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Preparation method and application of ruthenium carbon catalyst used for preparation of L-aminopropanol

A ruthenium carbon catalyst, aminopropanol technology, applied in the preparation of organic compounds, chemical instruments and methods, physical/chemical process catalysts, etc., can solve the problems of poor activity, high production cost, short continuous service life, etc. Less, short response time, economical cost saving effect

Inactive Publication Date: 2018-02-23
XIAN CATALYST NEW MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current ruthenium carbon catalysts on the market have poor activity and short continuous service life, resulting in high production costs for this step reaction

Method used

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  • Preparation method and application of ruthenium carbon catalyst used for preparation of L-aminopropanol
  • Preparation method and application of ruthenium carbon catalyst used for preparation of L-aminopropanol
  • Preparation method and application of ruthenium carbon catalyst used for preparation of L-aminopropanol

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Experimental program
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Effect test

Embodiment 1

[0028] The ruthenium carbon catalyst for the preparation of L-aminopropanol in this embodiment is composed of activated carbon and metal components loaded on the activated carbon, the particle size of the activated carbon is less than 300 mesh, and the specific surface area of ​​the activated carbon is 1600m 2 / g, the metal component is ruthenium and an auxiliary agent, the auxiliary agent is palladium, and the mass content of ruthenium in the catalyst is 5%, and the mass content of palladium is 1%; the L-aminopropanol uses ruthenium The preparation method of charcoal catalyst comprises the following steps:

[0029] Step 1: Add 10g of sieved activated carbon below 300 mesh into the nitric acid solution with a concentration of 12mol / L and stir evenly, then heat and boil for 2 hours, then stop heating, and after the boiled mixture is naturally cooled, use Wash with ionic water until the pH value of the lotion is neutral, and obtain pretreated activated carbon after filtration; ...

Embodiment 2

[0034] This embodiment is the same as embodiment 1, wherein the difference is that the auxiliary agent is one of platinum, rhodium, molybdenum, cobalt and nickel, or is one of platinum, palladium, rhodium, molybdenum, cobalt and nickel. Two or more.

Embodiment 3

[0036] The ruthenium carbon catalyst for the preparation of L-aminopropanol in this embodiment is composed of activated carbon and metal components loaded on the activated carbon, the particle size of the activated carbon is less than 300 mesh, and the specific surface area of ​​the activated carbon is 1600m 2 / g, the metal component is ruthenium and auxiliary agent, the average particle diameter of described ruthenium is 20nm~40nm, and described auxiliary agent is platinum, and the mass content of ruthenium is 5% in the described catalyst, and the mass content of platinum is 0.5%; The preparation method of described L-aminopropanol with ruthenium carbon catalyst comprises the following steps:

[0037] Step 1. Add 10 g of activated carbon that has been screened to below 300 mesh into the nitric acid solution with a concentration of 12 mol / L and stir evenly, then heat and boil for 1 hour, then stop heating, and after natural cooling, wash with deionized water until the washing l...

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Abstract

The invention provides a preparation method for an aruthenium carbon catalyst used for the preparation of L-aminopropanol. The method includes the following steps that 1, pretreatment is conducted onactivated carbon; 2, a soluble ruthenium compound and a soluble salt of an auxiliary agent are dissolved in a solvent, and a precursor solution is obtained; 3, the precursor solution is added in the activated carbon through atomization and dispersion, after uniform stirring, slurry is obtained, and then pH value adjustment, adsorption, filtration and washing are conducted; 4, after the solvent issubjected to beating, high-temperature and high-pressure reduction treatment is conducted, then, filtration and washing are sequentially conducted, and a ruthenium carbon catalyst is obtained. The invention further provides a method for applying the catalyst to the preparation of L-aminopropanol through catalytic hydrogenation of L-alanine. The prepared aruthenium carbon catalyst is high in activity and suitable for the preparation of L-aminopropanol through catalytic hydrogenation of L-alanine, the product yield is more than 90%, the catalyst performance is stable, the reaction time is short,and the catalyst is used repeatedly and has good repeatability.

Description

technical field [0001] The invention belongs to the technical field of noble metal catalysts, and in particular relates to a preparation method of a ruthenium carbon catalyst for preparing L-aminopropanol. Background technique [0002] L-Aminopropanol is an important intermediate for the synthesis of the third-generation quinolone antibacterial drug levofloxacin, which has a broad antibacterial spectrum, strong antibacterial effect, small toxic and side effects, and no cross-resistance with other antibiotics Etc. At the same time, L-aminopropanol is also widely used as a chiral modifier in the resolution of racemates, so there is a huge market demand. [0003] For a long time, the research on the synthesis method of L-aminopropanol at home and abroad can be mainly divided into two categories, one is the chiral resolution method, and its important process is to prepare DL-aminopropanol, which is obtained by chiral resolution. L-aminopropanol, but due to the high difficulty ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J23/46B01J23/89B01J35/00C07C213/00C07C215/08
CPCC07C213/00B01J23/462B01J23/8913B01J23/892B01J23/8993B01J37/0207B01J37/343B01J35/393B01J35/399B01J35/618C07C215/08
Inventor 李小虎张磊李岳锋曾利辉曾永康李钊牟博张之翔
Owner XIAN CATALYST NEW MATERIALS CO LTD
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