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Antivirus extract and preparation method thereof

An extract and antiviral technology, applied in the preparation of drugs for preventing and/or treating influenza virus, the extract of the classic traditional Chinese medicine compound "Qiaohe Decoction" and the field of preparation thereof, which can solve the problems of loss of volatile active ingredients and the like , to achieve the effect of high extraction rate, expanded use range and simple preparation process

Active Publication Date: 2010-04-07
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problem of large loss of volatile active ingredients in the direct water extraction method, and effectively enrich the main ingredients of each medicinal material

Method used

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  • Antivirus extract and preparation method thereof
  • Antivirus extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of "Qiaohetang" extract

[0029] Take 4.5 kg of Chinese medicinal materials mint, 4.5 kg of forsythia, 3 kg of raw licorice, 4.5 kg of black gardenia, 9 kg of platycodon, and 6 kg of mung bean skin, and dry them at a temperature of 50°C for 3 hours; crush the medicinal materials with a particle size between 200 meshes. Then add 0.6 kg of entrainer methanol, and extract in the separation tank of supercritical carbon dioxide extraction. Extraction conditions: first-stage decompression separation pressure is 5Mpa, temperature is 40°C, flow rate is 15-20L / h, extraction is 3-4h; The pressure of the stage decompression separation is 5Mpa and the temperature is 35°C. Sample 1 was collected from the extract.

[0030] The outstanding advantages of this process technology are: (1) High extraction efficiency; (2) The main active ingredients are effectively enriched, especially for terpenoids, etc., and the original decoction is based on direct decoction. A large...

Embodiment 2

[0031] Example 2 Preparation of "Qiaohetang" extract

[0032] Take 4.5 kg of Chinese medicinal materials mint, 4.5 kg of Forsythia, 3 kg of raw licorice, 4.5 kg of black gardenia, 9 kg of platycodon, and 6 kg of mung bean hull, and dry them at a temperature of 60°C for 3 hours; crush the medicinal materials with a particle size of 60 mesh. Place the dry powder in the extraction tank, add 15 kg of entrainer ethanol, and perform the first-stage decompression separation in the separation tank for supercritical carbon dioxide extraction. The pressure is 10Mpa and the temperature is 60℃; the second-stage decompression separation pressure is 10Mpa and the temperature is 50. ℃. Collect the extract as sample 2

Embodiment 3

[0033] Example 3 "Qiaohe Decoction" was prepared according to the traditional method recorded in the ancient prescription

[0034] Take 4.5 kg of Chinese medicinal materials mint, 4.5 kg of Forsythia, 3 kg of raw licorice, 4.5 kg of black gardenia, 9 kg of platycodon, and 6 kg of mung bean skin. According to the traditional preparation method: add water, heat and reflux for extraction twice, and concentrate the extract to dryness Extract, as sample 3. For comparison of samples 1, 2.

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Abstract

The invention relates to an antivirus extract, which comprises the following preparation medicinal materials in part by weight: 4.5 parts of mint, 4.5 parts of weeping forsythiae, 3 parts of unripe licorice, 4.5 parts of black gardenia husk, 9 parts of platycodon root, and 6 parts of mung bean seed-coat. The antivirus extract is prepared by a method through the following steps: 1) drying the medicinal materials, wherein the drying temperature is 50+ / -10 DEG C and the drying time is 3 to 4 hours; 2) crushing the medicinal materials into coarse powder; 3) putting the medicinal materials into a supercritical extraction tank, and adding an entrainer ethanol or methanol, wherein the extraction condition comprises: a first-stage decompression separation under a condition with a pressure of 5 to 10 MPa, a temperature of 40 to 60 DEG C and a flow of 15 to 20 L / h to perform extraction for 3 to 4 hours, and a second-stage decompression separation under a condition with a pressure 5 to 10 MPa and a temperature of 35 to 50 DEG C; and 4) dehydrating and drying the extract. Through the supercritical preparation process, total flavone, total saponin and total terpenoid components can be enriched effectively. The antivirus extract comprises the following components in characteristic percentage by weight over 6 percent of the total flavone, over 15 percent of the saponin, over 0.3 percent of phillyrin, and over 2 percent of total volatile oil. The antivirus extract has the characteristics of more significant anti-inflammatory and anti-influenza virus functions, simple preparation process, high extraction yield, low cost and the like.

Description

Technical field [0001] The invention relates to an antiviral extract and a preparation method thereof, in particular to an extract of a classical Chinese medicine compound "Qiaohe Tang" and a preparation method thereof, and the use of the extract in the preparation of a medicine for preventing and / or treating influenza virus application. Background technique [0002] Influenza virus, referred to as influenza virus, is an RNA virus that causes influenza in humans and animals. In terms of taxonomy, influenza virus belongs to the Orthomyxoviridae family. It causes acute upper respiratory tract infections and is quickly moved by air. The spread of, there are often periodic pandemics around the world. Influenza virus can cause severe symptoms such as pneumonia or heart and lung failure in elderly or children with weakened immune system and some patients with immune disorders. Traditional Chinese medicine has significant advantages in the treatment of influenza. From the extensive sc...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P31/12A61P31/16
Inventor 严启新高媛李勇李姿
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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