Preparation method for quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber

A technology of chlorinated natural rubber and quaternization, which is applied in botany equipment and methods, chemicals for biological control, biocides, etc. It can solve the problems of short duration of drug effect, high product price, poor heat resistance, etc. Problems, to achieve the effect of strengthening the action force and selectivity, low toxicity, and prolonging the action time

Active Publication Date: 2012-08-15
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The silver-containing inorganic antibacterial agents currently used have the characteristics of good durability and safety, good heat resistance, wide antibacterial range, and long validity period, but the color of the product will change, and the price of the product is relatively high.
The use of organic small molecule quaternary ammonium salts, quaternary phosphonium salts and other synthetic antibacterial agents has the characteristics of fast bactericidal speed, wide antibacterial range, and excellent anti-mold effect, but at the same time has high toxicity, poor heat resistance, and short duration of drug efficacy. and other shortcomings

Method used

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  • Preparation method for quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber
  • Preparation method for quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber
  • Preparation method for quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber

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Embodiment 1

[0032] 1. the preparation method of the quaternization modification of chlorinated rubber comprises the following steps:

[0033] (1) Dissolve 5g of the base material chlorinated rubber (CNR) in 100ml of DMF (N,N-dimethylformamide) and pour it into a flask for stirring to fully dissolve. The stirring rate is set at 300r / min. According to the mass ratio of chlorinated rubber and organic amine compound as 1:1, measure tri-n-butylamine and dilute it with 20ml of DMF, put it into a constant pressure dropping funnel for later use.

[0034] (2) Keep the reaction system at 80°C.

[0035] (3) When the reaction system reaches the set temperature, add the tri-n-butylamine diluent dropwise at 10 drops / min.

[0036] (4) After the dropwise addition, fill with nitrogen to exhaust the air, continue to fill with nitrogen under stirring to maintain the oxygen barrier atmosphere of the reaction system, and stop the reaction after 12 hours of reflux reaction.

[0037] (5) After the reaction is...

Embodiment 2

[0064] Example 2 Escherichia coli, Staphylococcus aureus and other biological experiments

[0065] According to the 2.7.7 shaking flask test in the "Disinfection Technical Specifications", the antibacterial performance test of the antibacterial agent was carried out.

[0066] The bactericidal performance of antibacterial samples on Escherichia coli was measured by flask shaking method. After 2 minutes and 24 hours of contact, the shaking solution was taken for plate culture, and it can be seen intuitively that tributylphosphonium chloride rubber and triphenylphosphonium chloride rubber have good antibacterial effects. The bactericidal rate of tributylphosphonium chloride rubber reached 100% after 2 hours of contact; the bactericidal rate of triphenylphosphonium chloride rubber reached 94.4% after 24 hours of contact. The bactericidal rate of tri-n-butylammonium chloride rubber reached 55% after 24 hours of contact, which was much lower than that of quaternary phosphonium sa...

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Abstract

The invention discloses a preparation method for quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber, which includes the steps: dissolving the chlorinated natural rubber by organic solvent, then adding an organic amine compound or organic phosphine compound for reaction, and obtaining the quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber after extraction, suction filtration, drying and the like. The quaternary ammonium or quaternary phosphonium modified chlorinated natural rubber prepared by the method is efficient, low in toxicity and broad-spectrum in antibiosis, can be applied to preparation of antibiotic rubber or plastic products, can also be applied to the fields such as water pollution microbiological treatment, agriculture or tumor targeting medicines and the like, and is wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a preparation method of quaternized or quaternized phosphonium modified chlorinated natural rubber. Background technique [0002] Pathogenic microorganisms such as bacteria and viruses are killers that threaten human health. All kinds of rubber and plastic products, especially medical products, are easily contaminated by pathogenic microorganisms, which pose a great threat to people's health and safety. According to reports, the number of deaths due to bacterial infection is more than ten million every year in the world. Therefore, the preparation of medical or daily life rubber and plastic products with broad-spectrum anti-pathogenic microorganisms is of great significance to reduce cross-infection of clinical medical devices, improve cure rate, reduce mortality rate, and protect people's health. [0003] The silver-containing inorganic antibacterial agents currently...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08C19/32C08C19/22C08C19/24A01N57/34A01N33/12A01N25/10A01P1/00
Inventor 敖宁建李淳
Owner JINAN UNIVERSITY
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