16 results about "Aminopropanols" patented technology

This application relates to the field of drug synthesis technology and provides a method for preparing levofloxacin. The method includes first mixing N,N-dimethylaminoacrylate, triethylamine, and toluene, then adding 2,3,4,5-tetrafluorobenzoyl fluoride dropwise and reacting it with L-2-aminopropanol. After post-treatment, a toluene solution of the amine is obtained. Next, using N,N-dimethylformamide or toluene as a solvent, a cyclization reaction is carried out with differentiated feeding methods and temperature control. The product is purified by hot slurrying with a non-alcoholic organic solvent or a saturated alcohol solution of the levofloxacin cyclase. Finally, the product is purified by acidic hydrolysis, piperacillin reaction, and dimethyl sulfoxide to obtain high-purity levofloxacin. This application optimizes solvent selection and process integration, shortens reaction time, improves product yield and purity, reduces waste emissions, allows for resource utilization of byproducts, and features a simple and easily industrialized process suitable for large-scale production.

This invention discloses a carbon dioxide collection absorbent, its use, and a method for collecting carbon dioxide, relating to the technical field of carbon dioxide collection. The absorbent comprises an absorbent, an activator, an auxiliary agent, and / or a non-aqueous solvent, wherein the absorbent is at least one selected from 3-amino-1-propanol, monoethanolamine, and diethanolamine. Compared to conventional phase-change absorbents, the absorbent has significant advantages such as low viscosity, high carbon dioxide absorption capacity, and low regeneration temperature, which have positive significance in reducing energy consumption and costs in the process of collecting carbon dioxide from exhaust gas.

The present application relates to the recombinant microorganism for producing 3-amino propanol by fermentation method and its construction method and application. Specifically, the present application provides a construction method of the recombinant microorganism for producing 3-amino propanol, which is introducing the coding gene of omega-transaminase into the microorganism producing 3-hydroxy propionaldehyde, wherein the omega-transaminase can catalyze the conversion of 3-hydroxy propionaldehyde into 3-amino propanol in the presence of amino donor. The present application introduces the omega-transaminase capable of catalyzing the synthesis of 3-amino propanol with 3-hydroxy propionaldehyde as the substrate into the microorganism producing 3-hydroxy propionaldehyde based on gene editing, molecular cloning and other technologies, which first creates a brand new full-path biosynthesis process route of 3-amino propanol.

The application belongs to the technical field of organic synthesis, and particularly relates to N-Boc-L-propanolamine and a preparation method and application thereof. The preparation method of the N-Boc-L-propanolamine comprises the following steps: (1) preparing N-Boc-propanolamine: reacting raw material 2-amino propanol with Boc anhydride to obtain N-Boc-propanolamine; (2) synthesizing N-Boc-L-propanolamine: dispersively dissolving N-Boc-propanolamine obtained in step (1), adding hydroxyl oxidase and a pH buffer system, and passing in oxygen, so that N-Boc-propanolamine is reacted with the hydroxyl oxidase; after the reaction is completed, extraction, filtration, alkali washing, concentration, crystallization and drying are performed to obtain the N-Boc-L-propanolamine. The preparation method has the advantages of easy availability of raw materials, low price, simple operation, high product yield and easy industrial production.

This invention discloses a multi-step high-entropy high-enthalpy phase transition hybrid double perovskite material and its preparation method. The preparation method includes the following steps: 1) Weigh at least one of 1,3-propanediamine, N-methyl-1,3-propanediamine, 1,3-diamino-2-propanol, ethylenediamine, N-ethylethylenediamine, and N-(2-hydroxyethyl)ethylenediamine, as well as a salt containing M1, a salt containing M2, and formic acid as raw materials according to stoichiometric ratio; 2) Add the above raw materials to a reaction vessel lined with polytetrafluoroethylene and mix evenly; 3) Seal the reaction vessel and heat it at a constant temperature of 80-110℃ for 36-72h; 4) Cool naturally to room temperature, collect the product, wash and dry it to obtain a material with the chemical formula [A]2[M1M2(HCOO)6]. This material achieves multi-step reversible high-entropy and high-enthalpy phase transitions through heterovalent bimetallic synergy and flexible cyclic ammonium cation design. It also features dielectric response and low-temperature photoluminescence. The phase transition temperature can be tuned to room temperature and near room temperature range, effectively solving the problems of limited phase transition steps, low entropy and enthalpy changes, and poor performance synergy of existing materials.

Provided is a method for preparing 3-aminopropanol by means of a bioenzymatic process, which method comprises: using 3-hydroxypropanal as a substrate and ω-transaminase as a catalyst to perform a catalytic reaction on the substrate 3-hydroxypropanal, thereby obtaining 3-aminopropanol.

Disclosed in the present invention are a 5-substituted indoline chiral amine compound I, a preparation method therefor, and a preparation method for silodosin. Silodosin is prepared from an indoline derivative and a (R)-2-aminopropanol derivative as starting materials by steps of converting the (R)-2-aminopropanol derivative into an aziridine derivative; halogenating the indoline derivative to obtain a compound of formula III, then forming a Grignard reagent from same, and in the presence of a Cu(I) catalyst, reacting same with the (R)-2-aziridine derivative to obtain the 5-substituted indoline chiral amine I; and performing a formylation reaction, an oximation reaction, a dehydration reaction, an N-alkylation reaction, deprotection of hydroxyl, deprotection of amino, and a hydrolysis reaction to obtain silodosin. The present invention uses an efficient chiral source introduction mode, wherein the 5-substituted indoline chiral amine is prepared by converting D-alanine into a chiral aziridine derivative and reacting same with an indoline moiety, thereby omitting an optical resolution step, such that the obtained compound has a high ee value and the yield is improved.

The invention belongs to the field of biological medicine, and discloses an AER270 diagnosis and treatment prodrug with hypochlorous acid response characteristic as well as a preparation method and application thereof, the AER270 diagnosis and treatment prodrug has a structure as shown in a general formula I. Based on a core structure of methylene blue (MB), gamma-aminobutyric acid (GABA), gabapentin or aminopropanol is used as a connecting chain, and is coupled with an AQP4 inhibitor AER270 through an ester bond or an ether bond, so that the prodrug is prepared. According to the present invention, the HOCl specific activation rupture release active molecules AER270 and GABA or gabapentin is achieved, the penetrability on the blood brain barrier and the selective treatment on the cerebral apoplexy focus are enhanced, the reduced methylene blue molecule is released, the cerebral apoplexy focus can be specifically lightened, and the diagnosis and treatment integration is achieved.

The invention discloses a low-temperature desorption and high-cycle-stability absorption liquid for capturing carbon dioxide and a preparation method and application thereof, and relates to the technical field of gas separation and purification, the absorption liquid comprises a main absorption component, an auxiliary agent and a solvent; the main absorption component is at least one of N-ethyl piperazine, 1-methyl piperazine and N-hydroxyethyl piperazine; the solvent is at least one of 1-dimethylamino-2-propyl alcohol, diethylaminoethanol and N, N-dimethylethanolamine; and the auxiliary agent is selected from a composite antioxidant and a desorption accelerator. Through the multi-component collaborative design, the system has excellent low-temperature desorption performance and long-term cycle stability on the premise of maintaining high trapping efficiency, long-term stable and efficient operation of the amine liquid is ensured, the operation cost caused by amine liquid degradation, equipment corrosion and high energy consumption is reduced, and good application prospects are achieved.

The application discloses a composite auxiliary agent and a preparation and application thereof in crude coal gas absorption and oil-water separation. The application uses dimethylaminopropanol as a starting agent, and carries out polymerization reaction with propylene oxide and ethylene oxide as monomers to prepare a block polyether; then, the block polyether is used as a functional main body, is responsible for efficient wetting, cleaning and oil-water separation, and a small amount of hyperbranched polyethylene imine is compounded as a demulsification enhancer, is responsible for electric neutralization and flocculation, so that an alkali-resistant and high-temperature-resistant composite auxiliary agent is obtained, the problems of incomplete crude coal gas absorption and difficult oil-water separation are solved, the crude coal gas-ammonia water system is used, the "secondary emulsification" is avoided from the source, and the absorption effect of the crude coal gas and the oil-water separation efficiency are far higher than those of a traditional auxiliary agent.

The invention provides a preparation process of high-purity D-panthenol, and belongs to the technical field of pharmaceutical chemistry synthesis. The preparation process comprises the following steps: mixing D-pantoic acid lactone and 3-aminopropanol in a solvent for reaction to obtain a D-panthenol crude product, adding an extracting agent into the D-panthenol crude product, carrying out extraction operation for 0-4 times at the temperature of 30-40 DEG C, separating out the D-panthenol crude product, dissolving the D-panthenol crude product with methanol, concentrating until the solvent residue accounts for 15-25% of the mass of the material, and distilling by using a molecular distiller to obtain the D-panthenol. The high-purity D-panthenol is obtained. The process provided by the invention can effectively control the content of 3-aminopropanol, D-pantoic acid lactone and other impurities in D-panthenol, and can ensure the limit level of the impurities in the stable placement period of the product. The method disclosed by the invention is strong in impurity removal capacity, high in distillation efficiency, simple and convenient to operate, good in product quality, high in stability and suitable for large-scale production.

The present application relates to the use of omega-transaminase in the preparation of 3-aminopropanol by biological enzyme method. Specifically, the present application provides a method for preparing 3-aminopropanol by biological enzyme method, which comprises using 3-hydroxypropionaldehyde as a substrate and using omega-transaminase as a catalyst to catalyze the substrate 3-hydroxypropionaldehyde, thereby obtaining 3-aminopropanol.

The application discloses a kind of low-temperature desorption and high cycle stability absorption liquid for capturing carbon dioxide and its preparation method and application, it is related to gas separation and purification technical field, including main absorption component, auxiliary agent and solvent;Main absorption component is at least one of N-ethyl piperazine, 1-methyl piperazine and N-hydroxyethyl piperazine;Solvent is at least one of 1-dimethylamino-2-propanol, diethylaminoethanol and N,N-dimethylethanolamine;Auxiliary agent is selected from composite antioxidant and desorption promoter.The multi-component synergistic design of the application makes the system maintain high capture efficiency under the premise, with excellent low-temperature desorption performance and long-term cycle stability, ensures that amine liquid long-term stable and efficient operation, reduces the operating cost caused by amine liquid degradation, equipment corrosion and high energy consumption, with good application prospect.

This invention relates to the field of multifunctional new materials technology, particularly to symmetrical multidentate Schiff base trinuclear rare earth complexes, their preparation methods, and applications. The structural formula is: R represents a trivalent rare earth ion. The complex molecule is cage-like, encapsulating reactants in catalytic reactions, reducing side reactions and byproduct formation, and improving reaction efficiency and purity. Simultaneously, the molecular cage selectively adsorbs and directionally regulates specific types of molecules through the size and chemical properties of its channels, promoting specific reaction pathways and further enhancing catalyst efficiency and selectivity. The method involves heating 3-amino-2-hydroxyacetophenone with 1,3-2-amino-2-propanol to generate an intermediate. This intermediate is then reacted with o-vanillin to generate ligand L. Ligand L is deprotonated, and a rare earth metal salt is added to obtain the symmetrical multidentate Schiff base trinuclear rare earth complex. This method is simple, low-cost, and suitable for industrialization. It solves the problems of low catalytic efficiency and poor selectivity in existing catalysts.

The present invention relates to a recombinant microorganism producing 3-aminopropanol by means of a fermentation method, a construction method therefor, and a use thereof. Specifically, the present invention provides a method for constructing a recombinant microorganism producing 3-aminopropanol. The method comprises: introducing an encoding gene for ω-transaminase into a microorganism producing 3-hydroxypropionaldehyde, wherein the ω-transaminase is capable of catalyzing the conversion of 3-hydroxypropionaldehyde into 3-aminopropanol in the presence of an amino donor. On the basis of techniques such as gene editing and molecular cloning, the present invention introduces ω-transaminase, which is capable of catalyzing the synthesis of 3-aminopropanol from 3-hydroxypropionaldehyde as a substrate, into a microorganism producing 3-hydroxypropionaldehyde, thereby creating a brand-new process route for full-path biosynthesis of 3-aminopropanol for the first time.

This invention belongs to the field of gas separation and carbon capture technology, specifically relating to a CO2 adsorbent suitable for treating hot flue gas, its preparation method, and its application, particularly suitable for the efficient capture and separation of CO2 in medium- and high-temperature industrial hot flue gas systems. The adsorbent is a ternary eutectic solvent, with 4-methylimidazole (4MI) as the first hydrogen bond acceptor, 3-aminopropanol (3AP) as the hydrogen bond donor, and monoethanolamine (MEA) as the second hydrogen bond acceptor; wherein the molar ratio of 4-methylimidazole (4MI) to 3-aminopropanol (3AP) is 1:3, and the mass of monoethanolamine (MEA) accounts for 20-40 wt% of the mass of the binary eutectic solvent composed of 4MI and 3AP. This invention solves the problem of decreased absorption capacity and inability to adapt to industrial hot flue gas scenarios of existing DES-type CO2 adsorbents at medium and high temperatures, achieving efficient CO2 capture in a temperature range of 20-100℃. Simultaneously, this adsorbent possesses characteristics of water resistance, good thermal stability, and excellent cycle performance, making it suitable for industrial applications.