Copper selenide/mesoporous silica core-shell nanoparticles and preparation method and application thereof

A technology of mesoporous silica and nanoparticles, applied in wave energy or particle radiation treatment materials, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of poor biocompatibility, large biological toxicity, and restrictions on wide application and other issues, to achieve the effect of reducing biotoxicity, low cytotoxicity, improving biocompatibility and stability

Inactive Publication Date: 2014-01-15
DONGHUA UNIV
View PDF1 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it was previously reported that copper selenide prepared by pyrolysis is hydrophobic (Nano Lett.2011, 11, 2560–2566), and its biocompatibility is poor, so it needs to be improved by polymer coating. However, it still has high biological toxicity, which limits its wide application in the biological field.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Copper selenide/mesoporous silica core-shell nanoparticles and preparation method and application thereof
  • Copper selenide/mesoporous silica core-shell nanoparticles and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Cu 2-x Synthesis of Se: Put 49 mg of cuprous chloride in a three-necked flask, add 10 mL of oleic acid to form a solution A, put 79 mg of selenium powder in a three-necked flask, add 5 mL of oleic acid and 5 mL of oleylamine to form a B solution. Put the two three-neck flasks into the heating mantle, blow in nitrogen, stir, heat to 120°C, and keep the temperature for 20 minutes to remove the moisture and oxygen in the device. Then the B solution was heated to 280°C, kept for half an hour, and then cooled to 220°C. At the same time, the temperature of solution A was raised to 220°C. Draw 5mL of solution B with a syringe, inject it into solution A, react for 5 minutes, and cool to room temperature. Add appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes. After washing with ethanol three times, add 5 mL of chloroform to form C solution and set it aside.

[0031] (2) Preparation of water-soluble Cu 2-xSe nanocrystals: Dissolve 1.5g of...

Embodiment 2

[0036] (1) Cu 2-x Synthesis of Se: Put 49 mg of cuprous chloride in a three-necked flask, add 10 mL of oleic acid to form a solution A, put 79 mg of selenium powder in a three-necked flask, add 5 mL of oleic acid and 5 mL of oleylamine to form a B solution. Put the two three-neck flasks into the heating mantle, blow in nitrogen, stir, heat to 120°C, and keep the temperature for 20 minutes to remove the moisture and oxygen in the device. Then the B solution was heated to 280°C, kept for half an hour, and then cooled to 220°C. At the same time, the temperature of solution A was raised to 220°C. Draw 5mL of solution B with a syringe, inject it into solution A, react for 5 minutes, and cool to room temperature. Add appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes. After washing with ethanol three times, add 5 mL of chloroform to form C solution and set it aside.

[0037] (2) Preparation of water-soluble Cu 2-x Se nanocrystals: Dissolve 1 g of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
sizeaaaaaaaaaa
Login to view more

Abstract

The invention relates to copper selenide/mesoporous silica core-shell nanoparticles and a preparation method and application thereof. The copper selenide/mesoporous silica core-shell nanoparticles are Cu2<-x>Se/mSiO2-PEG core-shell nanoparticles, where x is 0-1, and m is mesoporous. The preparation method comprises the following steps: preparing a Cu2<-x>Se nanocrystalline, transferring the hydrophobic Cu2<-x>Se nanocrystalline into an aqueous phase through CTAB (Cetyltrimethyl Ammonium Bromide), and growing a mesoporous silica layer on the surface of the CTAB through a sol-gel method by taking the CTAB as a template; and finally, modifying and coupling polyethylene glycol to the surface, and obtaining the copper selenide/mesoporous silica core-shell nanoparticles. The invention also discloses application in preparation of diagnosis and treatment preparations. The obtained Cu2<-x>Se/mSiO2-PEG has extremely low cytotoxicity, so that cancer cells can be effectively killed through light and heat, and the anti-cancer drug DOX can be effectively transmitted into the cells and has pH and laser-sensitive drug sustained release performance, so that a synergistic effect between photothermal therapy and chemotherapy can be realized.

Description

technical field [0001] The invention belongs to the field of core-shell nanoparticles and their preparation and application, in particular to a copper selenide / mesoporous silicon dioxide core-shell nanoparticle and its preparation method and application. Background technique [0002] With the acceleration of the steps of social life, malignant tumors have increasingly become a disease that threatens human life and health. Traditional tumor treatment methods, such as radiotherapy and chemotherapy, have caused great pain and side effects to patients. Therefore, There is an urgent need to find better and new treatments to replace traditional methods. Photothermal therapy technology is an emerging minimally invasive technology. It uses photothermal conversion materials to convert the light energy of near-infrared lasers into heat energy to achieve local high temperature, thereby killing cancer cells, and basically has no effect on normal tissue cells ( Chem.Rev.2003,103(2):577-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61K47/34A61K31/704A61K9/14A61P35/00
Inventor 胡俊青刘锡建邹儒佳王滕安磊王谦徐开兵宋国胜
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap