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Method for preparing forsythia suspense extraction

A forsythia extract and filtering technology are applied in the field of preparation of forsythia extract, and can solve the problems of low purity of forsythin and the like

Active Publication Date: 2007-12-12
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a method for extracting active extracts from Forsythia to solve the problem of low purity of active ingredients, mainly forsythin

Method used

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  • Method for preparing forsythia suspense extraction

Examples

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preparation example Construction

[0015] Referring to Fig. 2, a kind of preparation method of forsythia extract, the method comprises the following steps:

[0016] 1. Decoction and extraction: take the forsythia medicinal material, add water to decoct for 1-2 hours, filter the medicinal liquid, add water to the medicinal residue and decoct for 0.5-1 hour, filter the medicinal liquid, discard the medicinal residue; combine the two decoctions , concentrating the decoction to a relative density of 1.05-1.20 (60°C), cooling to normal temperature to obtain a decoction;

[0017] 2. Purification: add the alcohol solution to the decoction solution under stirring, so that the alcohol content reaches 60%-80%, refrigerate at 0-10°C for more than 12 hours, filter, and recover the alcohol solution from the filtrate until the filtrate has no alcohol smell , heated and concentrated to a relative density of 1.02-1.10 (60°C), cooled to room temperature, refrigerated at 0-10°C for more than 24 hours, and filtered to obtain a pu...

Embodiment 1

[0026] Weigh 1000g of forsythia, add 10 times the amount of purified water and 10000ml to decoct for 1.5 hours, filter to obtain the medicinal liquid, add 8 times the amount of water to decoct the medicinal residue for 50 minutes, filter to obtain the medicinal liquid, discard the medicinal residue, and combine the two Concentrate the second decoction to a relative density of 1.15 (60°C), let cool to obtain 700ml, slowly add ethanol under stirring to make the alcohol content reach 70%, refrigerate (5°C) for 24 hours, filter, and recover the ethanol from the filtrate to No alcohol smell, concentrate to a relative density of 1.05 (60°C), let cool, refrigerate (5°C) for 48 hours, take out, filter to obtain 800ml liquid medicine, extract 3 times with 2000ml water-saturated n-butanol, 680ml each time, Combine the n-butanol extracts, recover n-butanol under reduced pressure, dissolve the thick paste with water, refrigerate (5°C) for 48 hours, take it out, filter, concentrate the filt...

Embodiment 2

[0028] The method is the same as in Example 1, except that 3 extractions are replaced with 4 extractions, 500 ml each time, the yield of ointment is 3.2%, and the content of forsythin in the ointment is 5.50%.

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Abstract

The invention provides a preparation method of Fructus Forsythiae extract, and belongs to the field of preparative technique of Chinese traditional medicine. The inventive method comprises decocting Fructus Forsythiae with water for extraction, preliminary purifying through alcohol precipitation, and refining through water satured n-butanol extraction method. Compared with present technology, the invention obtains efficient extract with phillyrin as main ingredient, avoids the loss of phillyrin in each operation, especially guarantee extraction rate of phillyrin, completely transfers effective ingredient, improves purity, thus, the invention has simple operation, and can provide technological conditions in favor of industrial production.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, in particular to a method for extracting and purifying active ingredients of traditional Chinese medicines, in particular to a method for preparing a forsythia extract, and in particular to a method for extracting and purifying from forsythia to obtain forsythin-based effective extraction methods. Background technique [0002] Forsythia suspensa (Thunb.) Vahl is the dried fruit of Forsythia suspensa (Thunb.) Vahl, a plant of Oleaceae. The medicinal part of forsythia is mainly the fruit, which has the functions of clearing heat, detoxifying, dispelling stagnation and discharging pus. Indications for fever, sores, scrofula, erysipelas, rash, influenza. [0003] Forsythia contains forsythin, coumarin, oleanolic acid, saponins, vitamin P, volatile oils, phenylethanol glycosides, lignans, triterpenoids and other components, of which forsythin is the main effectiv...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61P31/16A61P17/02A61K131/00
Inventor 薛东升
Owner SHANGHAI KAIBAO PHARMA
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