3results about How to "Efficient intake" patented technology

The invention provides organic nanoparticles with high osteogenic performance as well as a preparation method and application thereof, and belongs to the technical field of osteogenic drug preparation. The preparation method of the organic nanoparticles with high osteogenic performance comprises the following steps: (1) preparing fluorinated polyethyleneimine, preparing double bonds from the fluorinated polyethyleneimine, and then grafting a targeting peptide E7 to obtain a carrier F-PEI-E7; and (2) entrapping an osteogenesis promoting drug in the carrier F-PEI-E7 to obtain the organic nanoparticles with high osteogenesis performance. The invention provides an innovative strategy: F-PEI is used as a carrier, an osteogenesis promoting drug (beta-GP) is entrapped, and through E7 targeting peptide (EPLQLKM) modification, precise targeting delivery of the drug is realized. The organic nanoparticles are high in stability, the in-vitro osteogenesis promoting effect is equivalent to that of a classical formula for in-vitro osteogenesis induction, and the organic nanoparticles have an excellent in-vivo osteogenesis promoting effect.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a triglyceride-derived ionizable lipid compound, a preparation method thereof, a drug delivery carrier and application. The chemical structural formula of the ionizable lipid compound derived from triglyceride is as shown in a formula (I): # imgabs0 # formula (I). The ionizable lipid compound has the advantages of being high in degradability, high in safety, beneficial to release of carried nucleic acid drugs and the like, and a drug delivery carrier containing the compound has the excellent performance of being good in in-vivo targeting, high in biological safety, high in mRNA expression efficiency and the like. Targeted organs and tissues of the drug delivery carrier containing the compound comprise tumors, heart, liver, spleen, lung, kidney and the like.

The application discloses a fullerene nanomaterial capable of targeting a mannose receptor and a preparation method thereof. The application connects a mannose molecule to a fullerene through an amidation reaction to prepare a fullerene-mannose derivative material with a determined molecular structure. The mannose group targets a mannose receptor overexpressed by a macrophage, so that the fullerene material is efficiently taken by the macrophage, and the superior antioxidant and anti-inflammatory properties of the fullerene are fully exerted in the cell.