Anti-tumor composition containing immune cells

An immune cell and anti-tumor technology, applied in the field of anti-tumor compositions, can solve problems such as immune escape, and achieve the effect of preventing and resisting tumors and inhibiting tumors.

Inactive Publication Date: 2019-07-12
广州沙艾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a small number of tumor cells can affect and change their immune microenvironment, resulting in immune escape, leading to the occurrence and development of tumors.

Method used

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  • Anti-tumor composition containing immune cells
  • Anti-tumor composition containing immune cells

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Experimental program
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Embodiment 7

[0044] This embodiment provides a preparation method of the antitumor composition of the present invention, comprising the following steps:

[0045] S1. Preparation of dendritic cells and T lymphocyte cultures

[0046] (1) Collect peripheral blood from the human body, and obtain PBMC and upper plasma by Ficoll density gradient centrifugation, and prepare autologous serum from the upper plasma through inactivation, freeze-thaw, high-speed centrifugation, and filtration;

[0047] (2) Configure cell induction medium for standby

[0048] T lymphocyte medium was produced by Life Technology Invitrogen MediumCTS TM T lymphocyte culture medium and dendritic cell culture medium are TexMACS immune cell culture medium produced by Miltenyi Company. Add 2-4 ml of autologous serum prepared in step (1) to the above two cell culture media respectively.

[0049] (3) Take (8-15)×10 from the isolated PBMC 6 Inoculate 2 cells into a cell culture flask, add 50-60ml of immune cell culture me...

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Abstract

The invention discloses an anti-tumor composition containing immune cells. The composition contains a dendritic cell culture, a T lymphocyte culture, a rosemary herb extract, a daffodil flower extractand a blueberry extract. The anti-tumor combination inhibits tumor growth through the mode that dendritic cells (DC) and T cells are in contact to stimulate an immune response. The dendritic cells (DC cells) express MHC type-I and type-II molecules at a high level, and when the DC cells expressing tumor-related peptide antigens and MHC type-I molecules activate CD4 and CD8 T cells, the T cells can exert effects to kill tumor cells. The composition contains the rosemary herb extract, the daffodil flower extract and the blueberry extract which all have an anti-tumor effect. The anti-tumor composition can protect cells against damage caused by external environmental factors while inhibiting tumors, and the tumors are prevented and resisted.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to an anti-tumor composition containing immune cells. Background technique [0002] Tumor has always been a major disease that plagues the world and seriously endangers human health. Therefore, it is an important research topic in the world medical community to find an effective tumor treatment method and completely conquer the tumor. At present, the traditional three main treatment methods are surgery, chemotherapy, and radiotherapy. Although these three main treatment methods are the basic means of global tumor treatment, their therapeutic effects are very limited. [0003] Immunotherapy is a new type of tumor treatment mode that is completely different from the previous treatment for tumor cells. Its main mechanism is to change the tumor microenvironment, so that the body's own immune function can resume its role to kill tumor cells. The immune system o...

Claims

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Application Information

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IPC IPC(8): A61K35/17A61K36/88A61P35/00
CPCA61K35/17A61K36/45A61K36/53A61K36/88A61P35/00A61K2300/00
Inventor 徐智峰张新洪加津李智耀黄智斌李雪
Owner 广州沙艾生物科技有限公司
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