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Synthesis method of 2-aminopropanol

A synthesis method and aminopropanol technology are applied in the preparation of amino hydroxy compounds, chemical instruments and methods, preparation of organic compounds, etc., and can solve the problems of high production cost, high risk, and many by-products, and achieve convenient operation, The effect of less by-product formation and emission reduction

Active Publication Date: 2020-04-10
杭州新本立医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0016] Therefore, there are problems such as high production cost, high risk, and many by-products in the 2-aminopropanol production process in the prior art, requiring researchers to innovate research ideas to design a 2-aminopropanol preparation method suitable for industrialized production

Method used

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  • Synthesis method of 2-aminopropanol
  • Synthesis method of 2-aminopropanol
  • Synthesis method of 2-aminopropanol

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Embodiment 1

[0034] Preparation of Rare Earth Modified Catalyst The hydrogen-type mordenite molecular sieve with a silicon-aluminum ratio of 22:1 and 0.3mol / L cerium nitrate were ion-exchanged at 80°C for 4 hours at a solid-to-liquid mass ratio of 1:15, and then washed, Filtrate and dry, and program the temperature to 550° C. to roast for 4 hours to obtain a cerium-modified hydrogen-type mordenite (H-MOR) molecular sieve catalyst.

[0035] Preparation of 2-aminopropanol In a tubular fixed-bed reactor, place a cerium-modified catalyst, raise the temperature of the system to 150°C, and then mix and pass it into the Stay in a tubular fixed-bed reactor for 30 seconds to obtain 2-aminopropanol.

Embodiment 2

[0037] Preparation of Rare Earth Modified Catalyst The hydrogen-type mordenite molecular sieve with a silicon-aluminum ratio of 22:1 and 0.3mol / L lanthanum nitrate were ion-exchanged at 80°C for 4 hours at a solid-to-liquid mass ratio of 1:15, and then washed, Filtrate and dry, and program the temperature to 550° C. to roast for 4 hours to obtain a lanthanum-modified hydrogen-type mordenite (H-MOR) molecular sieve catalyst.

[0038] Preparation of 2-aminopropanol In a tubular fixed-bed reactor, place a lanthanum-modified catalyst, raise the temperature of the system to 150°C, and then mix and pass it into the Stay in a tubular fixed-bed reactor for 30 seconds to obtain 2-aminopropanol.

Embodiment 3

[0040] Preparation of Rare Earth Modified Catalyst The hydrogen-type mordenite molecular sieve with a silicon-aluminum ratio of 22:1 and 0.3mol / L yttrium nitrate were ion-exchanged at 80°C for 4 hours at a solid-to-liquid mass ratio of 1:15, and then washed, After filtering and drying, the temperature was programmed to rise to 550° C. and calcined for 4 hours to obtain a yttrium-modified hydrogen-type mordenite (H-MOR) molecular sieve catalyst.

[0041] Preparation of 2-aminopropanol In a tubular fixed-bed reactor, a yttrium-modified catalyst was placed, the system was heated up to 150°C, and then mixed and passed into the Stay in a tubular fixed-bed reactor for 30 seconds to obtain 2-aminopropanol.

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Abstract

The invention discloses a synthesis method of 2-aminopropanol. According to the method, epoxypropane and liquid ammonia are taken as raw materials, epoxypropane and liquid ammonia are introduced intoa fixed bed reactor, the molar ratio of epoxypropane to liquid ammonia is 1: (5-20), and under the action of a rare earth modified catalyst, reaction is carried out for 10-60s at the temperature of 100-200 DEG C, so that 2-aminopropanol is obtained. The method is reasonable in process, simple and convenient to operate, high in atom economy and low in emission of three wastes, and meets the requirements of industrial production.

Description

technical field [0001] The present invention relates to a kind of synthetic method of 2-aminopropanol. Background technique [0002] Ofloxacin is a third-generation quinolone antibacterial drug, its chemical name is (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl )-7-oxo-7H-pyrido[1,2,3-de]-[1,4]benzoxazine-6-carboxylic acid. Ofloxacin has a wide antibacterial spectrum, definite curative effect, and low toxicity and side effects, so it is widely used clinically. At present, 2-aminopropanol is mostly used as the starting material for industrial production in China. [0003] In the prior art, the synthetic method of 2-aminopropanol mainly contains following several kinds: [0004] 1. Ammonolysis method of hydroxyacetone [0005] Using monochloroacetone as the raw material, using dimethyl carbonate as the solvent and KI as the catalyst, after acetylation, hydrolysis to obtain hydroxyacetone, and then reductive amination under the catalysis of Raney Ni to obtain ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/04C07C215/08
CPCC07C213/04C07C215/08Y02P20/584
Inventor 顾海宁琚建利
Owner 杭州新本立医药有限公司
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