Dietary supplements containing terpenoid acids of maslinic acid or oleanolic acid and process for enhancing muscle mass in mammals

Inactive Publication Date: 2010-08-12
IN INGREDIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]A process for increasing lean body mass in a mammalian subject is provided that includes administering to the subject a purified quantity of maslinic acid, oleanolic acid, or a combination thereof. The administration can be orall

Problems solved by technology

If protein requirements of the body are not met by dietary sources, a nitrogen deficit may develop.
This deficit results from urinary nitrogen excretion exceeding the amounts of dietary protein being consumed.
The current recommended da

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029]The inventive composition of Table 1 is administered in a double-blind study to a group of 6 body builders, with 4 body builders acting as negative controls. Each subject consumed a diet composed of between 25 and 30 total weight percent protein with the controls receiving the composition provided in Table 1 with the exception of the maslinic acid extract. The compositions are administered once daily for 6 weeks. The test subjects at the end of the trial show a 2% increase in lean body mass relative to the control group.

example 2

[0030]The trial of Example 1 is repeated with the inventive composition of Table 2 substituted for that of Table 1 while a repeat study control group received the Table 2 formulation lacking inventive acid with a comparable result to that of Example 1.

example 3

[0031]The procedure of Example 1 is repeated with the composition taken orally within 2 hours of completing the most strenuous exercise routine of the day with comparable results to that of Example 1.

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Abstract

A process for increasing lean body mass in a mammalian subject is provided that includes administering to the subject a purified quantity of maslinic acid, oleanolic acid, or a combination thereof. The administration can be orally and benefits from ingestion of an amino acid source such as dietary protein, oligopeptides, or amino acids. Administration within 2 hours of muscle-degrading exercise or on a daily basis for a period of time increases lean body mass.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority of U.S. Provisional Patent Application Ser. No. 61 / 151,369 filed Feb. 10, 2009, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to dietary supplement compositions containing maslinic acid and methods of enhancing nitrogen balance and lean body mass in humans and other mammals through administration thereof.BACKGROUND OF THE INVENTION[0003]Proteins in the body are continuously degraded and synthesized by processes that require energy. In a body, a positive nitrogen balance occurs when the total nitrogen excreted in the urine, feces and sweat is less than the total nitrogen ingested. This positive nitrogen balance must exist for new tissue to be synthesized.[0004]Most Americans consume a 12 weight percent protein diet, while most bodybuilders consume upwards of a 25% to 30% protein diet. This bodybuilding subgroup, in order to add lean body mass to their bod...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61K31/19
CPCA23L1/30A23L1/3051A23L1/3055A23L1/3056A61K45/06A61K31/192A61K2300/00A23L33/10A23L33/175A23L33/185A23L33/19A61P43/00
Inventor ROMERO, AUGUSTIN T.ROMERO, TIMMILLER, PETER
Owner IN INGREDIENTS
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