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The application discloses a fullerene nanomaterial capable of targeting a mannose receptor and a preparation method thereof. The application connects a mannose molecule to a fullerene through an amidation reaction to prepare a fullerene-mannose derivative material with a determined molecular structure. The mannose group targets a mannose receptor overexpressed by a macrophage, so that the fullerene material is efficiently taken by the macrophage, and the superior antioxidant and anti-inflammatory properties of the fullerene are fully exerted in the cell.