The invention provides a traditional Chinese medicine preparation for treating chronic persistent hepatitis. The preparation is prepared from, by weight, 10-20 parts of pericarpium arecae, 10-20 parts of lalang grass rhizome, 10-20 parts of cape jasmine, 10-20 parts of striga asiatica, 10-20 parts of radix bupleuri, 10-20 parts of herba artemisiae scopariae, 10-20 parts of rhizoma alismatis, 10-20 parts of fructus forsythiae, 10-20 parts of isatis roots, 10-20 parts of poria cocos, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of fructus schizandrae, 10-20 parts of gynostemma pentaphyllum, 10-20 parts of atractylodes macrocephala koidz, 10-20 parts of cornus officinalis, 10-20 parts of glossy privet fruit, 10-20 parts of radix paeoniae alba, 10-20 parts of scutellaria baicalensis, 10-20 parts of rhizoma cyperi, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of szechwan Chinaberry fruit, 10-20 parts of pseudo-ginseng and 10-20 parts of saposhnicovia divaricata. The preparation relieves liver, smoothes qi and dispels melancholy, invigorates blood circulation and eliminates weakness, tonifies qi and deficiency, clears away heat and toxic materials, promotes diuresis and expels toxin, clears away liver, gallbladder and stomach fire, protects liver and lowers enzymes. The preparation can disperses blood stasis and dredges collaterals, makes liver and spleen normally run, and makes qi function of human bodies harmonious and smooth. The preparation is low in treatment expenses, free of obvious toxic and side effects and worthy of powerful popularization.