The invention provides a combinable frequency hopping wireless transmitting-receiving system and an operation method thereof. The system comprises a transmitter and receiver. The transmitter comprises a data interface, a frequency hopping framing device, a transmitter differential frequency hopping module, a transmitter conventional frequency hopping module, a D/A converter and a front emission circuit which are connected in order. The receiver comprises a front receiving circuit, an A/D converter, a receiver conventional frequency hopping module, a receiver differential frequency hopping module, a frequency hopping decoding frame device and a data interface which are connected in order. According to the operation method of the system, a whole work frequency range is divided into M sub frequency ranges with an equal bandwidth, change of conventional frequency hopping is carried out between each segment of frequency band, and change of differential frequency hopping is carried out in a segment. Through conventional frequency hopping, differential frequency hopping and real-time full frequency range frequency hopping, the transmitter generates a frequency hopping signal to be sent. A receiving end completes de-hopping of a received signal according to an opposite sequence, and restores data information. In the invention, two kinds of frequency hopping are employed, two advantages are fully utilized, randomness, anti-interference and anti-investigation capability of the system are raised, and frequency hopping communication performance is effectively raised.