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Antivirulent drug composition, and preparation and application thereof

A composition and antiviral technology, applied in the directions of antiviral agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of low content, unable to achieve expected curative effect, unable to significantly extract active ingredients, etc. Reasonable ratio, excellent effect, stable quality effect

Active Publication Date: 2012-10-31
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing product formula either does not contain Radix isatidis, or although Radix isatidis is contained, its active ingredients cannot be significantly extracted due to the preparation method, and the content is too low to achieve the expected curative effect

Method used

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  • Antivirulent drug composition, and preparation and application thereof
  • Antivirulent drug composition, and preparation and application thereof
  • Antivirulent drug composition, and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: antiviral pharmaceutical composition

[0061] 1. Extraction method:

[0062] 1) Add 500g of Radix isatidis into 5L of water and soak for 10 hours;

[0063] 2) Weigh 500g of honeysuckle, 500g of Scutellaria baicalensis, 1000g of forsythia, add 15L of water, decoct together with Radix isatidis and soaking liquid for 2 hours, filter out the decoction; add 15L of water for the second time, decoct for 1 hour, combine the decoction, Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.17 (75°C), add ethanol to make the alcohol content 70%, stir well, let stand for 24 hours, filter, combine the ethanol liquid, recover the ethanol until it has no alcohol smell, Concentration to a relative density of 1.17 (75°C) yielded 637 g of the composition (25.5% yield).

[0064] 2. The testing method of each active ingredient is as follows:

[0065] 1) Determination of the content of Scutellaria baicalensis: determined according to high performa...

Embodiment 2

[0086] Embodiment 2: antiviral pharmaceutical composition

[0087] 1. Extraction method:

[0088] 1) Add 300g of Radix Radix to 3L of water and soak for 12 hours;

[0089] 2) Weigh 300g of honeysuckle, 300g of Scutellaria baicalensis, and 600g of forsythia, add 9L of water, decoct together with Radix isatidis and soaking liquid for 2 hours, filter out the decoction; add 9L of water for the second time, decoct for 1 hour, combine the decoction, Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.17 (75°C), add ethanol to make the alcohol content 72%, stir well, let stand for 18 hours, filter, combine the ethanol liquid, recover the ethanol until it has no alcohol smell, Concentrate to a relative density of 1.17 (75°C) to obtain 411 g of the composition (yield: 27.4%).

[0090] 2. Content detection: According to the detection method of Example 1, in the composition of Example 2, each gram of the composition contained: 17.5 mg of baicalin, 0.87 mg o...

Embodiment 3

[0091] Embodiment 3: antiviral pharmaceutical composition

[0092] 1. Extraction method:

[0093] 1) Add 500g of Radix Radix to 5L of water and soak for 15 hours;

[0094] 2) Weigh 500g of honeysuckle, 500g of Scutellaria baicalensis, 1000g of forsythia, add 15L of water, decoct together with isatidis and soaking liquid for 1 hour, filter out the decoction; add 15L of water for the second time, decoct for 1 hour, and filter out the decoction Add 15L of water for the third time, decoct for 1 hour, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.18 (75°C), add ethanol to make the alcohol content 78%, stir well, and let stand After 30 hours, filter, combine the ethanol liquids, recover the ethanol until it has no alcohol smell, concentrate to a relative density of 1.17 (75°C), and obtain 636 g of the composition (yield: 25.4%).

[0095] 2. Content detection: According to the detection method of Example 1, it is measured that...

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Abstract

The invention relates to an antivirulent drug composition, and a preparation and a preparation method thereof. The drug composition comprises scutelloside, chlorogenic acid and caffeic acid, and phillyrin, wherein the weight ratio of scutelloside to chlorogenic acid to caffeic acid to phillyrin is (10-18):(0.6-2):(0.3-1). The drug composition and the preparation provided by the invention have a better inhibition effect on avian influenza virus and influenza A H1N1, with the effect being superior to that in the prior art.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an antiviral pharmaceutical composition, including its preparation and application. Background technique [0002] Modern pharmacological research has higher and higher requirements for clarifying the active ingredients of traditional Chinese medicines, which puts forward higher requirements for the proportion of traditional Chinese medicine compositions. [0003] Scutellaria baicalensis, isatis root, honeysuckle, and forsythia are traditional Chinese medicines commonly used in clinical practice in China. They all have the effect of clearing away heat and detoxifying, among which: [0004] Honeysuckle has antibacterial, antiviral, anti-inflammatory, antipyretic, and immune-regulating effects. The main active ingredients include chlorogenic acid and caffeic acid. Chlorogenic acid is not only an effective antiviral and antibacterial ingredient, but also a suspected allergen. , and ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K31/7048A61P31/14A61P31/16A61K31/192A61K31/216A61K31/421
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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