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Medical composite prepared by Gynostemma pentaphylla, American ginseng and astragalus root

A composition and a technology of American ginseng, applied in the field of medicine, can solve problems such as unseen tumors

Inactive Publication Date: 2007-05-02
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the combination of Gynostemma pentaphyllum, American ginseng and Astragalus to treat tumors.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] The preparation of embodiment 1 Gypenosides

[0182] Take Gynostemma pentaphylla, add 75% ethanol to reflux and extract twice, each time for 2 hours, filter, recover ethanol from the liquid until it has no alcohol smell, add water to make a solution equivalent to 2g of crude drug per 1ml, stir well, let cool, and let it stand Place overnight, filter, and the filtrate passes through the treated macroporous resin column, first flush the column with 2 times the column volume of water, discard the water, and then elute with 3 times the column volume of 60% ethanol, collect the eluted liquid, recovering ethanol, concentrating to a concentrated solution with a relative density of 1.08 to 1.10, and spray drying to obtain.

[0183] Three batches of Gypenosides were prepared respectively, and the yield and content of the extracts are shown in Table 10.

[0184] Assay

[0185] Preparation of reference substance solution Accurately weigh an appropriate amount of Gypenoside-A ref...

Embodiment 2

[0191] The preparation of embodiment 2 American ginseng total saponins

[0192] Take American ginseng, add 10 times the amount of water, soak for 8 hours, filter out the soaking liquid, add 8 times the amount of normal water, decoct for 1 hour, a total of two times, combine the extracts, concentrate under reduced pressure to a density of 1.19-1.25 ( 60), spray-dried to obtain water extract powder. Add 8, 5, 5, and 5 times the amount of n-butanol in sequence, stir and extract in a boiling water bath for 1 hour, a total of 4 times, combine the extracts, recover n-butanol under reduced pressure, and dry in vacuo to obtain crude total saponins. Mix the crude total saponins into 20 times the amount (W / W)D 101 type macroporous resin, rinse with hot water until the washing water is nearly colorless, stir and elute twice with 4 times the amount of 80% ethanol, each time for 1h, combine the eluents, recover n-butanol under reduced pressure, and spray dry to obtain .

[0193] Identif...

Embodiment 3

[0209] The preparation of embodiment 3 astragalus polysaccharide

[0210] Take the Radix Astragali medicinal material, add 7 times the amount of 70% ethanol to extract twice, each time for 2 hours, discard the extract, take the dregs and add water to extract twice, combine the extracts, concentrate until the ratio of the volume of the extract to the raw medicinal material is 1.05: 1. Add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain a precipitate, wash the precipitate with 70% ethanol, dissolve it with an appropriate amount of water, filter, pass the filtrate through a macroporous resin, elute with water, collect the washing liquid, and wash the washing liquid Concentrate to a ratio of 1:2.5 between the volume of the medicinal solution and the medicinal material, add ethanol to make the alcohol content reach 70%, and obtain a precipitate, wash and dehydrate the precipitate with 95% ethanol and acetone, and dry under reduced pressure (60°C) to ob...

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Abstract

A composite medicine for preventing and treating primary liver cancer, lung cancer, rectum cancer, lymph cancer, gynecologic cancers, etc is proportionally prepared from gynostemma pentaphyllum or its extract, American ginseng or its extract, and astragalus root or its extract. Its preparing process is also disclosed.

Description

1. Technical field [0001] The present invention relates to a pharmaceutical composition with anti-tumor effect, in particular to a pharmaceutical composition composed of Gynostemma or Gynostemma extract, American ginseng or American ginseng extract, Radix Astragali or Radix Astragali extract and a preparation method thereof, and a pharmaceutical composition containing the drug The preparation of the composition belongs to the technical field of medicine. 2. Background technology [0002] Since the 1970s, the incidence and mortality of cancer in my country have been on the rise. In the 20 years to the 1990s, the cancer mortality rate increased by 29.42%, and the age-adjusted mortality rate increased by 11.56%. In 2000, the incidence of cancer was about 1.8 to 2 million, and the death toll was 1.4 to 1.5 million. Cancer is becoming the number one killer of human beings in the new century. At present, the treatment of cancer in modern medicine is mainly surgical treatment comb...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P35/00
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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