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Application of phillyrin in the preparing of medicine for treating or preventing acute and chronic liver injury and hepar fibrosis

A technology for acute liver injury and chronic liver injury, applied in drug combination, digestive system, pharmaceutical formula, etc., can solve problems such as damage to health, large toxic and side effects, and easy recurrence

Inactive Publication Date: 2008-01-02
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Interferon is the drug of choice, but there are disadvantages such as large dosage, high cost, high toxicity and side effects, low effective rate, and easy recurrence after drug withdrawal.
The therapeutic effect of traditional Chinese medicine is also unsatisfactory. The curative effect of the medicine is inaccurate, the treatment period is long, and the cost is high. Long-term use will cause side effects and damage the health of the body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Preparation of forsythin freeze-dried powder for injection

[0015] Forsythin, the material used in the present invention, can be prepared according to the literature method (“Extraction, Separation and Preparation of Natural Medicinal Components”, edited by Sun Wenji, first edition in November 1999, p. 277). Take 20.0g of forsythin, add 2000ml of water for injection to dissolve it, add 8g of mannitol, stir to dissolve, and ultra-filter to obtain a clear liquid without pyrogen, pour it into a 10ml vial, 2ml / bottle, press the freeze-dried powder injection The process is freeze-dried to make freeze-dried powder injections each containing 20.0 mg of forsythin.

Embodiment 2

[0016] Example 2 Preparation of Forsythin Tablets

[0017] prescription:

[0018] Forsythin 100.0g

[0019] Powdered sugar 35.0g

[0020] Lactose 40.0g

[0021] Sodium carboxymethyl starch 23.0g

[0022] 3% PVP K30 Aqueous solution

[0023] Magnesium Stearate 2.0g

[0024]

[0025] A total of 1000 pieces were made

[0026] Operation: Weigh the prescribed amount of forsythin, sugar powder, lactose and sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add 3% PVP K30 Appropriate amount of water solution to make soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add the prescribed amount of magnesium stearate, mix well, punch out tablets with dimples, adjust the weight of the tablets to about 200mg, and get ready.

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PUM

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Abstract

The invention provides the application of phillyrin in preparing medicine that prevents and treats acute or chronic liver injury and liver fibrosis. It can be produced into oral preparation or injection preparation. The dose for injection is 25-800mg, and for oral is 50 -1500mg.

Description

technical field [0001] The invention relates to a medicine for treating liver diseases, in particular to the application of forsythin in preventing or treating acute and chronic liver injury and liver fibrosis caused by viruses, chemical substances and medicines. Background technique [0002] Hepatitis means inflammation of the liver. Infection by many pathogenic microorganisms such as viruses, bacteria, fungi, rickettsia, spirochetes, and some protozoa and parasites may cause liver inflammation; Ethanol, etc.) and certain drugs (such as ramifen, indomethacin, chlorpromazine, etc.) poisoning can cause toxic hepatitis. The hepatitis caused by drug poisoning is called drug-induced hepatitis; the hepatitis caused by chemical substances is called chemical hepatitis; the hepatitis caused by viruses is called viral hepatitis, which includes various types of hepatitis virus, herpes virus, Epstein-Barr virus, cytomegalovirus , varicella virus, enterovirus and adenovirus. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/634A61P1/16
Inventor 曲桂武蒋王林田京伟
Owner SHANDONG LUYE PHARMA CO LTD
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