Medicinal composition of thin gauze for treating burn wounds and capable of detoxifying and astringing, preparation and preparation method

Abstract

The invention provides a medicine composition of a thin gauze for treating burn wounds and capable of detoxifying and astringing, a preparation and a preparation method, and relates to the technical field of traditional Chinese medicine, and the medicine composition is prepared from the following components in specific parts by weight: rheum officinale, carbonized sanguisorba root, gallnut, red halloysite, calamine and borneol. The preparation method comprises the following steps: grinding the medicines into fine powder, heating and dissolving the beewax in the oil, filtering out impurities, adding the medicine powder after the oil is slightly cooled, continuously stirring uniformly, and cooling to obtain the ointment. And after disinfection, the medicine is used clinically. The traditional Chinese medicine compound disclosed by the invention can effectively clear away heat and toxic materials, astringe and promote tissue regeneration, is supported by a solid classical theory of traditional Chinese medicine, is reasonable in component proportion, excellent in medicine compatibility, low in cost and easy in quality control, and is proved by animal and clinical experiments to be capable of resisting infection and exudation, exact in curative effect and free of toxic and side effects; the traditional Chinese medicine composition can be applied to preparation of the traditional Chinese medicine composition for shallow and deep I-degree burn wounds.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a drug composition, a preparation and a preparation method of a thin gauze for burn wounds capable of detoxification and astringency. Background Art

[0002] Burns refer to an acute injury disease caused by heat (flames, hot gases, liquids or solids), electricity, chemicals, radiation, etc. acting on the human body. They often injure the local part, spread to the whole body, and even cause death. Unlike other traumas, the main target organ damage of burns is the skin. After burns, due to the damage of the skin barrier and the increase of capillary permeability, a large amount of human tissue fluid exudates, which provides a favorable environment for the growth of pathogenic microorganisms. Excessive pro-inflammatory stimulation will further damage the skin barrier and affect the final healing of the wound. Moreover, the larger the burn area and the deeper the degree, the more severe the exudation, and the more serious the pathogen infection. In addition, the high metabolic state of the burn patient itself increases the probability and severity of infection, which often leads to the death of the patient. Therefore, how to combat the infection and exudation of the skin of burn patients is the key to improving clinical efficacy and prognosis, and has important research value.

[0003] Modern medicine has limited treatment methods for infected exudates in burn patients, and lacks drugs that can take into account anti-infection, anti-exudation and promotion of wound healing. Surgical debridement is still the main strategy for infection in clinical practice; however, for a large amount of exudate in burn patients, it can only be treated with simple gauze compression and frequent changes. Each time the gauze is changed, it will further tear the wound, causing great pain to the patient and new infection risks. External treatment is the biggest advantage and feature of Chinese medicine surgery, because its symptoms are mostly seen on the body surface, and the drug is given nearby, directly to the diseased area, which is conducive to the early removal of the evil. Therefore, it is said: "All diseases are mostly from the outside, so doctors have external treatment methods." The so-called "thin patch" is an external ointment used to treat skin sores, carbuncles, scrofula and other diseases. The entry for "thin patches" in the "Dictionary of Traditional Chinese Medicine" states: "There are two types of plasters used in traditional Chinese medicine surgery: one is cloth-backed, with thick and large medicine, commonly known as large plasters. The other is paper-backed, with thin and small medicine, commonly known as small plasters. Thin patches in a broad sense include plasters, ointments, and also ointments prepared with other matrices." Inspired by the Huanglian Detoxifying Ointment, Professor Kong Zhaoxia, a nationally renowned traditional Chinese medicine doctor in our hospital, has developed a thin Chinese medicine gauze patch that can treat II° burn wounds. This is specifically reflected in the fact that the Chinese medicine composition has the effects of detoxification and astringency, can reduce skin exudation while fighting infection, and limit the scope of wound infection exudation. Multiple components work synergistically to promote the healing of burn wounds.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] One of the purposes of the present invention is to provide a Chinese medicine composition and a preparation method for a thin gauze dressing for detoxification and astringency of burns, so as to at least solve one of the technical problems existing in the prior art.

[0006] A second object of the present invention is to provide a pharmaceutical preparation.

[0007] The third object of the present invention is to provide a method for preparing the above-mentioned pharmaceutical preparation.

[0008] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted:

[0009] The invention provides a detoxifying and astringent burn thin gauze patch and a preparation method thereof. The Chinese medicinal composition comprises, by 1000 parts by weight, 400-600 parts of rhubarb charcoal, 400-600 parts of sanguisorba officinalis charcoal, 400-600 parts of gallnut, 400-600 parts of red ochre, 400-600 parts of calamine, 50-100 parts of borneol, 400-600 parts of beeswax and 400-600 parts of sesame oil.

[0010] Furthermore, based on 1000 parts by weight, the invention includes: 400-600 parts of rhubarb charcoal, 400-600 parts of sanguisorba officinalis charcoal, 400-600 parts of gallnut, 400-600 parts of red ochre, 400-600 parts of calamine, 50-100 parts of borneol, 400-600 parts of beeswax, and 400-600 parts of sesame oil.

[0011] Furthermore, based on 1000 parts by weight, the composition includes: 500 parts of rhubarb, 500 parts of sanguisorba officinalis charcoal, 500 parts of gallnut, 500 parts of red ochre, 500 parts of calamine, 50 parts of borneol, 500 parts of beeswax and 500 parts of sesame oil.

[0012] The present invention also provides the use of the above-mentioned Chinese medicine composition in preparing a Chinese medicine thin plaster capable of detoxification and astringency.

[0013] The present invention also provides a pharmaceutical preparation, which comprises an active ingredient and a pharmaceutically acceptable excipient;

[0014] The active ingredients include the above-mentioned traditional Chinese medicine composition.

[0015] Furthermore, the dosage form of the pharmaceutical preparation includes an ointment.

[0016] Furthermore, the pharmaceutical preparation is an ointment, the above medicines are ground into fine powder and passed through a 100-mesh sieve. Beeswax is heated and melted in sesame oil, and impurities are filtered out with gauze. After the oil is slightly cooled, the powder is put in, and stirred evenly. After cooling, the ointment is obtained. A wide bandage is cut into 25 cm long, and the ointment is applied on the gauze, a layer of ointment is applied, and two layers of gauze are taken up, and two thick layers are made, and the ointment is put into an enamel box, and sterilized by high pressure for standby use.

[0017] Furthermore, the dosage form of the pharmaceutical preparation includes a method for using the pharmaceutical preparation.

[0018] Furthermore, for superficial II-degree and deep II-degree fresh burn wounds and wounds that are ready to dissolve scabs, use the first layer of thin burn patch gauze with more powder. For infected wounds, use the second layer of thin patch with less powder, or dip the gauze in antibiotic solution and apply it to the wound. Depending on the location and condition of the wound, dressing or semi-exposure therapy can be used.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] (1) The pharmaceutical composition of the present invention has solid theoretical support from classic Chinese medicine, conforms to the principle of monarch, minister and adjuvant components of Chinese medicine, is a family prescription handed down by a famous old Chinese medicine doctor in our hospital, has outstanding clinical efficacy, and has a complete system of principles, methods and prescriptions for burn wounds, providing reliable theoretical support for the treatment of burn wounds;

[0021] (2) Clinical application of this theory to guide the formation of the drug combination of the present invention, clinical treatment for more than 60 years, safe and reliable efficacy, no toxic side effects, safe to take, can be used in the preparation of detoxification and astringent burn thin gauze;

[0022] (3) The drug of the present invention has excellent compatibility, reasonable ratio, low cost, reduces the economic and mental burden of patients, and has good prospects for promotion and application. DETAILED DESCRIPTION

[0023] Unless otherwise defined herein, scientific and technical terms used in conjunction with the present invention shall have the meanings commonly understood by those of ordinary skill in the art. The meaning and scope of the terms should be clear, however, in the case of any potential ambiguity, the definitions provided herein take precedence over any dictionary or external definitions. In this application, unless otherwise stated, the use of "or" means "and / or". In addition, the use of the term "including" and other forms is non-limiting.

[0024] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] According to one aspect of the present invention, a detoxifying and astringent Chinese medicine composition for burn thin gauze is provided, which comprises, per 1000 parts by weight, 400-600 parts of rhubarb charcoal, 400-600 parts of sanguisorba officinalis charcoal, 400-600 parts of gallnut, 400-600 parts of red ochre, 400-600 parts of calamine, 50-100 parts of borneol, 400-600 parts of beeswax, and 400-600 parts of sesame oil.

[0026] The present invention is formed by the national famous old Chinese medicine practitioners based on their clinical experience. The prescription principle is to be compatible according to the principle of monarch, minister, assistant and envoy. The formula of the composition of the present invention is optimized and determined, so that the drugs can be strictly compatible, the prescription is excellent, and the symptoms and root causes are treated. The details are as follows:

[0027] Rhubarb is the main drug in the prescription. It can clear away heat and detoxify, cool blood and remove dampness. It can cool the heat in the blood and eliminate subcutaneous swelling. The bitter and cold Radix Sanguisorbae can purge fire and detoxify, and it is sour and astringent and can astringe sores and promote tissue regeneration. It is the main drug. Gallnut has a cold nature and can dissipate heat, toxic sores and swelling. Red ochre is astringent and has both astringent and dampness-removing effects. Phellodendron clears heat and dries dampness, detoxifies and treats sores. They are adjuvant drugs. Calamine astringes dampness and astringes sores. Borneol is better at moving while clearing heat and relieving pain. It can carry all the drugs directly to the affected area. It is the guiding drug. All the drugs are used together to achieve the effects of clearing heat and detoxifying, promoting tissue regeneration and astringing sores.

[0028] Modern pharmacological studies have shown that the rhubarb, sanguisorba officinalis and gallnut in the prescription all have strong antibacterial and anti-inflammatory effects. Sanguisorba officinalis and gallnut also have the effects of astringing and promoting tissue regeneration, reducing early tissue swelling in burns and scalds, reducing capillary permeability, reducing wound exudation, reducing tissue edema, and protecting wounds. Red ochre and calamine both have the effects of astringing and promoting tissue regeneration, absorbing moisture and healing wounds; borneol has antiseptic, anti-inflammatory and analgesic effects; the combination of these medicines can play a role in resisting exudation, anti-infection, relieving pain and healing wounds, and promoting healing of early burn and scald wounds.

[0029] The traditional thick application of ointment is not conducive to the drainage of exudate wounds, but is likely to aggravate the infection. Therefore, we have developed a thin gauze that can detoxify and astringe with medicine, and the gauze can absorb moisture and resist seepage, which meets the actual clinical needs.

[0030] It should be noted that the weight of the above components is calculated based on crude drugs. Each portion can be 1g, or kilograms or tons. If grams are used as the unit, the formula composition can be made into 1,000 doses of pharmaceutical preparations.

[0031] The above composition is based on weight ratio, which can be increased or decreased according to the corresponding ratio during production. For example, large-scale production can be based on kilograms or tons, and small-scale production can also be based on milligrams. The weight can be increased or decreased, but the weight ratio of the raw medicinal materials in the composition of the medicine remains unchanged.

[0032] In order to better improve the anti-infection and anti-exudation effects of the traditional Chinese medicine combination provided by the present invention, the dosage of each component of the formula is further adjusted and optimized. Preferably, based on 1000 parts by weight, the dosage includes: 400-600 parts of rhubarb charcoal, 400-600 parts of sanguisorba officinalis charcoal, 400-600 parts of gallnut, 400-600 parts of red ochre, 400-600 parts of calamine, 50-100 parts of borneol, 400-600 parts of beeswax, and 400-600 parts of sesame oil.

[0033] Based on the beneficial effects of the Chinese medicine composition provided by the present invention, the second aspect of the present invention further provides the use of the above-mentioned Chinese medicine composition in the preparation of a Chinese medicine thin gauze for detoxification and astringency.

[0034] According to a third aspect of the present invention, there is provided a pharmaceutical preparation comprising an active ingredient and a pharmaceutically acceptable excipient;

[0035] The active ingredient includes the above-mentioned Chinese medicine composition;

[0036] The pharmaceutically acceptable excipients include: one or more of solvents, propellants, solubilizers, cosolvents, emulsifiers, colorants, adhesives, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adhesives, antioxidants, chelating agents, penetration enhancers, pH regulators, buffers, plasticizers, surfactants, foaming agents, defoamers, thickeners, inclusion agents, humectants, absorbents, diluents, flocculants and deflocculating agents, filter aids or release retardants, and can be selected according to actual needs.

[0037] The above-mentioned Chinese medicine composition can be prepared into any externally acceptable preparation form, for example, it can be, but not limited to, an ointment.

[0038] According to a fourth aspect of the present invention, a method for preparing and using the above-mentioned pharmaceutical preparation is provided, wherein the pharmaceutical preparation is an ointment, wherein the above-mentioned medicines are ground into fine powder and passed through a 100-mesh sieve. Beeswax is heated and melted in sesame oil, and impurities are filtered out with gauze. After the oil is slightly cooled, the powder is put in, and the mixture is stirred evenly. After cooling, the ointment is obtained. A wide bandage is cut into 25 cm lengths, and the ointment is applied on the gauze, and a layer of the ointment is applied. Two layers of gauze are taken up, and two thick layers are made, and the ointment is put into an enamel box, and sterilized under high pressure for standby use.

[0039] The present invention is further described below by way of examples. Unless otherwise specified, the materials in the examples are prepared according to existing methods or directly purchased from the market.

[0040] Calculated in 1000 parts by weight, it comprises:

[0041] Further, based on 1000 parts by weight, it includes: Further, based on 1000 parts by weight, it includes:

[0042] Example 1

[0043] This embodiment provides a Chinese medicine composition for detoxification and astringency for burn wounds, which comprises, based on 1000 parts by weight:

[0044] 400 parts of rhubarb charcoal, 400 parts of sanguisorba officinalis charcoal, 400 parts of gallnuts, 400 parts of red ochre, 400 parts of calamine, 50 parts of borneol, 400 parts of beeswax, and 400 parts of sesame oil.

[0045] Example 2

[0046] The present embodiment provides a Chinese medicine composition for detoxification and astringency of burn wounds, which comprises, in 1000 parts by weight: 600 parts of rhubarb charcoal, 400-600 parts of sanguisorba officinalis charcoal, 600 parts of gallnut, 600 parts of red ochre, 600 parts of calamine, 100 parts of borneol, 600 parts of beeswax, and 600 parts of sesame oil.

[0047] Example 3

[0048] The present embodiment provides a Chinese medicine composition for detoxification and astringency of burn wounds, which comprises, in 1000 parts by weight, 500 parts of rhubarb, 500 parts of sanguisorba officinalis charcoal, 500 parts of gallnut, 500 parts of red ochre, 500 parts of calamine, 80 parts of borneol, 500 parts of beeswax and 500 parts of sesame oil.

[0049] Example 4

[0050] The present embodiment provides a Chinese medicine composition for detoxification and astringency of burn wounds, which comprises, in 1000 parts by weight, 450 parts of rhubarb, 450 parts of sanguisorba officinalis charcoal, 450 parts of gallnut, 450 parts of red ochre, 450 parts of calamine, 60 parts of borneol, 450 parts of beeswax and 450 parts of sesame oil.

[0051] Example 5

[0052] The present embodiment provides a Chinese medicine composition for detoxification and astringency of burn wounds, which comprises, in 1000 parts by weight, 550 parts of rhubarb, 550 parts of sanguisorba officinalis charcoal, 550 parts of gallnut, 550 parts of red ochre, 550 parts of calamine, 70 parts of borneol, 550 parts of beeswax and 550 parts of sesame oil.

[0053] Example 6

[0054] This embodiment provides a pharmaceutical preparation (ointment), which is prepared by the following method:

[0055] The 6 herbs provided in Example 1, including the pharmaceutical preparation described in the manufacturing process, are used as ointments. The above herbs are ground into fine powder and passed through a 100-mesh sieve. Beeswax is heated and melted in sesame oil, and impurities are filtered out with gauze. After the oil is slightly cooled, the powder is put in, stirred evenly, and the ointment is obtained after cooling. The ointment is obtained. A wide bandage is cut into 25 cm long, and the ointment is scraped on the gauze, a layer of ointment is applied, and the second layer of gauze is taken up, and two thick layers are made, and put into an enamel box, and sterilized by high pressure for standby use.

[0056] Comparative Example 1

[0057] The comparative example provides a Chinese medicinal composition for detoxification and astringency of burn wounds, which comprises, in 1000 parts by weight, 500 parts of rhubarb, 500 parts of sanguisorba officinalis charcoal, 500 parts of gallnut, 500 parts of red ochre, 500 parts of calamine, 80 parts of borneol, 500 parts of beeswax and 500 parts of sesame oil.

[0058] Comparative Example 2

[0059] This comparative example provides a Chinese medicinal composition for detoxification and astringency for burn wounds, which is different from Example 1 in that vaseline gauze is used to cover the wound.

[0060] Experimental example

[0061] Animal model preparation and treatment

[0062] Forty-four healthy SD rats of either sex, weighing 210-250 g, were purchased from the Experimental Animal Center of Anhui Medical University and randomly divided into three groups: sham injury group (n=12), scald group (n=16), and Chinese medicine group (n=16).

[0063] Establishment of deep second-degree burn model One day before the burn, the back of the rat was depilated with 10% sodium sulfide, washed with clean water, and dried. The rats were fasted for 12 hours before the experiment and had free access to water. A homemade iron rod with a diameter of 1 cm and a length of 25 cm, one end of which was smooth, was used as the burn surface. During the experiment, 10% chloral hydrate (0.3 mL / 100 g) was injected intraperitoneally to anesthetize the rat. The iron rod was placed in boiling water for 30 minutes in advance, and then quickly dried after being taken out and placed on the back of the rat without external pressure for 15 seconds. 5 mL of normal saline was injected intraperitoneally to resist shock. After the burn, the wound surface was white and swollen, and pathology confirmed that it was a deep second-degree burn. The iron rod of the normal group was placed in 25°C water, and the other conditions remained unchanged.

[0064] Treatment group: The wound was covered with Chinese medicine ointment, then covered with multiple layers of sterile gauze, and finally bandaged with pressure bandage.

[0065] Control group: The wound was covered with vaseline gauze, then covered with multiple layers of sterile gauze, and finally bandaged with pressure bandage.

[0066] Observation indicators

[0067] (1) Determination of wound surface moisture content: Rats were killed and the wound surface moisture content was determined by the dry-wet mass method: about 100 mg of the wound surface was cut and weighed, and then dried in an oven at 80°C for 48 h. The wound surface moisture content was calculated according to the following formula: moisture content = (W 1 -W 2 ) / W 1 ×100%.

[0068] (2) Determination of serum inflammatory factors: After scalding: Blood was collected from the femoral artery 3 days after scalding at 3 and 14 days, respectively. The supernatant was collected by centrifugation at 3,000 r / min for 10 min, and the IL-1B level was detected according to the requirements of the kit.

[0069] Statistical methods All data were analyzed using SPSS 19.0 software. SPSS 25.0 statistical software was used to analyze the data. Measurement data were expressed as mean ± standard deviation (x ± s), with p < 0.05 as a statistically significant difference and p < 0.01 as a statistically significant difference.

[0070] result

[0071] 1. Compared with vaseline gauze, Chinese medicine gauze can reduce the moisture content of the wound

[0072] The water content of the wound surface in the rat model group increased significantly 3 days after scald, and decreased after 14 days. The thin gauze with Chinese medicine can reduce the exudation of rats, and the difference is statistically significant (p < 0.01).

[0073] Table 1 Effect of Chinese medicine thin gauze on the water content of deep second degree burn wound in rats (x±s,%)

[0074]

[0075]

[0076] 2. Chinese medicine gauze is better than traditional vaseline gauze in anti-inflammatory

[0077] Compared with the control group, the serum IL-1β level in the model group 3 days after scald was significantly higher than that in the normal group, while that in the Chinese medicine thin gauze group was significantly lower than that in the model group, and the difference was statistically significant (p < 0.01).

[0078] Table 2 Effect of Chinese medicine thin gauze on serum IL-1β in deep II rats (x±s,%)

[0079]

[0080] in conclusion

[0081] (1) Compared with vaseline gauze, the Chinese medicine gauze can promote wound healing faster.

[0082] (2) Chinese medicine gauze is superior to traditional vaseline gauze in anti-inflammatory effect.

[0083] (3) Chinese medicine gauze patch has high safety and provides an effective treatment for clinical treatment.

[0084] Treatment methods.

[0085] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicinal composition for detoxification and astringency of burn wounds, characterized in that: The invention comprises, based on 1000 parts by weight, 400-600 parts of rhubarb, 400-600 parts of sanguisorba officinalis charcoal, 400-600 parts of gallnut, 400-600 parts of red ochre, 400-600 parts of calamine, 50-100 parts of borneol, 400-600 parts of beeswax and 400-600 parts of sesame oil.

2. The Chinese medicine composition according to claim 1, characterized in that The invention comprises, based on 1000 parts by weight, 400-600 parts of rhubarb charcoal, 400-600 parts of sanguisorba officinalis charcoal, 400-600 parts of gallnut, 400-600 parts of red ochre, 400-600 parts of calamine, 50-100 parts of borneol, 400-600 parts of beeswax and 400-600 parts of sesame oil.

3. The Chinese medicine composition according to claim 2, characterized in that: The invention comprises, based on 1000 parts by weight, 500 parts of rhubarb, 500 parts of sanguisorba officinalis charcoal, 500 parts of gallnut, 500 parts of red ochre, 500 parts of calamine, 50 parts of borneol, 500 parts of beeswax and 500 parts of sesame oil.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a Chinese medicine thin gauze for detoxification and astringency of burn wounds.

5. A pharmaceutical preparation, characterized in that The pharmaceutical preparation comprises an active ingredient and pharmaceutically acceptable excipients; The active ingredient comprises the Chinese medicine composition according to any one of claims 1 to 3.

6. The pharmaceutical preparation according to claim 5, characterized in that The dosage form of the pharmaceutical preparation includes ointment.

7. The method for preparing and using the pharmaceutical preparation according to claim 5 or 6, characterized in that: The pharmaceutical preparation is an ointment. The above medicines are ground into fine powder and passed through a 100-mesh sieve. Beeswax is heated and melted in sesame oil, and impurities are filtered out with gauze. After the oil is slightly cooled, the powder is put in and stirred evenly. After cooling, an ointment is obtained. The above method obtains an ointment. A wide bandage is cut into 25 cm lengths, and the ointment is applied on the gauze. A layer of ointment is applied, and two layers of gauze are picked up, and two thick layers are made, and the ointment is put into an enamel box, and sterilized by high pressure for standby use.

Images