Application formula for warming channels and relieving pain and preparation method thereof

Abstract

The invention relates to the field of traditional Chinese medicines, and discloses an application formula for warming channels and relieving pain and a preparation method thereof. The application formula comprises the following raw materials: fennel, caulis spatholobi, trogopterus dung, pollen typhae, angelica sinensis, asarum, radix paeoniae alba, turmeric, corydalis tuber, rhizoma drynariae, fructus psoraleae and pericarpium zanthoxyli. During preparation, all the raw materials are ground into 300-mesh medicine powder, so that the medicine components are not damaged, and meanwhile, the effective components of the medicine can fully play a role. Vaseline and folium artemisiae argyi and ginger oil are prepared into a mixed oil agent according to the mass ratio of 3: 1, then the mixed oil agent and medicine powder are mixed according to the mass ratio of 1: 2 to be prepared into paste, and the paste is completely covered with gauze after being applied and filled with a blank breathable adhesive patch, so that it is guaranteed that the medicine is fixed and does not seep out. According to the present invention, the pain relieving effect is mainly achieved by warming channels, expelling cold, promoting blood circulation and dredging collaterals, the root causes are treated by warming channels, the pain is relieved by dredging collaterals, and the symptoms are treated by dredging collaterals, such that the clinical application results show that the significant treatment effect on various pains such as waist, knee and leg pains, shoulder and neck pains, dysmenorrhea and the like is provided.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, and more particularly to a meridian-warming and pain-relieving patch formula and a preparation method thereof. Background Art

[0002] Pain caused by cold pathogen is a common clinical pain disease. Cold pathogen stagnates and causes pain, which can easily cause blood stagnation, contraction and spasm, and cause pain. It is especially easy to cause pain in the shoulders, neck, waist and back, because cold pathogen easily damages yang, and the yang is high, and the back is yang.

[0003] At present, Western medicine treatment mostly adopts anti-inflammatory and analgesic, dehydration and swelling, and hormone treatment. Western medicine treatment can relieve pain to a certain extent, but it cannot fundamentally solve the pain, which is easy to cause repeated attacks of pain. In addition, some drugs have certain side effects, and some patients have resistance. Oral Chinese medicine treatment has a certain effect, but oral Chinese medicine has a slow effect.

[0004] Therefore, how to develop a meridian-warming and analgesic patch formula and a preparation method thereof is an urgent problem to be solved by those skilled in the art. Summary of the invention

[0005] In view of this, the purpose of the present invention is to provide a composition for treating colds, a preparation method and a use method thereof. The composition is formulated in a specific ratio, and the Chinese medicinal materials are properly compatible with each other to enhance the therapeutic effect. It can treat pain caused by various cold pathogens. After one course of treatment (7 days), the therapeutic effect is significant, and some patients are significantly improved after 3 days of treatment.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] A meridian-warming and analgesic patch formula, characterized in that it comprises the following raw materials: fennel, Millettia reticulata, Aconiti lobata, Pollen Typhae, Chinese angelica, Asarum, White Peony Root, Curcuma longa, Corydalis yanhusuo, Drynaria fortunei, Psoralea corylifolia, and Sichuan pepper.

[0008] Preferably, the following raw materials are included in parts by weight: 2 parts of fennel, 2 parts of Millettia reticulata, 1 part of Atractylodes macrocephala, 1 part of Pollen Typhae, 1 part of Angelica sinensis, 1 part of Asarum, 1 part of White Peony Root, 1 part of Curcuma longa, 1 part of Corydalis yanhusuo, 1 part of Drynaria fortunei, 1 part of Psoralea corylifolia, and 1 part of Sichuan pepper.

[0009] The present invention also provides a method for preparing a meridian-warming and analgesic patch formulation, which specifically comprises the following steps:

[0010] (1) Weigh each raw material according to the above formula, grind it using a pulverizer to obtain a powder;

[0011] (2) dissolving vaseline into liquid by hot water, and then uniformly mixing the liquid vaseline with the mugwort leaf ginger oil to obtain a mixed oil;

[0012] (3) mixing the mixed oil and the drug powder evenly on a constant temperature heating pad to prepare a drug paste;

[0013] (4) Evenly cover the blank aerogel patch with the drug paste to ensure that it is fully filled with the drug and has a uniform thickness. Finally, cover it with medical gauze.

[0014] Preferably, the particle size of the medicinal powder in step (1) is 300 mesh.

[0015] The beneficial effects of the above technical solution are: the effective ingredients of the drug are not destroyed, and at the same time can more fully penetrate through the skin to produce effects.

[0016] Preferably, the high temperature water in step (2) is ≥ 70°C.

[0017] Preferably, the mass ratio of the liquid vaseline to the mugwort and ginger oil in step (2) is 3:1.

[0018] The beneficial effects of the above technical solution are: the wormwood leaf ginger oil can warm the meridians and dispel cold, and synergistically enhance the therapeutic effect. The ratio of wormwood leaf ginger oil and vaseline is obtained after repeated experiments. Its advantage is that it can better blend with the medicine powder, help the medicine powder to fully exert the drug effect, and can also play a role in preservation and prolonging the shelf life.

[0019] Preferably, the mass ratio of the mixed oil to the medicinal powder in step (3) is 1:2.

[0020] The beneficial effect of the above technical solution is that the ratio of the mixed oil and the drug powder is obtained through repeated experiments. Its advantage is that it can not only ensure that the drug adheres to the adhesive patch for a long time without falling off, but also assist the drug to continue to play a role and enhance the efficacy.

[0021] Preferably, the temperature of the constant temperature heating pad in step (3) is 50°C.

[0022] The beneficial effects of the above technical solution are: ensuring that the mixed oil agent is in a liquid state and ensuring that the mixed oil and the fine powder can be mixed into a uniform paste.

[0023] It can be seen from the above technical solution that compared with the prior art, the beneficial effects of the present invention are as follows:

[0024] (1) Compared with other plasters, the present invention warms the meridians and dispels cold to treat the root cause, and unblocks the meridians and relieves pain to treat the symptoms. Fennel warms the meridians and dispels cold, promotes qi and relieves pain as the main drug; Millettia reticulata relaxes muscles and activates collaterals, promotes blood circulation and relieves pain as the assistant drug, which enhances the analgesic effect of the main drug; Sichuan pepper and asarum warm the meridians and dispel cold to assist in enhancing the cold-dispelling effect of the main drug, while Ophiopogon japonicus, Pollen Typhae, Curcuma longa Millettia reticulata, and Corydalis yanhusuo promote blood circulation and relieve pain to assist in enhancing the cold-dispelling effect of the assistant drug, while Angelica sinensis replenishes blood, promotes blood circulation and relieves pain, Fangxin disperses blood consumption, and White Peony Root relieves urgency and relieves pain are all adjuvant drugs, which enhance the analgesic effect; Drynaria fortunei and Psoralea corylifolia replenish the kidney and strengthen the tendons, and guide the drug to the liver and kidney meridians, which are the guiding drugs. Clinically, pain is mostly caused by cold evil, and cold causes stagnation, and pain occurs when it is blocked. The patch of the present invention mainly achieves the effect of relieving pain by warming the meridians and dispelling cold, promoting blood circulation and unblocking collaterals. Clinical use has shown significant effects on treating various pains, including pain in the waist, knees, legs, shoulders and neck, dysmenorrhea and the like.

[0025] (2) The present invention is summarized based on many years of clinical experience, has significant clinical efficacy, and has a simple and economical preparation process, which is convenient for widespread clinical application and greatly saves medical resources. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Example 1

[0028] A meridian-warming and analgesic patch formula comprises the following raw materials in parts by weight: 2 parts of fennel, 2 parts of Millettia reticulata, 1 part of Aconiti Lateralis Preparata, 1 part of Pollen Typhae, 1 part of Angelica sinensis, 1 part of Asarum, 1 part of White Peony Root, 1 part of Curcuma longa, 1 part of Corydalis yanhusuo, 1 part of Drynaria Rhizoma, 1 part of Psoralea corylifolia, and 1 part of Sichuan pepper.

[0029] A method for preparing a meridian-warming and analgesic patch formulation comprises the following steps:

[0030] (1) Weigh each raw material according to the above formula, grind it using a pulverizer to obtain a powder;

[0031] (2) dissolving vaseline into liquid by hot water, and then uniformly mixing the liquid vaseline with the mugwort leaf ginger oil to obtain a mixed oil;

[0032] (3) mixing the mixed oil and the drug powder evenly on a constant temperature heating pad to prepare a drug paste;

[0033] (4) Evenly cover the blank aerogel patch with the drug paste to ensure that the drug is fully filled and the thickness is uniform, and finally cover it with medical gauze;

[0034] The particle size of the powder in step (1) is 300 mesh;

[0035] The high temperature water in step (2) is 70°C;

[0036] The mass ratio of the liquid vaseline to the wormwood and ginger oil in step (2) is 3:1;

[0037] The mass ratio of the mixed oil to the drug powder in step (3) is 1:2;

[0038] The temperature of the constant temperature heating pad in step (3) is 50°C.

[0039] The formula of the present invention can treat pain caused by various cold pathogens, and has significant therapeutic effects after one course of treatment (7 days). Some patients are significantly improved after 3 days of treatment.

[0040] Medical Record 1

[0041] Chen, female, 79 years old.

[0042] Chief complaint: Low back pain for more than 10 years, aggravated for 1 month.

[0043] Current medical history: low back pain, aggravated by fatigue or cold, phlegm in the throat, unformed stool, normal appetite and sleep, and normal urination. He went to a local hospital for treatment 3 years ago and was given closed therapy. After treatment, the low back pain improved slightly but the condition recurred. Closed therapy only temporarily relieved the pain and could not cure the disease, so the long-term effect was poor, and the patient did not receive drug treatment afterwards.

[0044] Past medical history: lumbar spondylosis for more than 15 years.

[0045] Physical examination: pale red tongue with thick and greasy coating, stringy and slippery pulse.

[0046] Initial diagnosis: arthritis

[0047] Treatment method: Warm the meridians and dispel cold, dredge the collaterals and relieve pain.

[0048] Treatment: Acupoint application treatment once a day for 7 consecutive days.

[0049] Follow-up: After the first diagnosis and treatment, the low back pain was relieved. A total of 7 times constituted a course of treatment. After the patient received 3 courses of acupoint application treatment, the low back pain basically disappeared. According to the four examinations, the patient in this case was diagnosed with cold stagnation and blood stasis. Blood stasis blocked the collaterals, and pain caused by obstruction can cause low back pain. The Chinese medicine composition of acupoint application includes cinnamon twig, asarum, fennel, and prickly ash to warm the meridians and dispel cold; angelica, Millettia reticulata, Pollen pollen, turmeric, aconitifolia, and Corydalis to promote blood circulation and remove blood stasis; "the waist is the home of the kidneys", psoralea corylifolia and bone-breaking tonify the kidneys and strengthen the bones; white peony root relieves and stops pain. The medicine in the prescription is mainly used to warm the meridians and dispel cold, unblock the collaterals and stop pain, so it has achieved good results.

[0050] Medical Record 2

[0051] Kou, female, 30 years old.

[0052] Chief complaint: Abdominal pain during menstruation for more than 2 years.

[0053] Current medical history: 2 years ago, there was no obvious cause. The patient had abdominal distension and pain on the 1st or 2nd day of each menstruation. She liked warmth and pressure. The menstrual flow was small and not smooth. The menstrual flow was purple and black with blood clots. The menstrual period was 5-7 days. The menstrual period was regular in the past. The menstruation started at the age of 13, 5-7 / 26-28 days, the flow was medium, the color was dark red, there were blood clots, and there was no dysmenorrhea. The last menstrual period was June 20, 2024. The patient usually had cold limbs, good appetite and sleep, and regular bowel movements. The patient did not receive any special treatment.

[0054] Past history: None.

[0055] Physical examination: dark tongue, thin white fur, deep and stringy pulse.

[0056] Initial diagnosis: Dysmenorrhea

[0057] Treatment method: Warm the meridians and dispel cold, dredge the collaterals and relieve pain.

[0058] Treatment: Acupoint application treatment once a day for 7 consecutive days.

[0059] Follow-up: After the first diagnosis and treatment, the abdominal pain gradually decreased, for a total of 7 times.

[0060] The second visit was 7 days before the onset of menstruation in the second month. The acupoint application treatment was continued for 7 consecutive days. When the menstruation came, the abdominal pain was significantly relieved. In the fourth month, the menstruation was normal and the abdominal pain disappeared. There was no dysmenorrhea after 1 year of follow-up. Dysmenorrhea is a common gynecological disease, mainly caused by poor circulation of qi and blood, which causes pain. Common causes are cold coagulation and blood stasis, and qi stagnation and blood stasis. According to the four examinations, the patient's dysmenorrhea in this case is related to "cold and stasis", so warming the meridians and dispersing cold, unblocking the meridians and relieving pain are the treatment methods. In the composition of the acupoint application medicine, cinnamon twig, asarum, fennel, and pepper warm the meridians and dispel cold; angelica, Millettia reticulata, pollen, turmeric, aconiti lobata, corydalis, bone drynaria, and psoralea corylifolia promote blood circulation and remove blood stasis; white peony root relieves and relieves pain. The combination of these medicines has the effect of dispersing cold and relieving pain, so the therapeutic effect is good.

[0061] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A meridian-warming and analgesic patch formula, characterized in that: The ingredients include: fennel, Millettia reticulata, Aconiti lobata, Pollen Typha, Chinese angelica, Asarum, white peony root, turmeric, Corydalis yanhusuo, Drynaria fortunei, Psoralea corylifolia, and Sichuan pepper.

2. A meridian-warming and analgesic patch formulation according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2 parts of fennel, 2 parts of Millettia reticulata, 1 part of Ophiopogon japonicus, 1 part of Pollen Typhae, 1 part of Angelica sinensis, 1 part of Asarum, 1 part of White Peony Root, 1 part of Curcuma longa, 1 part of Corydalis yanhusuo, 1 part of Drynaria fortunei, 1 part of Psoralea corylifolia and 1 part of Sichuan pepper.

3. A method for preparing a meridian-warming and analgesic patch formulation, characterized in that: The specific steps include: (1) Weighing each raw material according to the formulation of any one of claims 1 to 2, grinding using a pulverizer to obtain a powder; (2) dissolving vaseline into liquid by hot water, and then uniformly mixing the liquid vaseline with the mugwort leaf ginger oil to obtain a mixed oil; (3) mixing the mixed oil and the drug powder evenly on a constant temperature heating pad to prepare a drug paste; (4) Evenly cover the blank aerogel patch with the drug paste to ensure that it is fully filled with the drug and has a uniform thickness. Finally, cover it with medical gauze.

4. The method for preparing a meridian-warming and analgesic patch formulation according to claim 3, characterized in that: The particle size of the medicinal powder in step (1) is 300 mesh.

5. The method for preparing a meridian-warming and analgesic patch formulation according to claim 3, characterized in that: The high temperature water in step (2) is ≥70°C.

6. The method for preparing a meridian-warming and analgesic patch formulation according to claim 3, characterized in that: The mass ratio of the liquid vaseline to the mugwort and ginger oil in step (2) is 3:

1.

7. The method for preparing a meridian-warming and analgesic patch formulation according to claim 3, characterized in that: The mass ratio of the mixed oil to the medicinal powder in step (3) is 1:

2.

8. The method for preparing a meridian-warming and analgesic patch formulation according to claim 3, characterized in that: The temperature of the constant temperature heating pad in step (3) is 50°C.