence, a vector of the coding nucleic acid, host expression bacteria and other related information. Under the induction of metal ions, the self-assembled protein nanoparticles can be obtained by an escherichia coli expression system. The protein nanoparticles canbe applied in cancer diagnosis and treatment. Compared with conventional mitochondrial-targeting small molecules (TPP, MPP and the like), the protein nanoparticles can achieve properties of tumor enrichment, mitochondrial targeting, causing of increase of the ROS content in cells, induction of cell apoptosis, inhibition of tumor growth and the like.

A hinge device capable of locking a buffer switch position comprises a movable hinge cup and a hinge joint arm, wherein the movable hinge cup and the hinge joint arm are in hinge joint connection. A buffer mechanism is arranged on the movable hinge cup, the hinge joint arm at least acts on the buffer mechanism when a hinge is closed, the buffer mechanism comprises a damper and a gland, the damper is arranged in a concave position of the movable hinge cup, the gland is arranged on the damper, and the damper can slide back and forth on the gland. A damp switch component is arranged on the gland in a rotating or swing mode, and the limiting and/or restoration of a buffering stroke of the damper are/is achieved by rotating or swinging the damp switch component when the hinge is opened and/or closed. The gland and/or the damp switch component are/is made of plastic having certain elasticity, a limiting part is arranged between the gland and the damp switch component, and the damp switch component achieves position locking and the limiting and /or the restoration of the buffering stroke of the damper through the limiting part. The hinge device capable of locking the buffer switch position has the advantages of being simple and reasonable in structure, reliable in performance, long in service life, low in manufacturing cost, fast and convenient to adjust and accurate and firm in locating.

The invention provides a transgenic carrier with function of automatic control and elimination of selection marker and application thereof in zea mays marker-free transgenic breeding, and belongs to the technical field of breeding of zea mays molecules. The carrier uses a pEGAD carrier as a skeleton carrier, and a fusion gene of EGFP (enhanced green fluorescent protein) and IPT (isopentenyl transferase) genes is used for replacing a bar gene and is used as the selection marker; an expression framework of the selection marker is integrated into a Cre/lox site specific recombination system. Theapplication comprises the following steps of transferring the carrier into a zea mays embryonic callus, obtaining the zea mays embryonic callus with the green fluorescent expression effect; after heatshock, culturing the zea mays embryonic callus without the green fluorescent expression effect by differentiating and rooting, so as to obtain a transgenic plant. The carrier has the advantages thatthe selection efficiency is improved, the removal of the transgene selection marker is realized, and the theoretical and application basis is provided for the large-range development of marker-free zea mays transgene.

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma of the lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

The invention provides an output control method and device for physical factors. The output control method includes the steps of substituting received oscillation parameters and pre-stored power calibration parameters corresponding to the oscillation parameters into a preset function, and calculating duty ratios of PWM pulses corresponding to power gears of a therapeutic apparatus; enabling the oscillation high-end power to serve as the oscillation peak value and the oscillation low-end power to serve as the oscillation valley value, and outputting PWM pulse signals according to a preset oscillation mode with the duty ratio of the PWM pulse corresponding to the current power gear so that a power control circuit can control an output device in a set therapy time to output the physical factors according to the PWM pulse signals. Due to the fact that the power is continuously changed within any interval between zero and the rated maximum power, the biological tissues of a patient are prevented from generating tolerance caused by constant energy of the physical factors, the human body tissues of the patient are prevented from being damaged by excessively-large energy of the physical factors, the requirements of illness states of different bodies and in different stages for the energy of the physical factors are met, and the therapy adjuvant effect of the therapeutic apparatus is improved.

An airbag housing having elastically deflectable mounting tabs is disclosed. The mounting tabs allow for positionable attachment of an airbag module to a vehicle structural member. The mounting tabs may be defined by U-shaped slots in the airbag housing. The semi-flexible mounting tabs deflect during attachment of the airbag module to the steering wheel to provide good fit and finish between an associated decorative airbag cover and the steering wheel. The mounting tabs may also include attachment members to provide attachment location for coupling the airbag housing to the vehicle structural member.

The invention relates to a clamp. The clamp comprises a base, a supporting part arranged on the base and a sub-clamp arranged on the supporting part. The base comprises a body, a baffle and a connecting part connecting the body with the baffle, wherein the baffle and the body are arranged in a spaced mode, the surface, facing the body, of the baffle is a first surface, and the baffle is provided with a through groove penetrating through the first surface. The supporting part comprises a movable part arranged on the body and a supporting plate arranged on the movable part, wherein the supporting plate is located between the body and the baffle, and the movable part drives the supporting plate to move so that the supporting plate can move towards the baffle or far away from the baffle. The sub-clamp is arranged on the surface, facing the baffle, of the supporting plate and provided with an installation position where a workpiece to be machined is installed, and the sub-clamp moves along with the supporting plate so that a machining surface of the to-be-machined workpiece arranged on the sub-clamp can abut against the first surface and part of the machining surface can be exposed out of the baffle through the through groove. The clamp improves the machining accuracy.

The invention discloses a preparation method for quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber, which includes the steps: dissolving the chlorinated natural rubber by organic solvent, then adding an organic amine compound or organic phosphine compound for reaction, and obtaining the quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber after extraction, suction filtration, drying and the like. The quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber prepared by the method is efficient, low in toxicity and broad-spectrum in antibiosis, can be applied to preparation of antibiotic rubber or plastic products, can also be applied to the fields such as water pollution microbiological treatment, agriculture or tumor targeting medicines and the like, and is wide in application prospect.

The invention relates to a clamp which comprises a base, a sub-clamp arranged on the base and press plates arranged on the sub-clamp in a stacked manner. The sub-clamp comprises a bottom plate, a cover plate, elastic pieces and a plurality of supporting pieces used for containing workpieces to be machined. The bottom plate is provided with grooves. The cover plate is arranged on the bottom plate in a stacked manner and provided with a plurality of through holes communicated with the grooves, and the elastic pieces are contained in the grooves. The supporting pieces are in clamped connection with the cover plate and penetrate the corresponding through holes respectively. The ends, in clamped connection with the cover plate, of the supporting pieces abut against the elastic pieces. The press plate abuts against the cover plate and provided with a plurality of machining positions matched with the through holes. According to the clamp, the supporting pieces do not need to be independently fastened, the mounting time is shortened, the production efficiency is improved, and the machining precision can be guaranteed.

The invention relates to a robustness traffic flow prediction method based on a multitask graph convolutional network. The spatial-temporal relationship of traffic data is extracted by adopting GraphConvolutional Networks and combining time domain convolution, and the generalization ability of the model is enhanced by adopting a multi-task learning MTL (Multi-Task Learning) structure so as to resist traffic data missing and abnormality. According to the invention, a multitask graph convolution model combining graph convolution and multitask learning is designed, so that the model can predicttraffic flow more stably under the condition of abnormal data. The model provided by the invention has a multi-output structure, and can output three tasks at the same time. One task is to output traffic flow data in a target time period, and the remaining two tasks are auxiliary tasks for predicting the same road network in different time periods, namely a time period 15 minutes before the targettask and a time period 15 minutes after the target task. The robustness of model parameters can be realized by simultaneously training a target time period and early and later traffic flow predictiontasks thereof.

The invention relates to a double valve, having two inductors (1a, 1b) which can be controlled independently of each other and which each have a core (3a, 3b), having a common valve housing (5, 7) in which the inductors (3a, 3b) are arranged, having a flange housing (4) which is attached to the valve housing (5, 7) and in which two valve seats (10a, 10b) are arranged, and having a membrane (6) assigned to the two valve seats (10a, 10b). Each inductor (3a, 3b) is assigned to a valve seat (10a, 10b).

The invention discloses a Chinese herbal medicine additive for feeding laying hens and a feeding method of the additive. The Chinese herbal medicine additive is prepared from the following Chinese herbal medicines in parts by weight of 3-6 parts of rhizoma atractylodis macrocephalae, 2-5 parts of radix astragali, 1-4 parts of radix platycodonis, 1-4 parts of herba epimedii, 1-3 parts of radix angelicae sinensis, 2-4 parts of herba ephedrae, 2-5 parts of rhizoma dioscoreae, 3-6 parts of fructus hordei germinatus, 1-3 parts of massa medicata fermentata, 1-3 parts of pericarpium citri reticulatae, 2-4 parts of radix acanthopanacis semticosi and 1-3 parts of radix sanguisorbae. Various Chinese herbal medicines are ground and sieved, and the sieved materials are mixed in parts by weight to obtain a mixture, namely the Chinese herbal medicine additive. 1-3 kg of the Chinese herbal medicine additive is added into every 100 kg of chicken compound feed according to the weight ratio to obtain chicken feed. 10-36 g of the chicken feed is used for feeding each brooding chicken every day, 40-80 g of the chicken feed is used for feeding each growing chicken every day, and 85-120 g of the chickenfeed is used for feeding each laying hen every day. The additive has the characteristics of strong safety, small toxic and side effects and low residue, avoids tolerance of livestock and poultry to the additive, and basically realizes antibiotic-free breeding.

The invention discloses a multifunctional closestool supporting seat comprising a closestool. Fixing frames are symmetrically arranged on the two sides of the closestool; a plurality of rubber foot pads are fixed to the bottoms of the fixing frames; a connecting rod is arranged on the portion, corresponding to the rear side of the seat, of the surface of the closestool; the two ends of the connecting rod and the fixing frames are in a fixed state; and first telescopic rods are symmetrically arranged on the portions, corresponding to the two sides of the closestool, of the front side of the connecting rod. With a movable column, a movable groove, a movable block, a rotary block and a rotary groove, tolerances during production can be avoided and thus a certain gap is formed between every two parts, so thata phenomenon of low stability of the supporting rod is avoided; with a supporting rod, a situation that because the gravity center of force exerted by a user is located at the top endof the handrail, the pressure is generated at the included angle of the handrail for a long time, and consequently a certain breaking risk exists is avoided; the included angle of the handrail is supported through the supporting rod, so that the gravity bearing capacity and use safety of the handrail are improved.