The invention provides a traditional Chinese medicinal preparation for treating chronic persistent hepatitis, which is prepared from the following raw materials in parts by weight: 10-20 parts of Areca catechu peel, 10-20 parts of imperata cylindrica root, 10-20 parts of Gardenia jasminoides fruit, 10-20 parts of Striga asiatica, 10-20 parts Radix Bupleuri, 10-20 parts of oriental wormwood, 10-20 parts of Alisma orientalis, 10-20 parts of Forsythia suspensa, 10-20 parts of Isatis indigotica root,10-20 parts of Poria cocos, 10-20 parts of processed polygonum multiflorum, 10-20 parts of Schisandra chinensis fruit, 10-20 parts of Gynostemma pentaphyllum, 10-20 parts of Atractylodes macrocephala, 10-20 parts of cornus officinalis, 10-20 parts of ligustrum lucidum fruit, 10-20 parts of radix paeoniae alba, 10-20 parts of scutellaria baicalensis, 10-20 parts of Cyperus rotundus, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of Melia toosendan fruit, 10-20 parts of panax notoginseng, and 10-20 parts of Saposhnikovia divaricata. The traditional Chinese medicinal preparation has the effects of soothing the liver, regulating the flow of qi, relieving the depressed liver, promoting blood circulation, invigorating qi, restoring qi, clearing away heat and toxic materials, promoting urination, expelling toxins, purging fire of liver, gallbladder and stomach, protecting liver and lowing transaminase level. The traditional Chinese medicinal preparation has the effects of dispelling blood stasis and smoothing collaterals, so that the liver and spleen function normally, and the functional activities of qi are smooth. The traditional Chinese medicinal preparation has low treatment cost and no distinct toxic and adverse side effects, and is worthy for generalization.