16 results about "Methylene-lactone" patented technology

Provided is a method for producing a methylene lactone compound, whereby it is possible to efficiently produce a methylene lactone compound. The present invention relates to a method for producing a methylene lactone compound, which is characterized by comprising a step for reacting a specific gamma-butyrolactone compound with a specific aldehyde compound in the presence of an oxide or hydroxide of a metal comprising a group 2 element of the periodic table.

The present invention provides a method for producing a methylene lactone-based compound, the method being capable of efficiently producing the methylene lactone-based compound. The present invention relates to a method for producing a methylene lactone-based compound, the method being characterized by involving a step in which a specific γ-butyrolactone-based compound and a specific aldehyde compound are reacted in the presence of an oxide or hydroxide of a metal including an element in group 2 of the periodic table.

To provide a method for producing a resin which improves drying efficiency of a solvent, and can enhance productivity of an optical film.SOLUTION: A method for producing a resin including a structural unit derived from α-methylene lactone, and a structural unit derived from alkyl (meth)acrylate includes a polymerization step of suspending and polymerizing a monomer containing the α-methylene lactone and the alkyl (meth)acrylate in a solvent, in the presence of a first polymerization initiator, a second polymerization initiator and an emulsifier, wherein a 10-hour half-life temperature T2 of the second polymerization initiator is higher than a 10-hour half-life temperature T1 of the first polymerization initiator by 10°C or higher, and the polymerization step includes a first temperature holding step of holding the temperature of a reaction liquid to be suspended and polymerized at T1±10°C, and starting the polymerization, and a second temperature holding step of raising the temperature of the reaction liquid by polymerization heat, then holding the temperature of the reaction liquid at a temperature higher than the temperature of the reaction liquid in the first temperature holding step by 10°C or higher, and further polymerizing the reaction liquid.SELECTED DRAWING: None

The invention relates to a selenolactone compound. The preparation method comprises the following steps: firstly, chemically synthesizing a chiral selenium-containing alpha-exo-methylene lactone compound 1 to improve the selectivity of the compound 1 to tumor cells; then, a hydrophilic group is adopted to attack alpha-exo-methylene lactone to obtain a selenolactone-containing compound 2, the water solubility of the selenolactone-containing compound 2 is enhanced, tumor cells are expected to preferentially uptake a selenolactone-containing prodrug 2, then methylation is carried out under the action of in-vivo SAM enzyme to generate ammonia positive ions I, and finally alpha-exo-methylene lactone warheads 1 are released; therefore, the selectivity of the anti-tumor effect is improved. The selenolactone compound provided by the invention can effectively inhibit proliferation of various cancer cells, and has good selectivity to tumor cells; meanwhile, the growth speed and volume of tumors in vivo can be remarkably inhibited, and the compound has excellent anti-tumor activity and good safety. The invention provides sufficient scientific basis and theoretical basis for exploring the development of selenium antitumor drugs, and has important social value and scientific significance.

The present invention relates to anaerobically curable compositions made from renewable materials. In particular, an alpha-methylene-lactone is used with a (meth)acrylate component and a cure system to form an anaerobically curable composition.

The present disclosure provides a method for producing a powder containing a copolymer containing a structural unit derived from α-methylene lactone and a structural unit derived from an alkyl (meth)acrylate, the method being characterized by comprising: a polymerization step in which monomers including α-methylene lactone and an alkyl (meth)acrylate are subjected to suspension polymerization in a solvent in the presence of a polymerization initiator and an emulsifier to obtain a copolymer; a drying step in which the copolymer is dried to obtain a first powder; and a heat treatment step in which the first powder is heated at a temperature higher than that in the drying step to obtain a second powder in which the total content of the α-methylene lactone and the alkyl (meth)acrylate is smaller than that in the first powder.

The invention relates to an optical film and a flexible display. The invention provides an optical film 10, 20. This optical film (10, 20) is provided with: a base material layer (1) containing a copolymer containing a structural unit derived from alpha-methylene lactone and a structural unit derived from an alkyl (meth) acrylate; and a cover layer (2) that is disposed on one side of the base material layer (1) and contains a thermoplastic elastomer. The total light transmittance of the optical films (10, 20) is 90% or more.

The invention relates to a process for production and / or storage of α-methylenelactones, wherein a α- methylenelactone is present in a vessel, the α-methylenelactone is a α-methylenelactone of the following Formula I: and R1 is hydrogen, or a C1 to C10, in particular C1 to C5, linear or branched alkyl group, in particular R1 is hydrogen or a methyl group, and the vessel contains a gaseous phase and a liquid phase, wherein the gaseous phase comprises less than 15 vol.-%, based on the total gaseous phase, of oxygen, and the liquid phase comprises - 50.0000 wt.-% to 99.9995 wt.-%, based on the total liquid phase, of the α-methylenelactone, - 0.0000 wt.-% to 49.9995 wt.-%, based on the total liquid phase, of residuals, in particular carboxylic acids such as itaconic acid, hydroxycarboxylic acids such as 2-methylene-4-ol-butyric acid, hydroxycarboxylic esters such as γ-butyrolactone, water, further monomers, and / or organic solvents, and - 0.0005 wt.-% to 0.2000 wt.-%, based on the total liquid phase, of a polymerization inhibitor, wherein the polymerization inhibitor is an aminoxyl radical of the following Formular II: and R2 is hydrogen, oxygen, OH NH2, OMe or an alkyl-, ester- or amide group, wherein the polymerization inhibitor is in particular 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl.

This disclosure provides a method for manufacturing a powder containing a copolymer comprising structural units derived from α-methylene lactone and structural units derived from alkyl (meth)acrylate, characterized in that the manufacturing method comprises: a polymerization step in which monomers comprising α-methylene lactone and alkyl (meth)acrylate are suspended and polymerized in a solvent in the presence of a polymerization initiator and an emulsifier to obtain a copolymer; a drying step in which the copolymer is dried to obtain a first powder; and a heat treatment step in which the first powder is heated at a temperature higher than that of the drying step to obtain a second powder in which the total content of α-methylene lactone and alkyl (meth)acrylate is less than that of the first powder.

The present invention relates to scaberol C selenoether derivatives of sesquiterpene lactones and preparation methods and applications thereof, and belongs to the field of pharmaceutical technology. Sesquiterpene lactone compounds have significant anti-tumor activity, but have disadvantages such as poor targeting and easy metabolic inactivation. The present invention chemically modifies the α-methylene-γ-lactone fragment of scaberol C, designs and synthesizes a series of selenoether derivatives with high reactivity, aiming to enhance its anti-tumor effect and selectivity. A series of selenoether derivatives are successfully synthesized in the present invention, and these compounds can quickly release prototype compounds in vivo and enhance the covalent binding ability with tumor-related proteins. The selenoether derivatives provided by the present invention not only have excellent anti-tumor activity, but also show good biocompatibility and safety, provide powerful compound candidates for the development of anti-tumor drugs, and have important research value and application prospects.

To provide an optical film containing a copolymer comprising a structural unit derived from α-methylene lactone and having excellent resistance to bending.SOLUTION: An optical film 10, 20 is provided. The optical film 10, 20 includes: a base layer 1 containing a copolymer having a structural unit derived from α-methylene lactone and a structural unit derived from an alkyl (meth)acrylate; and a coating layer 2 disposed on one side of the base layer 1 and containing a thermoplastic resin. The total light transmittance of the optical film 10, 20 is 90% or more.SELECTED DRAWING: Figure 1

To provide an emulsion that enables formation of a coating film exhibiting superior film-forming capability and adequate hardness.SOLUTION: An emulsion is provided, the emulsion containing particles including a copolymer having structural units derived from α-methylene lactone and structural units derived from a (meth)acrylic ester, and an aqueous dispersion medium, wherein the (meth)acrylic ester includes a (meth)acrylic ester (A) whose glass transition temperature is 0°C or less when formed as a homopolymer, and the glass transition temperature of the copolymer is -40°C or more and 100°C or less.SELECTED DRAWING: None

To provide a containing a polymer having a structural unit derived from α - methylene lactone, which can achieve both antiblocking properties and transparency, an optical film and a method for producing the same, and a film roll using the optical film.SOLUTION: A comprising: a polymer having a structural unit derived from α - methylene lactone; and silica particles having a mean particle size of 5 to 100nm.SELECTED DRAWING: None

The present application relates to a kind of seleno lactone compounds.The present application first chemically synthesizes chiral selenium-containing alpha- exo- Methylene lactone compound 1, improves its selectivity to tumor cells;Then attack alpha- exo- Methylene lactone with hydrophilic group and obtain selenium-containing lactone compound 2, enhance its water solubility, and expect that tumor cells will preferentially uptake selenium-containing lactone prodrug 2, then methylate to generate amino positive ion I under the action of SAM enzyme in vivo, and finally release alpha- exo- Methylene lactone warhead 1, so as to improve the selectivity of antitumor effect.The seleno lactone compound provided by the present application can effectively inhibit the proliferation of various cancer cells, has good selectivity to tumor cells;At the same time, it can significantly inhibit the growth rate and volume of tumor in vivo, has excellent antitumor activity, and good safety.The present application provides sufficient scientific basis and theoretical basis for exploring selenium antitumor drug development, has important social value and scientific significance.

To provide an optical film that has excellent bending resistance and contains a copolymer including a structural unit derived from α-methylene lactone.SOLUTION: Optical films 10 and 20 are provided. The optical films 10 and 20 include: a substrate layer 1 containing a copolymer including a structural unit derived from α-methylene lactone and a structural unit derived from alkyl (meth)acrylate; and a coating layer 2 that is disposed on one side of the substrate layer 1 and contains thermoplastic elastomer. The optical films 10 and 20 have total light transmittance of 90% or more.SELECTED DRAWING: Figure 1

The present invention relates to sesquiterpene lactone scaberol C thioether derivatives and preparation methods and applications thereof, and belongs to the field of pharmaceutical technology. The existing scaberol C derivatives are limited by poor targeting, easy metabolic inactivation and other problems. The present invention chemically modifies the α-methylene-γ-lactone pharmacophore of scaberol C by Michael addition reaction and acylation or alkylation reaction, designs and synthesizes a series of thioether derivatives, and improves its anti-tumor effect and selectivity. These thioether derivatives can avoid inactivation by binding to high-content GSH in vivo, so as to better bind to targets in tumor cells. The present invention exhibits excellent anti-tumor activity and good biocompatibility, and provides valuable candidate compounds for the development of anti-tumor drugs.