50results about How to "Efficient intake" patented technology

A glass bottle with improved pouring characteristics. In some embodiments the bottle can hold pressurized liquid. The bottle includes a neck with a non-circular cross section. The cross sectional shape of the neck is adapted and configured to provide less turbulence in the liquid being poured out of the bottle, and further to assist in separating the in flow of single phase liquid from the turbulent mixed flow of two phase, gas-liquid substances.

An intake system for the combustion air of a motor of a hand held implement is provided. The system includes an air filter and a centrifugal separator. The air filter has a dirt chamber and a clean chamber that is separated therefrom by a filter medium. The clean chamber is fluidically connected with a carburetor of the motor to convey combustion air to the motor. The centrifugal separator splits the air stream into a core flow having low particle density and a peripheral flow having high particle density. The centrifugal separator includes at least two cyclones, wherein the discharged flows from the cyclones are respectively combined in pairs and open out into a common suction tube.

The invention relates to a heptamethine indocyanine dye containing N-fatty esters or N-fatty amide side chains, a synthetic method thereof and applications thereof in tumor targeting imaging and treatment. The heptamethine indocyanine dye which possesses or individually possesses near infrared absorption, fluorography and antineoplastic activity allows present research and development ideas and treatment levels of tumor targeting treatment medicaments to be greatly improved, and has great significances to aspects of early discovery, control and the like of various tumors.

Disclosed is a grinding tool, which includes a first disk having an installation hole in a center portion thereof such that the grinding tool is installed on a grinder, a second disk forming a discharge passage with partitions on a bottom surface of the first disk, wherein air intaken from a central lower portion of the grinding tool is discharged to an outside thereof through the discharge passage, and a ring-shaped shank disposed under the second disk and including grinding tips to grind a target.

An oil or fat composition according to the present invention contains a LCPUFA supply compound as a first component, and phospholipids as a second component, the LCPUFA supply compound containing LCPUFA in its structure and being hydrolyzable to remove its LCPUFA, wherein respective proportions of the first component and the second component are determined according to the number of hydrolyzable fatty acid bonds contained in the phospholipid molecules. The phospholipids and LCPUFA supply compound are metabolized to LCPUFA-PL in the body and absorbed. As a result, an oil or fat composition is provided that can efficiently increase the LCPUFA-PL level in the body. This is realized without directly using the phospholipids (LCPUFA-PL) whose constituents are long-chain polyunsaturated fatty acids (LCPUFA), taking into account the metabolism in the body.

The invention relates to a preparation method of carboxyl and polypeptide modified AIE polymer nanoparticles, the method comprises the following steps: 1) preparing an emulsifier aqueous solution; 2)dissolving AIE molecules and an Austrian ripening effect inhibitor in a mixed solution of carboxyl functional monomers and hydrophobic monomers to obtain an oil phase solution; 3) adding the emulsifier aqueous solution into the oil phase solution, stirring and pre-emulsifying to obtain crude emulsion, and performing ultrasonic treatment to obtain monomer miniemulsion; introducing nitrogen to remove oxygen, adding a water-soluble initiator to react; 4) dissolving a carbodiimide condensing agent in an acidic pH buffer solution, and adding the carbodiimide condensing agent into the emulsion prepared by the step 3) for activation; 5) dissolving omega-aminomaleimide in an alkaline pH buffer solution to obtain an omega-aminomaleimide solution; 6) adding the omega-aminomaleimide solution to the emulsion prepared in the step 4) for reaction; and (7) adding a polypeptide aqueous solution containing cysteine sequence units at the tail end to the emulsion prepared in the step (6) for reaction toprepare the carboxyl and polypeptide modified AIE polymer nanoparticles.

A case that is used for an electronic or electric device has an opening portion arranged at a vicinity of a fan motor that generates airflow inside and outside the case. The opening portion has a protection portion for preventing a finger or other matters from entering the fan motor. The protection portion includes a first rib group extending linearly in a lateral direction, a second rib group extending linearly in a second direction vertical direction. Each of the ribs has an inclined surface that is along a direction of the airflow exhausted from the fan motor and faces the inside or the outside of the opening portion.

A case that is used for an electronic or electric device has an opening portion arranged at a vicinity of a fan motor that generates airflow inside and outside the case. The opening portion has a protection portion for preventing a finger or other matters from entering the fan motor. The protection portion includes a first rib group extending linearly in a lateral direction, a second rib group extending linearly in a second direction vertical direction. Each of the ribs has an inclined surface that is along a direction of the airflow exhausted from the fan motor and faces the inside or the outside of the opening portion.

The invention discloses an application of a carbocyanine dye near infrared fluorescent compound in the preparation of a photosencitizer used for treating tumors or abnormal hyperplasia tissues, shown in formula I or II, wherein X is selected from iodine, chlorine, bromine, alkyl sulfide (OSO2-alkyl), BF4 or ClO4; R1 is selected from chlorine or bromine; R2 is selected from hydrogen, alkyl, hydroxyl group (-OH), carboxyl (-COOH), aryl, aromatic alkyl, alkyl sulfonate, alkyl carbonate and alkyl amine; and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, l1 or 12.

The invention provides a nanometer genetic medicine resistant to tumors and a preparation method and application thereof. The nanometer genetic medicine resistant to tumors comprises amphipathic cationic polymers, acid response functional molecules and small interference RNA, wherein the acid response functional molecules are coupled with the amphipathic cationic polymers, and the small interference RNA adheres to the surfaces of the amphipathic cationic polymers through electrostatic adsorption. The provided nanometer genetic medicine resistant to tumors is great in biocompatibility, low in toxic and side effect and high in bioavailability and has acid pH responsiveness and electric charge overturning performance; the nanometer genetic medicine resistant to tumors has a broad applicationprospect and a high application value in preparation of medicine resistant to tumors or in preparation of medicine for treating vascular normalization.

The invention relates to a preparation method of amino and polypeptide modified AIE polymer nanoparticles, the preparation method comprises the following steps of: 1) dissolving an emulsifier and an amino functional monomer in water to obtain an aqueous phase solution; 2) dissolving AIE molecules and an Austrian ripening effect inhibitor in a hydrophobic monomer to obtain an oil phase solution; 3)adding the aqueous phase solution into the oil phase solution, stirring and pre-emulsifying to obtain crude emulsion, and performing ultrasonic treatment to obtain monomer miniemulsion; introducing nitrogen to remove oxygen, adding a water-soluble initiator to react to prepare amino modified AIE polymer nanoparticle emulsion; 4) dissolving omega-maleimide alkyl acid and a carbodiimide condensingagent in an acidic pH buffer solution for activation to obtain an activated intermediate solution; 5) adding the activated intermediate solution into the emulsion prepared in the step 3) to react to prepare maleimide modified AIE polymer nanoparticle emulsion; and 6) adding an aqueous solution of a polypeptide containing cysteine sequence units at the end to the emulsion prepared in the step 5) for reaction to obtain the amino and polypeptide modified AIE polymer nanoparticles.

A method for preparing amino acid-and-polypeptide-modified AIE polymer nanoparticles comprises the following steps: (1) dissolving an emulsifier and an amino functional monomer in water to obtain an aqueous solution; (2) dissolving an AIE molecule, an Ostwald ripening effect inhibitor and an oil-soluble initiator in a hydrophobic monomer to obtain an oil phase solution; (3) adding the aqueous solution to the oil phase solution, stirring and pre-emulsifying the obtained mixture to obtain a crude emulsion, carrying out ultrasonic treatment to obtain a fine monomer emulsion, introducing nitrogento remove oxygen, and carrying out a reaction to produce an amino-modified AIE polymer nanoparticle emulsion; (4) dissolving omega-maleimido alkyl acid and a carbodiimide condensing agent in an acidicpH buffer solution, and performing activation to obtain an activated intermediate solution; (5) adding the activated intermediate solution to the emulsion prepared in step (3), and carrying out a reaction to obtain a maleimide-modified AIE polymer nanoparticle emulsion; and (6) adding an aqueous solution of a polypeptide containing a cysteine sequence unit at the end to the emulsion prepared in step (5), and carrying out a reaction to produce the amino acid-and-polypeptide-modified AIE polymer nanoparticles.

The invention discloses a high-yield disease-resistant planting method of trichosanthes kirilowii maxim. The method includes the steps of (1) field preparation, wherein the ground surface of a planting field is leveled, deep and wide gullies are dug at intervals, and after the soil of the planting field is defrosted in the early Spring, base fertilizer and attapulgite are applied into the soil; (2) sowing; (3) planting, wherein planting holes are dug, humic acid fertilizer and humic organic fertilizer are evenly blended and used for filling the planting holes, vegetable seedlings are buried into the planting holes after punning, planting soil covers the seedlings, and planting water is sprayed after punning; (4) management of fertilizer and water, wherein during the period from the later August to the middle September, organic slow release fertilizer is applied to the planting field; before accelerating germination, accelerating germination fertilizer is applied for dressing; 10 days before blossoming, compound fertilizer of nitrogen, phosphorus and potassium is applied for dressing, and boric fertilizer is applied to leaf surfaces in the process of applying the compound fertilizer of nitrogen, phosphorus and potassium. The high-yield disease-resistant planting method of trichosanthes kirilowii maxim can effectively improve disease resistance of trichosanthes kirilowii maxim, further increase yield of trichosanthes kirilowii maxim and further improve quality of trichosanthes kirilowii maxim.

The invention discloses cytomembrane nano-vesicles and a production method thereof. The cytomembrane nano-vesicles are composed of bi-molecule-layer lipid membranes and contents wrapped by the bi-molecule-layer membranes, wherein the membranes and the contents of the cytomembrane nano-vesicles all come from metrocytes used for production. The production method of the cytomembrane nano-vesicles comprises the following step: sequentially and repeatedly extruding a single-cell suspension to pass through polycarbonate membranes, with different pore diameters, of an extruder to obtain a clear solution, and conducting gradient centrifugation, separation and purification on the clear solution to obtain the cytomembrane nano-vesicles. The production method of the cytomembrane nano-vesicles is highin yield, the nano-vesicles are stable in property, the product uniformity is good, operation is simple and convenient, the quality is controllable, and the repeatability is high, so that large-scaleproduction is facilitated, and the cytomembrane nano-vesicles can be applied to treatment of Parkinson's disease.

The invention discloses an anti-tumor composition containing immune cells. The composition contains a dendritic cell culture, a T lymphocyte culture, a rosemary herb extract, a daffodil flower extractand a blueberry extract. The anti-tumor combination inhibits tumor growth through the mode that dendritic cells (DC) and T cells are in contact to stimulate an immune response. The dendritic cells (DC cells) express MHC type-I and type-II molecules at a high level, and when the DC cells expressing tumor-related peptide antigens and MHC type-I molecules activate CD4 and CD8 T cells, the T cells can exert effects to kill tumor cells. The composition contains the rosemary herb extract, the daffodil flower extract and the blueberry extract which all have an anti-tumor effect. The anti-tumor composition can protect cells against damage caused by external environmental factors while inhibiting tumors, and the tumors are prevented and resisted.

The invention discloses a VNSAK polypeptide and an application thereof. The VNSAK polypeptide sequentially comprises an epitope zone and an endoplasmic reticulum retention base sequence zone from an end N to an end C; the epitope zone comprises an SART3-109 epi-position, an HNRPL-501 epi-position and an NY-ESO-1 epi-position; the SART3-109 epi-position is indicated as amino acid residues from the first position to the tenth position of the N end of a sequence 1 of the sequence table, the HNRPL-501 epi-position is indicated as the amino acid residues from the eleventh position to the twentieth position of the N end of the sequence 1 of the sequence table, the NY-ESO-1 epi-position is indicated as the amino acid residues of the twenty-first position and the twenty-ninth position of the N end of the sequence 1 of the sequence table, and the endoplasmic reticulum retention base sequence zone is indicated as the amino acid residues of the thirty-third position to the thirty-sixth position of the N end of the sequence 1 of the sequence table. The invention also protects the application of the VNSAK polypeptide in preparing tumor treating medicines. The VNSAK polypeptide and the application thereof have an important significance on treating the tumor.

The invention discloses a folate receptor-targeted antihypertensive peptide composition and a preparation method thereof, and relates to antihypertensive peptide. The antihypertensive peptide composition is prepared from 0.5-10 parts of antihypertensive peptide VP5, 0.1-5 parts of folate-modified lipid, 1-30 parts of phospholipid, 0.25-10 parts of cholesterol and 10-100 parts of a polyester material. The preparation method comprises the steps that 1, polyester nanoparticles loaded with the VP5 are prepared; 2, the folate-modified lipid, phospholipid and cholesterol are dissolved in an organic solvent, pressure reduction is conducted, rotary evaporation is conducted to remove the organic solvent, a thin film is obtained, the polyester nanoparticles loaded with the VP5 are added, hydration is conducted to remove the thin film, homogenizing or extruding is conducted after ultrasonic treatment is conducted, and the antihypertensive peptide composition is prepared; or the folate-modified lipid, phospholipid and cholesterol are dissolved in the organic solvent, pressure reduction is conducted, rotary evaporation is conducted to remove the organic solvent, a homogeneous thin film is prepared, then a normal saline solution or a glucose solution or a phosphate buffer solution is added, hydration is conducted to remove the thin film, the polyester nanoparticles loaded with the VP5 are added, homogenizing or extruding is conducted after ultrasonic treatment is conducted, and the antihypertensive peptide composition is prepared.

The invention discloses health-care food, which is prepared from the following raw materials in part by weight: black beans, astragalus, cinnamon oil, honey, collocalia nest, rice vinegar and edible alcohol. The preparation method comprises: mixing the black beans with rice vinegar, sealing, soaking for 60 days, filtering out vinegar liquid, adding edible alcohol, sealing in an enamel pot for 24 hours, filtering out the edible alcohol, adding water into astragalus, performing decoction and extraction for three times, combining filtrate, concentrating the filtrate into extract of which the relative density at 50 DEG C is 1.20, forming collocalia nest into humongous pulp liquid, heating the honey in a honey blending pot till boiling, lowering the temperature to 60 DEG C, adding cinnamon oil, the extract and the humongous pulp liquid, fully and uniformly stirring, adding into the enamel pot, uniformly stirring, and filling. The health-care food does not contain any preservative, the effects of the components cooperate with one another to produce of synergetic effect, the food is suitable for people at all ages and can build body to prevent various diseases in human body, and the food has obvious beautifying and anti-aging effect.

The invention discloses a high-yield and high-quality planting method of lentinula edodes. The method includes the steps that firstly, raw materials are evenly mixed, heated, subjected to heat preservation and stirred; secondly, the mixture is contained in a polypropylene plastic bag to obtain a fungus bag; thirdly, the fungus bag is transferred into a sterilized strain shed; fourthly, open inoculation is used, and after inoculation is completed, the inoculated fungus bag is sterilized at normal pressure, heated and subjected to heat preservation; fifthly, the sterilized fungus bag is used for fungus growth, and after cultivation, the cultivation bag is full of mycelia; sixthly, after the cultivation bag is full of the mycelia, the cultivation bag is transferred into a greenhouse for growth, then fungus growth acceleration is conducted, and the fungus bag is sprayed with water to promote pileus differentiation; seventhly, the lentinula edodes is harvested after being ripe, and residual lentinula edodes feet and other debris are cleared away after harvesting. The planting method of the lentinula edodes is capable of effectively improving the yield and quality of the lentinula edodes.

The invention discloses a copolymerization micelle drug-loading nanoparticle. The copolymerization micelle drug-loading nanoparticle is a block copolymer comprising a discharged hydrophilic polymer chain block, a discharged hydrophobic polymer chain block and a cationic polymer chain block. The discharged hydrophilic polymer chain block and the cationic polymer chain block are positioned at two ends of the discharged hydrophobic polymer chain block through chemical bonds. The cationic polymer chain block is grafted with a lipid ligand. The nano drug-loading particle as a triblock copolymer self-assembled micelle system is capable of realizing co-transmission of siRNA and a chemotherapy drug. A triblock copolymer is amphipathic, and can be self-assembled into the micelle nanoparticle. Preparation cost is low and preparation is convenient. A hydrophilic part is capable of reinforcing circulation time. The discharged hydrophobic polymer chain block is used for wrapping adriamycin so as toform a hydrophobic kernel. The cationic polymer chain block carries positive charge, so that the negative charge siRNA can be carried. Cholesterol is connected to the cationic polymer chain block, sothat efficiency of endocytosis is improved.

The invention discloses a disease-resistant planting method of nursery stocks. The method comprises the following steps of 1, soil preparation, wherein sandy soil which is deep in soil layer, loose and fertile, and good in drainage is selected, base fertilizer is spread, the soil is covered with thin film for 5-7 days, the thin film is uncovered, the soil is subjected to deep ploughing and fine tillage, bedding is conducted, and the bed surface is flattened for use; 2, planting, wherein planting pits are dug, humate fertilizer and decomposed organic fertilizer are uniformly mixed to fill the planting pits with the mixture, after tamping, the nursery stocks are buried into the planting pits, then the planting pits are covered with planting soil, and after tamping, the pits are watered withenough field planting water; 3, fertilization, wherein ditching is conducted, organic slow release fertilizer is applied, after topdressing, watering is conducted, maize straw powder is utilized to cover the pits, the moisture is preserved, foliage dressing is conducted from June to July, and spraying is conducted at dawn or dusk when dew exists. The disease-resistant planting method of the nursery stocks can effectively improve the disease-resistant capability of the nursery stocks, and can improve the planting efficiency and planting quality of the nursery stocks.

The invention discloses an amphiphilic porphyrin-based photosensitizer and preparation and applications thereof. The amphiphilic porphyrin-based photosensitizer disclosed by the invention is prepared through the steps that: Pn-OH and diiodo-tetraethylene glycol are reacted under the action of potassium carbonate, so that a porphyrin intermediate Pn-I is obtained; the intermediate acts with triphenylphosphine, so that a target metal-free amphiphilic porphyrin-based photosensitizer Pn-P is obtained; and the metal-free amphiphilic porphyrin-based photosensitizer Pn-P can act with metallicacetate, so that a target metal-bearing amphiphilic porphyrin-based photosensitizer PMn-P is obtained. Through spectroscopic analysis, a situation that the amphiphilic porphyrin-based photosensitizer has extremely strong red fluorescence, and also has an extremely high singlet oxygen quantum yield (41-57%) is measured. Finally, test results of cellular uptake rate in tumor cells HK-1 show that the product has extremely good tumor cell permeability, and can be efficiently taken in by tumor cells.

An oral encapsulated preparation for aquatic animals, is an water / oil / water type encapsulated preparation which comprises on a weight basis: 50 to 80% of aqueous phase containing water-soluble active agent; 20 to 50% of oily phase containing one or more types of oil; 1 to 5% of the first emulsifying agent; 1 to 5% of the second emulsifying agent. In preparation, an oily material is mixed thoroughly with the first emulsifying agent to create a first mixture, then a portion of an aqueous material is added to the first mixture followed by fast shaking / agitation to create a second mixture; the unused, remaining portion of the aqueous material is then mixed thoroughly with the second emulsifying agent and is added to the second mixture followed by shaking / aggitation to prepare the oral encapsulated preparation of this invention.

The present invention addresses the problem of providing a dairy product with reduced milk odor specific to products in which fermented milk and whey protein are used. A method for manufacturing an edible gel, comprising: a starting material blending step for blending ß-lactoglobulin in a ratio of 70-100 wt% in the total protein of the starting material; a heating step performed after the starting material blending step; and a fermentation step by microorganisms after the heating step. The problem of the present invention is achieved by this method.

The invention relates to a preparation method for tumor antigen targeting DC cells. By means of the characteristic that an antibody can be combined with a tumor antigen and a DC cell surface FC receptor, the DC cells can specifically take in tumor cell debris through the antibody, so that the tumor cell specific antigen can be taken in and presented. Compared with a method for directly incubating DC cells and tumor cell lysates together, the preparation method for the tumor antigen targeting DC cells has the specificity for taking in the tumor cell antigen and is higher in efficiency, and therefore more and stronger tumor cytotoxicity lymphocytes.

Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and / or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.

The invention discloses an application of a carbocyanine dye near infrared fluorescent compound in the preparation of a photosencitizer used for treating tumors or abnormal hyperplasia tissues, shown in formula I or II, wherein X is selected from iodine, chlorine, bromine, alkyl sulfide (OSO2-alkyl), BF4 or ClO4; R1 is selected from chlorine or bromine; R2 is selected from hydrogen, alkyl, hydroxyl group (-OH), carboxyl (-COOH), aryl, aromatic alkyl, alkyl sulfonate, alkyl carbonate and alkyl amine; and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, l1 or 12.