A form-fitting foot covering (10, 34, 44) is provided including a sole portion (14, 36, 46) and a corresponding uppers portion (16, 38, 48) which is designed to be worn in a tightly fitting manner over a user's foot to provide protection and comfort. The inner surface (20) of the foot covering (16, 34, 44) may carry a medicament (22). The foot covering (10, 34, 44) may be integrally formed using a thin, resilient, stretchable resin material such as latex, vinyl or nitrile, and they may be equipped with a laminated resilient gel padding layer (30). Alternately, the uppers portion (38) may be formed of a woven cloth material (40) or a perforate synthetic resin material presenting air holes (52). An optional adhesive (60) may be used to hold the foot covering in place and create a watertight seal.