Methods and systems to calibrating a transmitter for I / Q imbalance and local oscillator feed-through include generating a test tone, frequency up-converting the test tone, monitoring one or more features of the up-converted test tone, and adjusting one or more features of the transmitter in response to the monitoring. The monitoring optionally includes monitoring a beating of the envelope of the up-converted test tone. In an embodiment, a first harmonic of the up-converted test tone is monitored for local oscillator feed-through (LOFT). Alternatively, baseband data inputs to the transmitter are disabled, and LOFT is measured by measuring power at the transmitter output. A second harmonic of the up-converted test tone is monitored for gain and phase imbalances. The adjusting optionally includes adjusting a gain imbalance, adjusting a phase imbalance, and / or adjusting DC offsets. The adjusting optionally includes an iterative refinement process. Such a refinement process optionally includes performing a first monitoring, applying a set of relatively coarse settings to the one or more features in the transmitter, monitoring the beating resulting from each of the coarse settings, selecting the coarse setting corresponding the smallest beating, applying a set of relatively fine settings centered around the selected coarse setting, wherein the fine settings are more closely related to one another than are the coarse settings, monitoring the beating resulting from each of the fine settings, and selecting the fine setting corresponding the smallest beating.