Copper selenide/mesoporous silica core-shell nanoparticles and preparation method and application thereof

Abstract

The invention relates to copper selenide / mesoporous silica core-shell nanoparticles and a preparation method and application thereof. The copper selenide / mesoporous silica core-shell nanoparticles are Cu2<-x>Se / mSiO2-PEG core-shell nanoparticles, where x is 0-1, and m is mesoporous. The preparation method comprises the following steps: preparing a Cu2<-x>Se nanocrystalline, transferring the hydrophobic Cu2<-x>Se nanocrystalline into an aqueous phase through CTAB (Cetyltrimethyl Ammonium Bromide), and growing a mesoporous silica layer on the surface of the CTAB through a sol-gel method by taking the CTAB as a template; and finally, modifying and coupling polyethylene glycol to the surface, and obtaining the copper selenide / mesoporous silica core-shell nanoparticles. The invention also discloses application in preparation of diagnosis and treatment preparations. The obtained Cu2<-x>Se / mSiO2-PEG has extremely low cytotoxicity, so that cancer cells can be effectively killed through light and heat, and the anti-cancer drug DOX can be effectively transmitted into the cells and has pH and laser-sensitive drug sustained release performance, so that a synergistic effect between photothermal therapy and chemotherapy can be realized.

Description

technical field [0001] The invention belongs to the field of core-shell nanoparticles and their preparation and application, in particular to a copper selenide / mesoporous silicon dioxide core-shell nanoparticle and its preparation method and application. Background technique [0002] With the acceleration of the steps of social life, malignant tumors have increasingly become a disease that threatens human life and health. Traditional tumor treatment methods, such as radiotherapy and chemotherapy, have caused great pain and side effects to patients. Therefore, There is an urgent need to find better and new treatments to replace traditional methods. Photothermal therapy technology is an emerging minimally invasive technology. It uses photothermal conversion materials to convert the light energy of near-infrared lasers into heat energy to achieve local high temperature, thereby killing cancer cells, and basically has no effect on normal tissue cells ( Chem.Rev.2003,103(2):577-...

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Problems solved by technology

However, it was previously reported that copper selenide prepared by pyrolysis is hydrophobic (Nano Lett.2011, 11, 2560–2566), and its biocompatibility is poor, so it needs to be improved by polymer coating. However, it still has high biological toxicity, which limits its wide application in the biological field.

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