38 results about "Group transformation" patented technology

The invention discloses a novel method for preparing 4-(3-chlorine-4-fluorophenylamino)-7-methoxyl-6-(3-morpholinepropoxy)quinazoline (gefitinib, I). The method comprises the following steps of: preparing an intermediate (VI), performing functional group transformation twice under a hydrogenation condition to generate 2-(N,N-dimethylformylimido)-4-methoxyl-5-(3-morpholinepropoxy)cyanophenyl (VIII), and performing ring closure rearrangement on the obtained (VIII) and 3-chlorine-4-fluoroaniline to generate the gefitinib (I). The method is short in steps and high in yield in each step, the intermediate is convenient to purify, a target product has high purity, and the method is suitable for industrial production.

The invention discloses a method for catalytically asymmetrically opening a ring of 3-substituted oxetane by using halogen. The method comprises the following steps: with 3-substituted oxetane and a halogen nucleophile as reaction substrates, under the action of a chiral acid catalyst, performing an asymmetric ring opening reaction to highly selectively synthesize chiral 2-substituted-3-halogenated propanol. The invention further provides preparation of a variety of chiral 2-substituted-3-Nu-propanol products through a reaction performed on the chiral 2-substituted-3-halogenated propanol product obtained in the asymmetric ring opening reaction and a variety of nucleophiles Nu. After adoption of the chiral ring opening method, the reaction for catalytically asymmetrically opening the ring of 3-substituted oxetane with the halogen nucleophile is achieved for the first time; through functional group transformation of halogenated groups in the products, the asymmetric ring opening reaction performed on the variety of nucleophiles and 3-substituted oxetane can be directly achieved; and a high-efficiency synthesis method is provided for preparing chiral 2-substituted-3-Nu-propanol compounds.

The present invention discloses a narrowband and broadband integrated wireless cluster communication system in the data radio station, interphone, cluster communication and wireless communication technology fields. The narrowband and broadband integrated wireless cluster communication system comprises a channel encoding module in electrical output connection with a SYM_MOD module, the SYM_MOD module is in electrical output connection with a sub-band mapping module, and the sub-band mapping module is in electrical output connection with an IFFT module. The IFFT module is in electrical output connection with a sub-phase time domain convolution module, the sub-phase time domain convolution module is in electrical output connection with a time domain signal sampling module, and the time domain signal sampling module is in electrical output connection with a unit delay module. A technical device provided by the present invention fully utilizes the aggregation and decomposition relation of a communication waveform of a narrowband cluster and a communication waveform of a broadband cluster, on the basis of rapid filter group transformation, dynamically adjusts the bandwidth of the system, and supports different businesses.

An optical touch system is provided. At least one light source is disposed at a side of a base plane. A first optical sensor and a second optical sensor detect a space in front of the base plane to generate a first signal and a second signal. When two groups of objects approach to or touch the base plane, a processing unit determines at least one first portion of the first signal corresponding to the two groups of the objects and at least one second portion of the second signal corresponding to the two groups of the objects, and converts the at least one first portion and the at least one second portion into a plurality of touch regions, and determines group transformations according to positions corresponding to at least part of touch regions. Additionally, a method of touch detection, and a computer program product are also provided.

The novel intermediate compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the practical synthetic process for preparing β-carotene by the use of the above novel compound are disclosed. The synthesis of β-carotene is characterized by the double elimination reactions of the C40 compound containing both the benzenesulfonyl group and the group X (either halogen or ether), which can be prepared by the coupling reaction of the novel C10 dialdehyde with two equivalents of the C15 allylic sulfone, followed by the functional group transformation of the resulting C40 diol either to the corresponding halide or to the ether, to produce the fully conjugated polyene chain.

The invention relates to a fully-substituted 3-nitroindole compound as well as a preparation method and application of the fully-substituted 3-nitroindole compound and belongs to the technical field of pharmaceutical chemistry. The compound has a structure shown as a formula (I): the formula (I) is shown in the description; an intermediate has a general structure shown as a formula (II): the formula (II) is shown in the description. A synthesis method of the fully-substituted 3-nitroindole compound and the intermediate of the fully-substituted 3-nitroindole compound, disclosed by the invention, has the characteristics of easiness of obtaining raw materials, moderate reaction conditions, short reaction steps, high yield, low synthetic cost and the like, and is especially suitable for industrial production. The structure of the fully-substituted 3-nitroindole compound has a plurality of fluorine atoms; the fluorine element is introduced so that the bioactivity of the compound is doubled; meanwhile, nitro of the compound is easily subjected to functional group transformation and a foundation is laid for further result modification. The fully-substituted 3-nitroindole compound has various potential pharmaceutical activities. The anti-tumor activity of the fully-substituted 3-nitroindole compound is primarily researched. A research shows that one part of the compound has certain anti-tumor activity and has a wide application prospect.

The invention provides a Gaussian N75 printable wide and narrow newspaper transformation method. Through the steps of triangular plate cutting, base platform hole expansion, moving quantity modification and main paper leading roller group transformation, the narrow-width newspaper printing requirements with great dimension differences can be further met on the basis of maintaining the original wide-width newspaper printing, in addition, the cost of the transformation method is low, and in addition, the wasted work hours are few. In addition, the invention simultaneously provides a printable wide and narrow newspaper double-width rotary press, which is different from ordinary products, through adopting a novel triangular plate structure, a main paper leading roller structure, a transmission structure and a design of sufficient triangular plate horizontal moving quantity, the fast regulation can be realized, so the narrow-width newspaper printing requirements with great dimension differences can be met.

The present invention relates to communication technology, in particular to a method for transforming the organizational structure of an instant messaging group to solve the problems of cumbersome operations and poor usability in the existing group transformation process. The manager supports drag-and-drop transformation, and then sends the keywords of the source group and the target group to the group server when it captures that the user drags and drops the source group to the target group; When the group keyword is a new keyword assigned by the source group, the source group information is modified according to the new keyword of the source group. The method of the present invention reduces the user's operation steps for group members and organizational structure management, reduces the number of protocol data packets sent to the server in a transformation process, reduces the pressure on the server, and improves the user's ability to use groups and manage groups. group experience.

The invention relates to a fully-substituted 3-nitroindole compound as well as a preparation method and application of the fully-substituted 3-nitroindole compound and belongs to the technical field of pharmaceutical chemistry. The compound has a structure shown as a formula (I): the formula (I) is shown in the description; an intermediate has a general structure shown as a formula (II): the formula (II) is shown in the description. A synthesis method of the fully-substituted 3-nitroindole compound and the intermediate of the fully-substituted 3-nitroindole compound, disclosed by the invention, has the characteristics of easiness of obtaining raw materials, moderate reaction conditions, short reaction steps, high yield, low synthetic cost and the like, and is especially suitable for industrial production. The structure of the fully-substituted 3-nitroindole compound has a plurality of fluorine atoms; the fluorine element is introduced so that the bioactivity of the compound is doubled; meanwhile, nitro of the compound is easily subjected to functional group transformation and a foundation is laid for further result modification. The fully-substituted 3-nitroindole compound has various potential pharmaceutical activities. The anti-tumor activity of the fully-substituted 3-nitroindole compound is primarily researched. A research shows that one part of the compound has certain anti-tumor activity and has a wide application prospect.

The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and β-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and β-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.

The invention provides a Gaussian N75 printable wide and narrow newspaper transformation method. Through the steps of triangular plate cutting, base platform hole expansion, moving quantity modification and main paper leading roller group transformation, the narrow-width newspaper printing requirements with great dimension differences can be further met on the basis of maintaining the original wide-width newspaper printing, in addition, the cost of the transformation method is low, and in addition, the wasted work hours are few. In addition, the invention simultaneously provides a printable wide and narrow newspaper double-width rotary press, which is different from ordinary products, through adopting a novel triangular plate structure, a main paper leading roller structure, a transmission structure and a design of sufficient triangular plate horizontal moving quantity, the fast regulation can be realized, so the narrow-width newspaper printing requirements with great dimension differences can be met.

The invention discloses a laboratory-scale synthesizing and curing method of a terminal carboxyl liquid fluorine elastomer. The method comprises the following steps: dissolving a fluorine elastomer in an organic solvent; carrying out oxidative degradation reaction in the presence of oxidant and alkali, in which the reaction time lasts for 8-24 hours, and the reaction temperature changes in a range of 10-40 DEG C; and controlling the dripping speed of the oxidant and the alkali via a peristaltic pump to obtain the terminal carboxyl liquid fluorine elastomer. The synthesizing method has the characteristics of few by-products, simplicity and controllability, and high yield. The terminal carboxyl liquid fluorine elastomer can be cured by reacting with carbodiimide-containing compounds under the normal temperature; the cured product has the characteristics of high mechanical performance, high resistance to high temperature and low temperature and high resistance to chemical media; the terminal carboxyl liquid fluorine elastomer can be used for preparing sealants and adhesives with resistance to chemical media and can also be used for preparing terminal-sealed liquid fluorine elastomers such as hydroxyl, silane, epoxy and amino and the like through terminal group transformation reaction.

The invention relates to a method of using the close-ring reaction of cyclopropane which is induced by the thermal rearrangement of methylene cyclopropyl aldehyde and hydrazide or hydrazine hydrate after the open-ring for synthesizing 2, 3-dibasic pyrrole amine derivatives. No matter substituents in substrates of the methylene cyclopropane aldehyde are aromatic rings with various withdrawing electron or donating electron groups or various alkyls and hydrogen for the substitution of various functional groups in the reaction, the reaction can be carried out successfully. And corresponding pyrrole amine derivatives can be obtained at the yield from medium to perfect. In the reaction, the substrates with pyrrole amine skeletons are generated and are proved to be provided with various perfect biological activities and pharmacological activities in previous researches. Simultaneously, the compounds have perfect modification characteristics. Especially in the synthesis of the pyrrole amine compounds without any protecting group, free amino groups with potential application value can realize various functional-group transformations conveniently. No catalysts and additives are required to be added in the reaction. Therefore, the method is environment-friendly, and products can be purified easily. The reaction can well satisfy the requirement of preparing compounds with high purity in medical chemistry.

A system for performing visible object determination. Visualization software executing on one or more processors searches a cone tree with respect to a hull tree. Both trees respect the same group of transformations. Thus, the cone tree as stored in memory need not store all branches down to ultimate resolution. For example, the cone tree may store a selected cone and all its subcones down to the ultimate resolution, while subcones of other cones at the same level as the selected cone may not be represented in the stored cone tree. When the visualization software encounters a nonstored cone and a given hull H in its search procedure, the visualization software may apply an appropriate one of the group transformations to the given hull, and search the tranformed hull with respect to the selected cone (or a subcone of the selected cone).

Provided are a method and device for performing sparsity-based anti-artifact filtering on video encoding and decoding. The apparatus comprises an encoder (400) for encoding at least a portion of an image by grouping regions within said portion based on a grouping metric, transforming the grouped regions, using de-artifact filtering included in the encoder A filter (413) adaptively performs de-artifact filtering on the transformed region, inverse transforms the de-artifacted region to create a replacement region, and restores the replacement region to the location where the image of the region was taken before grouping.

The invention discloses a construction method of a multi-dimensional similar-orthogonal pseudo-random extended matrix, which comprises the steps of screening and combining primitive polynomials of f1(x), f2(x), ..., fn(x), then carrying out group transformation and numerical conversion, constructing a similar-orthogonal pseudo-random matrix M, then passing through a comb filter with the thresholdof sigma 1, selecting a code group with good relevance and constructing a matrix PN; and then selecting another group of f1'(x), f2'(x), ..., fn'(x), screening, combining, carrying out the group transformation for obtaining a matrix M', then passing through the comb filter with the threshold of sigma 2 which is equal to 0, selecting the completely orthogonal code group, constructing a PN' matrix,finally carrying out direct product operation on the previously produced PN matrix and the completely orthogonal PN' matrix, and obtaining an MSPE matrix PN-PN' after extension. The MSPE matrix PN-PN' after extension through the method has the orthogonal property which is similar to the Walsh matrix, when the MSPE matrix PN-PN' after extension is applied in a CDMA system, the MSPE matrix PN-PN' can obtain the effects which are similar to those of the Walsh matrix. Meanwhile, the size of the matrix is different with the Walsh matrix which is limited by the order of 2, and can be arbitrary value.

The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and β-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and β-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.

The invention discloses a novel method for preparing 4-(3-chlorine-4-fluorophenylamino)-7-methoxyl-6-(3-morpholinepropoxy)quinazoline (gefitinib, I). The method comprises the following steps of: preparing an intermediate (VI), performing functional group transformation twice under a hydrogenation condition to generate 2-(N,N-dimethylformylimido)-4-methoxyl-5-(3-morpholinepropoxy)cyanophenyl (VIII), and performing ring closure rearrangement on the obtained (VIII) and 3-chlorine-4-fluoroaniline to generate the gefitinib (I). The method is short in steps and high in yield in each step, the intermediate is convenient to purify, a target product has high purity, and the method is suitable for industrial production.

The invention discloses an asymmetric full-synthesis method of a natural product (+)-Tanikolide, belonging to the field of organic synthesis. The (+)-Tanikolide has a structure as shown in the specification; and chiral tertiary alcohol is created through a synthesis strategy which is completely different from that of the existing document, and the synthesis of (+)-Tanikolide is correspondingly selectively finished. The synthesis path takes the optically active amino alcohol as a raw material and comprises the following steps of: performing an oxidation reaction to obtain amino aldehyde with maintained configuration; creating chiral quaternary carbon through three-step continuous reaction including Witting reaction, [2,3]-Meisenheimer rearrangement and catalytic hydrogenation; and finally performing functional group transformation to obtain a target product. The total yield is 35%. The operation is convenient, the reaction conditions are moderate, the method is suitable for large-scale preparation, and the optical rotation of the synthesis product is consistent with the optical rotation and optical rotation direction of the natural product (+)-Tanikolide.

Provided is a method for preparing organic montmorillonite by a dry method. Through surface coating, sodium-based conversion, surface modification, group conversion and incubation, the method prepares organic montmorillonite with high temperature resistance and large layer spacing. Soil removal simplifies the original process and increases the peelability of materials.