The invention discloses a construction method of a multi-dimensional similar-orthogonal pseudo-random extended matrix, which comprises the steps of screening and combining primitive polynomials of f1(x), f2(x), ..., fn(x), then carrying out group transformation and numerical conversion, constructing a similar-orthogonal pseudo-random matrix M, then passing through a comb filter with the thresholdof sigma 1, selecting a code group with good relevance and constructing a matrix PN; and then selecting another group of f1'(x), f2'(x), ..., fn'(x), screening, combining, carrying out the group transformation for obtaining a matrix M', then passing through the comb filter with the threshold of sigma 2 which is equal to 0, selecting the completely orthogonal code group, constructing a PN' matrix,finally carrying out direct product operation on the previously produced PN matrix and the completely orthogonal PN' matrix, and obtaining an MSPE matrix PN-PN' after extension. The MSPE matrix PN-PN' after extension through the method has the orthogonal property which is similar to the Walsh matrix, when the MSPE matrix PN-PN' after extension is applied in a CDMA system, the MSPE matrix PN-PN' can obtain the effects which are similar to those of the Walsh matrix. Meanwhile, the size of the matrix is different with the Walsh matrix which is limited by the order of 2, and can be arbitrary value.