Heptamethanindocyanine dye and its synthesis method and application

Abstract

The invention relates to a heptamethine indocyanine dye containing N-fatty esters or N-fatty amide side chains, a synthetic method thereof and applications thereof in tumor targeting imaging and treatment. The heptamethine indocyanine dye which possesses or individually possesses near infrared absorption, fluorography and antineoplastic activity allows present research and development ideas and treatment levels of tumor targeting treatment medicaments to be greatly improved, and has great significances to aspects of early discovery, control and the like of various tumors.

Description

technical field

[0001] The invention relates to the field of biology, in particular to a heptamethine indole cyanine dye and its synthesis method and application. Background technique

[0002] Malignant tumor is a major disease that seriously endangers human health and life. It has become the first cause of death in my country. At present, there is still a lack of specific early diagnosis methods and ideal treatment measures for malignant tumors. Improving the level of tumor diagnosis and treatment is an important aspect of my country's economy and society. and the major needs of people's health. The introduction of the concept of tumor molecular targeted therapy and the successful application of targeted therapy drugs are major advances in the field of tumor therapy and an inevitable trend of future development. The current method of targeted therapy mainly uses the specific (or relatively specific) biomolecules possessed by tumor tissues or cells as targets, and chemically...

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