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Preparation method for antivirus compound

A composition and anti-viral technology, applied in the directions of anti-viral agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of large loss of active ingredients, large doses of drugs taken by patients, inconvenient to carry, etc., and achieve natural Features, extraction process is simple, not easy to decompose and destroy the effect

Inactive Publication Date: 2010-03-17
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the preparation methods disclosed in the above two patent applications have been improved on the basis of traditional methods, the original water extraction and alcohol precipitation process is still used, and the active ingredients are greatly lost during the extraction process, and the obtained products still cannot overcome the content of active ingredients in traditional products. The shortcoming is that not only the efficacy of antiviral drugs cannot be fully exerted, but also a large waste of resources is caused, and patients take a large amount of drugs.
Secondly, the solution obtained by the above two patent applications is still a traditional liquid dosage form, which is inconvenient to carry and has a short shelf life.

Method used

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  • Preparation method for antivirus compound
  • Preparation method for antivirus compound
  • Preparation method for antivirus compound

Examples

Experimental program
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Effect test

example 1

[0147] The preparation of example 1 granules

[0148] 1. Extraction: Take 2.9Kg of patchouli and 2.5Kg of Acorus calamus, put them into an extraction kettle, extract at a pressure of 28MPa and a temperature of 55°C for 2 hours, and collect 198g of volatile oil, which will be used for later use.

[0149] Dregs and Forsythia 4.6Kg, Banlangen 12.9Kg, Curcuma 2.5Kg, Rehmannia 3.2Kg plus 8 times the amount of 80% ethanol, heated and refluxed twice, each time for 2 hours, released and extracted through a horizontal spiral discharge filter centrifuge solution, combined the two extracts and set aside.

[0150] Take 2.5Kg Anemarrhena, 5.7Kg gypsum, and 6.1Kg coarse powder of reed root, add 8 times the amount of water and extract twice at 80°C for 2 hours each time, release the extract through a horizontal screw discharge filter centrifuge, and combine Two extractions, spare.

[0151] 2. Concentration: Concentrate the water extract and the alcohol extract at a temperature of 100°C and...

example 2

[0157] The preparation of example 2 granules

[0158] 1. Extraction: Take 2.9Kg of Patchouli and 2.5Kg of Acorus calamus, put them into an extraction kettle, extract for 2 hours at a pressure of 28MPa and a temperature of 55°C, and collect 203g of volatile oil, which will be used for later use.

[0159] Dregs and Forsythia 4.6Kg, Banlangen 12.9Kg, Curcuma 2.5Kg, Rehmannia glutinosa 3.2Kg plus 10 times the amount of 80% ethanol, heated and refluxed once, 3 hours each time, released and extracted through a horizontal spiral discharge filter centrifuge solution, combined to obtain 56000ml of alcohol extract, which is set aside.

[0160] Take 2.5Kg Anemarrhena, 5.7Kg gypsum, and 6.1Kg coarse powder of reed rhizome, add 10 times the amount of water and extract once at 80°C for 1 hour each time, release the extract through a horizontal screw discharge filter centrifuge, and combine , to obtain 28000ml of water extract, for subsequent use.

[0161] 2. Concentration: the operation i...

example 3

[0167] The preparation of example 3 granules

[0168] 1. Extraction: The operation is the same as that in Example 1. Collect 202 g of volatile oil, 28000 mL and 56000 mL of water extract and 56000 mL of alcohol extract respectively, and set aside.

[0169] 2. Concentration: The operation is the same as that in Example 1, and the water extraction and alcohol extraction concentrates total about 11,900 mL (the density of which is measured at 50° C. and is 1.11 g / mL) for subsequent use.

[0170] 3. Drying: the operation is the same as that in Example 1, and 12000 mL of extract is obtained (the density is 1.15 g / mL when measured at 50 ° C), the temperature at the air inlet is 165 to 175 ° C, the temperature at the air outlet is 110 ° C, and the pressure is 1.2 bar Spray-drying was carried out under conditions to obtain 9.27Kg of yellow-brown dry powder.

[0171] 4. Preparation of clathrates: take the volatile oil obtained in step 1 and dilute it with absolute ethanol in a ratio of...

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Abstract

The invention provides a preparation method for an antivirus compound which adopts a supercritical carbon dioxide extraction method to extract a lipophilic active ingredient of patchouli and grass-leaved sweetflag, which is characterized in that the lipophilic active ingredient is volatile oil, the extracting efficiency is more than two times of the efficiency of steam distillation, no solvent toxicity remains, heat sensitive ingredient in natural active ingredient is not easy to de-compound and damage, and the natural characteristic of the extraction can be furthest maintained. Furthermore, active parts in antivirus compound are obtained by respectively exacting with water and alcohol, the extraction process is simple, scientific and reasonable, and active ingredient in medicinal materials can be furthest extracted. After impurities are removed, the active ingredient contents of mangiferin and phillyrin in medicine are respectively 16 time and 2 times higher than the same extracted with a prior method.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an antiviral compound preparation. Background technique [0002] WS3-49(X-39)-92(z) of "Ministry of Health of the People's Republic of China" discloses an antiviral oral liquid, which is composed of gypsum, Radix Radix, reed rhizome, rehmannia root, turmeric, Anemarrhena Nine flavors of traditional Chinese medicines, iris, patchouli and forsythia are prepared by water extraction and alcohol precipitation. They are widely used in viral infectious diseases such as wind-heat cold, upper respiratory tract infection caused by febrile fever, influenza and mumps. good clinical effect. However, due to the poor traditional preparation process, the product has low active ingredient content, especially the volatile oil component, and the product is a liquid preparation, which is difficult to store and inconvenient to carry. [0003] On January 24, 2007, the State Intellectual P...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P31/12A61K33/06
Inventor 祝晨蔯林朝展
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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