Preparation and application of mitochondrial-targeting self-assembled protein nanoparticles

A nanoparticle and protein technology, applied in peptide/protein components, preparations for in vivo tests, metallothionein, etc., can solve the problems of short half-life, limited application, and ineffective enrichment of small molecules, and achieve biocompatibility Good sex and water solubility, reduced damage, fast targeting effect
CN109529046AActive Publication Date: 2019-03-29PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PEKING UNIV
Publication Date
2019-03-29

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Abstract

The invention relates to mitochondrial-targeting protein nanoparticles, and relates to an amino acid sequence, a coding nucleic acid sequence, a vector of the coding nucleic acid, host expression bacteria and other related information. Under the induction of metal ions, the self-assembled protein nanoparticles can be obtained by an escherichia coli expression system. The protein nanoparticles canbe applied in cancer diagnosis and treatment. Compared with conventional mitochondrial-targeting small molecules (TPP, MPP and the like), the protein nanoparticles can achieve properties of tumor enrichment, mitochondrial targeting, causing of increase of the ROS content in cells, induction of cell apoptosis, inhibition of tumor growth and the like.
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Description

technical field

[0001] The present invention relates to the fields of bioengineering and medicine, in particular to the technical fields of tumor imaging and treatment and drug delivery, and in particular to a novel mitochondria-targeted protein nanoparticle (GSTP1-MT3). Functional disturbances, enrichment around tumors, and tumor growth inhibition are associated properties. Background technique

[0002] Cancer is currently a worldwide problem that people need to solve urgently. According to the statistics of the World Health Organization, nearly 14 million people die of cancer every year, and breast cancer is the second most common cancer in women after skin diseases. According to the US Department of Health statistics, nearly 260,000 women die of breast cancer each year. Therefore, more and more people pay attention to the treatment of breast cancer.

[0003] However, patients usually discover their own related symptoms in the late stage of cancer. At the same time, many...

Claims

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