Shuanghuanglian medicinal composition and preparation method thereof

A composition, technology of Shuanghuanglian, applied in the field of Shuanghuanglian pharmaceutical composition and its preparation, can solve common problems such as adverse reactions

Active Publication Date: 2010-09-29
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, with the wide application of Shuanghuanglian preparatio

Method used

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  • Shuanghuanglian medicinal composition and preparation method thereof
  • Shuanghuanglian medicinal composition and preparation method thereof
  • Shuanghuanglian medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation process of the Shuanghuanglian pharmaceutical composition of the present embodiment is as follows:

[0025] 1) Take 500g honeysuckle and 2000g forsythia, add 8 times the amount of water to soak for 30 minutes, decoct twice for 1 hour each time, combine the filtrates, concentrate to a relative density of 1.22 (measured at 75°C), and let cool to 40°C , slowly add ethanol to make the alcohol content reach 75%, stir fully, let it stand for 12 hours, filter the supernatant, recover the ethanol until there is no alcohol smell, add 3 times the amount of water, adjust the pH value to 7.0, stir fully and heat Bring to a boil, let it stand for 48 hours, filter the supernatant, concentrate to a relative density of 1.13 (measured at 75°C), let it cool to 40°C, add ethanol to make the alcohol content reach 85%, let it stand for 12 hours, and filter out the supernatant. Clear liquid, recover ethanol until it has no alcohol smell, and obtain Yinqiao extract.

[0026] ...

Embodiment 2

[0031] The preparation process of the Shuanghuanglian pharmaceutical composition of the present embodiment is as follows:

[0032] 1) Take 500g of honeysuckle and 2000g of forsythia, add 6 times the amount of water and soak for 30 minutes, decoct twice for 2 hours each time, combine the filtrate, concentrate to 70°C and measure the clear paste with a relative density of 1.20, let it cool to 40°C Slowly add ethanol at ℃ to make the alcohol content reach 75%, stir well, let it stand for 12 hours, filter the supernatant, recover the ethanol until it has no alcohol smell, add 4 times the amount of water, adjust the pH value to 7.0, stir fully and Heat to boiling, stand still for 48 hours, filter the supernatant, concentrate to 70°C and measure the relative density to 1.10, let cool to 40°C and carry out secondary alcohol precipitation, the concentration of alcohol precipitation is 85%, let stand for 12 hours, filter Take the supernatant, recover the ethanol until it has no alcohol...

Embodiment 3

[0038] Take 300 g of the composition of Example 1 and add 800 ml of water for injection to dissolve, add 5‰ medicinal charcoal, adjust the pH value to 7.0 with 40% sodium hydroxide solution, stir, boil for 15 minutes, cool, add water for injection to dilute to 1000 ml, stir for 15 Minutes, filtered through a 0.22μm microporous membrane, cooled to 30-50°C for ultrafiltration, and cooled to below 30°C, filtered through 0.45μm and 0.22μm filter elements, filled, sterilized, and packaged , get injection.

[0039] After testing, the content of baicalin in the injection was 7.02 mg / ml, the content of forsythin was 0.17 mg / ml, and the content of chlorogenic acid and caffeic acid were 0.21 mg / ml.

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Abstract

The invention provides a Shuanghuanglian medicinal composition. A method for preparing the Shuanghuanglian medicinal composition comprises the following steps of: mixing and extracting honeysuckle and fructus forsythiae to obtain a honeysuckle and fructus forsythiae extract; extracting scutellaria baicalensis to obtain a scutellaria baicalensis extract; and mixing the honeysuckle and fructus forsythiae extract and the scutellaria baicalensis extract to obtain the Shuanghuanglian medicinal composition, wherein the weight ratio of the honeysuckle to the fructus forsythiae to the scutellaria baicalensis is 1:2:1; and the medicinal composition comprises the following components in percentage by weight: 20 to 40 percent of total flavone, 5 to 20 percent of total saponins, 20 to 30 percent of total organic acid, 8 to 18 percent of saccharides, 0.2 to 2 percent of total amino acid and 0.35 to 1.0 percent of phillyrin. In the Shuanghuanglian medicinal composition, active ingredients are extracted and separated from the honeysuckle, the fructus forsythiae and the scutellaria baicalensis, the impurities and the inactive ingredients are removed, each active ingredient is proportioned reasonably, and the content of chlorogenic acid and caffeic acid is strictly limited, so that curative effect is ensured and safety is improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a Shuanghuanglian medicinal composition and a preparation method thereof. Background technique [0002] Shuanghuanglian, a traditional Chinese medicine preparation, is extracted and refined from honeysuckle, forsythia and scutellaria baicalensis, and mainly contains baicalin, forsythin, and chlorogenic acid. Modern pharmacological studies have proved that Shuanghuanglian preparation has antibacterial, antiviral, antipyretic and other effects, can clear away heat and detoxify, clear away wind-heat, and is suitable for fever, cough, sore throat and other diseases caused by exogenous wind-heat. Clinically, it is widely used to treat acute upper respiratory tract infection, acute bronchitis, acute tonsillitis, mild pneumonia, etc. [0003] However, with the widespread clinical application of Shuanghuanglian preparations, reports of adverse reactions are common. The adve...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/00A61P31/00A61P29/00A61P11/14A61P11/04A61P11/10A61P11/00A61K31/7048
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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