65 results about "Aminopropanols" patented technology

The invention discloses a phosphorus-nitrogen flame retardant and a flame-retardant polyvinyl alcohol composite material based on the phosphorus-nitrogen flame retardant, the phosphorus-nitrogen flame retardant is prepared by reacting phenyl phosphorus dichloride with 1, 3-diamino-2-propanol, and the flame retardance of the polyvinyl alcohol composite material can be remarkably improved by adding the phosphorus-nitrogen flame retardant into polyvinyl alcohol through a melt processing method. The phosphorus-nitrogen flame retardant synthesized by the invention combines the advantages of a phosphorus-based flame retardant and a nitrogen-based flame retardant, contains a large amount of hydroxyl groups, has good compatibility with polyvinyl alcohol, has stable properties at about 200 DEG C, is not acidic or alkaline, and can be suitable for the melting processing process of a polyvinyl alcohol film.

The invention belongs to the technical field of raw material preparation, and particularly relates to a production method for co-production of isopropanolamine and DL-2-aminopropanol. The production method for co-production of isopropanolamine and DL-2-aminopropanol comprises the following steps: adding ammonium carbonate, ammonium carbamate, epoxypropane and water into a high-pressure reaction kettle, uniformly stirring, heating to 88-90 DEG C, preserving heat for 30-35 minutes under 0.8 MPa, then heating to 100-103 DEG C, reacting for 40-45 minutes under 1.0 MPa, cooling to room temperature, filtering, washing, and drying to obtain the DL-2-aminopropanol. And after the reaction is finished, carrying out post-treatment to obtain a mixture of isopropanolamine and DL-2-aminopropanol. According to the production method for co-production of isopropanolamine and DL-2-aminopropanol, the process is simple, parameters are easy to control, reaction conditions are relatively mild, it is guaranteed that a large amount of monoisopropanolamine and DL-2-aminopropanol are generated, and meanwhile generation of by-products diisopropanolamine and triisopropanolamine is reduced.

The invention discloses an anti-boron salt-tolerant polymer suspension emulsion and a preparation method thereof, and relates to the technical field of suspension emulsions. The preparation method comprises the following steps: firstly, reacting 1, 3-bis (dimethylamino)-2-propanol with oxalyl chloride monoallyl ester to prepare double-bond modified tertiary amine when preparing the boron-resistant and salt-resistant polymer suspension emulsion; reacting the double-bond modified tertiary amine with propane sultone to prepare an amphoteric monomer; reacting the double-bond modified tertiary amine with 1-bromodecane to prepare a hydrophobic monomer; the preparation method comprises the following steps: copolymerizing acrylamide, maleic acid, an amphoteric monomer and a hydrophobic monomer to prepare modified polyacrylamide; and mixing the modified polyacrylamide, the slurry preparation soil, the polyacrylonitrile ammonium salt, the organic silanol, the emulsified paraffin and the boron inhibitor with water to prepare the boron-resistant and salt-resistant polymer suspension emulsion. The boron-resistant and salt-resistant polymer suspension emulsion prepared by the invention has the advantages of salt resistance, temperature resistance, good filtrate loss reduction performance and boron resistance.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a method for preparing L-aminopropanol by splitting DL-aminopropanol. The resolution method comprises the following steps: (1) preparing immobilized CALB lipase; (2) preparing a bimetallic catalyst; (3) performing transesterification with vinyl acetate under the action of a bimetallic catalyst and the immobilized CALB lipase; and (4) carrying out alkaline hydrolysis reaction with sodium hydroxide, and then carrying out post-treatment to obtain the L-aminopropanol. According to the method for preparing the L-aminopropanol by splitting the DL-aminopropanol, all the steps have a synergistic effect, and it is ensured that the prepared L-aminopropanol has the high yield and purity.

The present invention relates to the field of molecular sieve technology, and in particular to a TON molecular sieve, a preparation method and application thereof, and a TON molecular sieve composition and application thereof. The preparation method of the TON molecular sieve comprises: mixing a silicon source, a fluorine source, an organic template agent Q, water, and an optional heteroatom element X source, and performing a crystallization reaction; the organic template agent is 3-diethylamino-1-propanol, the silicon source in terms of SiO2, the XO in terms of m / 2 The X source is calculated in molar ratio, SiO2:XO m / 2 1:0~0.05, preferably SiO2:XO m / 2 The ratio is 1:0.005-0.04. This preparation method offers the advantages of a simple organic template structure, the absence of high-speed stirring during synthesis, and high product purity. Furthermore, heteroatoms (such as Al, Ti, Zr, and Fe) can be introduced into the framework to create diverse catalytically active centers to meet the needs of different catalytic reactions.

The present invention discloses a method for continuously producing 3-amino-1,2-propanediol, specifically relating to the technical field of producing 3-amino-1,2-propanediol. (1) Ammonolysis reaction; (2) Evaporation and recovery; (3) Coarse distillation and rectification. Beneficial effects: The present invention provides a method for continuously producing 3-amino-1,2-propanediol, which improves the product quality, simplifies the production process of 3-amino-1,2-propanediol, greatly reduces the production cost, by-produces high-value 2-amino-1,3-propanediol and 1,3-diamino-2-propanol (DAP) while synthesizing 3-amino-1,2-propanediol, without low-value by-products, and has good overall economic benefits.

The invention relates to a method for producing 2-aminopropane-1-ol from hydroxyacetone by reductive amination using ammonia water and a co-solvent. The method comprises the following steps: mixing hydroxyacetone and ammonia water at a temperature of not more than 20 DEG C to obtain an oxazoline intermediate product; and adding either a solvent alone or a solvent and a second ammonia water to the oxazoline product in the presence of a nickel catalyst and hydrogen, and hydrogenating at a temperature of not more than 90 DEG C and a pressure of not more than 12 barggage to obtain 2-aminopropan-1-ol.

The invention provides a method for removing heavy metals by acidizing bleaching earth. The heavy metals in the bleaching earth are removed by using a heavy metal adsorbent. Firstly, acrylate reacts with diethanol amine to generate an esterification product, then the esterification product reacts with trimethylolpropane to form a hydroxyl-terminated hyperbranched polymer, and then the hydroxyl-terminated hyperbranched polymer reacts with isocyanate acrylate to introduce double bonds to obtain hyperbranched acrylate. Meanwhile, sodium alginate reacts with 4-chlorophenylboronic acid to obtain boric acid modified sodium alginate, then the boric acid modified sodium alginate reacts with tannic acid to introduce a large amount of hydroxyl groups, and finally the boric acid modified sodium alginate reacts with 3-aminopropanol vinyl ether to introduce double bonds, so that the sodium alginate compound containing double bonds is prepared. And copolymerizing the two monomers with acrylic acid, N-(2-aminoethyl) acrylamide and 2-acrylamido-2-methylpropanesulfonic acid to obtain the adsorbent with a three-dimensional network structure and multiple functional groups. Through the treatment, the heavy metal content of the bleaching earth is obviously reduced, no foreign impurities exist, and the functions of high decolorization rate and strong adsorbability are reserved.

The invention discloses a compound additive, preparation thereof and application of the compound additive in raw gas absorption and oil-water separation. The preparation method comprises the following steps: by taking dimethylaminopropanol as an initiator and taking epoxypropane and ethylene oxide as monomers, carrying out polymerization reaction to prepare block polyether; block polyether serves as a functional main body and is responsible for efficient wetting, cleaning and oil-water separation, a small amount of hyperbranched polyethyleneimine is compounded to serve as a demulsification reinforcing agent and is responsible for electric neutralization and flocculation, and the alkali-resisting and high-temperature-resisting composite additive is obtained, solves the problems that raw gas is not thoroughly absorbed and oil-water separation is difficult, and is used for a raw gas-ammonia water system; secondary emulsification is avoided from the source, and the absorption effect of raw gas and the oil-water separation efficiency are far better than those of traditional auxiliaries.

Disclosed is a process for preparing a reaction product, the process including adding 1-amino-2-propanol into a liquid form of formaldehyde to form an intermediate reaction mixture, wherein the molar ratio of formaldehyde to 1-amino-2-propanol is from 1.4:1 to less than 2:1, and subsequently subjecting the intermediate reaction mixture to reactive distillation to form the reaction product, wherein the predominant compound present in the reaction product is 3,3′-methylenebis[5-methyloxazolidine]. Compositions prepared according to the process are also disclosed.

The invention provides a process method for recovering DL-panthenol mother liquor and application of the process method, and belongs to the technical field of chemical engineering, the process method comprises the following steps: firstly, carrying out solvent separation on the DL-panthenol mother liquor to respectively obtain a gas phase containing ethyl acetate, methanol and water and a liquid phase containing ethyl acetate, 3-aminopropanol, DL-panthenol, pantoic acid and water; carrying out gas phase treatment on the gas phase to obtain a mixed solution containing methanol and ethyl acetate; and carrying out liquid phase treatment on the liquid phase to obtain 3-aminopropanol and pantoic acid lactone. According to the process method provided by the invention, ethyl acetate, methanol, 3-aminopropanol and pantoic acid lactone in the DL-panthenol mother liquor can be recycled in a high-purity and high-yield manner and reused in a preparation link of DL-panthenol, so that the purposes of recycling resources and reducing the cost are achieved, and the process method is suitable for industrial application.

The invention discloses a method for recycling byproducts in preparation of 3-aminopropanol, and relates to the technical field of organic synthesis. The recycling method comprises the following steps: carrying out catalytic oxidation on amine byproducts in an anhydrous solvent to obtain imine, and then carrying out anaerobic hydrolysis to reduce the imine into the product 3-aminopropanol. According to the method, tetra-amino groups in the by-product can be converted into hydroxyl in the form of 3-aminopropanol through single treatment, the reaction yield and atom economy are improved, and the used catalytic system can be recycled.

The present invention discloses a 1-((piperidin-4-yl)amino)propan-2-ol compound, its preparation and application. The structural formula of the 1-((piperidin-4-yl)amino)propan-2-ol compound is shown in Formula I. The compound of the present invention has a low cost and is easy to synthesize, and can be used as an inhibitor of trehalose-6-phosphate synthase in the prevention and control of crop diseases, especially the prevention and control of crop pathogenic bacteria represented by Magnaporthe oryzae, Fusarium graminearum and Botrytis cinerea.

The present invention relates to the field of carbon dioxide capture technology, and discloses a carbon dioxide capture absorption liquid and its application and carbon dioxide capture method. The absorption liquid comprises an absorbent, an activator, an auxiliary agent, and / or a non-aqueous solvent; the absorbent is selected from at least one of 3-amino-1-propanol, monoethanolamine, and diethanolamine. Compared with traditional phase-change absorbents, the absorption liquid has significant advantages such as low viscosity, high carbon dioxide absorption capacity, and low regeneration temperature, and is beneficial for reducing energy consumption and costs in the flue gas carbon dioxide capture process.

The present invention discloses a low-corrosive phase-change absorbent and its application in carbon dioxide capture, belonging to the field of carbon dioxide capture and separation technology. The low-corrosive phase-change absorbent comprises the following components by weight: 10-30% of a main absorbent, 1-10% of an activator, 30-60% of a phase separator, and the balance being water. The phase-change absorbent of the present invention uses 3-aminopropanol (MPA) as the main absorbent, 3-dimethylaminopropylamine (DMAPA) as the activator, and polyethylene glycol dimethyl ether (NHD) as the phase separator, and has the advantages of low energy consumption and low corrosivity.

Provided herein are tablet compositions. Also provided herein are tablets comprising 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl] amino}-1, 3, 5-triazin-2-yl) amino] propan-2-ol or a pharmaceutically acceptable salt thereof.

The invention belongs to the technical field of shape memory high-molecular polymers, and particularly relates to coumarin-based light / heat dual response type shape memory polyurethane as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out a ring-opening polymerization reaction on 2, 2-bis (4-epoxypropoxyphenyl) propane and 3-amino-1-propanol as raw materials in a liquid phase to prepare a prepolymer, and carrying out a polymerization addition reaction on the prepolymer, an isocyanate monomer and a coumarin compound as raw materials in the liquid phase under a catalytic action to prepare the coumarin-modified polyurethane. Light / heat dual response type shape memory polyurethane based on coumarin is prepared; according to the invention, the photoresponse characteristic of the coumarin compound and the temperature response characteristic of the prepolymer are ingeniously combined, so that the dual response to photostimulation and temperature stimulation is realized, and the stimulation response speed and the programming precision controllability of the coumarin-based optical / thermal dual response type shape memory polyurethane are improved.

The invention provides an acyl coenzyme A transferase mutant and an application of the acyl coenzyme A transferase mutant in synthesis of 3-aminopropanol. The acyl coenzyme A transferase mutant comprises: 1) a protein having an amino acid sequence E249 mutated at the following sites of SEQ ID NO: 1 and having acyl coenzyme A transferase activity; and 2) protein which has an amino acid sequence with homology of at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% or at least 99% with the protein in 1) and has acyl coenzyme A transferase activity. The acyl-coenzyme A transferase mutant can be used for synthesizing 3-aminopropanol by taking beta-alanine as a substrate, so that the vacancy that the current market is lack of a biosynthesis method for synthesizing 3-aminopropanol is made up, and the acyl-coenzyme A transferase mutant has the advantages of greenness, environmental protection, simplicity, convenience and the like, and is wide in application prospect.

To provide a method for synthesizing a capped cationic polymer.SOLUTION: Provided is a method that includes: (a) contacting poly(ethylene glycol) diacrylate monomers and 3-amino-1-propanol to form a poly(ethylene glycol) diacrylate / 3-amino-1-propanol cationic polymer by Michael Addition, wherein the molar ratio of the poly(ethylene glycol) diacrylate monomers to 3-amino-1-propanol is greater than 1, and the cationic polymer is acrylate-terminated; and (b) contacting terminal acrylate groups of the cationic polymer with capping molecules comprising amine groups to form the capped cationic polymer by Michael Addition, wherein the capped cationic polymer comprises no acrylate groups.SELECTED DRAWING: Figure 1A

This application relates to the field of drug synthesis technology and provides a method for preparing levofloxacin. The method includes first mixing N,N-dimethylaminoacrylate, triethylamine, and toluene, then adding 2,3,4,5-tetrafluorobenzoyl fluoride dropwise and reacting it with L-2-aminopropanol. After post-treatment, a toluene solution of the amine is obtained. Next, using N,N-dimethylformamide or toluene as a solvent, a cyclization reaction is carried out with differentiated feeding methods and temperature control. The product is purified by hot slurrying with a non-alcoholic organic solvent or a saturated alcohol solution of the levofloxacin cyclase. Finally, the product is purified by acidic hydrolysis, piperacillin reaction, and dimethyl sulfoxide to obtain high-purity levofloxacin. This application optimizes solvent selection and process integration, shortens reaction time, improves product yield and purity, reduces waste emissions, allows for resource utilization of byproducts, and features a simple and easily industrialized process suitable for large-scale production.

The present invention belongs to the field of chemical engineering technology, and particularly relates to a method for synthesizing high-purity DL-panthenol. The method comprises the following steps: S1. Dewatering pretreatment of DL-pantolactone to make the water content in the DL-pantolactone raw material < 0.1%; S2. Using the dewatered DL-pantolactone and 3-aminopropanol as raw materials, with the molar ratio of the two being 1.02 to 1.05:1, and carrying out an acylation reaction in a temperature range of 60 to 90 °C after mixing, controlling the reaction time to be 2 to 3 h to obtain a DL-panthenol reaction solution; S3. After the acylation reaction is completed, adding a mixed solvent composed of ethyl acetate and water to the reaction system, heating to dissolve until clear, and then cooling to 10 to 20 °C for crystallization; filtering the crystallization solution to obtain wet DL-panthenol, and drying the wet product to obtain DL-panthenol. The DL-panthenol obtained by this method has a chromatographic purity > 99.5%, a yield as high as 96 to 98%, and there is no need to cool to a lower temperature during the synthesis.

The invention discloses bio-based polyesteramide as well as a preparation method and application thereof, the preparation method of the bio-based polyesteramide comprises the following steps: (1) dissolving a furyl dicarboxylic acid ester derivative in an organic solvent I to obtain a first mixed solution; (2) dissolving 1, 3-diamino-2-propanol and a catalyst in an organic solvent II to obtain a second mixed solution; (3) simultaneously pumping the first mixed solution and the second mixed solution into a microreactor module for mixed reaction; and (4) collecting a crude product, and carrying out post-treatment to obtain the bio-based polyesteramide. The obtained bio-based polyesteramide can be used as an adhesive and applied to metal ion detection. Polyesteramide synthesized through a one-step method by utilizing a continuous flow technology not only combines the mechanical property of polyamide and the biocompatibility of polyester, but also has good adhesion property and aggregation-induced emission property, and is a bifunctional material integrating an adhesive and a metal ion detection agent.

The present invention discloses a phosphorus-nitrogen flame retardant and a flame-retardant polyvinyl alcohol composite material based thereon. The phosphorus-nitrogen flame retardant is produced by reacting phenylphosphoryl dichloride and 1,3-diamino-2-propanol. Adding the phosphorus-nitrogen flame retardant to polyvinyl alcohol via a melt processing method significantly improves the flame retardancy of the polyvinyl alcohol composite material. The phosphorus-nitrogen flame retardant synthesized in the present invention combines the advantages of phosphorus-based and nitrogen-based flame retardants. Furthermore, due to the presence of a large number of hydroxyl groups, the flame retardant has good compatibility with polyvinyl alcohol. Furthermore, the flame retardant is stable at around 200°C and is neither acidic nor alkaline, making it suitable for the melt processing of polyvinyl alcohol films.

This invention discloses a carbon dioxide collection absorbent, its use, and a method for collecting carbon dioxide, relating to the technical field of carbon dioxide collection. The absorbent comprises an absorbent, an activator, an auxiliary agent, and / or a non-aqueous solvent, wherein the absorbent is at least one selected from 3-amino-1-propanol, monoethanolamine, and diethanolamine. Compared to conventional phase-change absorbents, the absorbent has significant advantages such as low viscosity, high carbon dioxide absorption capacity, and low regeneration temperature, which have positive significance in reducing energy consumption and costs in the process of collecting carbon dioxide from exhaust gas.

The present application relates to the recombinant microorganism for producing 3-amino propanol by fermentation method and its construction method and application. Specifically, the present application provides a construction method of the recombinant microorganism for producing 3-amino propanol, which is introducing the coding gene of omega-transaminase into the microorganism producing 3-hydroxy propionaldehyde, wherein the omega-transaminase can catalyze the conversion of 3-hydroxy propionaldehyde into 3-amino propanol in the presence of amino donor. The present application introduces the omega-transaminase capable of catalyzing the synthesis of 3-amino propanol with 3-hydroxy propionaldehyde as the substrate into the microorganism producing 3-hydroxy propionaldehyde based on gene editing, molecular cloning and other technologies, which first creates a brand new full-path biosynthesis process route of 3-amino propanol.

The invention discloses a tyrosine decarboxylase mutant as well as a preparation method and application thereof. The invention also discloses a method for synthesizing 3-amino-1-propanol by taking L-homoserine as a substrate and carrying out decarboxylation on the L-homoserine by using the tyrosine decarboxylase mutant. Experiments prove that the tyrosine decarboxylase mutant disclosed by the invention can efficiently catalyze a reaction of a substrate L-homoserine to generate 3-amino-1-propanol, and compared with wild tyrosine decarboxylase, the tyrosine decarboxylase mutant disclosed by the invention has the advantages that the catalytic activity of the tyrosine decarboxylase mutant is greatly improved, the highest yield of the 3-amino-1-propanol can reach 0.161 mM, and the highest conversion rate can reach 1.61%. Compared with the existing chemical synthesis method, the synthesis method of 3-amino-1-propanol provided by the invention has the advantages of greenness, environmental protection, low cost and the like, and lays a good foundation for large-scale industrial production of 3-amino-1-propanol.

The utility model discloses a filler replacement mechanism for 3-aminopropanol synthesis, which comprises a mounting cylinder, a mounting frame is detachably mounted on the mounting cylinder through a mounting port, a filler body is arranged on the mounting frame through a positioning component, one end of the mounting frame is provided with a limiting component for limiting and fixing the mounting frame, and the other end of the mounting frame is provided with a positioning component. A sliding groove is formed in the side face of the mounting frame, a sliding rail matched with the sliding groove is arranged on the inner wall of the mounting barrel, the mounting frame is mounted on the mounting barrel in a drawer mode through matching of the sliding groove and the sliding rail, the limiting assembly comprises a mounting base fixed to one end of the mounting frame, and a limiting inserting plate is arranged on the mounting base through a mounting groove. A spring is arranged between the limiting insertion plate and the inner wall of the mounting groove; compared with the prior art, the filling material can be conveniently replaced, the production efficiency can be improved, the reaction condition can be optimized, the production safety can be enhanced, and the production cost can be reduced.

A solvent composition for carbon capture is provided. According to a preferred embodiment, the solvent used for carbon capture comprises: (a) a first component selected from the group consisting of: diethylaminoethanol; 1-(2-hydroxhyl)pyrrolidine; 3-diethylamino-1,2-propanediol; 3-diethylamino-1- propanol; 1-diethylamino-2-propanol and combinations thereof; and (b) a second component selected from the group consisting of: hexamethylenediamine (HMDA); 4-amino-1-butanol and combinations thereof. A method of performing carbon capture using the carbon capture solvent compositions described herein is also provided. An apparatus for performing carbon capture using the carbon capture compositions described herein and / or the carbon capture methods described herein is also provided.

The application belongs to the technical field of organic synthesis, and particularly relates to N-Boc-L-propanolamine and a preparation method and application thereof. The preparation method of the N-Boc-L-propanolamine comprises the following steps: (1) preparing N-Boc-propanolamine: reacting raw material 2-amino propanol with Boc anhydride to obtain N-Boc-propanolamine; (2) synthesizing N-Boc-L-propanolamine: dispersively dissolving N-Boc-propanolamine obtained in step (1), adding hydroxyl oxidase and a pH buffer system, and passing in oxygen, so that N-Boc-propanolamine is reacted with the hydroxyl oxidase; after the reaction is completed, extraction, filtration, alkali washing, concentration, crystallization and drying are performed to obtain the N-Boc-L-propanolamine. The preparation method has the advantages of easy availability of raw materials, low price, simple operation, high product yield and easy industrial production.

The invention discloses a method for synthesizing and purifying levofloxacin hydrochloride, and particularly relates to the field of methods for synthesizing and purifying levofloxacin hydrochloride, which comprises the following steps: 1) a chiral construction stage: reacting (S)-(-)-2-aminopropanol with 2, 3, 4, 5-tetrafluorobenzoyl chloride under a low-temperature alkaline condition to generate a chiral intermediate, and inhibiting racemization through a compound alkali system; 2) a cyclization purification stage: after cyclization of the intermediate and a cyclopropylamine derivative, selectively removing small molecular byproducts by adopting a membrane separation system with molecular weight cutoff of 500Da; 3) a directional salifying stage: performing programmed temperature control crystallization in an acetone / water system, and regulating the crystal form by countercurrent recrystallization in combination with a mixed solvent containing an acetic acid additive; according to the method, integrated preparation of high-optical-purity levofloxacin is achieved, a traditional splitting technology is omitted, the problems of impurity control and crystal form stability are solved synchronously, and the method is suitable for industrial production of antibacterial drugs.